Articles tagged with Eye Diseases
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Researchers have discovered a genetic mutation in monkeys that causes Bardet-Biedl Syndrome, a devastating eye disorder. The discovery provides a promising animal model for developing gene and cell therapies to treat the condition in humans.
Researchers have identified glial and vascular cells as contributing to the development of age-related macular degeneration, a leading cause of blindness in the elderly. The study provides new insights into the disease, highlighting potential targets for novel therapies.
Researchers have identified a new class of therapy for dry eye disease by targeting anti-citrullinated protein autoantibodies (ACPA) with antibody-based eye drops. The treatment has shown statistically significant and clinically meaningful reductions in corneal damage and symptoms in patients with severe dry eye disease.
Researchers developed a new non-invasive optical imaging system to diagnose and treat dry eye disease. The Tear Film Imager images layers of the tear film with speed and precision, providing nanometer-level insight into subtle changes in each layer.
A Baylor University researcher's prototype smartphone app, CRADLE, detects early signs of various eye diseases in children by searching for abnormal reflections from the retina. The app surpassed the 'gold standard' of sensitivity and detected leukocoria with 80% accuracy.
Researchers have developed a new approach to delivering sight-saving gene therapy to the retina, using a small needle to inject harmless viruses into the suprachoroidal space. This method could provide a more permanent therapeutic option for patients with common diseases such as wet age-related macular degeneration and inherited retina...
Dr. Jin Liu is working on a $437,864 grant to develop more precise gene editing using CRISPR-Cas9 technology, aiming to reduce off-target effects and increase on-target effectiveness for treating life-threatening diseases such as cancer, eye diseases, and sickle cell anemia.
QUT researchers have developed a new method for analysing Optical Coherence Tomography (OCT) images using deep learning techniques to detect and track eye diseases such as glaucoma and macular degeneration. The team's findings show that their program is reliable and more accurate than standard image analysis methods.
Scientists at Columbia University have successfully miniaturized medical imaging technology using a microchip, producing high-quality images with improved depth resolution. The breakthrough could lead to affordable handheld devices for disease diagnosis outside of hospitals in low-resource settings.
Researchers found increased AGE levels in eyes of people with type 2 diabetes and prediabetes, indicating potential for early detection through lens autofluorescence measurement. A new biomicroscope can detect these levels without invasive procedures.
Researchers at the Complutense University of Madrid have identified areas of the retina that change in patients with mild Alzheimer's disease. The study used optical coherence tomography to measure retinal layer thickness and found significant thinning in certain locations, which can be used to diagnose the disease before other tests.
Researchers at the Lowy Medical Research Institute have discovered that MacTel is caused by low blood levels of serine, leading to toxic lipid accumulation and photoreceptor cell death. This breakthrough has implications for other retinal eye diseases and may lead to new treatments.
Researchers at the University of Utah Health have made a groundbreaking genetic discovery linking MacTel to HSAN1, revealing that toxic biomolecules deoxySLs cause damage to the macula. The study also found that lipid-lowering medication fenofibrate shows potential in protecting the retina from these biomolecules.
A NIH-funded clinical trial found that methotrexate was more effective than mycophenolate mofetil in controlling inflammation and treatment success for patients with severe forms of uveitis. At six months, 74% of participants in the methotrexate group achieved control compared to 55% in the mycophenolate group.
Dogs in Africa are susceptible to severe and often fatal disease if bitten by infected tsetse flies, characterized by symptoms such as corneal cloudiness. Researchers have developed molecular methods to accurately diagnose the disease, revealing a surprising link between canine and human cases.
A new DNA sequencing method can detect early-stage wheat diseases with high accuracy, addressing the limitations of traditional methods. This portable technology can also identify unknown pathogens and diagnose unexpected diseases, saving time and money in agricultural biosecurity monitoring.
Researchers at FAU's Schmidt College of Medicine are working on a novel project to identify the role of hypoxia in the formation of the eye lens and its potential as a therapeutic target for eye diseases such as cataracts. The grant will help advance regenerative medicine by developing ocular cells that can replace damaged tissues.
Scientists have developed a retina-on-a-chip technology that recreates the human retina's complex tissue architecture, enabling the efficient study of eye diseases and screening for drug side effects. The tool uses living human cells with an artificial tissue-like system, mimicking the body's environment and blood vessels.
A team of Australian scientists has created the world's most detailed gene map of the human retina, providing unprecedented insights into its genetic signals. This will help future research understand the factors that enable cells to function normally and identify the genetic 'mistakes' causing vision loss and blindness.
