Articles tagged with Metaanalysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A large-scale international study identified 15 new genetic regions associated with coronary artery disease, revealing a link between inflammation and plaque buildup in heart vessels. The research, which analyzed data from over 190,000 participants, provides insights into the molecular pathways causing the deadly disease.
A large group of patients with diabetes showed a lower risk of total and cardiovascular mortality with higher levels of physical activity, including leisure-time PA and walking. Moderately active individuals had the lowest mortality risk compared to those who were physically inactive.
A comprehensive review of 24 studies found acetazolamide has limited effectiveness unless baseline AMS risk is high, and some side effects occur at low doses. The authors suggest tailoring treatment to individual risk and acceptability of common side effects.
A new study published in Perspectives on Psychological Science suggests that employees' interests are a stronger predictor of job performance than overall interest scores. The research found that those whose interest profiles matched their job profiles were more likely to perform well, help others, and stay with the company longer.
A meta-analysis of 43,191 participants found statin therapy reduced recurrent cardiovascular events in both men and women. However, the benefits were not significant for women in terms of all-cause mortality or stroke risk. The study highlights the need for more female participants in cardiovascular prevention trials.
A study of 17 studies from seven countries found that smoking increases relative mortality by 83% for current smokers and 34% for former smokers. Quitting smoking at an older age is associated with a reduced risk of death, even after a longer follow-up period.
Patients treated with anti-TNF medications have a higher risk of developing herpes zoster, or shingles, than those treated with traditional DMARDs. The study suggests that prophylactic treatment may be necessary for those at risk.
A meta-analysis of eight clinical trials suggests that initial stent implantation for patients with stable coronary artery disease is not associated with improved outcomes compared to initial medical therapy. The study found no significant reduction in mortality, nonfatal heart attacks, or angina after a mean follow-up of 4.3 years.
A meta-analysis of 26 studies found that adults with mental illnesses are nearly four times as likely to experience violence, and those with intellectual impairments are 1.5 times more likely to be victims. The study highlights the need for improved identification and response to violence against people with disabilities.
A systematic review and meta-analysis of previous studies found that short-term exposure to major air pollutants is associated with an increased risk of heart attack. The study suggests three possible mechanisms for this association: inflammation, abnormal cardiac autonomic system regulation, and increased blood viscosity.
A review of 160 reports found that common mental health interventions, such as counselling and child-friendly spaces, often lack rigorous scrutiny. The authors call for increased research into these interventions to improve their effectiveness and sustainability in humanitarian settings.
A meta-analysis found a strong association between CCSVI and multiple sclerosis, but the low quality of included studies prevents a definitive conclusion. The variation in study results suggests that factors such as sample size, ultrasound techniques, and training of operators may contribute to the heterogeneity.
A meta-analysis predicts that cities will expand by 590,000 square miles globally by 2030, threatening biologically diverse areas. Rising incomes in China drive half of urban land expansion, while population growth drives expansion in India and Africa.
A Northwestern University meta-analysis reveals that leadership continues to be viewed as culturally masculine, perpetuating barriers to women's advancement. The study finds that women are seen as less qualified or natural in leadership roles, and adopting masculine behaviors can lead to being viewed as inappropriate.
A meta-analysis of previous studies found that patients with eating disorders have an elevated rate of death, especially those with anorexia nervosa. The study also highlighted the seriousness of bulimia nervosa and disordered eating not otherwise specified, which are often overlooked due to limited published data.
A study published in JAMA found that highly cited studies on biomarkers often reported larger effect size estimates than subsequent meta-analyses, suggesting potential for false-positive results. This can lead to wasted resources and inaccurate risk appraisal if not addressed by conducting more evidence.
A meta-analysis of 32 sport psychological studies found that self-talk improves sport performance, but different types of self-talk work better for different tasks. Instructional self-talk is more effective for fine skills, while motivational self-talk boosts confidence for endurance tasks.
A recent meta-analysis of 40,000 critically ill patients found no statistically significant difference in hospital mortality between those who received ICU telemonitoring and those who did not. The study suggests that telemonitoring may not be an effective solution for addressing the shortage of intensivist physicians.
A recent study found that only 2% of meta-analyses reported funding sources, while 62.5% of included RCTs had pharmaceutical industry funding. Author financial disclosures were also underreported. The lack of transparency may compromise readers' understanding and appraisal of the evidence.
A recent study by a team of investigators found that financial conflicts-of-interest are being hidden in published drug research through meta-analyses, which combine results from multiple individual trials. The study highlighted the lack of transparency in reporting funding sources and author-industry ties in these analyses.
