Articles tagged with Metaanalysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research analyzed 15 studies involving over 6,000 university students and found no significant difference in alcohol consumption or problems among fraternity members. The study suggests that stronger interventions may be needed for student members of Greek letter organizations.
A recent Iowa State University study found no evidence that grit improves performance, contradicting popular views on the trait. The research analyzed over 67,000 people and concluded that grit is not a unique predictor of success.
A study by April Cascasan and Thomas Marler reveals that cycad biologists have limited access to crucial information due to inadequate keyword use in historical publications. The authors suggest incorporating keywords like 'cycad' into article titles or index lists to improve discoverability.
A global review of 13,559 participants found that poverty was the most common reason reported by children and youth for being on the streets, followed by family conflict and abuse. The study highlights the urgent need for international collaborations to prevent street involvement and assist those already involved.
A meta-analysis of randomised controlled trials suggests that antibiotics can be used as primary treatment for mild appendicitis, reducing surgeries by 92% within the first month. However, recurrence rates remain high at 23% and long-term follow-up is needed to determine effectiveness.
A new meta-analysis supports the link between Omega-3 supplementation and reduced major depressive disorder (MDD) rates. The study found a comparable benefit to antidepressants in patients taking EPA and DHA supplements.
A meta-analysis published in European Urology found that vaginal delivery increases the risk of stress urinary incontinence by almost twice, with an absolute risk increase of 8%, compared to caesarean section. The effect is more pronounced in younger women and decreases over time.
A meta-analysis suggests that text messaging can increase medication adherence in chronic disease patients, but further research is needed to confirm the findings and determine their clinical significance. The study's results have implications for developing low-cost, widely available technologies to improve patient outcomes.
A new meta-analysis reveals that hookah smokers inhale a large load of toxicants, with one session delivering 25 times the tar and 125 times the smoke of a single cigarette. The study suggests that hookah tobacco smoking should be monitored more closely to address this growing health concern.
A new meta-analysis found that psychological therapies can reduce IBS symptoms for at least six months after treatment ends. The study analyzed 41 clinical trials involving over 2,200 patients, revealing no significant difference in effectiveness between different types of psychotherapy.
A meta-analysis of five RCTs found no significant differences between nalmefene and placebo in mortality, quality of life, or mental health outcomes. However, participants taking nalmefene had fewer heavy drinking days and lower total alcohol consumption compared to those on placebo.
A meta-analysis of structural MRI volumes found no significant difference in hippocampal size between men and women. The study challenges common claims about sex differences in the brain, citing minimal differences in key areas such as emotional expressiveness, verbal memory, and brain communication.
A large meta-analysis of over 68,000 adults found that low-fat diets do not lead to greater weight loss in the long term compared to higher-fat diets. The analysis suggests that alternative diets like low-carb or Mediterranean diets may be more effective for achieving long-term weight loss.
A meta-analysis of 21 studies found pesticide exposure increases diabetes risk by 61%, with some pesticides linked to higher risks for type 2 diabetes. The study suggests environmental contaminants like pesticides may play a role in diabetes pathogenesis, but results require caution due to observational data.
A systematic review and meta-analysis of 32 studies found that male doctors are more likely to have legal action taken against them. The researchers analyzed data from over 4 million cases of medico-legal action and found consistent differences between sexes across various years and study types.
A new study finds that perfectionistic concerns can lead to stress, burnout, and health problems. In contrast, perfectionistic strivings, which involve setting high standards and working towards goals, may help maintain a sense of accomplishment and delay burnout.
Researchers at Rice University found that consistent superior e-service quality is key to winning the e-commerce battle between Amazon and Wal-Mart. The study identified four core dimensions of e-service quality, including website design, fulfilment, customer service, and security/privacy, which strongly impact overall e-service quality.
A systematic review and meta-analysis concludes that benzodiazepines are not effective for posttraumatic stress disorder (PTSD) treatment and may even worsen symptoms. The study found that benzodiazepines were associated with no improvement in PTSD-related outcomes and increased the risk of developing PTSD in patients with recent trauma.
A meta-analysis published in The BMJ found that women who experience a stillbirth have up to a fourfold increased risk of stillbirth in a second pregnancy. Pregnancies should be closely monitored, and antenatal interventions offered for women at high risk. Improved care and research are needed to address this major public health concern.
A meta-analysis of existing data found that the Safe Surgery Checklist (SSCL) improves outcomes worldwide, reducing mortality by 21% in high-income countries and 35% in low-middle income countries. The checklist also significantly reduces surgical site infections and postoperative complications.
