Articles tagged with Blood Diseases
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Researchers found that microscopic blood vessel disease in the brain's white matter is associated with worse cognitive function and memory deficits in individuals with Alzheimer's. Lifestyle changes such as reducing hypertension, obesity, diabetes, and inactivity may help prevent or slow disease progression.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
A world-first study has confirmed the link between Alzheimer's Disease and multiple gut disorders, revealing shared genetic architecture. The study suggests that abnormal cholesterol levels play a key role in both conditions, and may lead to new potential treatments for Alzheimer's and gut disorders.
A new gene therapy for sickle cell disease was tested in mice but proved ineffective due to the complex genetic make-up of the Berkeley mice. The study suggests that researchers should carefully consider the genetics of the mice used to test human diseases.
A new review analyzes the efficacy of current non-invasive methods for assessing non-alcoholic fatty liver disease (NAFLD) and associated conditions. Blood-based biomarker tests and imaging methods are explored, with some showing promise in early diagnosis and staging liver disorders.
A new study from Tel Aviv University finds that women aged 55 and over who snore are at significant risk for sleep apnea, which can be fatal. The researchers warn that the phenomenon often occurs during sleep, causing women to be unaware of their condition.
A new Cambridge study has discovered that the sex of a fetus can affect placenta function, diet-induced maternal obesity, and stress. Designing sex-specific therapies and personalized lifestyle interventions could have lifelong health benefits for children.
Researchers developed mitapivat to target pyruvate kinase deficiency, a rare genetic condition leading to hemolytic anemia. The Phase 3 clinical trial showed significant improvements in hemoglobin levels and quality of life for patients with the disorder.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
A third dose of COVID-19 vaccine significantly increases immune responses in patients with multiple myeloma, but a subset remains vulnerable. The study found that 88% of patients developed antibodies after the third dose, leading to improved neutralization of the wild-type virus.
A new wireless implant has the potential to treat neuropathic pain resistant to medical therapy, offering a minimally invasive alternative to surgery. The device uses bioelectronic therapy to stimulate peripheral nerves from within blood vessels, providing precise placement and predictable outcomes.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
A recent study found that gene therapy delivery vectors were unlikely to cause the blood malignancies reported in trials; however, the exact cause remains a mystery. The study's results suggest that cancer risk in sickle cell disease may be more complex than initially thought, warranting further investigation.
Scientists from Japan and USA develop a microfluidic device for purification of tuberculosis genomic DNA fragments, enabling accurate diagnosis of diseases. The device uses transient ITP and electrokinetic trapping to detect and purify small cfDNA fragments.
Survival rates for adult patients with relapsed acute lymphoblastic leukemia (ALL) after hematopoietic cell transplantation have increased significantly over the past two decades. The two-year overall survival rate rose from 27.8% in 2000-2004 to 54.8% in 2015-2019, despite a significant increase in patient age at relapse.
A pilot study suggests that machine learning algorithms combining EKG and electronic health record data can more effectively screen for pulmonary embolisms than current tests. The fusion model was found to be 15-30% more effective at accurately identifying cases, especially severe ones.
A University of Birmingham-led study found that patients with a recorded history of gum disease are at higher risk of developing mental ill-health (37%), autoimmune diseases (33%), cardiovascular disease (18%), and cardiometabolic disorders, particularly Type 2 diabetes (26%). The study used UK primary care data to explore the associat...
Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
A recent study by NTU Singapore and Singapore General Hospital found that mutations in the DDX3X gene are responsible for chemotherapy resistance in some blood cancer patients. The study also discovered that STAT inhibitors can effectively kill lymphoma cells with DDX3X mutations, providing hope for new treatment options.
Researchers used next-generation DNA sequencing to detect residual disease in patients treated with CAR-T therapy for acute lymphoblastic leukemia. The study found that DNA sequencing was more sensitive and accurate than flow cytometry in predicting relapse, enabling earlier intervention.
The Helmholtz Munich researchers developed a neural network that outperforms previous machine learning algorithms for cell classification in terms of accuracy and generalizability. The database consists of over 170,000 single-cell images from more than 900 patients with various blood diseases.
