Articles tagged with Antidepressants
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Researchers identified a cluster of genes associated with antidepressant response in a mouse model, which were validated in human patients. The study suggests that molecular signatures can predict individual responses to treatment, potentially improving the quality of care for depressed patients.
Researchers at Johns Hopkins Medicine have uncovered how ECT rapidly relieves severe depression by enhancing communication between neurons in the hippocampus. Studies using genetically engineered mice found that Narp plays a key role in this process, regulating the formation of new synapses and potentially enacting antidepressive effects.
The PCORI Board approved a new funding opportunity to support research projects comparing medications with psychological treatments for moderate to severe anxiety disorders in children. The studies will assess effective treatment options and enable informed decision-making by patients, families, and clinicians.
Researchers at RUDN University have developed a way to produce benzofurans, a key component in various pharmaceutical substances, from cheap agricultural and woody waste. The new approach uses salicyl alcohols derived from low-cost chemicals, enabling the creation of new benzofuran-based drug substances.
A new drug compound, BU10119, has been developed by scientists at the University of Bath and shown significant potential as an antidepressant in mice. The compound works by blocking kappa opioid receptors, which have anti-depressant like effects in mice, offering a new potential treatment for those who don't respond to SSRIs.
A new study found that antidepressants are ineffective in treating depressed patients with chronic kidney disease, prompting experts to reconsider treatment approaches. Alternative therapies such as ketamine, electroconvulsive therapy, and psychotherapy may be more effective for these patients.
Research found associations between opioids and SSRIs with increased osteoporotic fracture risk in RA patients, particularly with long-term use. Patients who developed fractures had higher disease activity, longer disease duration, and more comorbidity at baseline compared to those who did not experience fractures.
A study found that nearly 20% of people taking prescription medications with impairment risks are not aware they could be driving impaired, despite receiving warnings or seeing labels. Researchers hope increased warnings and labeling can help drivers make informed decisions about their abilities to drive.
A new PSU study finds that Prozac in ocean water can cause Oregon shore crabs to exhibit risky behavior, increasing their vulnerability to predators. The research highlights the potential risks of pharmaceuticals in the environment on animal survival.
Scientists found that low concentrations of toxic chemicals can affect aquatic creature behavior, including feeding and swimming speed. The study calls for low dose and mixture toxicity testing to assess the impact of complex pollutant mixtures on aquatic ecosystems.
Postpartum depression affects over 5% of women after childbirth, with a risk of recurrence 21% for those with hospital contacts or antidepressant use. Treatment duration varies, with 27.9% still in treatment a year after first treatment.
A new meta-analysis of over 6,500 patients found that antidepressants work better than placebos across various mental disorders, with the difference varying by disorder type. The study also highlights the strong placebo effect in depression and its potential for new treatment concepts.
Researchers at McMaster University have found that antidepressants can increase the risk of death by 33% due to their impact on multiple organs, including the heart and kidneys. This finding challenges the common assumption that antidepressants are safe for most people.
A nationwide register-based cohort study in Denmark found that children born to mothers taking antidepressants during pregnancy were at increased risk of developing psychiatric disorders. The study suggests that medication alone may not be the sole cause, as heritability also plays a part in determining mental health later in life.
A study by Indiana University found that ICU survivors are at risk for depression, with young and African American survivors being the highest risk. The research emphasizes the need for better mental health care and suggests new approaches to treatment and antidepressant regimens.
A study published in The BMJ found an association between antidepressant use during pregnancy and a higher risk of psychiatric disorder diagnosis in children. Researchers stress that this finding should be interpreted with caution, as the underlying maternal illness may contribute to the increased risk.
A recent study found that almost all antidepressants present significant side effects, but some individuals may better tolerate certain side effects. Personalized medicine is recommended to match chronic pain patients with suitable antidepressant medication, taking into account their individual health profiles and existing health issues.
A long-term study on schizophrenia patients found that low cumulative exposure to benzodiazepine and antidepressant medications has no significant effect on cognition. However, high-dose use of antipsychotic drugs was associated with poorer cognitive functioning, while a break in treatment was linked to better outcomes.
Researchers found that an antidepressant drug, nortriptyline, slowed the growth of abnormal proteins associated with Parkinson's disease. The study suggests a potential new approach to treating the disease, which could be simpler and more effective than current therapies.
A small pilot study suggests that neurofeedback can improve symptoms and overall recovery in patients with treatment-resistant depression. Eight of the twelve patients responded well to treatment, with five achieving remission.
