Articles tagged with Asthma
The American Thoracic Society has published a clinical practice guideline on the use of fractional exhaled nitric oxide (FeNO) to guide asthma treatment. The guideline recommends using FeNO in addition to usual care for patients with asthma whose treatment is being considered, suggesting this may be eligible for the measurement.
The November issue of CHEST journal includes 69 articles on topics such as asthma, COPD, critical care and thoracic oncology. The journal also offers complementary web and multimedia activities to expand the reach of its research.
A new study reveals that Latinos with asthma who contract COVID-19 are 4.6 times more likely to experience severe asthma flares, and these episodes last significantly longer than in non-Latino populations.
A new study followed 5,000 kids with asthma in Los Angeles for 15 years and found no significant increase in allergic sensitizations to environmental allergens. Despite rising temperatures and pollen loads, children with asthma were not more likely to become sensitized to specific pollens.
A new study reveals that many young adults with asthma are not prepared to transition to adult asthma care. The survey found that half of all respondents did not receive sufficient transition preparation from their pediatric providers, highlighting the need for better education and support.
Itepekimab, a novel monoclonal antibody, has been found to be safe and effective in treating moderate-to-severe asthma. In a phase 2 trial, it significantly improved lung function and reduced asthma control events compared to placebo.
A new study published in the New England Journal of Medicine found that a psoriasis medicine worsened symptoms in patients with severe asthma. The trial tested risankizumab, an injectable treatment for psoriasis, and showed it did not improve asthma symptoms, but rather made them worse.
A new study published in Nutrients found that consuming fermented soy product ImmuBalance reduces eosinophilic-related inflammation in the bronchi of asthma model mice. The researchers also discovered a suppression of proteins that induce eosinophilic inflammation, suggesting beneficial effects for allergic asthma.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A group of researchers led by Indiana University School of Medicine's Benjamin Gaston will receive a research program project grant to fund the development of personalized therapeutic approaches for severe asthma. The grant will support three key projects focused on S-nitrosylation signaling, airway pH regulation, and androgen signaling.
A UK study found that social disadvantage in early childhood increases the risk of developing persistent asthma by 70%, with nearly two-thirds of the risk attributed to early life exposures. This highlights the need for public health measures and policies to support families and improve housing conditions.
A University of Illinois Chicago clinical trial aims to evaluate the impact of a healthy diet on asthma management in adults. Participants with uncontrolled asthma will be assigned to either an education-only group or a group receiving dietary counseling and guidance on the DASH eating plan, a diet approach proven for hypertension mana...
Researchers discovered that RSV's NS1 protein alters immune gene expression to evade the immune response. The study provides crucial data for targeting NS1 in drug or vaccine development and may shed light on the link between RSV and asthma.
Researchers developed a novel machine learning algorithm to identify previously unknown air pollutant mixtures linked to poor asthma outcomes in children. The study found that early exposure to individual and mixed pollutants can lead to longer-term problems with asthma, affecting about seven percent of US children.
Researchers investigated whether allergic diseases cause mental health conditions, finding little evidence of a causal relationship. The study used Mendelian Randomisation to identify genetic variants linked to allergies and mental health, but found no associations between the two.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
A new community-based approach to managing asthma symptoms will be implemented in up to 40 public schools across the Bronx, enrolling 416 students aged 4-12. The study aims to reduce asthma symptoms among high-risk urban school children through a cluster-randomized controlled trial.
A new study from Brigham and Women's Hospital identifies asthma, history of smoking, and chronic sinusitis as key risk factors for early COPD among US Hispanics/Latinos. The prevalence of early COPD was found to be 7.6 percent in this population, suggesting younger individuals are also susceptible to the disease.
Researchers found that certain species of gut bacteria accumulate human drugs, altering their types, activity, and metabolism. This can change the effectiveness of the drug both directly and indirectly, affecting side effects.
Research suggests that overweight and obese asthmatic children are less likely to respond to inhaled steroid medication, leading to more frequent asthma attacks. The study used genetic variants linked to BMI to investigate this link, finding a correlation between higher BMI z-scores and poor ICS response.
Patients with nontuberculous mycobacterial disease are hospitalized sooner and more often than their age- and sex-matched counterparts, according to a study published in CHEST. The risk is higher for people with compromised immune systems or damaged airways.
