Articles tagged with Eye Diseases
Researchers at UHN's Krembil Research Institute identified LXB4, a unique lipid that protects neurons against glaucoma in preclinical models. This discovery provides hope for devising a new strategy to protect vision in glaucoma patients and may have implications for other neurodegenerative diseases.
A new study warns skiers and snowboarders about the risks of UV exposure to their eyes. The study found that people often miss applying sunscreen to areas around their eyes and eyelids, with serious consequences.
Scientists have sequenced the genomes of two pumpkin species, Cucurbita maxima and Cucurbita moschata, to understand their contrasting desirable traits. The study reveals an interesting evolutionary history, with pumpkins being a paleotetraploid resulting from the combination of two ancient genomes.
The study identified a protein called ARF6, which plays a key role in the development of diabetic retinopathy. When inhibited with compound NAV-2729, vessel leakage and blood vessel overgrowth were significantly reduced in diabetic mice.
The Illinois River's dramatic recovery is attributed to the Clean Water Act, which reduced sewage effluent and improved water quality. As a result, populations of largemouth bass, bluegill, and other sportfish have increased dramatically, with catches now exceeding 100-300 fish per hour.
Scientists have identified distinct neural signatures for explicit and implicit learning, which could guide the development of training techniques to mitigate learning and memory deficits. The findings may also help diagnose Alzheimer's disease at an earlier stage.
Researchers at Monash University have discovered the presence of regulatory T cells in the retina, a potential target for treating retinopathy of prematurity. The study's findings suggest that boosting these cells may repair damaged blood vessels in the retina, reducing ROP risk.
A new study has identified potential lipid biomarkers in human blood plasma associated with age-related macular degeneration, which may lead to earlier diagnoses and better treatment options. The study's findings also suggest that metabolomics profiling may provide novel insights into the relationship between lipids and AMD.
Researchers found that teenage girls and boys with severe antisocial behavior have difficulty recognizing facial expressions, particularly those showing negative emotions. The study suggests that boys with Conduct Disorder may need more comprehensive interventions than girls due to their unique challenges in emotion recognition.
A new human stem cell model has been developed to study macular degeneration, a leading cause of vision loss in older adults. The model, created by researchers at the University of Rochester Medical Center, mimics key characteristics of the disease and could lead to new avenues of research and potential drug targets.
Dr. Richard McIndoe receives $12.8 million grant to continue leading a national research initiative focused on diabetic complications, including nerve and kidney damage, high blood pressure, cardiovascular disease, and stroke. The consortium supports short-term studies and summer programs for medical students.
Researchers conclude that a daily supplement combining antioxidants with zinc and copper is a relatively inexpensive and effective means of halting the progression of degenerative eye disease. The study shows that this treatment could save the NHS nearly £3000 per patient, adding up to around £131 million a year.
A new study published in PNAS identifies two key compounds that can reduce the severity of age-related macular degeneration (AMD) by regulating inflammatory immune cells. The findings have significant therapeutic implications for AMD and other conditions involving angiogenesis and inflammation.
Researchers developed a noninvasive eye scan to detect Alzheimer's disease years before symptoms appear, revealing amyloid-beta deposits and toxic proteins in the retina. The findings offer new hope for early detection and disease monitoring, with the potential to intervene and change the course of the disorder.
A new record of the Oriental eye fly transmitting conjunctivitis has been discovered in China. Three new species from the same genus were also identified, adding to the understanding of these disease-causing insects.
A new study suggests that an eye test could be a useful tool in diagnosing Autism spectrum disorders (ASD) by assessing the ability of individuals to adapt saccade amplitudes. This test may indicate deficits in the brain's emotional and social development areas, which are often impaired in individuals with ASD.
Researchers from Mass Eye and Ear successfully prevented mice from developing retinal angiogenesis using CRISPR-Cas9 gene-editing techniques. The technique targets VEGFR2, a critical protein responsible for angiogenesis, and showed promising results in preclinical models.
Researchers at LSU Health New Orleans found that docosahexaenoic acid (DHA) and its bioactive derivative NPD1 can reduce stroke damage and promote cell survival in the brain. DHA is essential for maintaining cellular homeostasis, which is disrupted in diseases such as Alzheimer's and Parkinson's.
Researchers have found that Ebola virus can persist in specific areas of the body, including the eye, brain, and testes, even after symptoms resolve. This knowledge holds promise for developing medical products to counter the disease in humans.
Researchers at LSU Health Sciences Center have discovered a new class of biochemical triggers called elovanoids, which are derived from omega-3 fatty acids. These molecules play a significant role in protecting retinal pigment epithelial and photoreceptor cells from damage.
