Articles tagged with Research and Development
Next-generation metabolomics may facilitate the discovery of new antidepressants by providing broader coverage and higher resolution than traditional methods. The technique has demonstrated great potential in accelerating pharmaceutical R&D, particularly for natural products like albiflorin, a promising multi-target drug candidate.
The US is experiencing constraints on human capital in software and IT fields, driving multinational firms to establish R&D hubs abroad. This shift is expected to strengthen US-based firms through access to global talent.
Researchers developed a new technique to decode human motor intention from EEG using subliminal sensory stimulation. This method achieved nearly 90% single-trial decoding accuracy across tested subjects, within 96 ms of the stimulation, with zero user training and no additional cognitive load.
The model uses mathematical equations to translate incompatible data streams into a neutral format, enabling comparison and analysis of satellite imagery and social media posts. Researchers tested the model using data from a 2013 flood in Colorado, resolving incompatibility issues and accurately estimating flooding locations.
Researchers at Shinshu University have developed proteins that can self-assemble into complex nanostructures, a breakthrough in biomolecular engineering and synthetic biology. The new protein complexes can be designed to produce various chain-like structures on demand, opening up possibilities for innovative applications in biotechnology.
The NYSCF Research Institute has developed a novel bioengineering technique called Segmental Additive Tissue Engineering (SATE), allowing for the creation of large-scale, personalized bone grafts. This technology overcomes limitations of current treatments, such as immune rejection and limited size and shape options.
A new prototype of a robot has been developed by Cornell University researchers to express emotions through changes in its outer surface. The robot's skin features an array of shapes that map to different emotional states, allowing for more effective social interaction.
A new body-to-machine interface for drones has been developed, enabling users to efficiently operate drones without piloting experience. The interface uses upper-body motions to control drones, showing promise for improved drone operation and accessibility.
Researchers found that uncertainty can actually help decision makers by allowing them to prioritize good information and reduce errors. In high-stakes situations like battlefields, this approach could lead to better outcomes.
A South Korean research team has developed an organic image sensor that captures vivid colors without color filters, increasing R/G/B color selection options. The new-concept image sensor uses a bonding technique between organic semiconductors and transparent electrodes, reducing surface defects and improving reproduction.
PharmaMar has signed a Memorandum of Understanding with the Indonesian Oceanographic Research Center to study Indonesia's marine biodiversity for new antitumor compounds. The collaboration aims to develop cutting-edge technology and address unmet medical needs in cancer research.
Researchers developed a safer component for lithium batteries, improving energy density and reducing safety concerns.
A special collection of papers published in PLOS Genetics explores the genetic basis of human facial formation, revealing advances in understanding facial development, birth defects, and normal facial variation. The research identifies numerous genes contributing to facial malformations and syndromes.
The Sandia National Laboratories' solar tower facility is conducting a year-round test of the thermal response of various materials to intense heat and cooling. Researchers are using this setup to evaluate material durability for the Air Force, with the goal of establishing material response thresholds after exposure.
A stress-related disorder was associated with an increased risk of developing autoimmune disease in a Swedish study involving over 106,000 patients. The study found that individuals with stress-related disorders were more likely to develop conditions like rheumatoid arthritis and psoriasis.
A longitudinal study found that having a good relationship with a sibling can protect against the negative consequences of witnessing repeated hostility between parents. Siblings who had good bonds were less likely to experience distress and subsequent mental health problems.
A KAIST research team developed a low-cost production technology for thin-film blue flexible vertical micro LEDs, achieving three times higher optical power density and longer device lifetime than lateral micro LEDs. This innovation enables the widespread adoption of micro LEDs in mobile and TV displays.
Researchers analyzed historical hurricane scenarios to model potential grid disruptions and identified clusters of businesses and community resources that could be outfitted with microgrids to improve resilience. Microgrids, also known as resilience nodes, enable enhanced adaptation and response to electric grid disruptions.
Researchers from the U.S. Army Research Laboratory and Texas Tech University demonstrated a 30-percent enhancement in TNT detonation velocity by adding novel aluminum nanoparticles. The AIH-coated nanoparticles showed improved reactivity due to their unique morphological feature, leading to enhanced explosive performance.
The new transmitter uses ultrafast 'frequency hopping' and data encryption to protect signals from being intercepted and jammed. This technology could secure medical devices, wearables, vehicles, and smart household technologies, making the internet of things a more secure place.
