Articles tagged with Adverse Effects
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Researchers found that transformational leadership can increase sickness absence levels among employees who ignore their ill-health and frequently show up for work while ill. The study suggests that managers should strike a balance between encouraging staff to perform well and prioritizing their health and well-being.
Researchers found that impaired Nrf2 activity leads to increased hemolytic anemia, vascular inflammation, and lung injury in SCD mice. Pharmacological activation of Nrf2 improved survival and reduced age-related adverse effects.
Julie Rovner received the Endocrine Society's Award for Excellence in Science and Medical Journalism for her article on ensuring more women are included in clinical trials. Her coverage highlights efforts to balance research on both sexes, as women have a higher rate of adverse effects from approved medications.
A Phase 2 study demonstrated the safety of deep brain stimulation (DBS) in treating mild Alzheimer's disease. No adverse effects were reported, but the next step is evaluating efficacy and longer-term safety in a larger patient population.
The American College of Physicians recommends cognitive behavioral therapy (CBT) and second-generation antidepressants (SGAs) as similarly effective treatments for adults with major depressive disorder. CBT is a reasonable approach for initial treatment, particularly when discussing treatment effects and patient preferences.
A study published in JAMA Oncology found that surgical castration was associated with lower risks of fractures, peripheral artery disease, and cardiac complications compared to medical castration. However, no significant difference was observed between the two treatments for diabetes and cognitive disorders.
A UCI study found that high doses of green tea polyphenols can cause developmental delays, reduced offspring output, and reproductive abnormalities in fruit fly larvae. The researchers recommend moderate consumption to avoid potential health risks.
Proton pump inhibitors are associated with rare but serious adverse effects, including heart attack, Clostridium difficile infection, and malabsorption of vitamin B12. Physicians should prescribe at the lowest dose possible and for the shortest length of time to minimize these risks.
A UK study found that each additional 10,000 people reassessed using the Work Capability Assessment was associated with an increase in suicides, self-reported mental health problems, and antidepressant prescribing rates. The most deprived areas experienced the greatest increases in these adverse outcomes, widening health inequalities.
Researchers from IMIM and partner institutions developed a new integrated computational method to predict adverse drug reactions more reliably. The method combines structure-based detection of labile fragments with information on the mechanism of action of the drug, resulting in improved ability to foresee possible adverse effects.
A new study by University of York academics reveals that green walls can lead to higher levels of ultrafine particles (UFPs) indoors due to the oxidation of outdoor plant species. This could have significant implications for indoor air quality, particularly in offices with high temperatures and pollution.
A study found that major postoperative complications significantly contribute to prolonged hospital stays, while delirium contributes to adverse outcomes including length of stay, institutional discharge, and rehospitalization. Delirium was found to exert the highest attributable risk compared with other adverse events.
An analysis of edible medical marijuana products found that many had inaccurate labeling, with some containing lower amounts of THC and higher amounts of CBD. Regulation and quality assurance are needed to ensure accurate product labeling.
A meta-analysis of e-cigarette studies found that while they significantly improve abstinence rates at 1 month compared to placebo, this effect is not sustained over longer periods. The device is associated with frequent short-term respiratory adverse events and may pose a higher risk of serious adverse events than nicotine patches.
A consultant cardiologist argues that private practice has direct adverse effects on the NHS, leading to increased waiting times and unnecessary tests. He believes doctors should not be allowed to work in both sectors due to conflicting priorities.
A study found that female liver cells are more susceptible to adverse effects of drugs than male counterparts, particularly postmenopausal women. The findings highlight the need for a sex-specific approach in toxicology and suggest that current theories cannot explain why women are generally more sensitive to drug toxicity.
A study by Helmholtz Munich researchers found that exposure to ultrafine particles can induce immediate changes in heart rate variability in individuals with impaired glucose metabolism or diabetes. The research suggests potential health risks and demands for threshold limit values for environmental standards.
Researchers found that BPA exposure in fish can lead to reduced fertilization rates and increased embryo mortality in subsequent generations. Exposure occurred during embryonic development, resulting in adverse effects on future reproductive health.
Wild blueberries (bilberries) have been shown to mitigate the negative effects of a high-fat diet on blood pressure and nutrition-derived inflammatory responses. The study found that bilberries reduced pro-inflammatory effects, prevented elevated blood pressure, and improved glucose tolerance in mice fed a high-fat diet.