Patients with chronic rhinosinusitis (CRS) who quit smoking experience improvement in symptoms and medication usage within 10 years. The study found that every year without smoking is associated with a statistically significant reduction in symptoms and medication usage.
Dr. McKay's research has shown that l-dopa can delay or prevent macular degeneration in individuals with Parkinson's disease. He will now investigate the role of dopamine signaling pathways in AMD prevention.
A study found that Swedish optometrists recommend nutritional supplements, dietary changes, and smoking cessation to patients at risk of or with early symptoms of AMD. Optometrists were more likely to provide advice on diet compared to ophthalmologists.
A large international team of researchers has identified genetic abnormalities that are the first definitive risk genes for Tourette Syndrome. The study, which analyzed a sample of 2,400 patients and 4,000 controls, found that variations in copy number at specific genes were associated with an increased risk of developing the disorder.
A study using Neuro Kinetics' I-Portal devices found that a battery of OVRT tests can accurately measure concussion symptoms both initially and during recovery. The study suggests that these tests may be used to monitor subacute concussion recovery and help determine the safest time for patients to return to activities.
Researchers will develop coral disease forecasting models for Hawai'i, U.S.-affiliated Pacific Islands, and the Great Barrier Reef using field work, experimental data, and satellite information. The project aims to identify local environmental stressors increasing disease susceptibility and prioritize management practices.
Sylentis has begun a Phase III clinical trial to evaluate the efficacy of SYL1001 in treating dry eye syndrome. The study aims to improve signs and symptoms of the condition, including chronic loss of lubrication and hydration on the ocular surface.
A genetic mutation contributing to childhood blindness has been identified in patients with ocular coloboma, a condition resulting in part of the eye being missing at birth. The study revealed mutations in 10 genes linked to actin activity, affecting eye development.
Researchers at Gladstone Institutes have discovered the key protein CTCF plays a crucial role in controlling DNA organization, reevaluating the cause of certain cancers and developmental defects. The study sheds new light on gene regulation and provides insights into fundamental genome organization processes.
Researchers found that impaired autophagy and lysosomal degradation lead to photoreceptor cell death in CLN5 deficient mice, mirroring human NCL diseases. The study suggests non-invasive retinal examinations could serve as biomarkers for neurological diseases.
Researchers found that pericyte loss worsens retinal environment and function in mouse models of diabetic retinopathy. Pericytes regulate a molecular pathway associated with vascular stabilization, and their absence accelerates disease progression.
Scientists at the University of Birmingham have developed a painless method to deliver anti-VEGF drugs to the eye, using a cell-penetrating peptide. This innovation has the potential to revolutionize the treatment of age-related macular degeneration (AMD), reducing adverse outcomes and healthcare costs.
A nutraceutical called Longevinex has been shown to reduce the time it takes for older eyes to adapt to the dark, predicting future onset of macular degeneration. The study found that 12 out of 14 eyes tested improved or were stable after using Longevinex.
A clinical trial found that the drug teprotumumab significantly reduces eye bulging, pain, and swelling in patients with moderate-to-severe active thyroid eye disease. The treatment, which blocks an autoimmune attack on muscles around the eyes, showed rapid therapeutic benefits within six weeks of infusions.
A study found that approximately 25% of eyes deemed normal had AMD, highlighting the need for correct identification and treatment in primary eye care. Undiagnosed AMD was associated with older patient age, male sex, and less than a high school education.
A new study by Rice University found that religious individuals are more likely to disapprove of reproductive genetic technologies than non-religious people. Evangelical Christians are the most opposed, with 23% deeming disease technologies morally wrong, while 80% of evangelicals reject enhancement technologies.
A team of Penn researchers has pinpointed the underlying mechanism leading to vision loss in Best disease, a condition affecting central vision. They discovered that differences in supporting structures between rods and cones contribute to lesion development in the macula.
A team of researchers identified the transcription factor RUNX1 as a novel therapeutic target for retinal neovascularization, a hallmark of advanced diabetic eye disease. By inhibiting RUNX1 with a small molecule drug, they achieved a 50% reduction of retinopathy in preclinical models.
Researchers at JAX will study mouse models of inherited RPE-driven disease to identify potential molecular pathways for druggable targets. Their goal is to prevent, delay onset or decrease the severity of age-related macular degeneration and other heritable retinal diseases.
Australian scientists have discovered five key genetic regions that increase the risk of developing Macular Telangiectasia type 2 (MacTel), a degenerative eye disease leading to blindness. The findings will help researchers understand the disease and explore ways to prevent or treat its progression.