A meta-analysis of over 100,000 DNA samples identified variants in two dozen previously unknown height genes, as well as confirmed associations with 30 known height genes. The study used a dense gene chip to discover genetic variants linked to complex traits and diseases.
A study published in The Lancet found that dispatcher-assisted CPR producing chest compression only results in improved survival rates compared to standard CPR. Continuous uninterrupted chest compressions are vital for successful CPR, and avoiding mouth-to-mouth ventilation increases the probability of a successful outcome.
A meta-analysis found that carotid artery stenting was associated with increased risks of short- and long-term adverse outcomes, including stroke, death, and restenosis. In contrast, carotid endarterectomy was linked to lower rates of these complications.
A meta-analysis of eight clinical trials found that folic acid supplements did not reduce the risk of cardiovascular events, cancer, or death over a five-year period. The study showed a significant reduction in homocysteine levels with folic acid supplementation but no corresponding benefit for cardiovascular health.
A study published in the American Journal of Public Health found that increasing taxes on alcoholic beverages significantly reduces disease, injury, crime, and death rates. Doubling state alcohol taxes could lead to a 35% reduction in mortality, as well as decreases in STDs, violence, and crime.
A new study from the University of Chicago finds that 85% of workers prioritize workplace safety over other labor standards. Despite public concern, workplace safety measures often fall short, with reports of injuries remaining high and worker stress contributing to accidents.
A new meta-analysis of individual patient data found that high-frequency oscillatory ventilation (HFOV) has outcomes comparable to conventional ventilation for preterm infants, without increased risk of bronchopulmonary dysplasia or brain damage. The study included 3229 participants and analyzed 10 randomized controlled trials.
A meta-analysis of fibrate drugs found significant reductions in major cardiovascular events and coronary events. Fibrates also showed a modest risk reduction for albuminuria progression, an early marker of kidney disease.
A new meta-analysis reports that hyperfractionated and accelerated radiotherapy regimens improve overall survival in non-small-cell lung cancer patients by 3% after 5 years. Modified fractionation of radiotherapy also shows benefits for small-cell lung cancer patients, although the difference is not statistically significant.
Adding chemotherapy to surgery or surgery plus radiotherapy significantly improves survival rates for patients with operable non-small-cell lung cancer. The meta-analysis found a 4% increase in survival at 5 years, regardless of the type of chemotherapy used.
A study published in PLOS Medicine found that replacing saturated fat with polyunsaturated fatty acids significantly reduces the risk of coronary heart disease events. The researchers reviewed 8 trials involving over 13,000 participants and found a 19% reduced risk of CHD risk compared to control groups.
A review and meta-analysis of previous studies suggests that withholding anticoagulation therapy after a negative whole-leg compression ultrasound is associated with a low risk of developing a blood clot during the subsequent 3 months. This finding may lead to reconsidering multiple ultrasounds for low-risk patients.
A new study published by the American Psychological Association finds psychodynamic psychotherapy to be highly effective in alleviating mental health symptoms, with benefits persisting after treatment has ended. The therapy's focus on self-reflection and examining relationship patterns leads to substantial treatment benefits.
A meta-analysis of 50 experiments found that consumers generally respond positively to having many choices, with a
Patients with resectable esophageal adenocarcinoma benefit from neoadjuvant chemoradiotherapy, showing improved overall survival and complete resection rates. However, the treatment is connected to a higher mortality rate after surgery.
A meta-analysis of 134 studies involving over 3,400 participants found that men's subjective and physiological measures of sexual arousal were more closely matched than women's. The researchers identified two methodological differences - the type of stimuli and timing of assessment - that may contribute to this gender difference.
A meta-analysis of over 28,000 toxicological tests challenges the notion that amphibians are uniquely susceptible to pollution. Researchers found that frogs range from moderately susceptible to 'bullet-proof' against environmental threats, with other factors contributing to their decline.
A meta-analysis of previously published research found that implantable cardioverter-defibrillator therapy does not significantly reduce all-cause mortality in women with advanced heart failure. This suggests that a larger study population may be needed to show any benefit of defibrillator implantation in women.
A meta-analysis of 50,000 patients reveals GPs struggle to identify depression, resulting in missed diagnoses and misidentifications. Researchers recommend reassessment of suspected cases and multiple appointments for uncertain diagnoses.
The PRISMA Statement updates guidelines for transparently reporting systematic reviews and meta-analyses, providing straightforward checklist and flow diagram templates. The updated guidelines aim to improve the quality and consistency of these studies in healthcare.