Research found that nearly one-quarter of ICU survivors suffer from post-traumatic stress disorder (PTSD), according to a recent Johns Hopkins study. The study identified possible triggers for PTSD, including existing psychological problems and large amounts of sedation medication, and suggested using ICU diaries as a potential prevent...
A new meta-analysis found that preschoolers and school-age children who can identify what others want, think, and feel are more popular in school than their peers. The study also found a weaker link between theory of mind and popularity for boys, highlighting potential gender differences in social interactions.
A review of evidence suggests a possible increase in mortality with no clear benefit when using the anti-clotting drug alteplase more than 3 hours after stroke. The current guidance is based on uncertain evidence, and researchers are urging for a re-evaluation of data to guide policy decisions.
A meta-analysis published in The Lancet found that longer dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation was associated with increased mortality. Shorter DAPT, on the other hand, was linked to lower rates of all-cause and non-cardiac mortality, as well as reduced risk of major bleeding.
A large meta-analysis involving over 200,000 people with type 1 diabetes found that women face a 40% increased excess risk of death from all causes and have more than twice the risk of dying from heart disease compared to men. Women with type 1 diabetes also face a greater excess risk of strokes and kidney disease.
A meta-analysis of multicomponent nonpharmacological interventions found significant reductions in delirium incidence and falls among hospitalized older patients. These strategies also trended toward decreases in length of hospital stay and institutionalization, suggesting a potential cost savings of over $16 billion annually.
A large-scale study has found that combining anti-inflammatory medications with antidepressants can have a positive impact on treating depression. The analysis confirms a correlation between inflammation and depression, suggesting that personalized treatment options may be possible.
A new study examines the trajectory of emerging chemical threats to human and environmental health over 30 years. The research reveals a common pattern of emergence, rising to peak concern within 14 years before declining, and identifies potential stages of concern related to these chemicals.
A systematic review and meta-analysis found that frontline health workers can accurately diagnose bacterial infections in young infants, but access to antibiotics is limited. The study suggests that improving diagnosis and antibiotic access can help reduce neonatal deaths in low- and middle-income countries.
A meta-analysis of 58 studies found that adolescents' perceptions of peers' sexual activity, approval, and pressure are associated with their own sexual behavior. The study suggests that role modeling by peers is the most influential factor, while peer pressure has a smaller effect.
A systematic review and meta-analysis of 19 studies found that airline pilots and cabin crews have a higher incidence of melanoma, with a combined standardized incidence ratio of 2.21 for any flight-based occupation. This increased risk is attributed to exposure to UV radiation during flights.
A study found that different meta-analysis approaches can yield varying treatment outcome estimates, with some methods producing larger results. The researchers recommend assessing the robustness of their results through sensitivity analyses and comparing to other strategies.
A meta-analysis of 6,700 stroke patients shows that alteplase treatment significantly improves chances of good outcome and reduces disability. Prompt administration within 4-5 hours of symptoms onset yields the best results.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that individuals with schizophrenia have lower levels of vitamin D than healthy people. People with vitamin D deficiency are 2.16 times more likely to have schizophrenia, highlighting a potential connection between vitamin D and psychi...
A systematic review and meta-analysis suggest that combined aerobic and resistance training is most effective for controlling blood sugar and blood fat profiles in people with type 2 diabetes. However, more high-quality trials are needed to confirm these findings.
A meta-analysis found that people with higher protein diets, especially from fish, may have a lower risk of stroke. The study analyzed data from seven studies involving over 254,000 participants and found that moderate protein intake was associated with a 20% lower risk of stroke.
A study of 55 million people worldwide adds evidence that weekend hospital admissions have a higher mortality rate compared to weekdays. The analysis found patients admitted on weekends had an increased risk of death, with subgroup analysis revealing this trend in nearly all categories.
A systematic review of 28 studies involving over 3,400 adult ICU survivors found that one quarter exhibited PTSD symptoms. Risk factors included younger age, benzodiazepine use, and frightening ICU experiences. PTSD symptoms were associated with worse health-related quality of life.
A meta-analysis by American Psychological Association found women rated as highly as men in leadership effectiveness, contradicting long-held stereotypes. The study also discovered that women are viewed more favorably when holding senior management positions, highlighting a shift towards greater gender equality in the workplace.
A meta-analysis of 14 randomized controlled trials found that whey protein can lead to a decrease in body weight by 4.2 kg and body fat by 3.74 kg, while increasing lean body mass by 2.24 kg. Whey protein's unique combination of branched-chain amino acids may be responsible for these benefits.
