Articles tagged with Adverse Effects
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that subretinal adeno-associated virus 8 injections trigger proinflammatory T-cell responses, but co-injection of immunodominant peptides can modulate the immune system. This study suggests a new approach to AAV gene therapy for retinal diseases.
TAS-303 reduces SUI episode frequency by 58% compared to placebo, while also improving urinary incontinence amount and health-related quality of life. The medication may offer a safer alternative for SUI treatment without adverse effects associated with existing medications.
A new study finds that over 100,000 oil and gas wells in the western US are at risk of wildfires, posing a compound hazard to nearby populations. The research highlights the need for proactive action to prevent future harms.
A prospective study found that medication abortion via no-test telehealth and mailing of medications was comparable in effectiveness to in-person care with ultrasonography. The research also revealed low adverse event rates across all groups.
A study of almost 400,000 live births found that paternal use of metformin monotherapy was not significantly associated with major congenital malformations. However, researchers noted that fathers prescribed metformin had higher rates of cardiovascular and metabolic conditions, which could affect reproductive health.
A study found that pesticides imidacloprid, pyraclostrobin, and glyphosate impair the mobility and immune system of Brazilian native stingless bees. Even if bees survive exposure to these pesticides, their immune systems are weakened, making them more prone to infections and increasing the risk of colony collapse.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
Researchers found two opportunistic bacteria significantly more abundant after three months of daily use, Fusobacterium nucleatum and Streptococcus anginosus. A decrease in Actinobacteria was also observed, crucial contributors to blood pressure regulation.
A new study found that pregnant women with lower socioeconomic status are exposed to higher levels of thyroid-disrupting chemicals, particularly polyaromatic hydrocarbons. This increased exposure has the potential to worsen health disparities among low-income populations.
A Korea University study reveals that gastrectomy decreases the risk of major adverse cardiovascular events in patients with gastric cancer. The research analyzed data from 2004 to 2013 and found a significantly lowered risk of cardiovascular disease in those who underwent gastrectomy.
Patients who received COVID-19 vaccines after acute coronary syndromes had similar rates of primary composite end point and major adverse cardiovascular events (MACE) compared to unvaccinated patients. Retrospective studies have shown a short-term reduction in MACE risk after COVID-19 vaccination.
Researchers assessed brain imaging for minor, moderate, and major ischemic strokes to evaluate early direct oral anticoagulant initiation. The study found no difference in treatment effects or adverse event rates among infarct sizes.
Researchers investigated the biological repercussions of UV-C radiation exposure from readily available domestic lamps and found that even brief exposure can lead to irreversible alterations in skin cells and retinal cells. The study highlights the need to prioritize safe utilization of these lamps to prevent potential harm.
A phase 3 trial found that pamrevlumab did not significantly improve lung function in patients with idiopathic pulmonary fibrosis. The study's results underscore the need for effective treatments to slow disease progression and improve patient outcomes.
A new study from the University of Copenhagen found that long-term exposure to air pollution accelerates cognitive decline and increases risk of dementia. The research, which followed a cohort of nurses for 27 years, also suggests that physical activity may mitigate the adverse effects of air pollution.
A UCL-led team of researchers warn that climate change will aggravate brain conditions such as stroke, migraine, and dementia. The study, which reviewed 332 papers, found that extreme temperatures and weather events can disrupt sleep, exacerbate cognitive impairment, and lead to increased hospital admissions and mortality.
Two studies based on the SELECT trial show semaglutide leads to sustained weight loss of 10% body weight and 7cm waist reduction after 4 years, regardless of starting weight or BMI. The medication also delivers cardiovascular benefits, with a lower risk of heart attack, stroke, or death.
A new study finds mail-order pharmacy dispensing of mifepristone for medication abortion is effective, acceptable to patients, and feasible. This care model can improve access to medication abortion services and reduce the need for in-person screening.
A secondary analysis of a randomized clinical trial found that home blood pressure self-monitoring plus medication self-titration reduces BP in the longer term without increasing healthcare use or adverse events. This simple, inexpensive intervention has potential to improve long-term hypertension control in routine clinical practice.
A recent study by Kyoto University reveals that expatriates' boundary-spanning activities can lead to role stress, emotional exhaustion, and a sense of being an outsider among local employees. The study highlights the need for careful management to mitigate these negative impacts.
