Articles tagged with Antidepressants
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A literature review suggests that depressive disorders in people with HIV/AIDS are vastly underdiagnosed and untreated. Evidence-based recommendations are available to improve assessment and management of these conditions, focusing on proper diagnosis, treatment, and addressing special challenges such as stigma and adherence.
Researchers at the University of Copenhagen have discovered a substance, Lu AF60097, that can regulate serotonin levels in the brain and reduce severe side effects associated with tricyclic antidepressants. This new approach may allow for more effective treatment of severe depression while minimizing potential harm.
Research in The Journal of the American Osteopathic Association finds that patients on antidepressants for years may face difficult withdrawal symptoms due to physical dependence. A tapering schedule with physician guidance is recommended to safely discontinue medication and manage mental health.
A new machine learning algorithm, SELSER, has been developed to analyze EEG data and predict individual treatment response to sertraline. The study found that specific brain signals, such as alpha waves, recorded when participants had their eyes open, can reliably identify people likely to benefit from the medication.
Researchers at Stanford Medicine have developed a brain-wave signature that can predict which individuals with depression are most likely to respond to sertraline, an antidepressant. The study used electroencephalography and AI to identify the pattern in participants before treatment, allowing clinicians to make informed decisions abou...
A national trial has produced a computer that can accurately predict which antidepressant will work for patients based on their brain activity. This breakthrough may lead to personalized depression treatments using AI and brain imaging.
Post-SSRI Sexual Dysfunction (PSSD) affects sexually active individuals, causing genital numbing, loss of libido and emotional numbing. Pharmaceutical companies are now warning that these effects can last even after treatment stops.
Researchers used a non-targeted approach to identify 64 previously unknown chemicals in Puget Sound, including pesticides and pharmaceuticals. The team found eight concerning chemicals at potentially hazardous concentrations that require further investigation.
A special issue of Harvard Review of Psychiatry explores new treatments for major depressive disorder (MDD) by examining five key areas, including gender differences, neuroscience-based interventions, the role of the microbiome, opioid-based therapies, and technology in treatment. The research aims to develop more effective treatments ...
A research team at INRS has modeled the interaction of commonly used antidepressants with estrogen and aromatase, a key enzyme in fetal development. The study suggests that not all types of antidepressants have the same hormonal affinity, and some may be less harmful to the developing fetus.
A study of seven US wastewater treatment plants found that granular activated carbon and ozonation can effectively remove pharmaceuticals like antidepressants and antibiotics. The technologies reduced the concentration of these medicines by more than 95%.
Research on mice suggests that antidepressant exposure during pregnancy can lead to long-term changes in brain activity and sensory processing. The study found abnormal brain activity in sensory areas of fluoxetine-exposed mice when stimulated with their front paws.
A study by University of Cincinnati researchers found that certain antidepressant medications cause more side effects in children and adolescents with OCD and anxiety disorders. SSRIs were associated with increased rates of agitation, while SNRIs showed no significant link to suicidality.
A new study reveals that approximately 30% of patients taking opioids experience adverse drug interactions, which can lead to decreased efficacy and increased risk of addiction and overdose. The authors emphasize the importance of a thorough medication history and consulting a pharmacist before prescribing opioids.
A study led by Professor Maureen Dollard explores the link between toxic workplaces and mental health issues in Australia, finding a strong correlation between corporate cultures and antidepressant use. The research aims to determine if unhealthy work environments contribute to Australia's high levels of depression and anxiety.
A new study from iPSYCH found that one in five people with depression have suicidal thoughts despite treatment with antidepressants. The researchers suggest that more intensive treatment could lead to better responses in patients who don't respond to medication within the first few weeks.
A recent study published in PLOS ONE found that babies born to mothers taking antidepressants during pregnancy are at increased risk of reduced breastfeeding rates, preterm delivery, and low birth weight. The study suggests that women prescribed antidepressants should be identified for closer monitoring and targeted support.
A Dartmouth study analyzed prescription records of 2.5 million Medicare beneficiaries and found that taking any one fracture-associated drug doubles a person's risk, while taking three or more increases it four-fold. The most hazardous combinations included opioids with sedatives, diuretics, or PPIs.
A new study from UChicago identifies 44 drugs that may prevent suicide attempts, including folic acid and several antidepressants. The research used a statistical tool to analyze data on 922 prescription medications and found that just 10 were associated with an increased rate of suicide attempts.
