Articles tagged with Asthma
African Americans with chronic obstructive pulmonary disease (COPD) are more likely to experience flare-ups due to inadequate sleep, which may boost their risk by up to 95%. The study, published on June 6, 2022, suggests that poor sleep quality may partially explain why African American patients tend to fare worse than white patients. ...
A study found epigenetic differences in airway cells of patients with asthma who have asthmatic mothers, suggesting impaired immune responses and potential new therapies for this subtype of asthma. The research was conducted in a diverse population and replicated in independent children's cells.
The NIH has launched a clinical trial testing dupilumab, an approved treatment for moderate-to-severe asthma, in children with poorly controlled allergic asthma living in low-income urban neighborhoods. The study aims to define the activity levels of gene networks associated with asthma attacks and improve lung function.
A study by NIH found that people with food allergies have a lower risk of becoming infected with SARS-CoV-2. In contrast, obesity and high body mass index (BMI) are associated with increased risk for SARS-CoV-2 infection.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
A recent study published in Annals of Allergy, Asthma and Immunology found that longer durations of exclusive breastfeeding are associated with lower odds of current asthma. The study analyzed over 2,000 mother-child pairs and discovered a 'dose-response' effect depending on how long the mother breastfed.
Researchers found no link between antibiotics given shortly before caesarean birth and early childhood conditions like asthma or eczema. The study, funded by the National Institute for Health and Care Research, used UK healthcare databases to analyze millions of children born between 2006 and 2018.
A global study found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. The combination of albuterol and budesonide lowers the number of sudden episodes of shortness of breath, wheezing, and coughing in patients.
The May issue of the CHEST journal features 56 articles on clinically relevant topics such as asthma, COPD, and critical care. The journal also includes a special Adult Cystic Fibrosis Series with latest epidemiologic data and challenges in managing CF.
Researchers found that hypoxia can activate immune cells called ILC2s, which respond to harmless environmental allergens and drive mucus production and inflammation in the lungs. The study identifies adrenomedullin as a new target for treating inflammatory and allergic lung diseases.
A new study published by the American College of Allergy, Asthma, and Immunology shows that COVID-19 has increased anxiety and asthma symptoms among adults with asthma, while reducing food allergy-specific anxiety for parents of children with food allergies.
A new study has found that adults with asthma are more likely to become obese later in life. The research, which included over 8,700 participants from 11 European countries and Australia, revealed that non-allergic asthma, longer disease duration, and corticosteroid treatment were associated with increased obesity risk.
Researchers found that a common asthma medication can bind to and block the Nsp1 protein of SARS-CoV-2, preventing it from shutting down vital proteins in human immune cells. The study suggests that targeting this region could be an effective way to reduce damage inflicted by the virus.
Researchers found that IL-3 production in controlled asthma correlates with anti-inflammatory effects. Administration of IL-3 improved asthma symptoms by regulating immune cells and reducing inflammation.
Researchers at Tokyo University of Agriculture and Technology discovered that double-stranded RNA molecules can activate the immune system response leading to bone deterioration in gum disease. The study found that dsRNA triggers the differentiation of osteoclasts, cells responsible for breaking down bone, leading to increased bone ero...
Researchers from Texas A&M University found that the absence of a functioning Nrf2 gene affects prenatal growth, especially when exposed to ultrafine particulate air pollution. This study highlights a possible mechanism by which ultrafine particles can impact placental function and prenatal health.
Researchers discovered that obesity changes molecular underpinnings of allergic inflammation in both mice and humans. The treatment in obese mice makes their skin worse instead of healing, but a specific drug can 'de-fatten' obese mice without changing body weight.
A new study found that follow-up care after an asthma-related emergency department (ED) visit can help prevent future ED visits for children. Patients who received follow-up care within two weeks of their ED visit were 12% less likely to return to the ED for asthma within 60 days and 13% less likely to revisit for asthma in the next year.
A population study found a significant link between mothers' exposure to disinfectants during pregnancy and their children's risk of developing asthma or eczema. The study, published in Occupational & Environmental Medicine, suggests that prenatal exposure to disinfectants may exert an effect on allergies in offspring.
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
A new study reveals that Latine children who prefer speaking Spanish are more likely to visit a community health center for their acute asthma symptoms than non-Hispanic white peers. Non-Hispanic Black children are also more likely to receive asthma-related care in emergency departments.
