Articles tagged with Adverse Effects
A new study found that high-intensity resistance and impact training for just 30 minutes, twice a week, improved bone density and structure in postmenopausal women with low bone mass. The exercise program was also associated with enhanced functional performance and reduced risk of osteoporotic fracture.
Research from Aarhus University found that 29% of referred women over 18 have been prescribed psychiatric medicine before vaccination, compared to 17% for HPV vaccinated women. Women referred to HPV centers often had mental health issues before receiving the vaccine.
Opioid-related problems in hospitalized children increased significantly over nine years, with white children being most affected. Adverse events included opioid withdrawal, constipation, altered mental status, and cardiac arrest.
A James Cook University scientist has discovered an alcohol-free antiseptic solution that is safe and effective for minor surgical procedures. The study found a slightly lower infection rate with the new solution compared to traditional water-based antiseptics.
Among patients unresponsive to an antidepressant, adding aripiprazole modestly increased remission rates from depression compared to switching or augmenting with bupropion. The study found symptom improvement was greater with aripiprazole than other treatments.
Dr. Matthew Stanbrook argues that Health Canada's proposed changes are a step forward but need further action to protect consumers. The new regulations aim to hold nonprescription drugs and natural health products to the same standards, but direct evidence is needed to determine risk.
The prevalence of daily supplemental vitamin D use above 1,000 IU increased from 0.3% in 1999-2000 to 18.2% in 2013-2014. Intake of 4,000 IU or more daily also rose, with 3.2% of participants using such supplements in 2013-2014. The trend was observed across most age groups, race/ethnicities, and sexes.
Researchers found that radiation therapy can alter neural networks and lead to cognitive decline in patients with brain tumors. The study suggests that the treatment may cause broader adverse effects, including thinning of the brain cortex and increased segregation between brain regions.
A meta-analysis of three randomized controlled trials shows that zinc acetate lozenges can increase the recovery rate from the common cold by 3 fold. The studies found no adverse effects at doses up to 92mg/day, making them a potentially effective treatment option.
A study published in JAMA found that early low-dose hydrocortisone treatment in very preterm infants did not result in adverse effects on neurodevelopmental outcomes at 2 years of age. The researchers analyzed data from the PREMILOC trial and found no significant differences in patients with or without neurodevelopmental impairment.
Two studies found that radical prostatectomy was associated with greater decreases in sexual function and urinary incontinence compared to active surveillance. However, no significant differences were found in bowel or hormonal function beyond 12 months.
A new study by Columbia University's Mailman School of Public Health found that B vitamins can increase plasma concentrations of folic acid, vitamin B6, and vitamin B12, reducing the impact of air pollution on the epigenome. The results have significant public health implications for regions with frequent PM2.5 peaks.
A new study examines the effect of adverse childhood experiences on health and biological outcomes in children, finding associations with weight changes, asthma, and sleep disruption. Researchers highlight the importance of early detection to protect children's health and well-being before long-term adult outcomes occur.
A nationally representative survey found that US adults' supplement use remained stable between 1999 and 2012, with 52% reporting use of any supplements in 2011-2012. Multivitamin use decreased during this time period, from 37% to 31%.
A document analysis found that orlistat trial reports underestimated adverse effects, with only 3-33% of reported events appearing in published papers. This suggests potential for bias in harms reporting and highlights the need for more accurate reporting practices.
Research from the University of East Anglia found that people switching to pill organizers are more likely to become unwell than those not using them. Patients should consult their GP or pharmacist before making the switch.
A study assessed the performance of direct-to-consumer teledermatology services, finding they often made incorrect diagnoses and provided inadequate treatment information. The services also failed to disclose potential adverse effects and pregnancy risks in prescriptions.
A study by SUNY Downstate Health Science University found associations between pregnant women's exposure to butyl paraben, triclocarban, and propyl paraben and adverse birth outcomes. Findings suggest potential risks of these chemicals in consumer products.
Researchers found that transformational leadership can increase sickness absence levels among employees who ignore their ill-health and frequently show up for work while ill. The study suggests that managers should strike a balance between encouraging staff to perform well and prioritizing their health and well-being.
Researchers found that impaired Nrf2 activity leads to increased hemolytic anemia, vascular inflammation, and lung injury in SCD mice. Pharmacological activation of Nrf2 improved survival and reduced age-related adverse effects.