Researchers found that vitamin B3 administration eliminated age-related molecular changes and provided robust protection against glaucoma. The treatment boosted metabolic reliability of aging retinal ganglion cells, keeping them healthier for longer.
Northwestern University scientists have developed a tiny, transparent device that can detect ultrasound waves, potentially helping diagnose diseases like macular degeneration and diabetes. The Micro-ring resonator detector uses optical ultrasound detection methods to create high-resolution images of biological materials.
Researchers found that using red-channel images improved the detection of diabetic macular edema, a complication of diabetes leading to blindness. The study suggests that this method could offer a clear-cut advantage in under-served groups with high rates of diabetic eye disease.
Researchers found that a slight increase in transforming growth factor beta (TGF-β) protects retinal blood vessels from damage in early diabetic eye disease. The study suggests that inhibiting TGF-β may accelerate the disease, while increasing its signaling could prevent or delay diabetic retinopathy.
Researchers discover mutations in the REEP6 gene as a significant contributor to retinitis pigmentosa, a leading inherited eye disorder. The study identifies seven new cases of patients with tunnel vision and vision loss, shedding light on the genetic basis of this devastating disease.
Study findings reveal that IL-7 and IL-15 signal Th17 cells to chronically reside in the body, contributing to autoimmune disorders. The study suggests targeting these cytokines may lead to new therapies for chronic autoimmune diseases.
Researchers at the University of Rochester Medical Center have developed a new imaging technique that can distinguish individual retinal ganglion cells, which bear most of the responsibility for relaying visual information to the brain. This breakthrough could enable earlier diagnosis and treatment of eye diseases like glaucoma.
This review explores the potential of nanoparticle drug delivery systems to improve solubility, permeability, and stability of ophthalmic drugs. The development of these systems may offer a solution to the limitations of traditional topically administered formulations.
A study published in PLOS ONE reveals the potential clinical utility of an integrated, multi-modal battery of oculomotor, vestibular, and reaction time tests for detecting concussions. The results show promising sensitivities and specificities, paving the way for objective diagnostic tools at the point of injury or in emergency rooms.
A substantial percentage of LASIK surgery patients experience new visual symptoms, including double images and glare, despite a decrease in overall prevalence. Researchers found that up to 43% of patients reported these new symptoms at 3 months post-op.
Research at RIT aims to understand vitreous humor properties that result in vision impairment. The study may unlock new treatments for vision disorders and improve drug delivery and eye surgery.
Researchers have made significant progress in understanding the genetic diversity of Onchocerca volvulus, the parasite that causes river blindness. The study reveals gene flow between savanna and forest strains, with genes from the savanna strain flowing into the forest strain due to differences in climate and black fly behavior.
Research from the University of Southampton discovered that Alzheimer's disease proteins can accumulate in the retina and damage it, leading to Age-related Macular Degeneration (AMD). The study found that Amyloid beta proteins entered retinal cells within 24 hours and damaged the cell's structure.
Researchers have identified a novel protein, Tmem135, that regulates retinal aging and causes age-dependent diseases like macular degeneration in mice. The study reveals that irregular levels of the protein lead to symptoms of macular degeneration.
Research by Dr. Przemyslaw Sapieha and colleagues suggests that a diet rich in fat can alter the gut microbiome, leading to inflammation and increased risk of wet AMD, a blinding form of age-related macular degeneration. The study provides new insights into the role of gut microbes in disease prevention.
A study of 564 patients found that women with long-term axial spondyloarthropathy are at higher risk for extra-articular manifestations, including uveitis, which is significantly more prevalent in women (46.7%) and those in late disease stages. IBD prevalence was also higher in women (16.5%), particularly those with elevated CRP levels.
Researchers discovered that activation of the aryl hydrocarbon receptor pathway blocks collagen production and myofibroblast proliferation in thyroid eye disease. The study suggests AHR ligands may be a novel target for treatment, offering hope for targeted therapies.
A new iPad game was shown to be more effective than traditional patching treatment in improving vision outcomes for children with amblyopia. After just two weeks of playtime, the game improved visual acuity by more than double that achieved with patching.
The journal Drug Delivery and Translational Research published a special issue on ocular drug delivery, highlighting the need for sustainable release of therapeutics to target tissues in the posterior segment. The market opportunity is significant, with the global pharmaceutical market projected to grow to $23 billion by 2018.
A study published in JAMA Ophthalmology estimates that approximately 30,000 individuals per year report to US emergency departments with sports-related eye injuries. The majority of these cases involve males playing basketball or baseball, with the latter leading to significant blowout fractures and impaired vision.