Researchers at Uppsala University have developed a new method to produce sustainable hydrogen using composite polymer nanoparticles. The 'polymer dots' showed promising performance and stability in laboratory tests, with a 7% efficiency rate at 600 nanometres.
A study published in Cell Death & Disease found that inhibiting the EZH2 protein can reduce cancer cell growth in multiple myeloma. The researchers discovered that certain metabolic pathways are altered in cells sensitive to EZH2 inhibition, providing potential markers for treatment response.
A new, more complete dog reference genome has been built using DNA sequencing and annotation techniques. The improved genome will aid in understanding the link between DNA and disease in dogs and their human counterparts.
A study found that higher blood pressure at night than day increases the risk of Alzheimer's disease in older men. Researchers analyzed data from 1,000 Swedish men and found a 64% increased risk of dementia diagnosis among those with reverse dipping blood pressure patterns.
New study by Uppsala University researchers identifies ACE2 and integrin beta3 as potential key players in SARS-CoV-2 cell infection. The proteins interact with cellular processes of uptake and disposal, suggesting hijacking during infection.
A new study by researchers at Uppsala University found that physical training during cancer therapy improves physical and mental health, regardless of intensity level. The study showed that both high- and low-intensity training had similar benefits, including reduced fatigue and improved leg muscle strength.
Researchers at Uppsala University used computer simulations to study ions in molten salts and found that they can interact and move in unexpected ways. The study's findings suggest that lighter anions like fluoride and chloride can be attracted to both lithium ions and the positive anode, leading to slower movement towards the cathode.
A new study found no link between countries' frequency of natural disasters and their propensity to take disaster risk reduction (DRR) measures. Despite this, national variation was observed, with some countries responding with extensive changes while others made no action.
A new study by Uppsala University researchers found that adverse childhood experiences (ACEs) have serious lifelong repercussions on people's lives and health. Couples who experienced ACEs had lower educational attainment, poor couple relationships, and higher rates of anxiety and depression.
A study from Uppsala University reveals that all European eels share the same gene pool, regardless of their location. The team used whole-genome analysis to compare DNA sequences from eels across Europe and North Africa, finding no significant differences in gene variants.
Researchers discovered that random DNA sequences can generate new genes producing antibiotic resistance, which can spread quickly among bacteria. The study used laboratory experiments with E. coli and found six peptides causing Colistin resistance by modifying the cell membrane.
Researchers at Uppsala University have discovered a link between faulty L-Dopa metabolism and severe side effects in Parkinson's patients. Abnormally elevated levels of L-Dopa and its metabolite were detected in brain regions outside the striatum, suggesting alternative mechanisms underlying motor disorders.
A study by Uppsala University found that parents of children diagnosed with cancer are differently financially affected. In contrast to previous research, which showed that mothers were more affected than fathers, this study reveals that fathers experience negative long-term effects on their income and employment.
A comprehensive study of over 250,000 women found oral contraceptives significantly reduce the risk of ovarian and endometrial cancer, with benefits persisting even years after use ends. The findings contradict previous associations with increased breast cancer risk.
Researchers at Uppsala University have developed a new analysis method that can predict the risks and effects of immunotherapy drug Rituximab. The study found differences in how the drug interacts with healthy individuals versus patients with chronic lymphocytic leukemia, providing valuable insights into individual responses to treatment.
A new study published in the American Journal of Psychiatry suggests that a progesterone receptor modulator may be an effective treatment for premenstrual dysphoric disorder (PMDD). The treatment showed significant improvement in mental symptoms, with half of women experiencing complete relief.
A large cohort study found that dog owners with diabetes are 38% more likely to develop type 2 diabetes than those without. In contrast, no shared risk was detected in cat owners and their cats.
A new study reveals that rare small cat species in the Indian subcontinent are insufficiently protected, with broadleaved forests and wetlands being critical habitats.
Researchers at Uppsala University have developed a new coating material for semiconductors that can produce fuels more sustainably using sunlight and electricity. The study shows that the coating reduces the voltage needed in the process, making it more energy-efficient.
A large international consortium has sequenced the genome of 130 mammals and analyzed existing data to identify important DNA positions. This information can help researchers understand disease mutations in humans and preserve endangered species.
New research at Uppsala University reveals Swedish, Finnish and Russian wolves share a common genetic constitution, indicating a virtually pure origin from Finland and Russia. Genetic analysis of over 200 wolf samples found no evidence of hybridization with dogs in the Fennoscandian wolf population.
Researchers found epigenetic biomarkers that indicate chronic stress in commercially raised chickens, potentially leading to improved animal welfare and quality meat. The study suggests a diagnostic tool could be developed to track recurrent stress in production animals.
Researchers have discovered embryo-like microfossils in Greenland, dating back 570 million years, which could provide new insights into the origin of animals. The finds are significant as they reveal that these organisms were dispersed throughout the world, challenging previous assumptions about their distribution.
Researchers at Uppsala University have discovered two previously unknown fungus species using a novel method based on DNA analysis of soil samples. These fungi are thought to play a key role in the ecosystem, but their exact function remains unclear.
A new treatment method increases the body's own degradation of protein building blocks, reducing all types of aggregates. The method uses somatostatin fused to a brain transport protein, allowing it to enter the brain and target the smallest, most toxic aggregates.
Researchers at Uppsala University developed a new AI-based method for analyzing gene activity in tissues using graph neural networks. This approach enables the detection of new cell types and intra- or intercellular functions without prior knowledge of expected cell types, greatly expanding our understanding of cellular behavior.