Julie Rovner received the Endocrine Society's Award for Excellence in Science and Medical Journalism for her article on ensuring more women are included in clinical trials. Her coverage highlights efforts to balance research on both sexes, as women have a higher rate of adverse effects from approved medications.
A Phase 2 study demonstrated the safety of deep brain stimulation (DBS) in treating mild Alzheimer's disease. No adverse effects were reported, but the next step is evaluating efficacy and longer-term safety in a larger patient population.
The American College of Physicians recommends cognitive behavioral therapy (CBT) and second-generation antidepressants (SGAs) as similarly effective treatments for adults with major depressive disorder. CBT is a reasonable approach for initial treatment, particularly when discussing treatment effects and patient preferences.
A study published in JAMA Oncology found that surgical castration was associated with lower risks of fractures, peripheral artery disease, and cardiac complications compared to medical castration. However, no significant difference was observed between the two treatments for diabetes and cognitive disorders.
A UCI study found that high doses of green tea polyphenols can cause developmental delays, reduced offspring output, and reproductive abnormalities in fruit fly larvae. The researchers recommend moderate consumption to avoid potential health risks.
Proton pump inhibitors are associated with rare but serious adverse effects, including heart attack, Clostridium difficile infection, and malabsorption of vitamin B12. Physicians should prescribe at the lowest dose possible and for the shortest length of time to minimize these risks.
A UK study found that each additional 10,000 people reassessed using the Work Capability Assessment was associated with an increase in suicides, self-reported mental health problems, and antidepressant prescribing rates. The most deprived areas experienced the greatest increases in these adverse outcomes, widening health inequalities.
Researchers from IMIM and partner institutions developed a new integrated computational method to predict adverse drug reactions more reliably. The method combines structure-based detection of labile fragments with information on the mechanism of action of the drug, resulting in improved ability to foresee possible adverse effects.
A new study by University of York academics reveals that green walls can lead to higher levels of ultrafine particles (UFPs) indoors due to the oxidation of outdoor plant species. This could have significant implications for indoor air quality, particularly in offices with high temperatures and pollution.
A study found that major postoperative complications significantly contribute to prolonged hospital stays, while delirium contributes to adverse outcomes including length of stay, institutional discharge, and rehospitalization. Delirium was found to exert the highest attributable risk compared with other adverse events.
An analysis of edible medical marijuana products found that many had inaccurate labeling, with some containing lower amounts of THC and higher amounts of CBD. Regulation and quality assurance are needed to ensure accurate product labeling.
A meta-analysis of e-cigarette studies found that while they significantly improve abstinence rates at 1 month compared to placebo, this effect is not sustained over longer periods. The device is associated with frequent short-term respiratory adverse events and may pose a higher risk of serious adverse events than nicotine patches.
A consultant cardiologist argues that private practice has direct adverse effects on the NHS, leading to increased waiting times and unnecessary tests. He believes doctors should not be allowed to work in both sectors due to conflicting priorities.
A study found that female liver cells are more susceptible to adverse effects of drugs than male counterparts, particularly postmenopausal women. The findings highlight the need for a sex-specific approach in toxicology and suggest that current theories cannot explain why women are generally more sensitive to drug toxicity.
A study by Helmholtz Munich researchers found that exposure to ultrafine particles can induce immediate changes in heart rate variability in individuals with impaired glucose metabolism or diabetes. The research suggests potential health risks and demands for threshold limit values for environmental standards.
Researchers found that BPA exposure in fish can lead to reduced fertilization rates and increased embryo mortality in subsequent generations. Exposure occurred during embryonic development, resulting in adverse effects on future reproductive health.
Wild blueberries (bilberries) have been shown to mitigate the negative effects of a high-fat diet on blood pressure and nutrition-derived inflammatory responses. The study found that bilberries reduced pro-inflammatory effects, prevented elevated blood pressure, and improved glucose tolerance in mice fed a high-fat diet.
A recent study found a significant association between statin use and an increased risk of developing cataracts. However, experts emphasize that the benefits of statins in preventing cardiovascular disease outweigh the potential risks. The study's findings add to the accumulating knowledge on the statin-cataract connection.
A recent review in the New England Journal of Medicine finds that marijuana use is associated with increased risks of addiction, impaired critical thinking and memory functions, and lower IQ in teens. The study also highlights the need for physicians to convey to families the potential health consequences of early marijuana use.
A study found no significant difference in effectiveness between long-acting injectable versions of second-generation and older antipsychotic medications. Participants taking paliperidone palmitate gained weight, while those taking haloperidol decanoate lost weight.