Researchers developed a novel drug to reduce airway mucus that exacerbates common lung diseases. The treatment works by blocking the secretion of mucins, which can block airways and cause life-threatening symptoms.
A metabolomic study of 14,000 individuals with asthma found that inhaled corticosteroid therapy leads to adrenal suppression, characterized by fatigue, headache, and abdominal pain. The study suggests that monitoring cortisol levels and prescribing the lowest effective dose may help mitigate side effects.
The Philadelphia Regional Center for Children's Environmental Health aims to identify and protect vulnerable communities from environmental exposures. The center will focus on four primary research areas: asthma prevention, lead exposure, air pollution, and endocrine disrupting chemicals.
A study of over 7,000 adolescents found that consuming a high-quality diet, such as the Mediterranean diet, was associated with significantly lower wheezing odds among those exposed to environmental tobacco smoke. This suggests that targeted public health interventions focused on improving access to higher quality foods may be effectiv...
Researchers have identified a unique population of memory CD4 T-cells that produce IL-9, which plays a key role in allergic memory responses. Blocking this cytokine may lead to reduced lung inflammation and improved treatment options for seasonal asthma.
A study found that higher doses of antibiotics are needed to eliminate bacterial infections with other microbes present. Researchers developed a model of the human airways to replicate poly-microbial infections, which often persist despite treatment in people with cystic fibrosis and other lung diseases.
Research led by Imperial College London estimates that higher cigarette taxes could have averted around 182,000 newborn deaths and 231,000 child deaths under one year old in 2018. The study found that increasing tobacco taxes in low- and middle-income countries can reduce neonatal and infant mortality rates.
The American College of Chest Physicians journal features cutting-edge original research on various chest medicine topics, including asthma, COPD, critical care, and sleep. The March issue includes a special series on nontuberculous mycobacterial pulmonary disease, offering insights into clinical epidemiology, risk factors, and diagnosis.
A national research study led by UCF physicians found that using inhaled corticosteroids significantly reduced severe asthma symptoms among Black and Latinx patients. The new guidelines resulted in improved asthma control, better quality of life, and fewer hospitalizations.
Scientists at Trinity College Dublin have identified Itaconate as a potential therapeutic target for severe asthma. The discovery could pave the way for effective new treatments, especially in children, who are disproportionately affected by the disease.
A new patient-centered intervention reduced severe asthma exacerbations by 15% in African American/Black and Hispanic/Latinx patients with moderate-to-severe asthma. The study also found improved asthma symptoms and days of impairment, mirroring previous recommendations for patients with similar conditions.
A new study found that molds and yeasts are more prevalent in daycare centers than outside environments. The indoor mycobiome is influenced by factors such as building features and child density, suggesting a potential link between fungi and chronic respiratory diseases like asthma and allergies.
The study defines the lung macrophage as a major target of IL-9, which promotes allergic lung inflammation. The researchers found a correlation between IL-9 and the diagnosis of asthma in patients, suggesting a potential therapeutic approach for treatment.
A study found that switching from a metered dose inhaler to a dry powder version for maintenance therapy reduces the carbon footprint of people with asthma by more than half. The researchers conclude that this substitution is an acceptable and worthwhile option for most patients who can safely manage their condition at home.
A new study found that Hong Kong's remote sensing enforcement program significantly reduced harmful chemicals at the roadside and in the atmosphere. The program led to a 22-39% reduction in total hydrocarbons, carbon monoxide, and nitric oxide emissions from high-emitting vehicles.
A large population-based study found a significant association between lifetime workplace exposure to pesticides and an increased risk of COPD. The study, which included over 500,000 participants, controlled for other risk factors and found that even low levels of pesticide exposure were linked to a heightened risk of COPD.
A recent study found that 84% of adults with asthma experience discomfort while wearing a mask, and 75% report trouble breathing or shortness of breath. The study also discovered an association between poorer asthma control and higher symptoms while wearing a mask.
A new mobile management intervention program aims to improve asthma control in young Black American adults. The project, led by Karen MacDonell, will assess the effectiveness of technological components in traditional asthma education among Black Americans aged 18-30.
Researchers analyzed hospital visits, admissions, and deaths for 50,393 children with asthma to track trends. The study used health information exchange data, revealing a significant increase in pediatric asthma death rates despite a decline in hospital admissions.