A recent UC Irvine study has found evidence of the molecular causes of heat stress's detrimental effects on the brain, gut, and liver in older adults. The research suggests that understanding the gut-liver-brain communication system is crucial for protecting human health from heat-related illnesses.
New research found that maternal grandmothers' investment in grandchildren who experienced adverse early life experiences can significantly reduce emotional and behavioral problems. The study suggests that supportive caregiving from grandparents can protect children from negative effects of early adversity-induced behavioral issues.
Researchers found that altering a male mouse's gut microbiota increases the probability of low birth weight and premature death in their offspring. The study suggests a 'gut-germline axis' exists, connecting the gut microbiota to the germline and potentially influencing inherited traits.
Researchers have discovered that rice bran-derived nanoparticles exhibit strong anticancer effects, selectively targeting cancer cells while sparing healthy tissue. The nanoparticles reduced tumor growth and inhibited metastatic cell growth in mice models.
Researchers investigate the neuroprotective effects of tocotrienols in alleviating obesity-induced cognitive decline. The study found that T3s treatment improved cognitive function and mitigated oxidative stress in mice fed with a high-fat, high-sucrose diet.
Hyperemesis gravidarum can significantly impact maternal health and infant well-being, leading to weight loss and dehydration. Treatment involves relieving symptoms with antiemetics and other medications, while remedies like ginger products may provide some relief.
A new study found that childhood maltreatment can continue to impact mental and physical health into adulthood due to its effects on risk factors such as obesity, inflammation, and traumatic experiences. Researchers used MRI brain scans to confirm that widespread changes in brain structure were associated with childhood maltreatment.
A recent study published in PLOS Global Public Health found that individuals remaining in Ukraine during the ongoing war are more likely to experience anxiety and post-traumatic stress disorder (PTSD) than refugees. Exposure to blasts and loss of community, housing, and economic resources contribute to these mental health issues.
A new study found that understanding racial inequities in healthcare access can have a negative impact on both Black and white populations' views of their own health. Accurate awareness is crucial, but also poses an additional burden on Black individuals, causing unnecessary stress.
A study published in PLOS ONE found that employees with volatile work schedules early in their career had worse sleep and more depressive symptoms at age 50. The study used data from the National Longitudinal Survey of Youth-1979 to examine the impact of employment patterns on health in middle age.
A study by Washington State University found that cats with the MDR1 genetic mutation are at high risk of experiencing serious adverse effects from products containing eprinomectin. Cats without this mutation appear safe when using these products, but many cases of severe reactions have been reported.
A recent study found that eating fortified eggs had no adverse effect on blood cholesterol levels and may even have beneficial effects on cardiovascular health. Subgroup analyses revealed potential benefits among older adults and those with diabetes.
A new study finds that e-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers. The researchers also found that some smoking-related epigenetic changes remain more stable after giving up smoking, suggesting that e-cigarettes may not be completely safe.
Preliminary research suggests that short-term heat exposure can lead to increased inflammation and impaired immune function, making individuals more susceptible to infections. Adults older than 60 and those with existing cardiovascular disease are particularly at risk.
A recent survey of parents whose infants were under six months old during the 2022 baby formula shortage found that 81% switched formulas, with 60% experiencing issues such as fussiness, gas, spit-up, constipation, and diarrhea. The study highlights the need for improved lactation education and support to prevent infant-feeding crises.
A new study found that consuming refined carbohydrates is associated with lower attractiveness ratings, regardless of factors such as BMI and age. The researchers also discovered sex differences in the relationship between refined carbohydrate consumption and facial attractiveness.
A Texas A&M professor will lead a team in evaluating the distribution and potential hazard of volatile organic compounds (VOCs) in East Palestine, Ohio, using a mobile platform. The research aims to inform response methods to measuring air quality following environmental disasters.
A new study reveals that young adults look and feel older on stressful days, especially when they lack control over their lives. Researchers found a significant correlation between stress levels and subjective age in younger adults.
A study by SLU professor SangNam Ahn found that childhood and adult adversity can increase the risk of mental illness and cognitive decline later in life. The research team analyzed data from over 3,500 individuals and discovered a strong correlation between adverse events and anxiety, depression, and cognitive impairment.
A recent study from Amsterdam UMC and the University of Glasgow found that loneliness increases physical frailty, leading to a higher risk of depression, falls, and cognitive decline in older adults. The research analysis more than 130 studies and revealed that reduced social functioning is associated with physical decline in older adu...