Researchers investigate how the internal circadian clock affects asthma severity. The study found that people with worse asthma experience greater drops in pulmonary function at night, and exhibit more symptoms-driven bronchodilator use during nighttime hours. This understanding could lead to new treatments for asthma.
A new study found office work triggers asthma in some workers, with poor ventilation and mould being common culprits. Employers who fail to make changes are more likely to lose employees, highlighting the importance of workplace adjustments to support staff.
A study of 814 babies found that those born to physically inactive mothers had lower lung function compared to those born to active mothers. Regular physical activity during pregnancy may reduce the risk of impaired infant lung function, potentially improving respiratory health later in life.
A new national study published in Annals of the American Thoracic Society found that bisexual Americans had over two times the rates of asthma and other lung diseases compared to heterosexual adults. Higher levels of discrimination experienced by bisexual people may lead to increased stress, inflammation, and worsened asthma.
A novel CT scan-based approach detects changes in lung tissue indicating emphysema and airway constriction in patients with asthma. This finding may explain why conventional anti-inflammatory treatments are ineffective in some asthmatics, paving the way for personalized management of the disease.
Computational modeling reveals that smaller drug particles can reach the distal region of airways, improving treatment efficacy. The study aims to enhance inhaler design and reduce drug loss, benefiting patients with respiratory illnesses.
Researchers have modelled how drugs are delivered to the respiratory tract via an inhaler to better treat lung diseases. Finer drug particles of around one micron are better able to travel further into the lungs.
Researchers found individuals with well-controlled asthma have significantly lower odds of hospitalization and ICU admission compared to those with uncontrolled asthma. Asthma patients using their medications showed a decrease in worsened COVID-19 outcomes.
The European Respiratory Society has announced the press registration and program for its upcoming International Congress 2021. Over 4,000 presentations on various lung health topics will be presented during the event.
A new clinical trial aims to test a personalized treatment for severe asthma targeting a specific mutation found disproportionately in people of color. The trial, led by Boston Children's Hospital, will test dupilumab, an existing drug that blocks the mutated IL-4 receptor, in patients with and without the mutation.
A study by University of New South Wales found that 80% of asthma-related hospital presentations in Australia are potentially avoidable through a comprehensive care pathway. The study identified variations in care pathways, including inconsistent use of clinical guidelines and inadequate follow-up with GPs.
A new evidence review finds that commonly used household products increase the risk of asthma due to volatile organic compounds (VOCs) emitted by paints, cleaning products, and more. The study suggests labelling these products with health warnings and advising people to ventilate their homes while using them.
Children's Hospital Colorado is part of a national clinical research network studying pediatric asthma. The hospital will conduct a seven-year study on early-life determinants of chronic asthma to potentially reduce exacerbations and prevent development.
A study published in Cell found a connection between breast milk, beneficial gut bacteria and the development of the immune system. The researchers discovered that babies whose intestinal flora can break down Human Milk Oligosaccharides have less inflammation in the blood and gut.
Researchers at Massachusetts General Hospital identified four biologically meaningful subtypes of RSV bronchiolitis, with one subtype linked to a 40% risk of developing asthma by age five. This study provides new insights into the complexity of bronchiolitis and may help improve care for affected children.
Dr. Sarah Goff's study examines the effects of Medicaid ACOs on asthma outcomes for children, aiming to improve pediatric asthma care and address social determinants of health. The research may inform other states considering ACO models for their Medicaid programs.
A new study suggests that exempting asthma medications from the deductible in high-deductible health plans may reduce medication use and exacerbations in children, but not adults. The research found small decreases in annual fills for some controller medications among children switching to HDHPs.
A new class of diabetes medication, GLP-1 receptor agonists, has been shown to improve asthma symptoms and reduce lung inflammation in patients with type 2 diabetes. The study found that these medications can help control asthma exacerbations and reduce breathing symptoms.
Researchers found that adding a third drug to dual-drug inhalers can reduce severe asthma exacerbations and improve asthma control in children, adolescents, and adults with moderate-to-severe asthma. The study included data from 20 randomized controlled trials involving almost 12,000 patients.
