Articles tagged with Adverse Effects
A study analyzing Medicare data found that racial and ethnic minority groups received fewer opioid prescriptions for new low back pain compared to white patients. This disparity persisted during the first wave of the opioid epidemic, despite growing awareness of its adverse effects.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
The study found that patients with low risk of exacerbations do not benefit from low to moderate dose inhaled corticosteroids, while high doses are associated with severe side effects. Tailoring treatment according to patient characteristics, such as age and blood cell count, can minimize over- and underuse of inhaled corticosteroids.
Researchers found that UVB phototherapy increases levels of romantic passion and aggression in both men and women. Exposure to sunlight affects the endocrine system's regulation of sexual hormones.
Researchers found Prozac reduces lipid concentrations in monkey brains, linked to potential side effects in young patients. The study suggests dietary changes may alleviate adverse effects by influencing lipid synthesis.
Researchers find wind turbine night noise contains 'amplitude modulation' (AM) sound that worsens sleep and annoyance after sunset. The 'swoosh' sound is detected up to 60% of the night-time at distances around 1 km from a wind farm.
A large-scale population-based study confirms that COVID-19 vaccines far outweigh the risk of Bell's palsy. The study found a small increased risk of Bell's palsy associated with CoronaVac vaccination, but not with BNT162b2.
A recent study found that weight fluctuations are associated with higher risks of cardiovascular-related problems and early death in adults with chronic kidney disease. The study included 84,636 patients with CKD who were listed in a national health screening database in South Korea.
A study of 4,661 Finnish children found that six hours of physical activity per week reduces the risk of being overweight at age 14 associated with heavy digital media use. Physical activity appears to reverse adverse effects of screen time.
A four-year cohort study identified a significant link between midazolam exposure and elevated posttraumatic stress symptoms in children. Symptoms were found to be persistent for up to 12 months, highlighting the need for early intervention and psychosocial support.
A new study published in DNA Repair shows that hydroxychloroquine exhibits DNA-damaging and mutagenic effects at a clinically achievable dose. The findings suggest the possibility of additional side effects, particularly in patient populations, and emphasize the need for careful risk assessment and informed consent.
A retrospective study of over 3,900 patients found that warming iohexol 350 contrast media did not significantly reduce adverse reactions or extravasations. The results suggest that maintaining the agent at room temperature is non-inferior to warming it to body temperature before injection.
A new study analyzing 1,200 RCTs found that reporting of adverse effects has only improved slightly over the past 17 years. Researchers argue that many trials focus on benefits rather than harms, and selective reporting can misinform clinical decisions.
A new study published in Chemical Senses found that patients who had their wisdom teeth extracted showed improved tasting abilities decades after surgery. The study challenges the notion that removal of wisdom teeth has only negative effects on taste and represents a significant finding in the field.
Researchers have developed a decision support system to identify the environmental impact of nanomaterials faster and more cost effectively. The library contains full physicochemical characterization of 69 nanomaterials, including calculated molecular descriptors.
A recent study found that mindfulness-based meditation programs have similar rates of adverse effects to other psychological treatments, and identified key obstacles to harms monitoring. The study provides a blueprint for accurately assessing the risks of these programs and maximizing their efficacy while minimizing harm.
A WHO expert panel recommends against the use of hydroxychloroquine to prevent COVID-19 infection in people without symptoms. The guideline is based on high certainty evidence from six randomized controlled trials involving over 6,000 participants.
A study published in Food and Chemical Toxicology found that some energy drinks have adverse effects on the muscle cells of the heart. Cardiomyocytes exposed to these beverages showed an increased beat rate and other factors affecting cardiac function.
A recent study found that divorcees experience poorer mental and physical health compared to the background population. Higher levels of conflict during the divorce process predict worse mental health outcomes regardless of other factors. Targeted interventions early in the process may help mitigate these effects.
A 2019 study found a contagion effect among boys, but an Annenberg Public Policy Center reanalysis concluded that the series had no clear effect on teen suicide. Recent commentaries challenge the reanalysis and defend it.
A randomized trial investigated carboxylic acid formulation of EPA and DHA, reducing cardiovascular outcomes in patients with atherogenic dyslipidemia. The study found omega-3 CA to be more effective than corn oil in reducing major adverse cardiovascular events in high-risk patients.
