Articles tagged with Adverse Effects
A recent study found semaglutide to be effective in improving various clinical outcomes in patients with frailty, with greater benefits observed in those with higher frailty indices. The medication demonstrated a positive impact on health-related quality of life, highlighting its potential as a treatment option for this population.
A randomized clinical trial found that daily zinc supplementation at 20 mg reduced all-cause infections in children with sickle cell anemia over 6 months compared to placebo. No adverse events were observed in the study, suggesting zinc supplementation may be a useful preventive measure for these children.
Researchers developed a method to inhibit lipid nanoparticle migration into the liver by coating hepatic sinusoidal walls with polyethylene glycol. This coating reduced liver accumulation by several dozen times and increased protein expression in the spleen, promoting safer nanomedicine with lower dosages.
Researchers found that ultraviolet irradiation and ozonation increased anti-androgenic activity in treated wastewater, exceeding an effect-based risk threshold. The study suggests balancing pollutant removal efficiency with assessment of transformation products' combined biological effects.
A randomized clinical trial found that dexamethasone eye drops reduced the progression of retinopathy of prematurity to severe disease requiring invasive treatment in preterm infants. However, no differences in adverse events were observed.
Direct patient or caregiver prior authorization engagement is associated with adverse outcomes, including delays and suboptimal care. This study may inform future research and intervention development to navigate PA-related administrative burden.
A cohort study found that smartphone acquisition at age 13 was linked to increased risk of insufficient sleep at age 14. Excessive smartphone use was also tied to higher odds of depression and obesity. Limiting screen time may protect adolescents from these outcomes.
Patients described GLP-1 RA therapy as a facilitator of lifestyle change, highlighting the need for standardized guidelines on patient education and clinical support. The quality of care was highly variable, leading to potential expectation management issues around adverse effects and long-term management.
Adults with lower measured glomerular filtration rates had a higher risk of all-cause mortality, kidney failure, and major adverse cardiovascular events. Lower GFR values were also associated with increased hospitalization for heart failure and acute kidney injury.
A study published in JAMA found that sitting less with greater light-intensity movement and steps was associated with significantly lower risks of adverse pregnancy outcomes. Adverse pregnancy outcomes include hypertensive disorders, gestational diabetes, preterm birth, and small for gestational age
A new study published in JAMA Neurology finds ecopipam to be effective in suppressing tics in patients with Tourette syndrome. The medication was well-tolerated and showed no significant adverse effects over a period of up to 24 weeks.
Brief delays in hepatitis B vaccine initiation result in substantial increases in virus infections, adverse health outcomes, and healthcare expenses. Economic evaluations reveal the significant financial burden of such delays on individuals and society.
A survey of 286 relatives and friends found that 45% experienced improvement, while 42% saw worsening symptoms. Many reported memory loss, difficulty concentrating, and relationship problems after ECT.
Long-term opioid therapy prescription rates declined in the US from 2015 to 2023, despite a growing population of older adults receiving these treatments. Approximately 4-5 million patients were prescribed long-term opioids in 2023, with Medicare covering a larger proportion, raising concerns about safety.
A meta-analysis of GLP-1 receptor agonist studies found potential safety signals for gastrointestinal side effects, while some evidence suggested a link to reduced respiratory disease risk. Further research is needed to confirm the latter association.
Patients with atrial fibrillation have a higher risk of adverse cardiovascular events, including stroke, heart attack, and cardiac arrest. Serum neurofilament light chain levels can serve as a biomarker for cardiovascular risk in these patients.
Research in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reveals that lifetime physical activity can reshape neural connectivity, strengthening the brain's internal communication and optimizing its response to stress. The study challenges traditional deficit-focused views of adversity, offering a more dynamic and hope...
Continuing GLP-1/GIP agonists before upper endoscopy increased clinically significant residual gastric volume, but did not elevate adverse event risk. Clear liquids the day prior to the procedure may mitigate this risk.
A cohort study found that adverse childhood experiences (ACEs) were associated with an increased risk of treatment-resistant depression in adults. Preventing ACEs and incorporating ACE history into clinical assessment may help identify individuals at elevated risk for treatment resistance.
A systematic review and meta-analysis found a small correlation between daily screen use and later sleep onset in youth. However, short-term fluctuations in screen time had limited effects on sleep duration, efficiency, or quality.