Researchers at Tampere University found voltage-gated sodium channels in epithelial tissue of the eye, which are involved in renewal of sensory cells and phagocytosis process in retinal pigment epithelium. This discovery reveals new insight on functioning of the eye and retinal diseases.
Researchers at Trinity College Dublin discovered that claudin-5 plays a crucial role in the development of dry Age-Related Macular Degeneration. The study suggests that regulating blood vessel integrity may prevent the disease.
Researchers have developed an artificial human eye replica, the blinking eye-on-a-chip, to model dry eye disease (DED). The device mimics the complex pathophysiology of DED, allowing scientists and drug developers to test experimental treatments.
A group of scientists recommends large-scale collaborative research to tackle dry macular degeneration, with proposed methods including integrated collaboration and biorepository development. The panel aims to bring about meaningful clinical results by promoting multidisciplinary investigator teams.
Researchers have discovered a molecular machine that reorganizes the inner mitochondrial membrane, which is essential for energy production in cells. The study sheds light on the hereditary disease optic atrophy and may lead to new therapies.
Researchers analyzed samples from over 1,000 type 1 diabetes patients for 50 years or longer and found a protective protein called RBP3. Injecting RBP3 into rodents blocked diabetic retinopathy without severe side effects.
Researchers at Joslin Diabetes Center have identified a protein found in the eye that protects against and potentially treats diabetic eye disease. Retinol Binding Protein 3 (RBP3) prevents the development of diabetic retinopathy, and introducing it early can reverse the effects of the complication in rodent models.
A new study from City, University of London suggests that patients diagnosed with dry AMD may experience considerable distress despite reasonable visual function. Effective communication with eye health professionals and timely information about the disease can alleviate anxiety and fear of going blind.
A new study reveals that the complement system, part of the innate immune system, plays a protective role in slowing retinal degeneration in a mouse model of retinitis pigmentosa. The research suggests that the complement system helps to clear away dead cells and maintain homeostasis in the retina.
Researchers found retinal vascular tortuosity, a microvascular abnormality, is associated with PAH and pulmonary vascular remodeling. The study suggests the eye may provide valuable information about pulmonary circulation health.
Scientists discovered differences in Müller cell shape and biology between the retina's macula and peripheral regions, shedding light on the eye's defense mechanism against disease. The study found that macula Müller cells produce more serine, a protective amino acid, but are more susceptible to stress when this production is blocked.
A phase I/II clinical trial of an enzyme-based treatment found reduced signs of disease and discomfort in participants with severe dry eye disease. The treatment, DNase, was shown to be safe and effective in improving corneal health and reducing symptoms.
Salil Lachke's research aims to understand the developmental disorders that cause anophthalmia and microphthalmia, rare eye defects occurring in 1 in every 5,300 babies born in the US. The NIH grant will support his investigation of Rbm24, a gene implicated in eye development and potentially other diseases.
Researchers have discovered an unexpected role for the gene GRIK5 in linking vascular biology to eye disease, utilizing biobanks, electronic health records, and zebrafish. The study found reduced expression of GRIK5 associated with 18 different eye diseases, including retinal detachment, cataract, and glaucoma.
A small study published in the British Journal of Sports Medicine suggests that doubles badminton players are at greatest risk of potentially serious eye injuries during matches. Protective eye wear is highly recommended for all competitors to prevent such injuries, which can cause permanent vision loss and even blindness.
Researchers have found and tested compounds from a group of plants that could be used to treat proliferative diabetic retinopathy and other degenerative eye diseases. The study suggests that these natural compounds may provide a new approach to treating blindness caused by diabetes, offering hope for future treatments.
Scientists at the University of Illinois Chicago are developing functional optical coherence tomography and OCT angiography to study minute changes in the retina indicating early stages of brain diseases. The technique, led by Xincheng Yao, aims to detect neurovascular coupling changes that precede clinical symptoms.
A recent NIH study found no evidence that eating a calcium-rich diet or taking supplements increases the risk of age-related macular degeneration. The study suggests that high calcium intake may be protective, but more research is needed to confirm this finding.
Researchers found a potential predictor of (future) Alzheimer's disease in eye fluid, linking low amyloid-β and tau protein levels to lower cognitive scores. The study suggests that proteins in the eye may be accessible for an affordable test to predict future AD.
A new University study highlights the high incidence and prevalence of visual problems in acute stroke survivors, with 48% of all stroke admissions and 60% of survivors experiencing new onset visual conditions. The study found that three quarters of patients had visual problems, including impaired central vision, eye movement abnormali...