A comprehensive register-based study from Aarhus University in Denmark found that the use of antidepressants by pregnant women decreased significantly by 33% between 2011 and 2023. This decline was mainly driven by a decrease in prescribing serotonin reuptake inhibitors (SSRIs) and citalopram, which is commonly used in Denmark.
China's obesity rates have nearly tripled over the past decade, reaching 14% for general obesity and 32.4% for abdominal obesity among adults. A cluster of high obesity prevalence was identified in the Beijing-Tianjin-Hebei region, highlighting the need for targeted interventions to address this growing health concern.
A cost-effectiveness analysis suggests that individuals with new diagnoses of major depression should have access to both antidepressants and cognitive behavioral therapy, as the costs and benefits are equivalent after five years. This study provides insights into treatment decisions and could inform future care and insurance coverage.
A new study has found that taking fluoxetine for 16 weeks did not significantly lower the frequency and severity of obsessive compulsive behaviors in children with autism spectrum disorders. The research suggests that up to one-third of children with ASD are prescribed antidepressants despite inconclusive evidence of their effectiveness.
Despite a significant increase in antidepressant use, the number of older people diagnosed with depression remains largely unchanged. Research suggests that depression affects one in 15 people aged over 65, and its impact is felt by individuals, families, and friends.
A new study of 45 meta-analyses found that antidepressants are not associated with strong adverse health outcomes, and most reported effects were likely due to underlying psychiatric conditions. The study suggests that antidepressants are generally safe but cautionary measures should still be taken during treatment
The study graded 45 meta-analyses of observational studies, assessing the association between antidepressant use or exposure and adverse health outcomes. The findings indicate mixed results across different populations, highlighting the need for further research to determine the causal relationship.
Research published in BMJ Open found a significant association between antidepressant use during pregnancy and an increased risk of gestational diabetes. Venlafaxine and amitriptyline were linked to the greatest risks, with long-term use associated with a 29% heightened risk.
A UCL-led clinical trial found that antidepressant sertraline reduces anxiety symptoms earlier than depressive symptoms, with participants showing improvement in mental health overall. The study suggests antidepressants like sertraline may benefit a wider group of people beyond those diagnosed with depression or anxiety.
Researchers found that controlling inflammation can increase the effectiveness of antidepressant drugs by promoting neural plasticity. In mice studies, fluoxetine reduced inflammation when housed in a stressful environment, but not in a relaxing one.
Researchers found that psychiatric medications like antidepressants can alter gut bacteria in rats, sparking questions about specificity of psychoactive drug action and potential benefits or drawbacks for human patients. The study aims to explore these findings further through a large-scale human observational study.
A new study reveals that serotonin and certain antidepressants can significantly impact the gut's microbiota, a crucial system of 100 trillion microorganisms. The research identifies Turicibacter sanguinis as a key bacterium responding to serotonin levels, which can influence its growth and presence in the gut.
A Canadian study found that individuals taking anti-depressants and/or anti-psychotics can lose weight with a weight management program, regardless of their medication use. The study analyzed data from 17,519 patients and showed significant weight loss in both men and women.
Researchers found that frequent interruptions to sitting time with simple resistance activities lowered postprandial insulin responses and insulin:glucose in adults with overweight or obesity. An agent-based model also showed community diffusion strategies as key drivers of pediatric programs for childhood obesity prevention.
A new study published in The Lancet Psychiatry has found that psychotherapy should be the first line of treatment for depression in young people. The study involved 153 participants aged 15-25 and found no significant differences in symptom improvement between those receiving cognitive behavioural therapy with or without fluoxetine.
Researchers at Johns Hopkins clarify ketamine's antidepressant properties, stating it binds to NMDA receptors rather than opioid receptors. This mechanism allows ketamine to turn off the master control switch mTOR, enabling its therapeutic effects. The FDA has approved ketamine as a nasal spray for depression treatment.
Researchers found that fluoxetine treatment can rearrange hippocampal nerve fibers in mouse brains, reducing their number and size. This structural change could contribute to the medication's antidepressant effects.
A new study published in JAMA Internal Medicine found that strong anticholinergic medication daily for three years or more may increase the risk of dementia by nearly 50% among patients aged 55 and over. The research highlights the importance of carefully considering medication risks alongside benefits.
Researchers found that antidepressant treatment, rather than depression itself, leads to reduced neural responses and empathy towards pain in patients. This effect may help patients recover from social interactions more easily.
A systematic review found that serotonin and norepinephrine reuptake inhibitors (SNRIs) led to more harmful events compared to placebos in older adults. Antidepressants like SSRIs may increase the risk of falls, highlighting the need for careful consideration when prescribing these medications.
