Articles tagged with Asthma
Younger male exposures to Ascaris roundworms show striking reductions in lung function and nearly five times higher odds of having asthma. The study highlights a previously overlooked risk factor for respiratory health in Europe.
Associate Professor Morten Arendt Rasmussen from the University of Copenhagen aims to develop a personalized dietary profile using a cohort of young people with asthma and other inflammatory diseases. The goal is to provide tailored diet recommendations that can help alleviate symptoms and improve health outcomes.
A new medication dupilumab has been added to the treatment options for children with moderate-to-severe asthma. The international multicenter Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations and improved lung function in children aged 6 to 11.
Researchers found that the risk of developing asthma in infants depends on a complex interplay among the infecting virus, airway microbial composition and function, and the infant's immune response. Infants with distinct metatranscriptome profiles had unique risks of developing asthma by age five.
A research group from Tohoku University discovered that melatonin, a sleep hormone, exacerbates asthma by potentiating bronchoconstriction. Melatonin weakens the relaxing effect of bronchodilators through the activation of the melatonin MT2 receptor.
Researchers found that asthma causes immune cells to behave in a way that prevents brain tumor growth, suggesting a potential new therapeutic approach. The findings suggest reprogramming T cells to act like those in asthma patients could be a new treatment for brain tumors.
A new study ranks live oaks and American sycamores as champions among 17 "super trees" that can mitigate air pollution and climate change in urban areas. The research provides a three-part framework for selecting suitable trees, identifying high-impact planting sites, and engaging with community leadership to make the project a reality.
The Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations by nearly 60% and improved lung function and asthma control in children ages 6 to 11. Dupilumab was also shown to be safe, with minimal adverse reactions.
Seasonal air pollution may contribute to asthma emergency department visits even in areas with generally low pollutant levels. The study used Bayesian time-stratified case-crossover models to examine associations between air pollution and asthma seasons.
Research found a significant correlation between increased atmospheric temperature and asthma attacks in children. Lower SO2 levels during the state of emergency also contributed to reduced asthma exacerbations, suggesting that environmental factors play a crucial role in asthma management.
A large UK study found that individuals with atopic diseases like eczema or hay fever had a 23% lower risk of developing COVID-19. In contrast, people of Asian/Asian British ethnicity and those in crowded households faced a higher risk. The study suggests that some risk factors for severe disease may differ from those for infection.
A study of over 950 children with asthma found that those with well-controlled symptoms were less likely to be bullied, but reported worse control if teased about their condition. Children who experienced bullying/teasing were more likely to report activity restrictions and had poorer asthma control.
A national analysis found that children with poorly controlled asthma are more likely to require hospitalisation than those with well-controlled asthma or without asthma. Vaccinating this group can reduce the risk of COVID-19 infection and associated illness.
A University of South Florida Health-led team discovered a lead candidate that selectively relaxes airway smooth muscle cells with no detectable drug desensitization. The biased beta-agonist, C1-S, offers a therapeutic option for asthma and obstructive lung diseases without the rapid loss of effectiveness seen with traditional β-agonists.
A study by Katariina Koivusaari found that high cow's milk consumption is associated with a higher risk of developing preclinical type 1 diabetes in genetically predisposed children. The study also linked high-temperature treated infant formula to an increased risk of asthma in children.
The American Thoracic Society has published a clinical practice guideline on the use of fractional exhaled nitric oxide (FeNO) to guide asthma treatment. The guideline recommends using FeNO in addition to usual care for patients with asthma whose treatment is being considered, suggesting this may be eligible for the measurement.
The November issue of CHEST journal includes 69 articles on topics such as asthma, COPD, critical care and thoracic oncology. The journal also offers complementary web and multimedia activities to expand the reach of its research.
A new study reveals that Latinos with asthma who contract COVID-19 are 4.6 times more likely to experience severe asthma flares, and these episodes last significantly longer than in non-Latino populations.
A new study followed 5,000 kids with asthma in Los Angeles for 15 years and found no significant increase in allergic sensitizations to environmental allergens. Despite rising temperatures and pollen loads, children with asthma were not more likely to become sensitized to specific pollens.
A new study reveals that many young adults with asthma are not prepared to transition to adult asthma care. The survey found that half of all respondents did not receive sufficient transition preparation from their pediatric providers, highlighting the need for better education and support.