Dry eye disease is linked to an increased risk of migraine headaches, with symptoms including stinging, burning, or scratchy sensations. The study suggests a possible association between the two conditions, warranting further research into diagnostic and treatment options.
Researchers found Ebola survivors in Liberia had higher rates of uveitis, muscle pain, fatigue, and joint pain compared to a control group. Physical exams also revealed abnormal findings in abdominal, chest, and neurologic areas.
UVA is expanding its telehealth capacity to help patients manage chronic conditions like diabetes, prediabetes, and heart disease. The initiative includes remote monitoring, screenings, home rehabilitation programs, and training for healthcare providers.
Research from Anglia Ruskin University found that calibrated smartphone cameras can significantly improve accuracy in eye examinations. The study used three smartphones and compared results to clinician diagnoses, highlighting the importance of camera calibration for telemedicine and AI applications.
A team of researchers has identified 261 new genes linked to blindness and vision disorders in mice, which could help identify new causes of hereditary blindness in humans. The study uses a large database of gene-knockout mice to accelerate the application of genomics in clinical medicine.
Researchers at Portland State University have developed a 3-D image of the membrane channel to better understand cell-to-cell communication, opening doors to new treatments for diseases associated with gap junction malfunction. The discovery may pave the way for pharmaceuticals that can control heart disease and other conditions.
A study found that prions, infectious proteins causing Creutzfeldt-Jakob disease, accumulate in the retina and other parts of the eye. The discovery could lead to new diagnostic tests and treatments for the disease.
Researchers have developed a painless and efficient alternative to current treatment methods for eye diseases, using biodegradable microneedles that deliver drugs into the eye. The patch has been shown to be 90% more effective than eye drops in alleviating corneal vascularisation.
High levels of prions were found throughout the eyes of deceased sCJD patients, suggesting the eye as a potential source for early detection and prevention of disease transmission. Researchers also discovered that prion seeds accumulate in the retina, with implications for diagnostic tests before symptoms become apparent.
A study published in Optometry and Vision Science found that dry eye syndrome can slow a person's reading speed by up to 10% and make it difficult to read for more than 30 minutes. The condition affects millions of adults in the US, causing ocular discomfort and visual problems.
Researchers at the National Eye Institute combine adaptive optics and angiography to visualize live neurons, epithelial cells, and blood vessels in the retina. This technology could lead to earlier detection of diseases like age-related macular degeneration.
Maternal smoking is associated with a higher risk of strabismus in children, which can lead to visual impairment and emotional problems. A study of 11 relevant articles found that maternal smoking during pregnancy increases the risk by up to 79 percent.
A new editorial and free resource clarify corneal dystrophy diagnoses based on corrected medical literature, with the International Committee for Classification of Corneal Dystrophies providing an updated standard classification. The IC3D nomenclature has become internationally accepted.
Researchers identified a novel missense mutation in tyrosyl-tRNA synthetase (YARS) causing severe recessive disorder. The study found that affected individuals exhibited poor growth, developmental delay, and various organ dysfunctions, including liver disease, pancreatic insufficiency, and hearing loss.
Researchers trained neural nets to detect pneumonia in chest X-rays and found reduced accuracy when tested on external data. A random forest model can predict future diagnosis of high myopia among Chinese school-aged children up to 8 years in advance with clinically acceptable performance.
Uveitis, a serious eye disease, affects 200,000 people in the US and can lead to irreversible blindness. MDM2 inhibitors have been found to inhibit ocular inflammation, suggesting a new treatment option with reduced systemic side effects.
Researchers developed an antisense oligonucleotide therapy to halt or reverse SCA7-induced vision loss. Studies in mice and humans show promise for treating the rare condition with fewer side effects than existing medications.
Researchers reviewed published studies and found at least seven patients who experienced devastating harm from unapproved cell therapy. Clinics that offer such treatments often omit poor outcomes in their reports, leading to a significant under-reporting of complications.
The American Academy of Ophthalmology has received a $2 million gift from the Knights Templar Eye Foundation to establish a permanent research fund focused on pediatric ophthalmology. The fund will leverage the IRIS Registry to uncover optimal approaches to prevention and treatment for common and rare eye diseases affecting children.
Researchers at the University of Nottingham have discovered a characteristic of the Descemet membrane that can cause difficulties for surgeons performing corneal transplants. The study found that elastin, an elastic-like fiber, governs the direction of the membrane's roll and may be responsible for its unidirectional behavior.
A study found that inhibiting atypical protein kinase C reduces increased vessel permeability and blocks inflammation, potentially helping protect vision in patients with eye diseases. The therapy has therapeutic potential for diabetic retinopathy, uveitis, and retinal vein and artery occlusions.