Researchers developed an algorithm to predict sex-specific adverse drug effects, identifying 20,817 adverse drug effects posing sex-specific risks. The algorithm addresses confounding biases and provides an opportunity to minimize adverse events by tailoring drug prescription and dosage to sex.
Researchers have created a genetically engineered mosquito strain with a Cas9/guide RNA-based gene drive that targets the cardinal gene to prevent malaria transmission. The drive achieved an average efficiency of 96.7% in both sexes, ensuring every mosquito carries at least one copy within six generations.
A critical EPA insecticide study on chlorpyrifos was found to have been based on incomplete data, leading to an incorrect safe exposure limit. Researchers argue that this oversight had significant public health implications and potentially allowed approvals for unsafe uses of the chemical.
A recent study suggests that an increase in immigration to the US has little impact on the wages of native citizens. However, it does benefit low-skill workers, with average wage gains of around 4%. The study also found a small positive effect on high-skill natives' wages and reduced local real wage inequality.
The COVID-19 pandemic has resulted in fewer women submitting manuscripts to JAMA Surgery, potentially hindering their academic career progression. Women face challenges in academia due to publications being a key metric for promotion and tenure.
A study by Erasmus University Rotterdam and IESE Business School found that collective layoff announcements lead to decreased sales, lower advertising elasticity, and reduced advertising spending for affected brands.
Chloroquine, hydroxychloroquine, and azithromycin can lead to rare but potentially life-threatening adverse events, including cardiac arrhythmias, hypoglycemia, and neuropsychiatric effects. Patients should be aware of the risks before treatment.
A new study engineered a form of botulinum toxin B with improved binding to nerve cells, increasing potency and reducing diffusion into surrounding tissue. The modified toxin demonstrated enhanced therapeutic potential and reduced adverse effects.
The new guidelines establish evidence-based limits for exposure to high-frequency electromagnetic fields, setting thresholds below which no adverse effects can occur. The report provides guidance on basic restrictions and reference levels to ensure safe exposure in various settings, including occupational environments.
Researchers analyzed online forum data from 2008-2015 to find health problems associated with e-cigarettes existed before the 2019 VAPI outbreak. The study suggests many more users may have serious symptoms, and cases similar to those in the current epidemic have likely existed previously.
The study found measurable adverse biologic effects on lung health and cells in humans, animals, and tissue samples. Vaping has been linked to increased respiratory symptoms, including bronchitis-like symptoms and asthma, as well as possible lung damage and immunosuppression.
A new study from Brigham Young University found that having good neighbors, teachers, or caregivers can counteract the negative impact of adverse childhood experiences. The study showed that even with four or more ACEs, high amounts of advantageous childhood experiences led to better adult physical and mental health.
Research from University of California - San Diego found a significant association between tramadol use and an increased risk of developing hypoglycemia. The study analyzed over 12 million reports and identified a 10-fold greater risk compared to other opioids, with methadone being the only other drug with comparable effect.
Researchers surveyed 1,029 people ages 18 to 40 at EDM parties in NYC and found that one-third experience a drug-related adverse effect over the past year. The study also revealed that alcohol use was associated with the greatest number of adverse outcomes.
A study analyzing published research found Nordic walking reduces swelling and improves physical fitness in breast cancer patients. However, more well-designed studies are needed to explore its full potential.
Exposure to fine particulate matter during pregnancy impairs fetal development, leading to smaller organs and metabolic disorders in adulthood. The study highlights the importance of reducing prenatal air pollution exposure to prevent long-term health consequences.
A new mathematical model could be key to designing effective therapies for brain disorders by quantifying the bias of biological signals through G-protein-coupled receptors. The model enables the discovery and development of drugs that are agonist, neutral antagonist, and inverse antagonist.
Researchers suggest that combining glucocorticoids with antioxidants could further improve clinical treatment for premature babies while minimizing potential risks. The proposed therapy aims to overcome adverse effects associated with existing glucocorticoid treatment and accelerate lung maturation in infants.
A study by UC Davis researchers found that DMT microdosing helped rats overcome a fear response associated with anxiety and PTSD, while also reducing immobility in tests measuring antidepressant effects. However, the regimen caused weight gain in male rats and neuronal atrophy in female rats, highlighting potential risks.
Carla Ng will use her NSF CAREER award to study the health and environmental impact of per- and polyfluorinated alkyl substances. She aims to identify ways to eliminate them from the environment and design selective sorbents for efficient removal.
