Articles tagged with Asthma
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Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
A new community-based approach to managing asthma symptoms will be implemented in up to 40 public schools across the Bronx, enrolling 416 students aged 4-12. The study aims to reduce asthma symptoms among high-risk urban school children through a cluster-randomized controlled trial.
A new study from Brigham and Women's Hospital identifies asthma, history of smoking, and chronic sinusitis as key risk factors for early COPD among US Hispanics/Latinos. The prevalence of early COPD was found to be 7.6 percent in this population, suggesting younger individuals are also susceptible to the disease.
Researchers found that certain species of gut bacteria accumulate human drugs, altering their types, activity, and metabolism. This can change the effectiveness of the drug both directly and indirectly, affecting side effects.
Research suggests that overweight and obese asthmatic children are less likely to respond to inhaled steroid medication, leading to more frequent asthma attacks. The study used genetic variants linked to BMI to investigate this link, finding a correlation between higher BMI z-scores and poor ICS response.
Patients with nontuberculous mycobacterial disease are hospitalized sooner and more often than their age- and sex-matched counterparts, according to a study published in CHEST. The risk is higher for people with compromised immune systems or damaged airways.
Researchers investigate how the internal circadian clock affects asthma severity. The study found that people with worse asthma experience greater drops in pulmonary function at night, and exhibit more symptoms-driven bronchodilator use during nighttime hours. This understanding could lead to new treatments for asthma.
A new study found office work triggers asthma in some workers, with poor ventilation and mould being common culprits. Employers who fail to make changes are more likely to lose employees, highlighting the importance of workplace adjustments to support staff.
A study of 814 babies found that those born to physically inactive mothers had lower lung function compared to those born to active mothers. Regular physical activity during pregnancy may reduce the risk of impaired infant lung function, potentially improving respiratory health later in life.
A new national study published in Annals of the American Thoracic Society found that bisexual Americans had over two times the rates of asthma and other lung diseases compared to heterosexual adults. Higher levels of discrimination experienced by bisexual people may lead to increased stress, inflammation, and worsened asthma.
A novel CT scan-based approach detects changes in lung tissue indicating emphysema and airway constriction in patients with asthma. This finding may explain why conventional anti-inflammatory treatments are ineffective in some asthmatics, paving the way for personalized management of the disease.
Researchers found individuals with well-controlled asthma have significantly lower odds of hospitalization and ICU admission compared to those with uncontrolled asthma. Asthma patients using their medications showed a decrease in worsened COVID-19 outcomes.
Computational modeling reveals that smaller drug particles can reach the distal region of airways, improving treatment efficacy. The study aims to enhance inhaler design and reduce drug loss, benefiting patients with respiratory illnesses.
Researchers have modelled how drugs are delivered to the respiratory tract via an inhaler to better treat lung diseases. Finer drug particles of around one micron are better able to travel further into the lungs.
The European Respiratory Society has announced the press registration and program for its upcoming International Congress 2021. Over 4,000 presentations on various lung health topics will be presented during the event.
A new clinical trial aims to test a personalized treatment for severe asthma targeting a specific mutation found disproportionately in people of color. The trial, led by Boston Children's Hospital, will test dupilumab, an existing drug that blocks the mutated IL-4 receptor, in patients with and without the mutation.
A study by University of New South Wales found that 80% of asthma-related hospital presentations in Australia are potentially avoidable through a comprehensive care pathway. The study identified variations in care pathways, including inconsistent use of clinical guidelines and inadequate follow-up with GPs.
A new evidence review finds that commonly used household products increase the risk of asthma due to volatile organic compounds (VOCs) emitted by paints, cleaning products, and more. The study suggests labelling these products with health warnings and advising people to ventilate their homes while using them.
Children's Hospital Colorado is part of a national clinical research network studying pediatric asthma. The hospital will conduct a seven-year study on early-life determinants of chronic asthma to potentially reduce exacerbations and prevent development.
A study published in Cell found a connection between breast milk, beneficial gut bacteria and the development of the immune system. The researchers discovered that babies whose intestinal flora can break down Human Milk Oligosaccharides have less inflammation in the blood and gut.
Researchers at Massachusetts General Hospital identified four biologically meaningful subtypes of RSV bronchiolitis, with one subtype linked to a 40% risk of developing asthma by age five. This study provides new insights into the complexity of bronchiolitis and may help improve care for affected children.