A recent study published in JNCCN found that only 31% of hospitals have immediate availability of all-trans retinoic acid (ATRA), a crucial blood cancer medication. This medication is essential for treating acute promyelocytic leukemia, which has a better prognosis when treated appropriately. The lack of ATRA availability poses a signi...
People with blood cancers are at higher risk of severe COVID-19 illness; research suggests they don't always achieve optimal protection from vaccination. A new study found that patients with lymphoma were more likely to develop post-vaccination COVID-19 infection compared to those with other blood cancers.
A study suggests that suppressing the protective mechanisms of rogue blood stem cells can help curb clonal hematopoiesis and prevent leukemia. The researchers used zebrafish with colored 'barcodes' to track the dominance of cancerous clones, revealing a connection between anti-inflammatory genes and resistance to inflammation.
A team of Lehigh University undergraduates has won the National Institutes of Health's Healthcare Technologies for Low-Resource Settings Prize for developing a diagnostic device to detect sickle cell disease in infants. The $15,000 prize will support further development and testing of the device, which could improve healthcare outcomes...
Ulrich Steidl, a leading cancer researcher, has received an NCI grant to study the molecular mechanisms of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The goal is to develop new treatments and cures for these fatal disorders.
Researchers have discovered that red blood cells bind to cell-free DNA during sepsis and COVID-19, leading to their removal from circulation and triggering inflammation. This finding opens the door to new treatments for inflammatory diseases and acute anemia.
Researchers at the University at Buffalo have developed a new treatment that pairs essential proteins with lysophosphatidylserine to build immune tolerance and prevent antibody development, potentially treating autoimmune disorders and allergies.
A new precision medicine test has been developed using blood proteins to identify patients with idiopathic multicentric Castleman disease (iMCD) most likely to respond to siltuximab. The study also reveals Janus kinase (JAK) inhibitors as a promising alternative treatment option for those who do not respond to siltuximab.
A validated definition for iMCD-TAFRO has been established to differentiate it from other iMCD cases, enabling timely diagnosis and proper treatment. The new definition includes four clinical criteria: thrombocytopenia, anasarca, fever, and organomegaly.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
Researchers at Ural Federal University create enzyme-free electrocatalytic sensors using palladium and silver, increasing sensitivity and accuracy. The new method reduces storage needs and costs, making glucose measurement more reliable and accessible.
Researchers discovered epigenetic variations in individuals with severe COVID-19, associating them with excessive inflammatory response and poor health state. These findings enable the identification of a high-risk group (EPICOVID), warranting special care and personalized medicine approaches.
A multiyear workplace health promotion program was shown to prevent health risks among working-age individuals. The study found that participants remained at the same level or improved their rating, while only a small percentage deteriorated.
Researchers analyzed data from over 3.6 million women to identify differences in hypertensive disorders of pregnancy among US states. The study found significant variations in prevalence rates, suggesting regional disparities in maternal health care.
Research from Edith Cowan University found that consuming higher amounts of cruciferous vegetables daily can lower the risk of extensive calcification on the aorta, a key marker for structural blood vessel disease. Vitamin K may play a role in inhibiting this calcification process.
Researchers are studying gene transcription in blood of patients undergoing buprenorphine treatment to understand its therapeutic effects. The study aims to identify key genes and their association with clinical results, potentially leading to new treatments for opioid use disorder.
A study of nearly 1,000 mother-child pairs found an association between fetal exposure to acetaminophen and increased risk of childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). The research used umbilical cord blood samples to investigate potential developmental effects.
Researchers found elevated first trimester blood pressure increases risk for pregnancy hypertensive disorders, such as gestational high blood pressure and preeclampsia. Women with higher systolic or diastolic pressures had a greater risk of developing these conditions.
Stem cells derived from fat tissue can now be used to produce functioning platelets in just 12 days. This breakthrough could provide a reliable and safe supply of platelets for patients with cancer and other disorders, reducing the reliance on donated platelets.
Research found that individuals with diabetes who switched to high-deductible health plans experienced delays in seeking care for symptoms of blood vessel diseases, including cardiac chest pain and transient ischemic attacks. The study suggests that increased out-of-pocket costs lead to changes in healthcare behavior.