A study found that patients taking antihypertensive drugs had a decreased risk of developing dementia, with calcium channel blockers showing the most significant association. The study analyzed data from over 12,000 patients and suggested that these medications may help delay or reduce dementia onset.
A Japanese study found that cognitive therapy maintained its effects more than a year after therapy for patients with social anxiety disorder (SAD) who did not respond to antidepressant drugs. Cognitive therapy helped patients overcome negative thoughts and behaviors, allowing them to enjoy social interactions more.
A research team at DGIST discovered that changes in hippo campal mossy cells play a crucial role in the treatment efficacy of serotoninergic antidepressants. This finding contributes to the development of next-generation antidepressants with enhanced effects and speed.
Researchers at University of Malaga identify a fragment of the brain molecule Galanin as involved in anhedonia, a key symptom of depression. The study suggests potential new therapeutic strategies for treating depression and related addictions.
A new study published in the American Journal of Psychiatry supports the effectiveness and safety of esketamine nasal spray for treating moderate to severe depression in people who have not responded to previous treatment. The study found significant improvements in depression symptoms within 24 hours of taking the medication.
Researchers have found that smokers with COPD have significant unmet mental health care needs, particularly anxiety and depressive symptoms. These symptoms can impact many COPD-related outcomes, including hospital readmissions and exacerbations.
A study found a potential link between autistic-like behaviour in adult mice and exposure to fluoxetine, a common antidepressant, in the womb. The researchers identified a treatment that improved memory loss and social interactions.
Scientists have discovered the three major shapes of the serotonin transporter using cryo-EM technology. The study provides new avenues for developing medications to treat addiction without hallucinogenic properties.
Researchers found that ketamine restores dendritic spines in the prefrontal cortex of mice with depression-like behavior. Healthy dendritic spines are crucial for long-term antidepressant effects, suggesting interventions to enhance their survival may be helpful in sustaining ketamine's benefits.
A meta-analysis of international studies found that anti-inflammatory medicine can have a beneficial effect on symptoms of depression. Six different medications showed an antidepressant effect, and the results were present when compared to a placebo in patients with physical diseases and depressive symptoms.
Rapastinel, an antidepressant-turned-opioid-reversal-drug, has shown promising results in reducing withdrawal signs in rats, potentially leading to a new treatment option for opioid dependence. The drug binds to the same receptor as ketamine but with a milder effect, offering a safer alternative to existing treatments.
Researchers identified discrepancies in 363 reports (15%) of adverse drug reactions between men and women. Drugs like thyroid hormones and antidepressants showed higher frequencies among female patients.
Researchers at UMSOM have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants like ketamine. The discovery could lead to better treatments for depression by understanding how the brain reacts to Ketamine.
A new 12-year longitudinal study found that consistent treatment with methylphenidate-based medications during childhood increases the risk of antidepressant use during adolescence. Children with high adherence (above 50%) were at significantly greater risk of being prescribed antidepressants between the ages of 12-18.
A research collaboration between Columbia University and a genomicist has identified specific genetic pathways associated with antidepressant resistance. The team hopes to develop new treatments that can circumvent resistance in millions of people who do not respond to current medications.
Researchers at CAMH have discovered a new target for developing treatments for depression by finding higher levels of the brain protein MAO-B in people with clinical depression. The study found that individuals with depression had 26% higher MAO-B levels in their prefrontal cortex compared to those without depression.
A study published by University of Sydney found a significant increase in self-poisonings among young Australians aged 5-19 years from 2006 to 2016. The incidence rose by 98% and was predominantly caused by substances widely available, such as household products and prescribed medications.
A new study published in JAMA Psychiatry found that combining antidepressants with antipsychotic drugs may have benefits for individuals with schizophrenia. The research suggests that antidepressant use can reduce the risk of hospitalization by 16% compared to antipsychotics and by 22% compared to benzodiazepines.
A study from the University of Virginia Health System suggests that an antidepressant drug could stop deadly sepsis by regulating inflammation. The researchers tested the drug in a mouse model and found it to be effective, paving the way for potential human trials.
A Stanford University School of Medicine investigation discovered that common opioids are less effective for patients taking selective serotonin reuptake inhibitors (SSRIs) for depression. This interaction may lead to reduced pain relief and increased risk of opioid abuse.
A large UK population-based study found no association between the antidepressant trazodone and a reduced risk of dementia. Researchers analyzed data from over 15 million patients and compared them with users of other antidepressants, but found higher incidence rates among trazodone users.