Dr. Sarah Goff's study examines the effects of Medicaid ACOs on asthma outcomes for children, aiming to improve pediatric asthma care and address social determinants of health. The research may inform other states considering ACO models for their Medicaid programs.
A new study suggests that exempting asthma medications from the deductible in high-deductible health plans may reduce medication use and exacerbations in children, but not adults. The research found small decreases in annual fills for some controller medications among children switching to HDHPs.
A new class of diabetes medication, GLP-1 receptor agonists, has been shown to improve asthma symptoms and reduce lung inflammation in patients with type 2 diabetes. The study found that these medications can help control asthma exacerbations and reduce breathing symptoms.
The NAVIGATOR study showed that tezepelumab significantly reduced annualized asthma exacerbation rates across all eosinophil level subgroups, including a 70% reduction in EOS ?300. The therapy also prolonged the time to first exacerbation requiring hospitalization or ED visit.
Researchers found that adding a third drug to dual-drug inhalers can reduce severe asthma exacerbations and improve asthma control in children, adolescents, and adults with moderate-to-severe asthma. The study included data from 20 randomized controlled trials involving almost 12,000 patients.
Children with a family history of asthma are two to three times more likely to develop the condition by age 4. Research also found that black children have higher asthma rates than white children during preschool years, but the gap closes later in childhood.
Research presented at ATS 2021 International Conference found that e-cigarette users have a higher odds of developing asthma and having asthma attacks. Current smokers also had an increased risk, with former smokers facing the highest odds.
Researchers found that individuals with asthma living in historically redlined neighborhoods have lower lung function than those in non-redlined areas. This association was independent of race and co-occurring diseases, suggesting that environmental factors play a significant role in worsening asthma outcomes in these communities.
A web-based survey found that e-cigarette users had a higher risk of asthma, wheezing, and shortness of breath compared to non-users. The study also showed that past 30-day e-cigarette use was associated with increased respiratory symptoms even after controlling for cigarette and cannabis use.
A population-based study found that children born in Sarnia, Ontario have a higher risk of developing asthma compared to neighboring cities. Air pollution exposure in the first year of life was associated with the development of asthma in children.
The study found that nearly half of people with asthma closest to the fire were unaware of the pollution problem and unable to take steps to avoid exposure. The incident led to an 80% increased risk of worsened asthma symptoms for those living within a 10-mile radius of the plant.
The NIH has established a new clinical research network called Childhood Asthma in Urban Settings (CAUSE) to study pediatric asthma in low-income urban settings. The network aims to develop tailored treatment and prevention approaches for children living in these communities.
A study published in eLife found that an overgrowth of yeast in the gut within the first few months of life may increase the risk of asthma later on. The period after birth is critical for immune system development and gut microbiome health, and disruptions to gut bacteria can lead to asthma.
A recent study has identified two distinct immune profiles in severe asthma patients, which could lead to personalized treatment approaches. The research, conducted by a team of scientists at the University of Pittsburgh and Stanford University, used advanced tools to characterize immune cells within the airways of severe asthma patients.
A new study identifies non-Th2, or non-atopic childhood asthma, as a distinct disease with early exposure to airborne Benzo[a]pyrene linked to its development. The findings suggest that air pollution is a likely contributor to the most severe form of asthma.
The Binational Early Asthma and Microbiome Study (BEAMS) examines how the 'hygiene hypothesis' affects children's risk of asthma in Mexico and the US. The study explores the role of microbiomes, family health history, and environmental exposures in developing asthma.
The study reveals that air pollution in the San Francisco Bay Area causes over 3,000 deaths and 5,500 new childhood asthma cases each year. Health impacts vary dramatically within neighborhoods, with certain areas experiencing a much larger burden.
During the COVID-19 pandemic, fewer people with severe asthma attacks sought medical help or were hospitalized for asthma exacerbations. A combination of factors, including reduced air pollution and improved self-management, may have contributed to this reduction. Additionally, a study in South Korea found a decrease in hospital admiss...
A school-based telehealth program in South Carolina provides accessible care to underserved children, improving academic performance and reducing ER visits. The program uses a time-efficient process that removes geographic barriers, ensuring timely treatment and medication administration.
Researchers discover that serotonin release from mast cells contributes to airway hyperresponsiveness in asthma, revealing a new mechanism for this common respiratory disease. The study uses a mouse model of asthma to demonstrate how mast cells react to methacholine, leading to increased airway constriction.