The NAVIGATOR study showed that tezepelumab significantly reduced annualized asthma exacerbation rates across all eosinophil level subgroups, including a 70% reduction in EOS ?300. The therapy also prolonged the time to first exacerbation requiring hospitalization or ED visit.
Children with a family history of asthma are two to three times more likely to develop the condition by age 4. Research also found that black children have higher asthma rates than white children during preschool years, but the gap closes later in childhood.
A web-based survey found that e-cigarette users had a higher risk of asthma, wheezing, and shortness of breath compared to non-users. The study also showed that past 30-day e-cigarette use was associated with increased respiratory symptoms even after controlling for cigarette and cannabis use.
Research presented at ATS 2021 International Conference found that e-cigarette users have a higher odds of developing asthma and having asthma attacks. Current smokers also had an increased risk, with former smokers facing the highest odds.
Researchers found that individuals with asthma living in historically redlined neighborhoods have lower lung function than those in non-redlined areas. This association was independent of race and co-occurring diseases, suggesting that environmental factors play a significant role in worsening asthma outcomes in these communities.
A population-based study found that children born in Sarnia, Ontario have a higher risk of developing asthma compared to neighboring cities. Air pollution exposure in the first year of life was associated with the development of asthma in children.
The study found that nearly half of people with asthma closest to the fire were unaware of the pollution problem and unable to take steps to avoid exposure. The incident led to an 80% increased risk of worsened asthma symptoms for those living within a 10-mile radius of the plant.
The NIH has established a new clinical research network called Childhood Asthma in Urban Settings (CAUSE) to study pediatric asthma in low-income urban settings. The network aims to develop tailored treatment and prevention approaches for children living in these communities.
A study published in eLife found that an overgrowth of yeast in the gut within the first few months of life may increase the risk of asthma later on. The period after birth is critical for immune system development and gut microbiome health, and disruptions to gut bacteria can lead to asthma.
A new study identifies non-Th2, or non-atopic childhood asthma, as a distinct disease with early exposure to airborne Benzo[a]pyrene linked to its development. The findings suggest that air pollution is a likely contributor to the most severe form of asthma.
A recent study has identified two distinct immune profiles in severe asthma patients, which could lead to personalized treatment approaches. The research, conducted by a team of scientists at the University of Pittsburgh and Stanford University, used advanced tools to characterize immune cells within the airways of severe asthma patients.
The Binational Early Asthma and Microbiome Study (BEAMS) examines how the 'hygiene hypothesis' affects children's risk of asthma in Mexico and the US. The study explores the role of microbiomes, family health history, and environmental exposures in developing asthma.
The study reveals that air pollution in the San Francisco Bay Area causes over 3,000 deaths and 5,500 new childhood asthma cases each year. Health impacts vary dramatically within neighborhoods, with certain areas experiencing a much larger burden.
During the COVID-19 pandemic, fewer people with severe asthma attacks sought medical help or were hospitalized for asthma exacerbations. A combination of factors, including reduced air pollution and improved self-management, may have contributed to this reduction. Additionally, a study in South Korea found a decrease in hospital admiss...
A school-based telehealth program in South Carolina provides accessible care to underserved children, improving academic performance and reducing ER visits. The program uses a time-efficient process that removes geographic barriers, ensuring timely treatment and medication administration.
Researchers discover that serotonin release from mast cells contributes to airway hyperresponsiveness in asthma, revealing a new mechanism for this common respiratory disease. The study uses a mouse model of asthma to demonstrate how mast cells react to methacholine, leading to increased airway constriction.
Researchers have identified a gene variant associated with childhood asthma using a diverse patient population. The study found that African Americans were more likely to carry the protective variant, which resulted in an increased risk of developing asthma.
A new study reviews data from 57 studies and finds that people with asthma have a 14% lower risk of getting COVID-19 and are significantly less likely to be hospitalized. The study included over 350,000 participants and found no apparent difference in the risk of death from COVID-19 in people with asthma.
Using sensor-based asthma inhalers may improve control of the condition and enhance the quality of life for caregivers. The study found that non-Hispanic Black participants experienced the greatest gains in asthma symptom control.
A new five-year study of over 100,000 people in Wales found that those from deprived backgrounds have worse asthma outcomes, including higher hospital admissions and risk of death. The study highlights the need for targeted health education strategies to improve asthma management in these communities.