Itepekimab, a novel monoclonal antibody, has been found to be safe and effective in treating moderate-to-severe asthma. In a phase 2 trial, it significantly improved lung function and reduced asthma control events compared to placebo.
A new study published in the New England Journal of Medicine found that a psoriasis medicine worsened symptoms in patients with severe asthma. The trial tested risankizumab, an injectable treatment for psoriasis, and showed it did not improve asthma symptoms, but rather made them worse.
A new study published in Nutrients found that consuming fermented soy product ImmuBalance reduces eosinophilic-related inflammation in the bronchi of asthma model mice. The researchers also discovered a suppression of proteins that induce eosinophilic inflammation, suggesting beneficial effects for allergic asthma.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A group of researchers led by Indiana University School of Medicine's Benjamin Gaston will receive a research program project grant to fund the development of personalized therapeutic approaches for severe asthma. The grant will support three key projects focused on S-nitrosylation signaling, airway pH regulation, and androgen signaling.
A UK study found that social disadvantage in early childhood increases the risk of developing persistent asthma by 70%, with nearly two-thirds of the risk attributed to early life exposures. This highlights the need for public health measures and policies to support families and improve housing conditions.
A University of Illinois Chicago clinical trial aims to evaluate the impact of a healthy diet on asthma management in adults. Participants with uncontrolled asthma will be assigned to either an education-only group or a group receiving dietary counseling and guidance on the DASH eating plan, a diet approach proven for hypertension mana...
Researchers discovered that RSV's NS1 protein alters immune gene expression to evade the immune response. The study provides crucial data for targeting NS1 in drug or vaccine development and may shed light on the link between RSV and asthma.
Researchers developed a novel machine learning algorithm to identify previously unknown air pollutant mixtures linked to poor asthma outcomes in children. The study found that early exposure to individual and mixed pollutants can lead to longer-term problems with asthma, affecting about seven percent of US children.
Researchers investigated whether allergic diseases cause mental health conditions, finding little evidence of a causal relationship. The study used Mendelian Randomisation to identify genetic variants linked to allergies and mental health, but found no associations between the two.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
A new community-based approach to managing asthma symptoms will be implemented in up to 40 public schools across the Bronx, enrolling 416 students aged 4-12. The study aims to reduce asthma symptoms among high-risk urban school children through a cluster-randomized controlled trial.
A new study from Brigham and Women's Hospital identifies asthma, history of smoking, and chronic sinusitis as key risk factors for early COPD among US Hispanics/Latinos. The prevalence of early COPD was found to be 7.6 percent in this population, suggesting younger individuals are also susceptible to the disease.
Researchers found that certain species of gut bacteria accumulate human drugs, altering their types, activity, and metabolism. This can change the effectiveness of the drug both directly and indirectly, affecting side effects.
Research suggests that overweight and obese asthmatic children are less likely to respond to inhaled steroid medication, leading to more frequent asthma attacks. The study used genetic variants linked to BMI to investigate this link, finding a correlation between higher BMI z-scores and poor ICS response.
Patients with nontuberculous mycobacterial disease are hospitalized sooner and more often than their age- and sex-matched counterparts, according to a study published in CHEST. The risk is higher for people with compromised immune systems or damaged airways.
Researchers investigate how the internal circadian clock affects asthma severity. The study found that people with worse asthma experience greater drops in pulmonary function at night, and exhibit more symptoms-driven bronchodilator use during nighttime hours. This understanding could lead to new treatments for asthma.
A new study found office work triggers asthma in some workers, with poor ventilation and mould being common culprits. Employers who fail to make changes are more likely to lose employees, highlighting the importance of workplace adjustments to support staff.
A study of 814 babies found that those born to physically inactive mothers had lower lung function compared to those born to active mothers. Regular physical activity during pregnancy may reduce the risk of impaired infant lung function, potentially improving respiratory health later in life.
A new national study published in Annals of the American Thoracic Society found that bisexual Americans had over two times the rates of asthma and other lung diseases compared to heterosexual adults. Higher levels of discrimination experienced by bisexual people may lead to increased stress, inflammation, and worsened asthma.
