Articles tagged with Cancer Treatments
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University of Oklahoma researchers create bioactive sugars to develop novel antibiotics against multi-drug-resistant infections in cancer patients. By using abundant, inexpensive, iron or metal-free, non-toxic blue light, the team can more easily and rapidly synthesize these important carbohydrates.
Researchers at Nagoya University found that patients with high-risk stigmata and invasive nodules in their pancreatic cysts had a significant impact on their survival. The presence of invasive nodules led to improved survival rates after surgery, while those without invasive nodules had favorable outcomes even without surgery.
Researchers have discovered RNA pseudouridine as a novel diagnostic target for colorectal cancer. The study found correlations between pseudouridine modifications and clinical markers, enabling potential non-invasive diagnosis. The findings provide a molecular framework for RNA epigenetics-based stratification and targeted interventions.
A UC Riverside-led study found that adult stem cells rely on histone chaperones to maintain their regenerative capacity. The researchers discovered that disrupting these proteins can lead to specific changes in stem cell identity, potentially guiding them into desired cell types.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
The University of Missouri is partnering with a consortium to design and license a new research reactor, NextGen MURR, which will produce critical medical isotopes for cancer treatment. The project aims to enhance Missouri's role as a leader in nuclear science and medical research.
Researchers analyzed CRC tumors with high tumor mutation burden to characterize BRAF-associated mutations and decipher their role in carcinogenesis. They found TMB-high tumors likely arise from a heterogeneous population of cells harboring numerous gene mutations distinct from driver oncogenes.
A new study found that a gene-based blood test can accurately predict skin cancer recurrence in stage III melanoma patients. The test measures circulating tumor DNA levels to identify those most likely to respond well to therapy.
A new study published in The Annals of Thoracic Surgery found that Medicaid expansion significantly improved access to timely treatment for patients with early-stage non-small cell lung cancer. High-volume hospitals associated with decreased postoperative complications and in-hospital mortality rates compared to low-volume hospitals.
A novel compound ML233 inhibits melanin production with no significant toxic side effects, offering a potential new strategy for treating pigment-related skin conditions. The study demonstrates promising results in reducing melanin synthesis and proliferation of melanoma cells.
The SNMMI Mars Shot Research Fund has awarded a $100,000 fellowship to Dr. Randy Ye for his research on FAPI PET imaging for detecting invasive lobular carcinoma. The study aims to assess the ability of FAPI PET and FDG PET to detect tumors and evaluate its impact on patient care.
Researchers discovered blocking CCR1 increases glucocorticoid sensitivity in multiple myeloma cells, offering a new strategy to improve treatment outcomes. The study found that high levels of CCR1 are linked to worse outcomes and plays a critical role in drug resistance.
Hepatocellular carcinoma is the most prevalent form of liver cancer, and liver transplantation offers a curative treatment option for appropriately selected patients. Bridging therapies, such as radiofrequency ablation and transarterial chemoembolization, can improve survival outcomes post-transplant by preventing tumor progression.
A multicenter retrospective study found that routine caudate lobe resection does not significantly improve long-term survival and recurrence for patients with HCCA. However, achieving a negative margin is crucial for improving prognosis.
Researchers have developed an innovative optical genome mapping technique that can identify structural variants and copy number variations across the entire genome in a single test. The method has been shown to reduce material requirements and improve prognostic stratification for patients with multiple myeloma.
Researchers have developed a pioneering method that combines atomic force microscopy with artificial intelligence to detect changes in cancer cells at a small scale. This enables more accurate and reliable diagnoses, potentially leading to earlier detection and better treatment outcomes.
Lower-intensity electrical pulses reshape the tumor environment, increasing blood vessel density and boosting lymphatic vessel growth. This may guide immune cells to the tumor, improving the body's natural ability to fight cancer.
Researchers developed a simple, cost-effective blood test that detects Parkinson's disease long before symptoms emerge by analyzing transfer RNA fragments. The test has an accuracy surpassing existing clinical diagnostic tools and may alleviate uncertainty faced by patients and clinicians.
The study found that fecal microbiota transplantation (FMT) can outcompete H. pylori, producing antimicrobial peptides and metabolic byproducts to create a hostile environment. FMT may also mitigate adverse effects of antibiotic treatments, improving patient tolerance.
Researchers found significant disparities in quality of care and outcomes for patients with metastatic pancreatic cancer. Patients with higher social vulnerability indices were less likely to receive guideline-concordant systemic therapy, palliative care, or survive over 12 months.