A new study suggests that olive oil supplements can counteract the negative cardiovascular effects of exposure to air pollution particles. The study found that olive oil supplementation improved endothelial function and reduced blood markers associated with vasoconstriction after exposure to fine/ultrafine particulate matter.
A real-world study evaluating the benefit of treating asthma with small particle treatments like QVAR compared to larger particle treatments revealed interesting differences in asthma exacerbation outcome rates. The study found that initiating dosing with small versus large particle ICS treatments can impact asthma control rates.
A recent study published in Annals of the Rheumatic Diseases found that allopurinol, a commonly used gout medication, is associated with a reduced risk of death in hyperuricemic patients. The study also suggests that treatment with allopurinol may protect against premature death, outweighing rare but serious adverse effects.
A study by University of Kent psychologists found that listening to 'sad' music with high aesthetic value directly predicts mood enhancement. Music selection strategies were linked to individual expectations and emotions.
The Endocrine Society's new statement highlights the prevalence and medical consequences of performance-enhancing drug (PED) use among non-athlete weightlifters. PEDs can lead to various health issues, including cardiovascular, psychiatric, metabolic, renal, and musculoskeletal disorders.
A recent study found no significant increase in serious diseases among HPV-vaccinated girls compared to unvaccinated peers, despite monitoring over 900,000 participants. The researchers also noted that mild adverse reactions such as fever and swelling are common but not considered a concern.
A recent study found that exposure to hardcore pornography was associated with higher levels of sexism in a subgroup of Danish adults, particularly those low in agreeableness. The study suggests individual differences play a significant role in the impact of pornography on attitudes towards women.
Good asthma control is crucial during pregnancy to prevent adverse effects on maternal and fetal outcomes. Studies suggest that poor asthma control can lead to increased risks of hypertension, caesarean section, and low birth weight.
The VDI guidelines provide a state-of-the-art approach to GMO monitoring of Lepidoptera. The study aims to increase detection success and inform the European Community's requirements.
A recent study has found that physicians are often poorly informed about the side effects of prescription drugs, with medical sales reps dominating discussions and rarely disclosing serious risks. The research highlights a concerning trend in the pharmaceutical industry's information practices.
A new study projects that heat-related deaths in Manhattan will increase by 20 percent by the 2020s and potentially up to 90 percent or more by the 2080s. Higher winter temperatures may offset some of these deaths, but overall temperature-related mortality is expected to rise.
The number of prescription drugs that interact with grapefruit is significantly increasing, putting patients at risk of serious adverse effects. Older adults are especially vulnerable due to decreased tolerance and age-related changes in drug metabolism.
A study of almost 1,000 men diagnosed with prostate cancer found that active surveillance can reduce or avoid side effects such as incontinence and impotence. Many low-risk tumours are slow-growing and may never develop symptoms during a lifetime.
Researchers developed a new radiation treatment method that reduces the risk of permanent neurocognitive damage in children with brain tumors. The study found that proton therapy and photon therapy techniques significantly decreased the risk of these adverse effects, potentially leading to better quality of life for affected children.
A Danish study found that women who drink five or more cups of coffee a day have a 50% reduced chance of success in IVF treatment. The live birth rate was also lower by 40%. The researchers suggest that women should not consume more than five cups of coffee a day when undergoing IVF.
The Endocrine Society proposes a streamlined definition for EDCs and offers recommendations to strengthen current screening programs. The new statement outlines key issues related to identifying EDCs and protecting against adverse effects.
A study published in CMAJ found that oral zinc treatments significantly reduced the duration of common cold symptoms in adults, with high doses being more effective. However, there was no apparent effect in children and a higher risk of adverse effects such as bad taste and nausea.
A recent study compared the adverse effects of intensity-modulated radiation therapy (IMRT), proton therapy, and conformal radiation therapy in treating localized prostate cancer. The results showed that IMRT was associated with fewer gastrointestinal adverse effects and hip fractures but more erectile dysfunction, while proton therapy...
A systematic review of 94 trials found that drugs are effective in achieving continence and improving quality of life, but with small improvements and frequent side effect discontinuation. Fesoterodine was more effective than tolterodine, while solifenacin showed the lowest rates of treatment discontinuation due to adverse effects.
The natural health products industry lacks robust regulation, putting consumers at risk. The authors argue that uniform regulations can protect consumers while allowing choice.