Articles tagged with Cancer Treatments
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Recent AI-based models, such as Asian Prostate Cancer Artificial Intelligence and Galen Prostate, optimize screening and reduce unnecessary biopsies. These models use multimodal clinical parameters and convolutional neural networks to detect prostate cancer and identify aggressiveness of cancer cells.
This book presents cutting-edge approaches to combat cancer, including exosomal delivery systems, CRISPR/Cas9 gene editing, and immunotoxin therapy. Natural compounds are also examined for their anticancer potential.
A recent study identified four genes associated with treatment resistance to immunotherapy in melanoma patients. The genes, CD24, NFIL3, FN1, and KLRK1, were found to be linked to mechanisms of immune evasion and suppression of the inflammatory response. Patients with high expression of these genes had significantly lower overall survi...
Lydia Kavraki, a pioneering researcher in robotics and AI, has been elected to the European Academy of Sciences. Her work on physical AI, transforming robotics and biomedicine, and leadership at Rice University's Ken Kennedy Institute have earned her this prestigious honor.
Researchers found that certain antibodies can reduce antitumor immune cells, highlighting the need to consider ADCC activity when designing or selecting ICI therapeutics. This study could help improve cancer treatment by engineering antibodies that avoid damaging essential immune cells.
Researchers propose a synergistic combination strategy using systemic type I interferons (IFN-I) and local TLR7/8 agonists to enhance dendritic cell activation and inhibit metastatic tumors. This approach enhances early innate immune control and later induces CD8+ T cell responses.
Researchers discovered a compound, EPS3.9, produced by deep-sea bacteria that triggers pyroptosis to inhibit tumor growth and exhibit potent anti-cancer effects. The study highlights the importance of exploring marine microbial resources for developing new drugs.
Researchers have identified CDX1 and CDX2 as key molecules that counteract β-catenin and suppress stemness in colon cancer. Deletion or overexpression of these proteins increased tumor aggressiveness and expression of cancer stemness-related genes, suggesting a potential therapeutic target.
A study documents elite-level strength training during active breast cancer treatment, showing rare retention of squat strength despite chemotherapy. LaShae Rolle, a competitive powerlifter and breast cancer survivor, completed the first-of-its-kind study, demonstrating the feasibility of high-intensity training when carefully managed.
Researchers at the University of Ottawa have made a breakthrough in developing nanoparticles that not only deliver drugs but also contribute to treatment. Their proof-of-concept study shows that particles can be armed with therapeutic potential, revolutionizing the field of nanomedicine.
The University Hospitals Seidman Cancer Center has become the first in the US to implement Akesis' Galaxy RTI device, advancing Stereotactic Radiosurgery (SRS) with enhanced precision and treatment efficiency. The center will also serve as a research hub for this innovative technology.
A recent study identified 37 human-specific genes linked to brain development and cognitive abilities, which are hijacked by cancer to drive tumor growth. The researchers discovered nearly half of these genes become aberrantly activated in cancerous tissues, promoting tumor cell proliferation.
New research from Sylvester Comprehensive Cancer Center shows that partial match transplants can achieve good outcomes with cyclophosphamide treatment. Additionally, lifestyle medicine is playing a pivotal role in improving patient outcomes for cancer survivors.
Researchers at the University of Pennsylvania designed a new recipe for mRNA vaccines by adding phenol groups, which reduce inflammation and improve vaccine effectiveness. The modified lipids improved vaccine performance in various diseases, including COVID-19, cancer, and genetic diseases, with enhanced efficacy and reduced side effects.
A new study published in JAMA Network Open found no statistical relationship between pathologic complete response (pCR) and overall survival in rectal cancer patients. This challenges the FDA's use of pCR as a surrogate endpoint for drug approval, which may lead to treatments being fast-tracked without evidence of improved long-term su...
Researchers have discovered a key role of centrosomes in signaling cells to proliferate despite DNA damage, enabling cancer resistance. The study suggests targeting Polo-like kinase 1 could prevent adaptation to therapy-induced DNA damage and drug resistance.
Chemotherapy-induced pyroptosis in bladder cancer can actually make the disease more resistant to treatment by fueling cancer stem cells. Blocking this inflammatory process with belnacasan may overcome chemoresistance in preclinical models.
A team led by University of Houston engineer Tianfu Wu aims to find better biomarkers for ovarian cancer using autoantibodies and machine learning. By detecting ovarian cancer earlier, mortality rates could be reduced by 10-30%.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
MiROM identifies proteins by detecting molecular vibrations and detects structural changes in proteins, such as misfolding, allowing for real-time assessments of treatment effectiveness. This technology holds great potential for other diseases linked to protein misfolding, including Alzheimer's and Parkinson's.