A physiologically based pharmacokinetic model suggests BUP exposure decreases during pregnancy, requiring dose increases to maintain efficacy. After delivery, a reduction in buprenorphine dose is necessary.
Researchers developed an acoustic belt that uses machine learning techniques to identify complex features and patterns of bowel sounds. The preliminary results showed high accuracy in predicting IBS with sensitivity of 90% and specificity of 92%. This new technology may offer a less-invasive way to diagnose the painful condition.
A new study by Iowa State University researchers found that a tax on medical devices significantly reduced R&D investment, sales revenue, and earnings. The tax, part of the Affordable Care Act, affected operating and marketing costs as well, but firms diversified their customer base and increased global market sales to offset the impact.
The collaboration aims to use clinical insights to fine-tune early device testing, focusing on preclinical support, proof of concept studies, de-risking medical device translation, and rapid prototyping. Tufts CTSI and MIT will provide resources and expertise to research teams to efficiently turn device concepts into testable prototypes.
The NIH summit recommends a precision medicine approach to Alzheimer's treatment and prevention, with a focus on developing interventions tailored to an individual's unique risk profile. The recommendations aim to build a collaborative research ecosystem capable of delivering urgently needed cures for people at all stages of the disease.
Research suggests that younger toddlers benefit more from interactive digital media than traditional TV and videos. Interactive features help children connect screen experiences to real-world interactions. However, not all types of interactivity are beneficial, and individual differences play a significant role in learning outcomes.
The PLOS AMR Channel offers access to the latest research, commentaries, blogs, news, and discussions on antimicrobial resistance (AMR). Key challenges include improving infection prevention, limiting unnecessary antibiotic use, and using existing antibiotics appropriately.
The University of Texas at San Antonio's RISE program will support eight undergraduate and 20 Ph.D. students with research experience, training, and financial support. The five-year grant aims to diversify doctoral programs and increase opportunities for underrepresented students.
Researchers at UBC's Okanagan campus have developed a new method to measure phytocannabinoids, leading to faster, safer and more accurate information for producers and regulators. The new method can test for over 100 phytocannabinoid variants in under 7 minutes.
The Estée Lauder Companies presents research on autophagy's role in skin aging, as well as the impact of ozone pollution and blue light on skin cells. This study reveals that exposure to blue light at night can disrupt circadian rhythm and accelerate skin aging.
A new camera system is tracking Antarctic penguin breeding and population dynamics, providing a low-cost window into the health of the ecosystem. The network includes 51 cameras across Antarctica's Peninsula and Islands, monitoring three species of penguins with high accuracy.
Researchers discuss traditional Chinese medicine approaches for cardiovascular disease, including acupuncture, moxibustion, Qigong, and Tai Chi. They highlight the need for modern TCM research into active ingredients and their applications.
Novices organize mental models based on natural language connections, while journeymen rely on procedural connections. Expert mental models display abstract connections and subnetworks as they gain expertise. This study has potential applications for training programs and game design.
New research from the University of Notre Dame shows that firms can protect their intellectual property by operating regionally through downstream commercialization activities. This approach helps substitute weak country-level protection with complementary assets offered at the regional level, creating barriers to imitation for competi...
Research suggests that the volume of carbohydrates, proteins, and calories consumed by very low birthweight preemies significantly contributes to increased brain volume and white matter development. However, specific nutritional approaches to support these infants' developing brains require further investigation.
A new state-by-state analysis reveals US government investment in global health research and development generates considerable economic benefits, creating jobs and injecting millions of dollars into local economies. The study also highlights the dangers of ignoring neglected diseases in an increasingly interconnected world.
Researchers have discovered that formate supplementation can prevent most neural tube defects in mice that are resistant to folic acid treatment. The study found that disrupting formate synthesis was linked to the development of these defects, and that providing pregnant mice with extra formate could prevent them. These findings offer ...
A Northwestern University research team has developed a new semiconductor device that can detect gamma rays and identify radioactive isotopes at room temperature. The device, made of cesium lead bromide, offers high spectral resolution and can be scaled up for widespread use in biomedical imaging, astronomy, and spectroscopy.
The UNC-Chapel Hill-led Clinical and Translational Science Award Program will broaden its reach across North Carolina by continuing its alliance with RTI International and NC A&T State University and adding a formal partnership with North Carolina State University. The grant will support the advancement of clinical and translational re...
Researchers from Dartmouth College introduced two smartwatch innovations, WrisText and Jetto, designed to enhance the overall user experience. WrisText enables one-handed text entry using wrist gestures, while Jetto provides immersive interaction through lateral force feedback, blurring the lines between physical and virtual worlds.