Researchers have developed a new approach to overcome treatment resistance in estrogen receptor-positive (ER+) breast cancer. Dual aromatase-steroid sulfatase inhibitors (DASIs) show promise in effectively blocking both enzymes involved in oestrogen production, potentially reducing tumour growth.
The study found that patients with coaxial silicone drains had lower analgesic consumption and better-preserved respiratory muscle strength during the first 2 postoperative days. This suggests that coaxial SIL drains can reduce postoperative pain and improve patient comfort and recovery following VATS lobectomy.
Living in disadvantaged neighborhoods is associated with a higher risk of mortality from breast cancer in Black women. Community-level interventions aimed at reducing environmental stressors and improving access to high-quality cancer care could help reduce racial disparities in breast cancer survival.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.
Researchers develop innovative MSOT-AI technology to improve basal cell carcinoma diagnosis and surgical planning, reducing repeat procedures and improving patient outcomes. The technique captures detailed 3D views of tumours, enabling clearer insights into tumour boundaries.
A new case report presents a highly unusual combination of two benign ovarian tumors: serous cystadenofibroma and collision lesions. Accurate preoperative diagnosis is critical for effective treatment planning, and this case emphasizes the need for personalized evaluation of each ovarian mass.
Researchers have discovered a key cellular mechanism regulating mRNA vaccine delivery and stability, proposing a new paradigm for mRNA therapeutics. The study highlights the importance of N1-methylpseudouridine modification in enhancing mRNA vaccine effectiveness.
The National Comprehensive Cancer Network (NCCN) has awarded four early-career oncologists with $150,000 in funding to tackle pressing challenges in cancer care. The recipients will support studies aiming to improve cancer outcomes through molecular residual disease-guided adjuvant therapy and electronic symptom monitoring.
The NCCN 2025 Annual Conference showcased the critical impact of cancer research on improving lives. The conference featured new research, discussions on AI in oncology care, and strategies for ensuring high-quality, person-centered cancer care.
Researchers at USC Viterbi have developed a new type of immune cell that can sense and destroy cancer cells for extended periods using focused ultrasound. This technology could overcome obstacles in treating tumors with immunotherapy while keeping healthy tissue safe.
Researchers at Osaka University identify a specific molecule, HLA-DRB1, that can be targeted by CAR-based therapy for AML. Engineered CAR T cells showed strong and specific anti-AML effects in vitro and in vivo with mice, without overt toxicity.
Researchers at Cornell University discovered that the FGR protein can induce cell differentiation in leukemia cells similar to retinoic acid treatment. The presence of FGR alone was enough to make these cells mature, producing well-known markers of maturation and expressing inhibitor of the cell cycle p27.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Researchers created a highly detailed map of gastric cancer tissues using advanced mapping technologies, identifying distinct subgroups of cancer cells and evolutionary pathways that influence tumour behaviour. These insights could lead to more precise, targeted treatments that improve survival rates and reduce side effects.
Researchers have developed a TIM-3 decoy that improves the effectiveness of CAR-T cell therapy in treating B-cell Acute Lymphoblastic Leukemia. The decoy blocks the interaction between the tumor and immune cells, allowing CAR-T cells to persist and attack cancer cells more effectively.
UC San Diego Health has earned The Joint Commission's Gold Seal of Approval for Advanced Certification in Spine Surgery, reflecting its dedication to patient safety and surgical innovation. The health system continues to provide consultation to other organizations exploring the certification.
A study published in the British Journal of General Practice found a significant link between chest x-ray referrals and earlier lung cancer diagnosis and better survival rates. Patients attending practices with high chest x-ray usage were more likely to be diagnosed at an earlier stage, leading to improved survival rates.
Patients from American Indian and Black communities are less likely to have elevated CA-125 levels at diagnosis, suggesting current thresholds may miss diverse patients. Inclusive diagnostic guidelines are needed to address disparities in ovarian cancer diagnosis and treatment.
A recent study has found that people diagnosed with colorectal cancer are more likely to die from cardiovascular causes, particularly in the first two years after diagnosis. The study analyzed data from over 630,000 US adults and found a 16% increased risk of cardiovascular mortality among those with colorectal cancer.
A comprehensive review of studies reveals that over 15% of caregivers of adult cancer patients suffer from post-traumatic stress disorder (PTSD). Caregivers with pre-existing mental health conditions and high caregiver burden are at greater risk. The study highlights the urgent need for proactive screening and support to prevent long-t...
