Articles tagged with Adverse Effects
The American College of Physicians recommends using cognitive behavioral therapy (CBT) or second-generation antidepressants as initial treatment for adults with moderate to severe major depressive disorder. The guideline also suggests considering combination therapy and discussing patient preferences when selecting a treatment.
A systematic review and meta-analysis of 17 studies found mRNA COVID-19 vaccination to be associated with lower risks of SARS-CoV-2 infections, severe illnesses, and hospitalizations. While vaccination was linked to higher adverse event rates, the frequency of severe adverse events remained low.
Researchers investigated micro-sized polyethylene's toxicity on human colorectal cancer cells, finding decreased cell viability and increased reactive oxygen species production. Exposure to high doses caused cell death and oxidative stress responses.
A large cohort study found that long-term low-dose hydroxychloroquine use is associated with a low risk of developing retinopathy, while higher doses increase the risk. Regular screening can identify the issue at an early stage.
A study published in the Journal of the American Geriatrics Society found a sharp increase in cannabis-related emergency department visits among California adults ages 65 and older from 2005 to 2019. The rate increased by 1,808%, with more than 12,000 visits reported in 2019.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
Research from the University of Ottawa finds that oral contraceptives' effects on brain and mood in women may be linked to age of onset and gut microbiome. The study suggests adolescence as a critical period for understanding OCs' impact, as it influences brain development and hormonal changes.
A study by Edith Cowan University found that home-based exercise programs can accelerate recovery from cancer-related fatigue and improve health-related quality of life during radiotherapy. The research included 89 women who completed a 12-week program, with no adverse effects reported.
A new study explores how corporal punishment impacts neural systems, linking it to increased anxiety, depression, and altered brain activity. The research found that adolescents who experienced physical punishments showed a larger neural response to error and a blunted response to reward.
New research from King's College London found increasing CBD content in cannabis does not significantly change the effects of THC on cognitive performance or psychotic symptoms. The study suggests that choosing cannabis with higher CBD:THC ratios may be safer due to lower THC levels, but CBD has no impact on intoxication quality.
Researchers found that exposure to e-cigarettes, marijuana, and tobacco led to increased scarring, decreased blood vessels, and changes in heart nerves, all contributing to an increased risk of arrhythmias. These substances can cause similar harm to the heart as traditional cigarettes.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
A recent study published in Science of The Total Environment found that many household wells in Nevada are contaminated with heavy metals such as arsenic, which can cause adverse health effects. The study suggests that frequent testing and improved treatment systems are necessary to ensure safe drinking water for rural communities.
A recent study found that alligators in the Cape Fear River basin have elevated levels of PFAS chemicals in their blood serum, leading to clinical and genetic indicators of immune system effects. The research team detected a significant association between PFAS exposure and autoimmune-like phenotypes in the affected alligators.
A study published in JACC: CardioOncology found that exercise during chemotherapy improves long-term cardiorespiratory fitness and alleviates adverse effects of cancer treatment. After treatment, an exercise program can recover lost function. The optimal timing of exercise intervention is during chemotherapy.
Researchers found that 12% of cancer survivors lived in poverty, experiencing negative effects on physical and mental health. Financial burden of cancer care persists years after diagnosis, leading to poor health outcomes and increased mortality.
Researchers report two cases of successful treatment with oral tecovirimat for patients with monkeypox and severe proctitis. The medication rapidly alleviated rectal pain with no serious adverse effects. Early use of tecovirimat may be a promising treatment option until randomized controlled trials can be conducted.
A new study estimates that over 5.5 million U.S. adults used hallucinogens in the past year, with a significant increase in LSD use between 2002 and 2019. The study found that PCP use decreased during this period, while Ecstasy use also declined since 2015.
Research shows that exposure to commonly used insecticides can profoundly impair honeybees' visually guided behavior, crucial for flight and survival. The study found that pesticide-exposed bees have impaired optomotor responses, with increased asymmetry in left and right turns.
A recent study combined elevation data of the Antarctic ice sheet from two different satellites, CryoSat-2 and Sentinel-3, to obtain a more accurate map of latest elevation changes. The results showed that the average elevation of the ice sheets had decreased at a rate of 4.3 cm/year during 2016-2019.