A tiny jaw from Greenland has revealed the earliest known example of dentary bone with two rows of cusps on molars and double-rooted teeth, offering insights into mammal tooth evolution. The discovery suggests that complex occlusion and double-rooted teeth developed together in early mammals.
A study by Uppsala University researchers suggests that nitric oxide may be an effective treatment for COVID-19, with antiviral properties that inhibit the replication of the SARS-CoV-2 virus. The compound is produced naturally in the body and has been shown to reduce inflammation and boost blood-oxygen saturation levels.
Researchers developed a new method to determine the effectiveness of combining two antibiotics, providing greater scope for customizing treatment. The CombiANT method allows laboratories to easily test interactions and can provide crucial information for treating bacterial infections.
Researchers at Uppsala University have reconstructed the birth of a male sex chromosome in Atlantic herring, identifying a tiny region with only three genes. This discovery sheds light on the evolution of sex determination and provides insights into the genetic mechanisms underlying sex-based traits.
The BATTERY 2030+ initiative aims to create more environmentally friendly and safer batteries with better performance, storage options, and longer life. The seven projects will focus on developing sensors for real-time monitoring, self-healing components, and new battery concepts.
Researchers develop 'PhenoChip' to select and propagate single photosynthetically active cells, enabling fundamental industry applications and improved ecosystem understanding. The technology helps identify resilient cells in natural environments, such as coral reef health, and can aid in mitigating climate change impacts.
Researchers at Uppsala University found that a key mechanism of clot formation in COVID-19 may be activation of the complement system, triggered by elevated mannose-binding lectin (MBL) levels and activity. MBL can contribute to a massive activation of the blood coagulation system, resulting in thrombosis.
New research from Uppsala University reveals that Swedish construction workers' wages rose by 176% between 1831 and 1900, surpassing other European cities like Amsterdam and Paris. This unexpected trend can be attributed to high labor market mobility and mass emigration to America, which reduced the supply of unskilled labor.
Researchers found Anoxychlamydiales, a group of Chlamydiae living without oxygen, with hydrogen-producing genes. These genes were likely exchanged with eukaryotes during the evolution of complex life, providing insight into the origins of eukaryotic cellular complexity.
Researchers at Uppsala University have discovered that the ACE2 enzyme is present throughout the human body, but at very low levels in the respiratory system. This finding suggests that other factors may be necessary for SARS-CoV-2 infection and disease progression.
Researchers at Uppsala University have discovered new ways to combine drugs for glioblastoma patients, tailoring therapy to individual tumours. The study characterised how genetic aberrations influence drug effectiveness, revealing two main subgroups based on response and mutations.
Researchers used synchrotron microtomography to visualize ancient fossils and found that acanthothoracid teeth were attached to jaw-bones like modern fish and land animals. This discovery challenges the common perception that sharks are primitive living vertebrates.
A new study reveals that palm trees are the most abundant tree species in American rainforests, outnumbering other tropical forest plants by a significant margin. The research, led by scientists at Uppsala University and University of Campinas, Brazil, has quantified palm numbers globally for the first time.
A new mathematical model for solar irradiance prediction has been developed at Uppsala University and proved highly reliable. The MCM model provides accurate forecasts of solar power production fluctuations, enabling greater control over solar energy use.
Researchers discovered that platelet-derived growth factor B (PDGFB) plays a key role in maintaining the vascular barrier in tumors, reducing the spread of cancer cells. In mouse models, PDGFB deletion from platelets led to increased circulating tumor cells and metastasis.
Researchers developed new microscopy approach to directly observe transcription factor proteins sliding along DNA and their binding mechanisms. The study reveals that these proteins frequently miss their target site, employing a 'hopping' mechanism to trade thorough scanning for speed.
Researchers at Uppsala University have resurrected billions-year-old enzymes and repurposed them to catalyse new chemical reactions. The study develops sustainable solutions in biotechnology and chemically degrades environmental toxins.
Researchers at Uppsala University have developed a method to identify functional mutations in non-coding regions that contribute to the development of glioblastoma. The study reveals that specific mutations in these regions can disrupt gene regulation and lead to cancer progression.
A new study finds that temperate insects are as threatened by climate change as tropical species due to their inactive periods. The researchers analyzed insect populations and found temperatures close to optimal or critical limits, risking population decline and ecosystem disruption.
Researchers analyzed DNA from 25 Stone Age individuals and found that those buried in typical Pitted Ware culture graves were genetically similar to earlier Scandinavian hunter-gatherers. The presence of Battle Axe culture influences in some graves suggested trade and cultural exchange between the groups, rather than genetic migration.
Researchers at Uppsala University developed a new test method to measure hydroxychloroquine levels in patients with systemic lupus erythematosus (SLE). The analysis method, based on high-resolution mass spectrometry, reveals significant individual variations in medication metabolism.
Cold-adapted enzymes from low-temperature organisms exhibit distinctive properties that enable them to function in freezing conditions. However, they often stop functioning at around room temperature, until they start melting. Researchers have now explained this phenomenon through extensive computer simulations.
Researchers at Uppsala University used synchrotron X-rays to study the organ of balance and surrounding blood vessels. The discovery of a drainage system may improve understanding of how Ménière's disease arises from fluid accumulation in the inner ear.
Researchers developed an AI tool to automatically diagnose atrial fibrillation and five common ECG abnormalities, comparable to human diagnosis. The AI was trained on a large database of manually diagnosed ECGs and shows great potential for improved cardiovascular care in low-income countries.