A recent study found a significant association between statin use and an increased risk of developing cataracts. However, experts emphasize that the benefits of statins in preventing cardiovascular disease outweigh the potential risks. The study's findings add to the accumulating knowledge on the statin-cataract connection.
A recent review in the New England Journal of Medicine finds that marijuana use is associated with increased risks of addiction, impaired critical thinking and memory functions, and lower IQ in teens. The study also highlights the need for physicians to convey to families the potential health consequences of early marijuana use.
A study found no significant difference in effectiveness between long-acting injectable versions of second-generation and older antipsychotic medications. Participants taking paliperidone palmitate gained weight, while those taking haloperidol decanoate lost weight.
A new study suggests that olive oil supplements can counteract the negative cardiovascular effects of exposure to air pollution particles. The study found that olive oil supplementation improved endothelial function and reduced blood markers associated with vasoconstriction after exposure to fine/ultrafine particulate matter.
A real-world study evaluating the benefit of treating asthma with small particle treatments like QVAR compared to larger particle treatments revealed interesting differences in asthma exacerbation outcome rates. The study found that initiating dosing with small versus large particle ICS treatments can impact asthma control rates.
A recent study published in Annals of the Rheumatic Diseases found that allopurinol, a commonly used gout medication, is associated with a reduced risk of death in hyperuricemic patients. The study also suggests that treatment with allopurinol may protect against premature death, outweighing rare but serious adverse effects.
A study by University of Kent psychologists found that listening to 'sad' music with high aesthetic value directly predicts mood enhancement. Music selection strategies were linked to individual expectations and emotions.
The Endocrine Society's new statement highlights the prevalence and medical consequences of performance-enhancing drug (PED) use among non-athlete weightlifters. PEDs can lead to various health issues, including cardiovascular, psychiatric, metabolic, renal, and musculoskeletal disorders.
A recent study found no significant increase in serious diseases among HPV-vaccinated girls compared to unvaccinated peers, despite monitoring over 900,000 participants. The researchers also noted that mild adverse reactions such as fever and swelling are common but not considered a concern.
A recent study found that exposure to hardcore pornography was associated with higher levels of sexism in a subgroup of Danish adults, particularly those low in agreeableness. The study suggests individual differences play a significant role in the impact of pornography on attitudes towards women.
Good asthma control is crucial during pregnancy to prevent adverse effects on maternal and fetal outcomes. Studies suggest that poor asthma control can lead to increased risks of hypertension, caesarean section, and low birth weight.
The VDI guidelines provide a state-of-the-art approach to GMO monitoring of Lepidoptera. The study aims to increase detection success and inform the European Community's requirements.
A recent study has found that physicians are often poorly informed about the side effects of prescription drugs, with medical sales reps dominating discussions and rarely disclosing serious risks. The research highlights a concerning trend in the pharmaceutical industry's information practices.
A new study projects that heat-related deaths in Manhattan will increase by 20 percent by the 2020s and potentially up to 90 percent or more by the 2080s. Higher winter temperatures may offset some of these deaths, but overall temperature-related mortality is expected to rise.
The number of prescription drugs that interact with grapefruit is significantly increasing, putting patients at risk of serious adverse effects. Older adults are especially vulnerable due to decreased tolerance and age-related changes in drug metabolism.
A study of almost 1,000 men diagnosed with prostate cancer found that active surveillance can reduce or avoid side effects such as incontinence and impotence. Many low-risk tumours are slow-growing and may never develop symptoms during a lifetime.
Researchers developed a new radiation treatment method that reduces the risk of permanent neurocognitive damage in children with brain tumors. The study found that proton therapy and photon therapy techniques significantly decreased the risk of these adverse effects, potentially leading to better quality of life for affected children.
A Danish study found that women who drink five or more cups of coffee a day have a 50% reduced chance of success in IVF treatment. The live birth rate was also lower by 40%. The researchers suggest that women should not consume more than five cups of coffee a day when undergoing IVF.
The Endocrine Society proposes a streamlined definition for EDCs and offers recommendations to strengthen current screening programs. The new statement outlines key issues related to identifying EDCs and protecting against adverse effects.
A study published in CMAJ found that oral zinc treatments significantly reduced the duration of common cold symptoms in adults, with high doses being more effective. However, there was no apparent effect in children and a higher risk of adverse effects such as bad taste and nausea.