The EVOaware project aims to develop an innovative platform that addresses tumour resistance to therapies by using advanced tissue imaging technologies and integrating genetic screening, lineage tracing, and spatial omics techniques. This platform has the potential to accelerate the discovery and development of new cancer therapies.
A new study from Uppsala University found that most men with prostate cancer who receive recommended treatment have a good prognosis, with a lower risk of dying from prostate cancer than other causes. The study's findings highlight the importance of assessing a patient's life expectancy in choosing an appropriate treatment strategy.
Researchers developed a novel immunotherapy that disrupts the IL-33/IL1RL1 signaling loop to boost immune function and improve survival in leukemia patients. The treatment targeted leukemia stem cells, reducing relapse rates and improving survival without major side effects.
Researchers found that CAR-T cells age and lose effectiveness due to premature senescence, a previously unrecognized mechanism of therapy failure. The discovery highlights the need for next-generation therapies with improved durability.
Researchers discovered a cancer signaling pathway's role in regulating the blood-retina barrier, potentially damaging protective mechanisms. The study also identified a new gene linked to inherited eye condition FEVR, highlighting the need for further investigation into vascular disorders.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
A new study from the University of Michigan Rogel Cancer Center identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment. The researchers found that docetaxel could be a good option earlier on in patients whose tumor harbors a specific gene program linked to extreme no...
Researchers highlight the benefits of artificial intelligence in glioblastoma management, including improved diagnosis, treatment planning, and personalized therapy. AI-based models can analyze radiological images, predict tumor characteristics, and suggest effective treatments, promising to improve patient outcomes and survival rates.
Research on MCL-1 protein reveals its critical role in cell survival and energy production, offering a roadmap for designing targeted cancer therapies with reduced side effects. The findings also shed light on fatal metabolic diseases in infants, providing potential new targets for future treatments.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
Researchers at Fujita Health University discovered benzaldehyde's mechanism to halt therapy-resistant pancreatic cancer growth and spread. Benzaldehyde prevents key interactions that enable cancer cells' survival and treatment resistance.
A new review recommends combining enfortumab vedotin with pembrolizumab as the first-line therapy for advanced urothelial cancer, offering a more effective and better-tolerated alternative to traditional chemotherapy.
Researchers analyzed blood cell genomes from 23 patients treated with various chemotherapies, discovering new patterns of DNA damage and mutational signatures associated with specific drugs. The study suggests using genomic data to choose chemotherapies that minimize premature ageing and potential secondary cancer risks.
Scientists have developed a miniature device that mimics human bone marrow and immune environment, enabling predictive testing of cancer immunotherapy success in patients. The device recreates three regions of bone marrow where leukemia develops and retains the complex immune environment of the tissue.
A new AI tool, iSeg, has been developed to accurately outline lung tumors on CT scans and identify areas that may be missed by doctors. The study found that iSeg consistently matched expert outlines across hospitals and scan types, and flagged additional areas that some doctors missed.
Scientists developed a method to use ultrasound to chemically activate drugs, selectively targeting tumors and stimulating immune cells. This approach achieved a 99% tumor suppression rate in colon cancer models without harming healthy tissues.
This study identifies pre-neadjuvant carcinoembryonic antigen (CEA) and neutrophil-to-lymphocyte ratio (NLR) as significant predictors of postoperative recurrence-free survival in non-small cell lung cancer (NSCLC) patients after neoadjuvant therapy. Smoking history is also a predictor of recurrence in LUSC patients.
Researchers developed patient-specific Cancer Chips to model esophageal tumor microenvironments, enabling accurate prediction of chemotherapy responses. The approach can rapidly stratify patients into responders and non-responders, paving the way for personalized medicine.
The American Society for Radiation Oncology (ASTRO) has updated its guideline on radiation therapy for high-grade diffuse gliomas, the most common primary brain tumor in adults. The new guideline provides evidence-based recommendations for multidisciplinary treatment and addresses optimal radiation dosing, fractionation, and techniques.
Researchers at the University of Oklahoma investigate the overlap between cognitive decline caused by chemotherapy and aging, discovering decreased blood flow, disrupted blood-brain barriers, and senescent cells. Removing these cells with senolytics can improve cerebral blood flow, cognition, and overall brain health.
A new gene therapy delivery device called NANOSPRESSO could revolutionize how hospitals treat rare diseases by allowing them to create personalized nanomedicines in-house. This democratized approach to precision medicine could boost access to low-cost bespoke gene and RNA therapies, especially in low-resource settings.