A new study has detected high concentrations of antidepressants and their metabolites in the brain tissue of fish species in the Niagara River, raising environmental concerns. The levels of these drugs have accumulated over time, posing a risk to biodiversity.
A new study by researchers at the University of Gothenburg supports the notion that Selective Serotonin Reuptake Inhibitors (SSRIs) exert a specific antidepressant effect. Contrary to the 'placebo effect' theory, SSRIs are shown to be effective in treating depression, even in patients without side effects.
Researchers have identified serotonin's role in inhibiting a specific brain cell type, which may lead to faster-acting and more effective antidepressants. By targeting this protein, scientists hope to develop more targeted treatments with fewer side effects.
The study found a substantial increase in neonatal abstinence syndrome among infants whose mothers were prescribed opioids and psychotropic medications. The absolute risk was highest among women exposed to gabapentin, with concurrent exposure to psychotropic medications increasing severity of withdrawal symptoms.
A substantial number of US adults reported misusing prescription opioids, with 11.5 million admitting to misuse and 1.9 million having a use disorder. The majority of these individuals had low income or behavioral health problems, while relief from physical pain was the most common motivation for misuse.
A team of Rockefeller scientists has identified a specific type of nerve cell, called cholecystokinin (CCK)-expressing neurons, as the site where selective serotonin reuptake inhibitors (SSRIs) initiate their action. This discovery may pave the way for new antidepressants that act more quickly and produce fewer side effects.
A study found that pregnant women who took antidepressants were 45% more likely to have children diagnosed with autism, but the effect was limited. The research suggests that only a small proportion of cases would be prevented if antidepressant use was completely cut off during pregnancy.
A large Swedish study found a link between antidepressant use in pregnancy and autism risk, with 4.1% of exposed children developing autism compared to 2.9% of unexposed children. However, the absolute risk was small, and researchers stress that these results should not be considered alarming.
A study examined the risk of intellectual disability (ID) in children born to mothers treated with antidepressants and found a slightly elevated risk, but it was not statistically significant. The researchers suggest that other factors such as parental age and psychiatric history may contribute to the risk.
A study of 179,007 children found no association between antidepressant medication use and intellectual disability when other factors were considered. The researchers estimated a relative risk but it became statistically insignificant after adjusting for parental age and underlying psychiatric disorder.
Among patients unresponsive to an antidepressant, adding aripiprazole modestly increased remission rates from depression compared to switching or augmenting with bupropion. The study found symptom improvement was greater with aripiprazole than other treatments.
A new study from UT Southwestern Medical Center has identified the key protein responsible for ketamine's rapid antidepressant effects in the brain. The study reveals that ketamine blocks the N-methyl-D-aspartate (NMDA) receptor, creating an initial antidepressant reaction and extending its duration.
A study of 10 high-income countries found that prescription drug costs varied by more than 600% across different primary care medicines. The study, published in the Canadian Medical Association Journal, highlights differences in drug prices among countries with universal healthcare.
A new study published in the Journal of Clinical Psychiatry found that taking antidepressants during pregnancy is not associated with neonatal problems at two to four weeks after birth. Instead, preterm birth was the major factor linked to newborn signs of agitation and restlessness.
Researchers found that taking certain antidepressants, tranquilizers, sedatives, or antipsychotic medications significantly increased veterans' risks for developing dementia. The study also revealed that veterans who used three classes of these medicines were more likely to be diagnosed with dementia.
Researchers analyzed FDA Adverse Effect Reporting System data to find that ketamine alleviates depression symptoms in patients taking pain medication. The study also identified three other drugs with previously under-appreciated antidepressant effects: Botox, diclofenac, and minocycline.
A study by NIH-funded researchers found that policies restricting pharmaceutical promotion to physicians resulted in fewer prescribed promoted drugs and more non-promoted drugs in the same drug classes. The analysis encompassed over 16 million prescriptions, showing a modest but significant decline in the use of promoted drugs.
A study published in JAMA found that policies restricting pharmaceutical detailing associated with modest but significant reductions in prescribing of detailed drugs across six major drug classes. The implementation of these policies led to a shift away from detailed drugs and towards generic drugs, potentially representing a large red...
A new study suggests that adjusting psychiatric medication can reduce the risk of falls among older adults. The research found an association between depressive symptoms and falls, with moderate increases in depressive symptoms linked to a 30% higher risk of experiencing a fall over two years.
Researchers at Osaka University have identified a novel mode of action for an antidepressant activator that functions independently of SSRIs and increases nerve cell growth in the hippocampus. The activator shows faster response times than fluoxetine, offering new hope for patients with depression who do not respond to current medication.