A study by UC San Francisco researchers found that daily cannabis users had a 25% increased risk of heart attack and a 42% increased risk of stroke compared to non-users. The study also found significant cardiovascular risks associated with cannabis use, including coronary heart disease and the combination of heart attack and stroke.
A recent Mayo Clinic study found that daylight saving time has a minimal impact on heart health. Researchers analyzed data from 36 million adults and found a slight increase in cardiovascular events during the spring and fall transitions, but this was deemed clinically insignificant.
A UCF-developed technology uses a plasmonic platform to detect the chirality of molecules with high precision, enabling more accurate drug development and therapies. The platform improves upon current methods with sensitivity nearly 13 orders of magnitude greater.
A new study reveals that Agent Orange damages frontal lobe brain tissue in laboratory rats, causing molecular and biochemical abnormalities similar to early-stage Alzheimer's disease. This research has important implications for the long-term brain health of aging veterans and people exposed to biologically similar herbicides.
A recent study at the University of Eastern Finland gathered information on psychotherapy-associated adverse events, their content and scope. The researchers found no significant negative outcomes in included studies, but highlighted the need for standardised methods to assess adverse effects.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
Research finds that stable caregiver relationships in childhood may increase optimal heart health, while adversity and abuse can lead to poor cardiovascular health. Lower income as an adult may also introduce additional adversity, making the relationship between caregiver-child adversity difficult to see.
Researchers at Tohoku University developed a novel approach for treating lymph node metastasis by administering anticancer drugs directly into the LNs, improving efficacy and reducing side effects. The Lymphatic Drug Delivery System (LDDS) targets sentinel lymph nodes, generating antitumor effects locally.
Clinicians use specific cues to detect and address drug-drug interactions, which can be addressed by investigating alternative treatments, altering dosage, or stopping a medication. The study provides recommendations for EHR system alert design to improve clinician decision-making and patient safety.
Korea Maritime & Ocean University researchers have developed a new method for assessing the path-following performance of autonomous ships in adverse weather conditions. The computational fluid dynamics model can provide more accurate predictions of path-following performance and enhance safety in autonomous marine navigation.
Private equity acquisition of hospitals was associated with increased hospital-acquired adverse events, suggesting poorer quality of inpatient care. These findings highlight concerns about the implications of private equity on healthcare delivery, particularly among Medicare beneficiaries.
Recent urology treatment studies have improved the reporting of harms in randomized trials, addressing adverse events, side effects, and complications. The analysis found a significant increase in reporting harms criteria from 2012 to 2020, with more than three-fourths of items addressed by 2020.
A new study examines the impact of public benefit programs on child maltreatment rates across different racial and ethnic groups. The research suggests that these programs may exacerbate existing disparities, with white children facing lower rates of investigation compared to their Black and Hispanic counterparts.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
Two studies found moderate to high risk scores for cancers and non-cancer health effects associated with lead, arsenic, and cadmium exposure. Exposure to these heavy metals through contaminated food is linked to increased risks of various types of cancer, including lung, bladder, skin, and prostate cancers.
Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not show a reduction in composite neonatal adverse outcomes. The study suggests that the effect of reducing large-for-gestational-age infant risk after adding metformin to insulin warrants further investigation.
A new study by Texas A&M University researchers found a significant decrease in measles antibody concentrations with increasing urinary arsenic levels in children with low serum folate levels. Folate intake may mitigate the toxic effects of chronic arsenic exposure, but the unequal impact of arsenic by sex remains unclear.
A new study found that adverse childhood experiences are associated with greater muscle dysmorphia symptoms in Canadian adolescents and young adults. Adverse childhood experiences, such as domestic violence and emotional abuse, may lead to body dissatisfaction and the pursuit of muscularity as a coping mechanism.
Two papers advance understanding of PFOS effects on aquatic life, particularly fish, by testing multiple concentrations and confirming its presence in water. The results indicate that earlier findings were non-repeatable and likely due to biological variation rather than PFOS toxicity.
A comprehensive meta-analysis led by Dr. Micheal Sandbank reveals that many low-quality studies are driving intervention recommendations and patient outcomes in early childhood autism care. The study highlights the need for more rigorous research to understand the positive and negative effects of various interventions.