A new study finds that exercise interventions can significantly improve physical activity levels, decrease sedentary time, and reduce asthma symptoms in individuals with asthma. Digital interventions, such as video appointments and mobile apps, may help overcome barriers to participation.
A new study estimates that nitrogen dioxide from traffic pollution contributes to nearly 2 million cases of pediatric asthma annually. Cleaner air in urban areas has led to a decline in these cases, but more work is needed to curb harmful emissions.
A recent study published in The Lancet Planetary Health found that approximately 2.5 billion people worldwide lived in areas exceeding the WHO guideline for annual average PM2.5 exposure, resulting in an excess of 1.8 million deaths. Additionally, nearly 2 million asthma cases among children were attributable to NO2 pollution in 2019.
A study published in Cell Reports reveals that LPS protects against developing asthma when combined with allergens containing cysteine protease enzymatic activity, but promotes development when paired with allergens lacking this enzyme. This protective effect relies on the production of GM-CSF by non-classical monocytes.
Younger male exposures to Ascaris roundworms show striking reductions in lung function and nearly five times higher odds of having asthma. The study highlights a previously overlooked risk factor for respiratory health in Europe.
Associate Professor Morten Arendt Rasmussen from the University of Copenhagen aims to develop a personalized dietary profile using a cohort of young people with asthma and other inflammatory diseases. The goal is to provide tailored diet recommendations that can help alleviate symptoms and improve health outcomes.
A new medication dupilumab has been added to the treatment options for children with moderate-to-severe asthma. The international multicenter Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations and improved lung function in children aged 6 to 11.
Researchers found that the risk of developing asthma in infants depends on a complex interplay among the infecting virus, airway microbial composition and function, and the infant's immune response. Infants with distinct metatranscriptome profiles had unique risks of developing asthma by age five.
Researchers found that asthma causes immune cells to behave in a way that prevents brain tumor growth, suggesting a potential new therapeutic approach. The findings suggest reprogramming T cells to act like those in asthma patients could be a new treatment for brain tumors.
A research group from Tohoku University discovered that melatonin, a sleep hormone, exacerbates asthma by potentiating bronchoconstriction. Melatonin weakens the relaxing effect of bronchodilators through the activation of the melatonin MT2 receptor.
A new study ranks live oaks and American sycamores as champions among 17 "super trees" that can mitigate air pollution and climate change in urban areas. The research provides a three-part framework for selecting suitable trees, identifying high-impact planting sites, and engaging with community leadership to make the project a reality.
Seasonal air pollution may contribute to asthma emergency department visits even in areas with generally low pollutant levels. The study used Bayesian time-stratified case-crossover models to examine associations between air pollution and asthma seasons.
The Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations by nearly 60% and improved lung function and asthma control in children ages 6 to 11. Dupilumab was also shown to be safe, with minimal adverse reactions.
Research found a significant correlation between increased atmospheric temperature and asthma attacks in children. Lower SO2 levels during the state of emergency also contributed to reduced asthma exacerbations, suggesting that environmental factors play a crucial role in asthma management.
A study of over 950 children with asthma found that those with well-controlled symptoms were less likely to be bullied, but reported worse control if teased about their condition. Children who experienced bullying/teasing were more likely to report activity restrictions and had poorer asthma control.
A national analysis found that children with poorly controlled asthma are more likely to require hospitalisation than those with well-controlled asthma or without asthma. Vaccinating this group can reduce the risk of COVID-19 infection and associated illness.
A large UK study found that individuals with atopic diseases like eczema or hay fever had a 23% lower risk of developing COVID-19. In contrast, people of Asian/Asian British ethnicity and those in crowded households faced a higher risk. The study suggests that some risk factors for severe disease may differ from those for infection.
A University of South Florida Health-led team discovered a lead candidate that selectively relaxes airway smooth muscle cells with no detectable drug desensitization. The biased beta-agonist, C1-S, offers a therapeutic option for asthma and obstructive lung diseases without the rapid loss of effectiveness seen with traditional β-agonists.
A study by Katariina Koivusaari found that high cow's milk consumption is associated with a higher risk of developing preclinical type 1 diabetes in genetically predisposed children. The study also linked high-temperature treated infant formula to an increased risk of asthma in children.