A new study at the University of Missouri found that prenatal opioid exposure can trigger long-term neurological or behavioral effects in children. The research suggests that opioids impact the developing fetus' gut microbiome, leading to changes in metabolic pathways and potentially affecting overall health and wellness.
Researchers at Columbia University Irving Medical Center developed a novel algorithm that identified nearly 20,000 adverse drug events (ADEs) signals across seven pediatric development stages. The study utilizes predictive modeling on real-world data to overcome limited data within individual stages.
Researchers assessed the safety and adverse events of mRNA COVID-19 vaccines in long-term care residents in Quebec, Canada. No significant adverse events were reported following the third dose, highlighting the vaccine's effectiveness in this vulnerable population.
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many to avoid surgery and hospitalization. This treatment approach is associated with fewer serious adverse effects compared to hospitalization.
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A new study found that pregnant women's use of alcohol correlates with that of their partner, highlighting the importance of both parents reducing their alcohol consumption. The research, which analyzed data from 14,822 Finnish women and their partners, showed that exposure to alcohol can have detrimental effects on fetal development.
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
A study suggests switching from intramuscular to subcutaneous injection may ease post-vaccination fatigue in humans, similar to findings in mice. Researchers identified molecular characteristics linked to increased fatigue and correlated them with baseline gene expression of immune cells.
Research found that e-cigarette users spent more on healthcare services, including hospital stays, ER visits, and doctor appointments. The study estimated $15.1 billion in annual healthcare expenditures attributable to e-cigarette use in the US.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
A study found that regular pharmacist visits reduced medicine-related problems by 60% and improved cognition scores. The research highlights the need for personalized pharmaceutical support within the aged-care sector to prevent harm from medicines.
A recent study found that a single course of antibiotics disrupts the balance of gut bacteria and fungi in infants, leading to increased competition for space. This disruption can result in long-term adverse effects on human health, including antibiotic-associated diarrhea and chronic inflammatory diseases.
A study by Durham University found that 90% of bidi workers are women who face numerous health issues and limited job options. Researchers suggest alternative employment like spice or fabric production could provide better working conditions and personal circumstances.
A new study from Boston Medical Center found that COVID-19 infection during pregnancy is associated with elevated inflammatory markers in infants, potentially impacting growth and brain development. Researchers emphasize the importance of COVID-19 vaccinations for pregnant women to avoid long-term adverse consequences for their infant.
A new study found that native species in southwestern Washington floodplains adapt to bullfrogs and sunfish by changing their feeding strategies. The researchers analyzed carbon and nitrogen stable isotopes in predators and prey to understand food webs, finding that some species shifted towards more abundant food sources.
A new study found that Black kidney transplant recipients exhibit a faster clearance rate of tacrolimus, an immunosuppressive drug. The study suggests that considering both sex and race when dosing tacrolimus may reduce adverse effects and enhance transplant outcomes.
A recent study found that older adults who received a booster dose of the Pfizer-BioNTech COVID-19 vaccine experienced short-term adverse events. The study assessed over 60,000 participants aged 60 or older in Israel and reported various side effects including fatigue, headache, and muscle pain.
A decision-support framework was developed by management science researchers to help clinicians make informed decisions about opioid prescribing. The framework incorporates multiple factors, including recovery time, pain intensity, and patient history, to provide a quantitative model of the prescribing process.
A study of 48,000 individuals found that third-dose vaccination against SARS-CoV-2 with mRNA vaccines was associated with increased reporting of low-severity adverse events. However, there was no significant increase in the reporting of severe adverse events.
A national survey found that 47% of parents experienced negative birth experiences, with uncertainties about restrictions causing increased anxiety. Good communication from healthcare providers was key to a positive experience, with families reporting reduced levels of anxiety and stress when provided with support.
This cross-sectional study investigated the association between adverse childhood experiences and poor neuropsychiatric health in former NFL players. Football-related concussions were found to be significantly associated with increased risk of dementia and poor neuropsychiatric health among these athletes.