A four-year grant will support the Program on Water, Health & Development (WHD) in Burkina Faso, Ghana, Mali, Niger, Ethiopia and Uganda. WHD aims to develop concrete plans for expanding water services to all residents within a target district, guided by the United Nations' Sustainable Development Goals.
The American College of Physicians is calling for a revised approach to performance measurement, citing 32 valid and 30 invalid measures in Medicare's MIPS program. The ACP analyzed 86 performance measures and found that many were inadequately specified, leading to misclassification of high-quality care as low-quality care.
The U.S. Army Research Laboratory has developed an artificial intelligence technique that produces a visible face image from thermal images captured in low-light conditions. The technology leverages advanced domain adaptation techniques to enhance discriminability and recognition accuracy.
Researchers at KAIST have developed a technology to increase the stability of amine-containing adsorbents by fifty times. This advancement brings solid carbon dioxide adsorbents closer to commercialization and paves the way for efficient capture of greenhouse gases.
Research shows high-quality clone apps negatively affect original app downloads, while low-quality ones positively impact sales as they advertise the original, but with no significant competition.
Seven OU graduate students earned one-year fellowships to conduct research in aeroecology and environmental sustainability. The program aims to train interdisciplinary STEM leaders with effective research skills.
A KAIST team created a technology to print heat patterns on a micron scale for controlling biological activities remotely. They achieved this by integrating precision inkjet printing with bio-functional thermo-plasmonic nanoparticles.
Researchers have developed a polymer-based material that stiffens and changes color, mimicking the dynamic properties of skin. The material combines rigid-while-flexible and soft-while-stiff properties, shifting towards blue or red colors when elongated or condensed.
Researchers captured microglia nibbling on brain synapses for the first time, showing they help synapses grow and rearrange. The findings suggest that microglia may actually strengthen synapses rather than weaken them.
Researchers at Tufts University developed miniaturized sensors that can detect nutrients, chemicals and physiological states, offering a non-invasive way to monitor dietary intake. The sensors, with a footprint of 2mm x 2mm, transmit data wirelessly in response to radiofrequency signals.
A team of researchers has developed an open-source, clinically validated template for a 3D printed stethoscope that can be created using recycled plastic and costs less than $3 to produce. The device has been shown to have the same acoustic quality as premium brand stethoscopes.
Cass Sunstein has made significant contributions to research in constitutional law, democratic theory, and behavioral economics. He was awarded the Holberg Prize for his work, which has had a far-reaching impact on public policy. Meanwhile, Norwegian political scientist Francesca R. Jensenius received the Nils Klim Prize for her outsta...
The EPA has shifted focus to high-throughput computational models to quickly identify chemicals that require more scrutiny, following a slow start in its previous approach. Researchers have made significant progress, including the development of estrogen and androgen receptor models.
A recent study by University of Delaware professors found that while interventions for stigma-based bullying have increased, their implementation and evaluation need improvement. The researchers suggest increasing the capacity of school health professionals to address LGBTQ bullying and developing strategies to reduce stereotypes and p...
Researchers at Bar-Ilan University develop Nano-Drops, a technology that corrects refractive errors by modifying the corneal refractive index. The treatment involves laser stamping onto the cornea to create tiny spots for nanoparticles to enhance optical power.
A new study has developed an automated approach to select and seed teams for the NCAA March Madness basketball tournaments, providing an objective and unbiased starting point. The algorithm achieved high accuracy rates, matching 24 of 38 top teams in seeding and 89.6% being within two seeds of committee rankings.
Researchers at University of Plymouth are developing robots to work alongside farmers in Cornwall, ensuring availability gaps are filled and reducing manual labor costs. The 'ABC project' aims to create small, mobile machines that can perform tasks like harvesting, weeding, and pesticide application with increased efficiency and accuracy.
A new startup, Borês Technologies, is working on low-power-consumption electronics that will enable the haptic revolution in mobile technologies. The technology has the potential to change the way people interact with their electronic devices and with each other remotely.
Researchers developed a new approach that uses a single PET scan to assess PD-L1 positive tumors, enabling personalized cancer treatment. The study demonstrates the feasibility of this non-invasive method, which may help guide treatment decisions and assess treatment response.
Researchers at KAIST developed a hybrid energy storage device that can be charged in less than half a minute using aqueous electrolytes and graphene. The device facilitates rapid charging and high energy density, making it suitable for portable electronic devices.