Researchers have identified a gene variant associated with childhood asthma using a diverse patient population. The study found that African Americans were more likely to carry the protective variant, which resulted in an increased risk of developing asthma.
A new study reviews data from 57 studies and finds that people with asthma have a 14% lower risk of getting COVID-19 and are significantly less likely to be hospitalized. The study included over 350,000 participants and found no apparent difference in the risk of death from COVID-19 in people with asthma.
Using sensor-based asthma inhalers may improve control of the condition and enhance the quality of life for caregivers. The study found that non-Hispanic Black participants experienced the greatest gains in asthma symptom control.
A new five-year study of over 100,000 people in Wales found that those from deprived backgrounds have worse asthma outcomes, including higher hospital admissions and risk of death. The study highlights the need for targeted health education strategies to improve asthma management in these communities.
Research published in the Archives of Disease in Childhood suggests a link between fetal exposure to antibiotics in mid-to-late pregnancy and an increased risk of childhood asthma. The study found that children born vaginally were more likely to develop asthma, with higher odds for more serious cases.
A study of over 100,000 patients found a significant drop in asthma attack rates during the first Covid-19 lockdown, with milder attacks being reduced, but potential biases due to hospitalization data. The results suggest lower air pollution and fewer cold and flu infections may have played a role in the observed decrease.
A Swedish study found a significant association between proton pump inhibitor use in children and adolescents and the development of asthma. The researchers analyzed data from over 10,000 children and adolescents, revealing a higher risk of asthma among those taking PPIs for gastrointestinal issues.
A study found that Black children have significantly higher rates of shellfish and fish allergies, as well as wheat allergy, compared to White children. The study also showed a higher prevalence of asthma in Black children with food allergies, highlighting the importance of reducing exposure to cockroaches.
Research into INNA-X shows it is effective against rhinovirus, the main cause of the common cold, reducing viral load and inflammation. The nasal spray works by stimulating the innate immune system, making it harder for viruses to take hold.
A new study suggests that consuming long chain omega-3 fatty acids in childhood can reduce the risk of developing asthma, but only in children with a specific genetic make-up. The research found a significant association between higher intake of long chain omega-3 fatty acids and lower risk of asthma.
A new study at Karolinska Institutet in Sweden has developed a urine test to identify and verify the type of asthma. The test uses lipid biomarkers to measure urinary metabolite levels of certain prostaglandins and leukotrienes, which are known mediators of asthmatic airway inflammation.
A study published in Thorax found that higher intake of advanced glycation end-products (AGEs) from non-seafood meats is associated with increased wheezing in children. Researchers examined data from the National Health and Nutrition Examination Survey and found a significant link between AGE intake and respiratory symptoms.
Research published in Thorax journal links advanced glycation end products (AGEs) from cooked meat to increased risk of childhood wheezing and respiratory symptoms. Higher AGE scores were associated with increased odds of wheezing, sleep disruptions, and medication use.
A new study published in PLOS ONE found that maternal asthma medication is associated with an increased risk of premature births and small birth weights. The study analyzed data from over 117,000 births in Wales and found that prescriptions for asthma medicines were linked to lower birth weights and higher rates of preterm birth.
A new survey found that nearly a third of young adults with asthma do not comply with COVID-19 guidelines, highlighting the need for healthcare professionals to advise patients on basic measures and medication use. The study also revealed alarming misconceptions about COVID-19 risk among asthmatic individuals.
Researchers from RUDN University have developed a new method to analyze cytokines in nasal swabs to predict disease flow and prevent complications in asthma patients with accompanying diseases. The study found that monitoring specific cytokine profiles can help identify dangerous tendencies and allow for timely intervention.
A new study published in the Annals of the American Thoracic Society found a significant decrease in pediatric asthma-related emergency department visits during the spring 2020 COVID-19 lockdown. The rate of ED visits dropped by 80% compared to previous years, indicating improved symptom control and reduced exacerbations.
A large long-term study found that hormonal contraceptives may lower the risk of severe asthma bouts in women of reproductive age. However, the protective effect is relatively small and does not include progestogen-only Pill.
Researchers found a link between microorganisms in bed dust and children's bacteria, suggesting a potential reduction in asthma and allergy risks. The study analyzed bed dust samples from 577 infants and respiratory samples from 542 children, revealing a correlation between the two.