Researchers found high-density lipoprotein (HDL) cholesterol and remnant lipoprotein (RLP) cholesterol levels are linked to CHD risk. HDL3 subfractions, not traditional HDL cholesterol, were more predictive in assessing and reducing CHD risk.
A meta-analysis of 19 studies involving over 760,000 participants found that people with pre-high blood pressure were 66% more likely to develop a stroke. The study also found that nearly 20% of strokes in the study population were due to pre-high blood pressure.
A systematic review and meta-analysis found that outbursts of anger can trigger heart attacks, strokes, and other cardiovascular problems in the two hours immediately afterwards. The risk is particularly high for those with existing cardiovascular problems or a history of heart attack or stroke.
A meta-analysis of 46 studies found that positive feelings about race or ethnicity are associated with fewer symptoms of depression and emotional problems. Minority youth who feel positively about their racial or ethnic identity tend to have better social interactions, self-esteem, and academic performance.
A recent study finds that narcissistic leaders face a double-edged sword, with extremely high or low levels of narcissism leading to poorer organizational outcomes. Moderation is key, as confidence without antisocial tendencies can lead to effective leadership.
A meta-analysis found that the XRCC1 Arg399Gln polymorphism is associated with an increased risk of glioma, especially in Asian populations. The study suggests that this genetic variation may serve as a biomarker for glioma susceptibility and provide scientific basis for population screening.
A genome-wide meta-analysis of COPD patients has identified novel gene variants associated with bronchodilator responsiveness. The study used data from over 6,000 patients and found that genetic determinants likely influence response to inhaled medication.
A meta-analysis found that receiving an influenza vaccination was associated with a lower risk of major adverse cardiovascular events. The greatest treatment effect was seen among patients with recent acute coronary syndrome (ACS), such as heart attack or unstable angina.
A large meta-analysis of 23 studies involving over 4,000 healthy adults found no significant benefit from vitamin D supplements in preventing osteoporosis. The study's authors conclude that continuing widespread use of vitamin D for osteoporosis prevention in healthy adults without specific risk factors is inappropriate.
A meta-analysis of 16 randomized controlled trials found that Transcendental Meditation (TM) practice reduced trait anxiety in people with high anxiety levels. Studies showed significant reductions in anxiety, especially in those with elevated anxiety levels.
A comprehensive review of medical literature reveals a link between PTSD and metabolic syndrome. The study suggests that the relationship is not clear and may be influenced by various factors such as socioeconomic status and lifestyle habits. Further investigation is needed to fully understand this connection.
A new meta-analysis of 29 randomized studies involving over 4,500 patients with knee osteoarthritis found significant improvement in pain and function with intra-articular hyaluronic acid (HA) injections compared to saline injections. The study confirmed the safety profile of FDA-approved HA products.
A recent meta-analysis of 14 studies found that statin use is associated with a statistically significant decrease in cataract cases. The analysis suggests that younger individuals and those using statins for longer periods may benefit most from this effect.
A global systematic review and meta-analysis found that newborns of mothers with bacterial infection or colonization are at higher risk for early-onset neonatal infections. The study analyzed data from 83 studies and found a significant association between maternal infection and newborn infection, with odds ratios ranging from 2.3 to 9.4.
Researchers found that reciprocity is a significant factor in food sharing, similar across humans, monkeys, and apes. Humans tend to exchange food for food, while primates barter for services like grooming or coalition support.
A new systematic review and meta-analysis found that people with diabetes are at least 50% more likely to develop physical disability. The study also showed a significant association between diabetes and functional disability, including impaired mobility and ability to perform daily activities.
A new study reveals substantial bias in animal studies reporting, which may lead to misleading conclusions about potential treatments' effectiveness in humans. The researchers analyzed 160 meta-analyses of animal studies and found that over twice as many studies reached statistical significance than expected.
A new set of guidelines for abstracts in systematic reviews and meta-analyses aims to provide a robust summary of research. The PRISMA for Abstracts checklist helps authors present an explicit summary of results, facilitating quick assessment and efficient perusal.
For most patients with small aneurysms, surveillance intervals can be extended, reducing the number of scans from 15 to 7 per year, without significantly increasing rupture risk. The study found that men's rupture risk increased by a factor of 1.9 for every 0.5-cm increase in baseline AAA diameter.
A meta-analysis of 12 studies involving 116,000 participants found no evidence of an association between job strain and overall cancer risk. Stress can cause chronic inflammation, leading to unhealthy behaviors such as smoking and excessive alcohol consumption.