A recent study compared the adverse effects of intensity-modulated radiation therapy (IMRT), proton therapy, and conformal radiation therapy in treating localized prostate cancer. The results showed that IMRT was associated with fewer gastrointestinal adverse effects and hip fractures but more erectile dysfunction, while proton therapy...
A systematic review of 94 trials found that drugs are effective in achieving continence and improving quality of life, but with small improvements and frequent side effect discontinuation. Fesoterodine was more effective than tolterodine, while solifenacin showed the lowest rates of treatment discontinuation due to adverse effects.
The natural health products industry lacks robust regulation, putting consumers at risk. The authors argue that uniform regulations can protect consumers while allowing choice.
A study found that ICD patients are living longer, with an average of nine years after implantation. However, right ventricular pacing negatively affects survival rates, while cardiac resynchronization therapy (CRT) improves outcomes.
A new study published in Archives of Dermatology found that beta-blocker propranolol was more effective than oral corticosteroids in treating infantile hemangiomas, with higher rates of lesion clearance and fewer adverse effects. Propranolol treatment also led to significant cost savings.
Research found vitamin D supplementation in healthy pregnant women to be both safe and effective, with no adverse effects on mothers or newborns. Daily dosages of up to 4,000 IU were necessary to reach optimal circulating levels of vitamin D.
A new study at the University of Gothenburg found that cellulose powder reduces seasonal allergic rhinitis symptoms in children, especially when pollen levels are low to moderate. The treatment has no adverse effects and is suitable for self-care and as a supplement to other treatments.
A new animal study suggests that fetal programming of disease risk to the next generation depends on parental gender. The study found that exposure to stress hormones in the womb can program potential health effects, but the effects differ between mothers and fathers.
Research by Northwestern University and Wake Forest University found that fast disclaimers undermine consumers' trust in unfamiliar brands, while trusted brands remain unaffected. Trusted brands can use fast disclaimers without impact on purchase intention.
A new study suggests that systematic reviews should evaluate a broad range of study designs, including randomized controlled trials and observational studies, to build a complete picture of potential harm. This approach may improve the generalizability of the review without loss of validity.
The use of stored red cells during transfusions may cause adverse effects in patients due to impaired oxygen delivery. Researchers are exploring the impact of stored blood on respiratory gases to improve blood storage methods and mitigate patient risks.
A new study published in Pain journal finds that acupuncture has little convincing evidence of effectiveness in reducing pain, while causing serious adverse effects. The authors call for better training of acupuncturists to minimize avoidable harm.
A study found that older adults are willing to take cardiovascular disease prevention medications if the benefits outweigh the risks. However, many participants were unwilling or uncertain about taking medications with mild adverse effects, highlighting the need for emphasis on both benefits and harms in clinical guidelines.
A new study by Rice University researchers found that customers who participate in firm-sponsored surveys after a service experience may delay their next purchase. However, the study also found that these surveys can have net positive effects on customer behavior over time.
A study by the University of Washington found that 25 commonly used scented products release an average of 17 chemicals each, with nearly a quarter classified as toxic or hazardous. The majority of these chemicals were not listed on product labels or disclosed to consumers.
A new study found that experiencing some lifetime adversity can contribute to the development of resilience, leading to lower global distress, functional impairment, and increased life satisfaction. Researchers analyzed a national sample of 2,398 subjects and discovered a U-shaped relationship between lifetime adversity and outcomes.
Researchers found that GSK-3 inhibitors may cause enlarged heart muscle cells and inability to contract optimally in mice. The study suggests that therapeutic GSK-3 inhibitors might have serious adverse effects on the heart.
Scientists at the University of Gothenburg have created a method to develop safer drugs by simulating metabolism and identifying potentially toxic metabolites. This approach has been successfully applied to the antimalarial drug amodiaquine, which was withdrawn due to liver damage and immune system impairment.
A study of over 800 epileptic patients found that individual susceptibility, AED type, and physician skills are key factors determining adverse effects. Despite high polytherapy rates, no major difference was observed in adverse effect frequency between monotherapy and polytherapy groups.
Severe adverse effects, such as burns and scarring, have been reported from untrained laser hair removal operators. The Canadian Medical Association Journal recommends setting minimum training standards for operators to ensure safe and effective procedures.
A new review emphasizes the need for cardio-oncology to address cardiovascular side effects of cancer treatments. The authors suggest identifying high-risk patients with biomarkers and imaging techniques to reduce morbidity and mortality.