Researchers identified three key proteins that determine blood vessel growth and behavior, which may become new therapeutic targets. A novel approach focusing on endothelial cell metabolism could outperform current anti-VEGF therapies in efficacy.
The study estimated high mortality rates among civilians in Mosul, Iraq, with a rate of 2.09 deaths per 1,000 person-months during the 9 months of military liberation, compared to 0.71 and 0.50 deaths per 1,000 person-months during ISIS control periods for males and females, respectively.
A new study from The George Institute for Global Health at the University of Oxford found a strong link between high blood pressure and mitral regurgitation, a condition that makes the heart less efficient at pumping blood. Lowering blood pressure through exercise, diet or medication may reduce the risk of developing this condition.
A new study found that women with preeclampsia are seven times more likely to have severe preeclampsia or eclampsia if they also have pregnancy-associated stroke. Infections and chronic high blood pressure were also linked to an increased risk of stroke in these women.
The Endocrine Society has issued a statement advising healthcare providers on how to spot hormonal causes of high blood pressure that can be cured with surgery or treated effectively with medication. Screening for underlying conditions is crucial to prevent cardiovascular disease, renal disease, and even death.
A new color-coding tool enables scientists to track live blood stem cells over time, revealing how blood disorders and cancers like leukemia arise. The tool has many implications for hematology and cancer medicine, including understanding clonal diversity and regulating its development.
A single mutated gene, SNORD118, has been found to cause leukoencephalopathy with calcification and cysts (LCC), a progressive white matter degeneration in the brain. This discovery opens up possibilities for genetic testing and future treatments.
A Phase III trial shows the engineered clotting protein rvWF is safe and effective in controlling bleeding episodes in patients with severe vW disease. The protein increases naturally produced FVIII levels, reducing the need for additional infusions.
A study published in The Journal of Cell Biology provides new insights into the relationship between two proteins associated with cerebral cavernous malformations. Researchers found that CCM3 has an independent role in cell proliferation or survival pathways, contributing to the severity of symptoms.
AP39 replenishes hydrogen sulfide levels, lowering heart rate and blood pressure, with potential for new cardiovascular therapies.
A pilot study found using a smartphone app for education and feedback about heart-healthy behavior decreased the risk of heart disease in young black women. The treatment group showed improved blood pressure, cholesterol levels, stress, anxiety, and healthy habits compared to the control group.
A new theory proposes that preeclampsia is caused by the body's response to insufficient oxygen and nutrient supply to the growing fetus, leading to high blood pressure and organ damage. The condition can have fatal complications for pregnant women and their babies if left untreated.
Researchers developed synthetic platelet-like particles that can augment natural blood clotting, potentially reducing trauma-related bleeding deaths. The particles were tested in animal models and human blood, showing effectiveness in slowing bleeding without causing adverse effects.
Rice University researchers have discovered a biochemical link between blood clotting and the immune system, which could lead to new treatments for patients with inflammatory diseases. The study found that a protein involved in blood clotting also triggers the body's immune response.
Researchers propose a novel risk stratification model for bladder cancer patients treated with radical cystectomy, utilizing clinico-pathological and pre-operative hematological factors. The study found that low hemoglobin and high C-reacted protein levels are independent prognostic indicators for disease-specific survival.
Researchers examined current treatment standards for patients with clotting disorders, aiming to reduce toxicities and relapse rates. Maintaining hematocrit levels below 45% was associated with a lower risk of thrombosis compared to a more liberal approach.
Researchers at UW-Madison have identified a small DNA sequence, the +9.5 GATA2 switch site, that plays a crucial role in controlling GATA2 production and generating self-renewing blood stem cells.
A Finnish research team has uncovered the protein structure that regulates cell signalling and blood cell formation, shedding light on haematological disorders. The study provides new opportunities for disease-specific treatment and may lead to targeted therapeutics for common myeloproliferative diseases.
Researchers discovered that 40% of LGL patients have a STAT3 mutation, which may aid in diagnosing and treating the disease. The mutation is also associated with an increased risk of rheumatoid arthritis, opening new avenues for understanding its pathogenesis.