A novel CT scan-based approach detects changes in lung tissue indicating emphysema and airway constriction in patients with asthma. This finding may explain why conventional anti-inflammatory treatments are ineffective in some asthmatics, paving the way for personalized management of the disease.
Computational modeling reveals that smaller drug particles can reach the distal region of airways, improving treatment efficacy. The study aims to enhance inhaler design and reduce drug loss, benefiting patients with respiratory illnesses.
Researchers have modelled how drugs are delivered to the respiratory tract via an inhaler to better treat lung diseases. Finer drug particles of around one micron are better able to travel further into the lungs.
Researchers found individuals with well-controlled asthma have significantly lower odds of hospitalization and ICU admission compared to those with uncontrolled asthma. Asthma patients using their medications showed a decrease in worsened COVID-19 outcomes.
The European Respiratory Society has announced the press registration and program for its upcoming International Congress 2021. Over 4,000 presentations on various lung health topics will be presented during the event.
A new clinical trial aims to test a personalized treatment for severe asthma targeting a specific mutation found disproportionately in people of color. The trial, led by Boston Children's Hospital, will test dupilumab, an existing drug that blocks the mutated IL-4 receptor, in patients with and without the mutation.
A study by University of New South Wales found that 80% of asthma-related hospital presentations in Australia are potentially avoidable through a comprehensive care pathway. The study identified variations in care pathways, including inconsistent use of clinical guidelines and inadequate follow-up with GPs.
A new evidence review finds that commonly used household products increase the risk of asthma due to volatile organic compounds (VOCs) emitted by paints, cleaning products, and more. The study suggests labelling these products with health warnings and advising people to ventilate their homes while using them.
Children's Hospital Colorado is part of a national clinical research network studying pediatric asthma. The hospital will conduct a seven-year study on early-life determinants of chronic asthma to potentially reduce exacerbations and prevent development.
A study published in Cell found a connection between breast milk, beneficial gut bacteria and the development of the immune system. The researchers discovered that babies whose intestinal flora can break down Human Milk Oligosaccharides have less inflammation in the blood and gut.
Researchers at Massachusetts General Hospital identified four biologically meaningful subtypes of RSV bronchiolitis, with one subtype linked to a 40% risk of developing asthma by age five. This study provides new insights into the complexity of bronchiolitis and may help improve care for affected children.
Dr. Sarah Goff's study examines the effects of Medicaid ACOs on asthma outcomes for children, aiming to improve pediatric asthma care and address social determinants of health. The research may inform other states considering ACO models for their Medicaid programs.
A new study suggests that exempting asthma medications from the deductible in high-deductible health plans may reduce medication use and exacerbations in children, but not adults. The research found small decreases in annual fills for some controller medications among children switching to HDHPs.
A new class of diabetes medication, GLP-1 receptor agonists, has been shown to improve asthma symptoms and reduce lung inflammation in patients with type 2 diabetes. The study found that these medications can help control asthma exacerbations and reduce breathing symptoms.
Researchers found that adding a third drug to dual-drug inhalers can reduce severe asthma exacerbations and improve asthma control in children, adolescents, and adults with moderate-to-severe asthma. The study included data from 20 randomized controlled trials involving almost 12,000 patients.
The NAVIGATOR study showed that tezepelumab significantly reduced annualized asthma exacerbation rates across all eosinophil level subgroups, including a 70% reduction in EOS ?300. The therapy also prolonged the time to first exacerbation requiring hospitalization or ED visit.
Children with a family history of asthma are two to three times more likely to develop the condition by age 4. Research also found that black children have higher asthma rates than white children during preschool years, but the gap closes later in childhood.
A web-based survey found that e-cigarette users had a higher risk of asthma, wheezing, and shortness of breath compared to non-users. The study also showed that past 30-day e-cigarette use was associated with increased respiratory symptoms even after controlling for cigarette and cannabis use.
Research presented at ATS 2021 International Conference found that e-cigarette users have a higher odds of developing asthma and having asthma attacks. Current smokers also had an increased risk, with former smokers facing the highest odds.
Researchers found that individuals with asthma living in historically redlined neighborhoods have lower lung function than those in non-redlined areas. This association was independent of race and co-occurring diseases, suggesting that environmental factors play a significant role in worsening asthma outcomes in these communities.