The review article examines the relationship between anemia and retinopathy of prematurity, focusing on iron deficiency and underlying molecular mechanisms. Anemia reduces oxygen delivery to the retina, exacerbating hypoxia and promoting pathological neovascularization.
Researchers argue that the current paradigm of cancer as a genetic disease is unproductive due to inconsistencies in sequencing data. Alternative paradigms considering non-genetic processes, such as disruptions in gene regulatory networks and tissue organization, are proposed to guide future experiments.
This cohort study found that geographic access to cancer care is associated with guideline-recommended treatment for early-stage non–small cell lung cancer. Socially marginalized patients benefited from improved treatment outcomes and prognosis when accessing care in their local area.
Researchers have discovered a protein called MdfA that enables bacteria to shut down into dormant spores under extreme conditions. This process allows bacteria to survive in uninhabitable places and evade hospital cleaning, making them potentially deadly superbugs.
Researchers have found a way to reactivate the body's natural ability to destroy excess cancer proteins by introducing synthetic RNA fragments that increase poison exon inclusion. This discovery could lead to game-changing therapies for aggressive cancers such as triple-negative breast cancer and certain brain tumors.
A team of researchers from Chiba University has developed a novel radioactive drug that targets and treats metastatic melanoma. The treatment utilizes astatine-211 labeled peptide analog, which shows high accumulation in tumors, rapid clearance from non-target organs, and significant tumor suppression.
Recent research suggests that some invasive cancers diagnosed in early-stage breast cancer may not need immediate surgery, highlighting the importance of more precise screening methods for DCIS. The COMET trial found that at least half of invasive breast cancers take years to progress or may never progress at all.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
Dr. Ronald Newbold has been appointed as the permanent CEO of Empire Discovery Institute (EDI), a non-profit drug discovery and development accelerator. With over 30 years of business development experience, Dr. Newbold will lead EDI's growth and expansion, including the addition of new programs and partnerships.
Researchers have identified ubiquitin-specific proteases as key regulators of programmed cell death pathways in breast cancer. The review explores the complex interactions between ubiquitination, cell death mechanisms, and cancer biology, laying the foundation for novel therapeutic strategies.
A study of nearly 2,500 postmenopausal women found that taking more daily steps and engaging in moderate-to-vigorous physical activity were associated with a significantly reduced risk of death from cardiovascular disease. Even walking fewer than 5,000 steps per day showed a risk reduction.
Professor Robert T. Schooley will present a talk at the 8th World Congress on Targeting Phage Therapy, exploring phage therapy advancements and necessary steps for widespread adoption. The congress will gather experts to discuss latest advances, challenges, and clinical applications of bacteriophage therapy.
Recent developments in fluorescent probes offer improved specificity and sensitivity for detecting hepatocellular carcinoma (HCC). Next-generation probes are being developed to enhance tissue penetration depth and probe specificity, potentially improving surgical outcomes.
Researchers develop a potential new treatment for rare genetic diseases characterized by low levels of specific proteins. By adding an artificial poly(A) tail to mRNA, they boost protein production and aim to improve symptoms in people with protein-deficient disorders.
Targeted alpha therapy shows promise in treating resistant NETs, offering a precision tool for patients exhausted by conventional treatments. Early preclinical trials have delayed tumour growth with minimal toxicity, while clinical studies have reported high disease control rates.
A research team discovered that a genetically engineered bacterial strain, Designer Bacteria 1 (DB1), efficiently survives in tumor tissues while being cleared from normal tissues. This is due to the interactions between DB1 and tissue-resident memory CD8+ T cells, which are reinvigorated and expanded following therapy. The high expres...
Cervical cancer incidence increased in rural US counties, with higher rates among white women, likely due to lower screening coverage and diagnostic care utilization. Rural areas may experience heightened access barriers, contributing to lower HPV vaccine uptake.
Researchers have developed a specialized nanoscale material that illuminates cancer cells under freezing conditions, improving surgical precision. This technology enhances surgeons' ability to detect and remove cancer cells during cryosurgery.
A study uncovered new genetic clues explaining why some prostate cancers grow slowly while others become life-threatening, identifying 223 mutations that determine tumor progression. The research shows germline and somatic variability work together to initiate and drive prostate cancer.
A new genetic testing technique is being developed to help young cancer patients receive more targeted and less toxic treatments. The test analyzes DNA released into the bloodstream by cancer cells, offering a less invasive way to monitor tumor progression and identify new treatment targets.