A review published in Advances in Nutrition suggests that noncaloric sweeteners have a negligible impact on daily energy intake and do not significantly alter the composition of human gut microbiota. The study concludes that there is not enough evidence to support adverse effects on health, including cancer or diabetes risk.
A new study found sufficient evidence to raise concerns about prenatal BPA exposure's effects on ovarian development and function. The researchers believe their findings are relevant to both fetal and women's health, particularly in relation to infertility and endocrine disrupting chemicals.
A study reveals that 1 in 3 complementary medicine users do not disclose their CM use to medical providers. This can lead to unsafe concurrent use and harm due to adverse effects. The researchers emphasize the importance of disclosure for patient management and care.
A new US study found that prescription opioids are negatively affecting labor force participation and unemployment rates nationwide. The study discovered a strong adverse effect of opioids on labor markets, with a 10% increase in opioid prescriptions per capita leading to a 0.6 percentage point drop in labor force participation rates.
A new study published in the journal Addiction found that allowing smokers to determine their own nicotine intake while quitting can lead to higher success rates. The results suggest that most smokers can tolerate doses four times higher than those normally recommended, making them more likely to stay smoke-free.
Researchers found that mice exposed to weightlessness during a 30-day spaceflight displayed altered immune systems, with impaired B lymphocyte production and persistent effects after return to Earth. The study suggests potential concerns for astronauts' health and highlights the need for countermeasures.
A recent systematic review found that health information exchanges can significantly reduce healthcare costs and usage. Community-based exchanges showed more promising results than proprietary ones. The study's lead investigator attributed the difference to more mature systems being examined in the current review.
Researchers at St Joseph's Hospital and Medical Center discovered a mechanism that causes TRPV1 blockers to affect body temperature. The team found that blocking this activation can prevent hyperthermia and hypothermia in new compounds.
New research from Chapman University found that 40% of teens aged 13-19 reported an adverse effect while consuming energy drinks. The most common side effects included insomnia, jittery feelings, and heart palpitations. Additionally, some teens mix alcohol with energy drinks and use them for weight loss.
The Anticholinergic Cognitive Burden Scale (ACB) is associated with increased risk of emergency department visits, hospitalizations, and incident dementia in older adults. High ACB scores are linked to a dose-response relationship between anticholinergic burden and adverse clinical outcomes.
Wayne State University will analyze 20 years of fetal alcohol spectrum disorders data to refine the new diagnosis and provide support for official recognition in the DSM. The study aims to identify key developmental outcomes, prenatal alcohol exposure levels, and critical dose effects.
A new study found that high-intensity resistance and impact training for just 30 minutes, twice a week, improved bone density and structure in postmenopausal women with low bone mass. The exercise program was also associated with enhanced functional performance and reduced risk of osteoporotic fracture.
Research from Aarhus University found that 29% of referred women over 18 have been prescribed psychiatric medicine before vaccination, compared to 17% for HPV vaccinated women. Women referred to HPV centers often had mental health issues before receiving the vaccine.
Opioid-related problems in hospitalized children increased significantly over nine years, with white children being most affected. Adverse events included opioid withdrawal, constipation, altered mental status, and cardiac arrest.
A James Cook University scientist has discovered an alcohol-free antiseptic solution that is safe and effective for minor surgical procedures. The study found a slightly lower infection rate with the new solution compared to traditional water-based antiseptics.
Among patients unresponsive to an antidepressant, adding aripiprazole modestly increased remission rates from depression compared to switching or augmenting with bupropion. The study found symptom improvement was greater with aripiprazole than other treatments.
Dr. Matthew Stanbrook argues that Health Canada's proposed changes are a step forward but need further action to protect consumers. The new regulations aim to hold nonprescription drugs and natural health products to the same standards, but direct evidence is needed to determine risk.
The prevalence of daily supplemental vitamin D use above 1,000 IU increased from 0.3% in 1999-2000 to 18.2% in 2013-2014. Intake of 4,000 IU or more daily also rose, with 3.2% of participants using such supplements in 2013-2014. The trend was observed across most age groups, race/ethnicities, and sexes.
Researchers found that radiation therapy can alter neural networks and lead to cognitive decline in patients with brain tumors. The study suggests that the treatment may cause broader adverse effects, including thinning of the brain cortex and increased segregation between brain regions.