New studies published in JAMA Network report no increased risk of autism spectrum disorder and attention-deficit/hyperactivity disorder among children exposed to antidepressants during pregnancy. The research suggests alternative explanations for previous findings may be responsible.
A large-scale analysis suggests that mothers' use of antidepressants during early pregnancy does not significantly increase the risk of autism or attention deficit hyperactivity disorder (ADHD) in their children. However, a slightly higher risk for premature birth was found among exposed offspring.
A new Northwestern University study finds that teaching positive emotion skills to men with HIV reduces their viral load and improves mental health. The intervention, which consisted of eight weekly sessions, also led to increased happiness and a stronger immune system.
A recent article reviews studies on fetal exposure to antidepressants and autism spectrum disorders (ASDs) during pregnancy. The analysis of 10 relevant studies found inconsistent results regarding ASDs risk associated with prenatal exposure to antidepressants.
Veterans with heart disease who are also depressed are more likely to struggle with medication costs and delayed medical care. Researchers found that these patients often have higher rates of chronic conditions, such as high blood pressure and obesity.
A new blood test measures C-reactive protein levels to guide depression treatment, potentially improving success rates. Researchers found a strong correlation between CRP levels and medication regimens, providing a biological explanation for treatment selection.
Researchers found that specific brain scan patterns can identify which treatment is most effective for individual patients with depression. Patients with positive connectivity in certain brain regions were more likely to achieve remission with cognitive behavioral therapy, while those with negative connectivity were more likely to resp...
A systematic review found moderate evidence that duloxetine and venlaxine were effective in reducing neuropathy-related pain, while pregabalin and oxcarbazepine showed weak evidence. However, gabapentin was not more effective than placebo.
Researchers at University of California - San Diego School of Medicine identified a new approach to treat depression by inhibiting the brain enzyme Glyoxalase 1 (GLO1). The study showed that inhibiting GLO1 alleviated depression symptoms in mice, with faster results compared to conventional antidepressant Prozac.
A WSU researcher has discovered that activated enzyme MAOA facilitates the spread of prostate cancer to bones by activating osteoclasts and enhancing bone degradation. Treatment targeting this enzyme shows promise in reducing bone metastasis.
A recent study found that older adults who suffered a hip fracture were more likely to use antidepressant and anti-anxiety medications. The analysis measured drug levels in blood samples, revealing a surprising number of patients took the drugs despite no medical record evidence.
A study published in the Journal of Alternative and Complementary Medicine found that participating in twice weekly yoga classes, combined with home practice, significantly reduces depressive symptoms. The intervention targets the parasympathetic and gamma aminobutyric acid system, providing a new avenue for treatment.
A new study published in the Canadian Medical Association Journal suggests that publicly funding essential medicines for all Canadians could save over $4 billion a year. The researchers identified a list of 117 essential medicines that accounted for 44% of all prescriptions filled at retail pharmacies in 2015.
Adding universal public coverage of essential medicines to the existing system in Canada would significantly reduce financial barriers for Canadians and save $3 billion per year. The list of 117 essential medicines accounted for 44% of all prescriptions written in 2015, suggesting a feasible step towards improving access.
A recent study published in The BMJ found that nearly all off-label antidepressant prescriptions (around 29%) were not supported by strong scientific evidence. Only 16% of these prescriptions had direct evidence backing the drug's use for the indication, while 40% relied on another drug in the same class with strong evidence.
A study found that seniors taking three or more brain-affecting medications increased by over 100% between 2004 and 2013, with falls and driving problems being major concerns. The combination of opioids, antidepressants, tranquilizers, and antipsychotics carries special risks for older adults.
Researchers found that brain activity patterns, particularly within two networks involved in error detection and interference processing, can predict treatment response. Patients who showed stronger communication between these networks were less likely to benefit from antidepressants.
A new study from the University of Montreal found that antidepressants prescribed to pregnant women may increase the chance of having a baby with birth defects. The risk is significant enough to merit caution in their use, especially considering the marginal effectiveness of these medications.
Antidepressant use nearly doubles hip fracture risk among community-dwelling elderly with Alzheimer's, highest risk seen at the start of treatment. The association remains elevated even after adjusting for other fall and fracture risks.
Patients taking antidepressants for depression are more likely to report gastrointestinal and cardiovascular side effects if they also have panic disorder, according to a new study. Co-occurring panic disorder is associated with an increased risk of worsening depressive symptoms.