A systematic review and meta-analysis found GLP-1 RAs produce significant weight loss across various subpopulations, including women who show improved outcomes compared to men. These findings have implications for clinical decision-making.
Adverse experiences throughout life increase dementia and stroke risks, with depression as a mediating factor. Implementing life-course interventions addressing psychological trauma and mental health can reduce neurovascular disease burden.
A recent survey study found a significant association between generative AI use and increased depressive symptoms in US adults. The magnitude of the effect varied by age group, suggesting that further research is needed to understand the causal relationship and underlying factors.
A large cohort study found no association between community water fluoridation and adverse birth outcomes, providing reassurance about its safety during pregnancy. The study highlights the importance of rigorous causal designs in evaluating public health interventions.
An updated Cochrane review of 21 clinical trials involving over 2,100 adults found no high-quality evidence that cannabis-based medicines reduce neuropathic pain more than placebo. Small improvements were reported by patients using products with both THC and CBD, but these changes were not clinically meaningful.
This cohort study found that exposure to Migrant Protection Protocols was associated with higher rates of trauma during migration among asylum seekers. The Migrant Protection Protocols may have potential downstream implications for U.S. public health and security, including adverse health outcomes for asylum seekers.
A study published in JAMA found that cryopreserved platelets were less effective than liquid-stored platelets in achieving hemostasis, particularly at 24 hours after ICU admission. The research suggests that alternative storage methods may be needed for efficient surgical bleeding treatment.
A recent study suggests that adverse childhood experiences may increase the risk of obesity in Latinx and Hispanic youths. The study found that promoting resiliency-focused skills may help improve pediatric weight trajectories among these populations, potentially mitigating the impact of adverse experiences on health outcomes.
The study found a positive shift in the prevalence of adverse childhood experiences (ACEs) among U.S. children between 2016 and 2023, with an increase in individuals reporting 0 ACEs and a decrease in severe ACEs. This trend suggests a reduction in severe ACEs among specific racial and ethnic groups and low-income families.
A new observational study found that semaglutide, tirzepatide, and dulaglutide have similar gastrointestinal safety profiles among patients with type 2 diabetes. The medications were assessed in a large database of adults with T2D, who underwent treatment with these GLP-1 RA medications between 2019 and 2024.
A large national cohort study found associations between adverse pregnancy outcomes and increased risk of atrial fibrillation up to 46 years later. Women with these outcomes require early preventive actions and long-term clinical follow-up.
Full-term children exposed to antenatal corticosteroids are at higher risk of infections until age 21, a new study finds. Preterm children, however, show no association between ACS and infections.
Research found that mothers with two or more adverse childhood experiences had a 12.6% preterm birth rate, double that of those with zero to one experiences. Adverse childhood experiences include abuse, neglect, and household instability, which can have lasting impacts on health and well-being.
A systematic review and meta-analysis of 18 trials found GLP-1 RAs significantly improved glycemic and weight outcomes in children and adolescents with type 2 diabetes or obesity. However, gastrointestinal adverse effects warrant attention in long-term management.
A survey study found that food insecurity declined between 2019 and 2021 but exceeded pre-pandemic levels by 2023, with new food insecurity being a major contributor. This increase is concerning as households experiencing new food insecurity face elevated risk for adverse health outcomes.
A study found no association between semaglutide treatment and diabetic retinopathy, but suggested a potential link to nonarteritic anterior ischemic optic neuropathy. Further research with larger sample sizes is needed to clarify this risk.
A nationwide cohort study of 1 million adults found no increased risk of 29 adverse events after vaccination with the updated COVID-19 mRNA vaccine containing the SARS-CoV-2 Omicron JN.1 lineage. The study provides reassuring safety data on the new vaccine, which has been widely adopted in response to the Omicron variant
Patients with common cancers face significant out-of-pocket costs after diagnosis, with the most advanced cases having the highest expenses. Further research is needed to understand the clinical and financial implications of these costs.
Proposed Medicaid reforms would have far-reaching consequences beyond federal budget savings, including negative health outcomes and economic losses. Rural and underserved communities are disproportionately affected by these policy changes.
Delays in hypertension diagnosis were common, associated with delayed treatment initiation and adverse cardiovascular outcomes. The study highlights the need for earlier identification and intervention to improve treatment and patient outcomes.