Intermittent fasting produces mild to moderate weight loss and improves cardiometabolic risk factors, comparable to traditional calorie-restricted diets. The review also dispels myths about intermittent fasting, including the misconception that it leads to weakness and decreased concentration.
A study of 29,000 Medicare claims data found a strong association between midlife BMI and later-life health outcomes. The research suggests that individuals with higher BMIs in midlife are more likely to experience adverse health and reduced longevity.
A study of insurance claims data found that state laws governing opioid prescribing had a negligible effect on opioid prescribing trends. The authors suggest that shifting clinical guidelines, professional norms, or other factors may be driving the decline in opioid prescribing. In contrast, a post-hoc analysis of an ASPREE trial found...
A large US study found that 92% of reported adverse events following mRNA COVID-19 vaccination were non-serious, with most side effects being mild and decreasing substantially after one day. The study also found that less than 1% of participants reported seeking medical care after vaccination.
A study by University of Turku found that grandparents' support decreases with adverse experiences in children's families. However, maternal grandmothers' support remains consistent. The study suggests that future prospects for successful reproduction may impact grandparents' willingness to offer support.
A new synthetic substance, PECS-101, has been shown to prevent neuropathic pain caused by chemotherapy while improving cancer treatment outcomes. The study, conducted in mice, found that PECS-101 had no adverse effects and did not cause dependence.
The anticholinergic burden scale helps identify patients at risk of cognitive decline from these medications. The editorial highlights the complexity of safely reducing or stopping these medications due to their risks.
Adults with spinal cord injuries have a near-80% increased risk of developing psychological conditions compared to those without the injury. Chronic pain is equally negatively impacting mental health, associated with post-traumatic stress disorder and other mental health conditions in most cases.
A new study published in Clinical Nutrition found that drinking less than the UK's recommended 14 units of alcohol per week increases the risk of cardiovascular events. Moderate alcohol consumption is associated with a 23% increased risk of suffering a cardiovascular event for every additional 1.5 pints of beer consumed.
Researchers at Brigham and Women's Hospital conducted a scoping review of 78 articles to identify key use cases for AI in preventing or mitigating adverse drug events (ADEs). Genetic information is thought to be critical in improving AI algorithm performance, but systematic evaluations are necessary to generate evidence for this field.
A study of nearly 20,000 adults found that serious COVID-19 vaccine side effects are extremely rare among those who received vaccination. The online survey collected data on health and COVID-19-related events for daily, weekly, and monthly periods.
A recent study, published in JAMA Network Open, investigated the relationship between food insecurity and allostatic overload in older adults. Researchers found that food insecurity is associated with increased allostatic overload, which can have negative effects on health outcomes.
A randomized clinical trial investigated the effects of a Mediterranean diet and mindfulness-based stress reduction on preventing small-for-gestational age birth weights. The study found that these interventions significantly reduced the risk of this adverse pregnancy outcome.
A new study from Keck School of Medicine of USC shows that vaping is associated with dysregulation of mitochondrial genes and immune response genes, similar to smoking. The research found that over 80% of gene dysregulation in vapers correlated with the intensity and duration of current vaping.
Extreme heat events are associated with a greater risk of death from ischemic heart disease, stroke, and heart failure. Preventive strategies aim to reduce hyperthermia and dehydration to minimize cardiovascular risk during extreme heat events.
A new study from the University of Eastern Finland introduces an electric soot collector that achieves a 45% fine particle reduction efficiency in logwood-fired masonry heaters. The technology uses natural charges of flames to collect particles, but further optimization is needed for higher reduction efficiencies.
A systematic review of social media research identified 46 harmful effects, ranging from psychological harms like jealousy and loneliness to security and privacy issues. The study highlights the need for user moderation and software development strategies to mitigate these negative effects.
A recent study published in the American Journal of Clinical Nutrition found that consuming whole fat milk has no negative impact on children's health. The research, which involved 49 healthy children aged four to six, showed that both groups consumed similar amounts of calories and fat.
A large Ontario study confirms SARS-CoV-2 variants of concern like Delta increase the risk of severe outcomes, including hospitalization and death. Vaccination blunts severity, reducing risk in partially and fully vaccinated individuals by about 80-90%.