A meta-analysis of 190,000 patients from 56 studies found no overall differences in death and myocardial infarction between drug-eluting stents (DES) and bare metal stents (BMS), with significant reductions in target vessel revascularization procedures.
A meta-analysis of surveys suggests that altering or making up data is more frequent than previously estimated, particularly in medical research. Up to 14% of respondents knew someone who had fabricated or falsified data, and up to 72% knew someone who had committed other questionable practices.
A meta-analysis of 128 clinical trials has found that nonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced breast cancer. The use of these regimens led to a significant relative risk reduction in overall mortality.
A systematic review and meta-analysis found that homeless people in Western countries experience substantially higher rates of mental health problems compared to the general population. The prevalence of serious mental disorders was found to be raised, with notable increases in alcohol and drug abuse, as well as psychosis.
A meta-analysis found that longer psychodynamic psychotherapy lasting at least a year is effective and superior to shorter-term therapy for patients with complex mental disorders. The study suggests that short-term therapy may be insufficient for these patients, who often require more intensive treatment.
A meta-analysis of 22 studies found that endoscopic ultrasound (EUS) is highly accurate in staging gastric cancer, with higher sensitivity and specificity for advanced disease. EUS can help determine the most appropriate treatment approach for patients with gastric cancer, including curative or palliative therapies.
A meta-analysis of randomized trials found that tight glucose control in critically ill adults is not associated with a reduced risk of death, but does increase the risk of hypoglycemia. The study challenges common practice guidelines recommending tight glucose control for these patients.
A new study by University of Missouri researcher Vicki Conn found that behavior-changing strategies, such as goal setting and self-monitoring, significantly increased physical activity levels among adults with chronic illnesses. These interventions were more effective than cognitive approaches in motivating patients to exercise.
A meta-analysis of 12 studies finds no association between sugar-sweetened beverage consumption and weight gain in children and teens. Reducing or eliminating these drinks would have little impact on their weight, according to the study.
A recent meta-analysis of 15 studies involving over 70,000 participants identified six new genes linked to type 2 diabetes. The study, published in Nature Genetics, confirms that insulin-producing cells play a crucial role in the disease's development.
The American Society of Cataract and Refractive Surgery (ASCRS) will participate in a study with the US FDA to examine the impact of LASIK on patients' daily lives. The study aims to identify ways to enhance patient care, improve screening and counseling, and better understand quality of life.
The study analyzed 180,000 patients from 52 studies, demonstrating small non-significant reductions in death and myocardial infarction with a greater than 50% decrease in subsequent TVR procedures. Significant 20% and 11% reductions in death and MI were also observed, even after adjustment for confounding variables.
A meta-analysis of 18 studies found that vitamin D supplements may reduce the risk of death from any cause by 7% over an average six-year follow-up period. Higher blood levels of vitamin D were also associated with a lower risk of death.
A meta-analysis of 17 studies found that calcium supplementation reduced fracture risk by 24% in individuals with high compliance rates. Vitamin D supplementation also showed significant benefits, with a 16% reduction in bone loss at the spine.
Cancer incidence is higher among people with HIV/AIDS and organ transplant recipients due to immune system dysfunction. The study found a broad range of cancers at increased incidence across various sites.
A meta-analysis suggests that half of blood-thinning drug-related complications can be prevented through improved anticoagulation control. This study highlights the importance of closely monitoring patients taking these medications to avoid serious side effects.
A study published in Archives of Internal Medicine found that higher consumption of cereal fiber and magnesium may reduce the risk of type 2 diabetes. Participants who consumed more cereal fiber had a 27% lower risk of developing diabetes compared to those who ate less, while those who consumed more magnesium had a 23% lower risk.
A recent study by Drs. John Ioannidis and Thomas Trikalinos found that many meta-analyses employ asymmetry tests to detect publication bias, but these tests are often not statistically valid. As a result, the findings of these meta-analyses may be misleading or incorrect.
A new study published in The Annals of Pharmacotherapy found that phenylephrine may not be as effective as previously thought, with some studies showing no significant benefit. The study's findings suggest that higher doses of the drug could increase the risk of adverse effects, and the FDA is urged to require additional research.
A meta-analysis found that sustained oral contraceptive use prior to pregnancy increases a woman's risk of developing breast cancer. Premenopausal women who used oral contraceptives before having children are at a significantly increased risk of breast cancer, with a 44% higher risk compared to those who did not use them.