A study published in The Lancet Global Health found serious quality defects in a significant number of cancer medications from sub-Saharan Africa. Researchers evaluated 251 samples and discovered that one in six medications contained the incorrect quantity of active pharmaceutical ingredient, posing patient safety risks.
A new study reveals that SETD1B plays a critical role in supporting the growth of aggressive acute myeloid leukemia (AML) cells, particularly in those with FLT3-ITD mutations. By targeting SETD1B, researchers believe it may be possible to develop more effective treatments.
The new NCCN Guidelines Navigator tool offers an interactive platform for accessing evidence-based guidelines, facilitating easier searching and navigation. The initiative aims to improve patient care and outcomes by providing healthcare professionals with up-to-date recommendations.
Two Purdue researchers received funding to advance university innovations. Andrew Mesecar aims to develop new treatments for hepatocellular carcinoma using patented enzyme inhibitors. Meanwhile, Pablo Zavattieri is working on a patent-pending system to address saltwater intrusion in the Panama Canal.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have turned a deadly fungus into a potent cancer-fighting compound. The new compound, called asperigimycins, has shown promising results against leukemia cells, rivaling FDA-approved drugs.
Researchers discuss advancements in pancreatic cancer detection using biomarkers, imaging techniques, and molecular diagnostics. Novel therapies targeting the tumor microenvironment and immune evasion mechanisms are explored to improve survival outcomes.
Researchers discovered that aggressive melanomas overactivate mitochondrial pathways, which can be targeted by antibiotics and energy-production inhibitors. The findings suggest a new therapeutic vulnerability in melanoma cells, highlighting the safety and specificity of these treatment approaches.
Researchers have discovered that TAF2 plays a pivotal role in the growth of liver cancer and can help promote tumor formation. The study's findings suggest that targeting TAF2 could lead to more effective treatments for liver cancer.
Researchers developed nanomachines that can efficiently deliver antisense oligonucleotides to sentinel lymph nodes, reducing TGF-β1 levels and reactivating depleted CD8-positive T cells. This enhances cancer treatment outcomes for advanced breast cancers with no effective treatments.
A new test developed by CNIO scientists can predict which patients will not respond to common chemotherapy drugs, allowing for targeted treatment and reducing side effects. The test uses biomarkers based on chromosomal instability patterns to identify resistant patients.
This study evaluated the surgical outcomes of median sternotomy (MST) in treating intrathoracic tracheal malignancies, with MST providing superior surgical exposure and results in fewer complications. MST was found to preserve vascular integrity, protect the left recurrent laryngeal nerve, and achieve longer resectable tracheal lengths.
Researchers have developed a new technology to predict how bowel cancer adapts to treatment, enabling the design of personalized drugs that can keep patients alive longer. By analyzing cancer cell evolution, scientists hope to identify new targets for treatment and improve existing drugs.
A comprehensive review highlights the impact of anti-cancer treatments on bone health, increasing the risk of fractures and bone fragility. The International Osteoporosis Foundation advocates for a multidisciplinary approach to early screening and proactive bone-protective strategies.
The University of Texas Health Science Center at San Antonio is targeting hard-to-treat cancers and boosting HPV vaccination rates with a $3.4 million funding from CPRIT. The institution will expand its core facilities laboratories to increase researchers' ability to identify therapeutic targets and develop new cancer technologies.
ASTRO welcomes Karen Davis as its first Vice President of Business Development and Marketing, leading the organization's business growth strategy. Davis will focus on public- and private-sector partnerships to advance ASTRO's mission and broaden its impact on cancer care.
Researchers at MD Anderson have made significant progress in treating non-small cell lung cancer (NSCLC) by combining chemotherapy, immunotherapy, and surgery. They found that pre-surgical combination therapy showed promising results, with high rates of pathological complete response and major pathological response.
Mayo Clinic has opened its first carbon ion therapy program in the Western Hemisphere, providing new hope for patients with treatment-resistant cancers. The Duan Family Building will also offer advanced proton therapy and other cancer treatments.
Experts from the National Comprehensive Cancer Network (NCCN) and African Cancer Coalition gathered in Nairobi, Kenya to update NCCN Clinical Practice Guidelines in Oncology for Sub-Saharan Africa. The meeting aimed to improve cancer care in the region by sharing evidence-based recommendations.
A new study of 591 women with early-stage breast cancer found that nearly two-thirds opted for continued endocrine therapy beyond the initial five years. Patients with higher-risk stage 2 disease were more likely to continue treatment, highlighting potential benefits in extending hormone-based therapy for these patients.