A new study found that extending Medicaid coverage for 12 months after birth improved access to medical and behavioral health services. This expansion may help mitigate adverse outcomes, including chronic condition management.
Acupuncture was found to be an effective treatment for nocturia in survivors of prostate cancer, reducing symptoms comparable to other medications while causing fewer side effects. The study suggests acupuncture may offer a new hope for managing this common issue affecting half of prostate cancer survivors.
GLP1-RA treatment is associated with improvements in quality of life, restrained eating, and emotional eating behavior. The treatment also provides reassurance regarding its psychiatric safety profile.
Nearly 19 million children in the US are living in households with a parent struggling with substance use disorder. Children exposed to parental substance abuse are more likely to experience adverse health problems compared to those without such exposure.
A cohort study found that exposure to conversion therapy increased systolic and diastolic blood pressure, inflammation, and high blood pressure in SGM individuals. The findings highlight the need for stronger public health interventions to ban conversion therapy practices.
A cohort study found maternal hypertension and preeclampsia independently associated with cognitive and language development delays in preterm infants. Recognizing hypertensive disorders of pregnancy is crucial for targeted risk management strategies.
A cohort study found that vaccination against influenza alone or with COVID-19 was associated with a small but temporary change in menstrual cycle length. This finding may help clinicians confirm the utility of vaccination for patients concerned about menstrual side effects.
Researchers found that introducing moderate natural light into the bedroom before waking improves wakefulness and reduces sleepiness. The study suggests controlling natural light in the sleep environment may help promote a more comfortable awakening.
A study found no increased risk of suicidal events among adults taking GLP-1 receptor agonists for diabetes or obesity, but continued monitoring is warranted to identify at-risk patients. The findings ease concerns about these potential adverse effects, allowing extended use of GLP-1 RAs.
A cohort study found no significant association between preoperative GLP-1 RA use and short-term postoperative aspiration pneumonia. The study suggests reassessing preoperative withholding guidelines for GLP-1 RAs. Researchers hope this finding can help alleviate growing concerns about adverse effects of these medications after surgery.
A University of Turku study reveals that mothers' weight and diet during pregnancy influence their child's motor skills up to age 5-6. Children of overweight or obese mothers are almost three times more likely to develop a developmental coordination disorder, highlighting the importance of healthy prenatal nutrition.
Children exposed to low to moderate levels of prenatal alcohol showed characteristic facial changes that persisted until age 6 or 8. No linear association between alcohol exposure and facial shape was found, suggesting other factors at play.
A cross-sectional study found that underrepresented in medicine internal medicine residents remained underrepresented compared to their program's county populations. The findings highlight the need for racial and ethnic diversity policies to address the continuing disparity among graduate medical education physicians.
Researchers developed a novel inhalable therapeutic delivery system for lung cancer using mucoadhesive protein nanoparticles inspired by marine mussels. The approach leverages the adhesive properties of mussel proteins to enable selective payload release and minimize adverse effects.
A recent study found that pregnant individuals with opioid use disorder enrolled in Medicaid are at a disproportionately high risk of severe maternal morbidity. Targeted interventions, such as early Medicaid enrollment and coverage continuity, may be necessary to reduce adverse outcomes in this group.
A case-control study found that flu vaccination protects children from all levels of severe influenza illness, emphasizing the importance of vaccination for this population. The findings suggest that vaccine should be administered to pediatric patients to prevent severe influenza.
A randomized clinical trial found that a brief outpatient rehabilitation program improved physical function in patients with post-COVID condition. The intervention showed sustained benefits over time, with negligible adverse effects.
A randomized clinical trial found that cannabidiol (CBD) significantly reduced anxiety levels 2-4 hours after ingestion in women with advanced breast cancer. CBD's anxiolytic effect suggests its potential as a treatment for scan-related anxiety.
Researchers at Ohio State University found that prolonged exposure to wildfire pollution can decrease life expectancy by about one week. Living in green neighborhoods with more extensive greenspaces can be beneficial for health, but even small increases can lead to slight life expectancy gains.
Researchers developed a nasal vaccine combining traditional pertussis antigens with an innovative adjuvant called T-vant to boost immune response. The new vaccine was shown to prevent the bacteria's colonization in the respiratory tract, significantly curbing whooping cough spread.