Articles tagged with Eye Diseases
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Researchers at Karolinska Institutet have discovered a connection between metabolic disturbance in retinal ganglion cells and high intraocular pressure. Rapamycin and pyruvate treatments showed protective effects in animal and cell models.
In a groundbreaking study, gene therapy injection in one eye significantly improved vision in both eyes, with 78% of patients experiencing significant visual improvement. The treatment has shown promise in treating Leber hereditary optic neuropathy (LHON), a blinding condition affecting approximately 1 in 30,000 people.
A phase 3 clinical trial involving 37 patients showed sustainable improvements in vision after 96 weeks, suggesting the gene therapy could be a safe and effective treatment for Leber hereditary optic neuropathy. The treatment unexpectedly seemed to work in both eyes, with DNA from the vectors found in both treated and untreated eyes.
Researchers developed a potential new treatment for glaucoma using a natural, biodegradable hydrogel that opens an alternate pathway for excess fluid to leave the eye. The treatment could provide an efficient alternative to current treatments without daily drops or surgery.
Scientists at the University of Southampton have made a breakthrough in reconstructing eye tissues from the outer retina using serial block face scanning electron microscopy. The study provides a clear picture of the 3D organisation of the retinal pigment epithelium, which could help understand causes of damage leading to sight loss.
Scientists from Trinity College Dublin have developed a new gene therapy approach that successfully protected the visual function of mice with dysfunctional mitochondria. The treatment also improved mitochondrial performance in human cells with OPA1 gene mutations, offering hope for treating diseases like Alzheimer's and Parkinson's.
Researchers at the University of Barcelona have identified a new function of the ataxin 3 gene, which causes Machado-Joseph disease, in the development of retina photoreceptors. This discovery provides insights into the molecular causes of rare diseases like ataxia and macular degeneration.
Researchers developed an AI-powered method to detect Parkinson's disease from retinal images, identifying smaller blood vessels as key features. The approach is less costly and more accessible than traditional brain imaging techniques.
A new study from City University London suggests that glaucoma eye tests can be accurately performed at home using a tablet-based device called Eyecatcher. The study found high accuracy rates (98%) and adherence, with potential to detect rapidly progressing cases of glaucoma earlier.
Researchers developed a novel deep learning method that requires less annotated image data to screen for diabetic retinopathy, achieving the same diagnostic performance as human experts. The method enables clinics to automate screenings and reduce referrals to specialized eye care centers.
A study found a high prevalence of type 2 diabetes (60.5%) among the Xavante population, with severe cases threatening sight. The researchers used a portable retinograph to detect diabetic retinopathy and found 16 cases, highlighting the need for screening in remote communities.
A team of researchers from Rensselaer Polytechnic Institute developed a deep neural network that can perform nearly as well as more complex dual-energy CT imaging technology. The algorithm produced high-quality approximations with a relative error of less than 2% using single-spectrum CT data.
Researchers will analyze stem cell activation with a focus on identifying novel mechanisms for how immature eye cells become mature visual cells. The goal is to develop regenerative therapies for diseases such as cataract, retinal degeneration, and heart disease.
Researchers developed SeSBAT, a computer program that analyzes magnetic resonance images to detect early signs of neurodegenerative diseases. The tool identifies biomarkers before symptoms appear, allowing for individualized monitoring and more accurate management.
A Chinese study suggests that wearing eyeglasses for over eight hours a day may provide some protection against SARS-CoV-2 infection. However, an infectious disease expert at Johns Hopkins Medicine cautions that the findings are not conclusive and more research is needed to confirm their validity.
Researchers identified a compound that disables abnormal blood vessels, potentially reversing vision loss in patients with retinopathy of prematurity and diabetic retinopathy. The treatment targets only the abnormal vessels, sparing healthy ones.
A new study published in Current Biology reveals that subanesthetic ketamine is effective in treating adult amblyopia, also known as 'lazy eye', by reactivating brain plasticity. The treatment promotes functional recovery of visual acuity defects resulting from the condition.
The pathoconnectome is a map of how eye disease alters retinal circuitry, offering insights into other neurodegenerative diseases like Alzheimer's and epilepsy. The research findings provide fundamental rules on how neural networks are rewired by disease, paving the way for new therapies.
Researchers developed an AI-based deep learning platform, DystoniaNet, to diagnose dystonia from brain MRIs with high accuracy. The platform detected cases of dystonia with 98.8 percent accuracy and identified a new microstructural neural network biological marker.
Researchers identified Neurofilament light chain in vitreous humor, a potential biomarker for Alzheimer's and Parkinson's diseases. Higher levels were associated with higher levels of other biomarkers known to be linked to neurodegeneration.
Dr. Joseph Arboleda-Velásquez will investigate genetic links to Alzheimer's resistance using a rare genetic variation that provided protection in a Colombian woman. The goal is to discover related drug and gene therapies for the devastating disease.
Scientists accelerated vision restoration by visualizing photoreceptors' response to light in the living eye. Researchers modified OCT technology to detect minute changes, enabling high-resolution visualization of cone photoreceptors and potential therapies like stem cells or gene therapy.
Campylobacter cases increased by 18.5% in Denmark, mainly attributed to outbreaks related to chicken meat. The study highlights the need for better controls on campylobacter in food production chains and emphasizes the importance of reliable data for effective prevention measures.
Despite severe health problems, 93% of flat-faced dog owners want to own their breed again in the future. Positive behavioral attributes and suitability for a sedentary lifestyle are common reasons for reacquisition or recommendation. However, owners acknowledge significant health risks, including respiratory disease and heat stroke.
A new study found that ideal cardiovascular health is associated with lower odds for developing ocular diseases, particularly diabetic retinopathy. Practicing healthy lifestyles such as regular physical activity, healthy diet, and maintaining normal weight may also contribute to good eye health.
Researchers developed AI-powered software to assess geographic atrophy, a common cause of blindness in industrialized nations. The study found that integrity of light-sensitive cells outside main lesions predicts disease progression.
Researchers found that human-based milk fortifiers have better health outcomes for underweight, premature babies, reducing the risk of necrotizing enterocolitis and retinopathy of prematurity. This study suggests that entirely human milk diets can meet nutritional needs without negative health effects.
Researchers found that blocking IL-17A increases the presence of other inflammatory molecules produced by Th17 cells, immune cells involved in neuroinflammation. The study suggests a combination approach involving both IL-17A and IL-24 may be more effective in treating autoimmune disorders of the nervous system.
Researchers successfully deliver gene therapy using nanoparticles to inhibit abnormal blood vessel growth in rats and mice eyes, providing evidence for treating wet age-related macular degeneration and inherited retinal diseases.
Researchers found molecular changes in pre-symptomatic tissue of Fuchs' endothelial corneal dystrophy (FECD) patients, which may lead to new screening and treatment methods. The study suggests that disease-causing changes occur decades before noticeable symptoms appear.
Researchers at Thomas Jefferson University discovered that after eye injury, immune cells travel along ciliary zonules to the lens, surveilling and protecting it from adverse impacts. This finding adds to evidence overturning accepted dogma in the field, suggesting an alternative mechanism for immune cell delivery.
Researchers at Hong Kong University of Science and Technology developed an adaptive optics two-photon excitation fluorescence microscopy system for high-resolution in vivo fluorescence imaging of mouse retina. This breakthrough enables detailed study of retinal structures and dynamics, shedding new light on neurodegenerative diseases.
A new clinical trial will assess the effectiveness of adalimumab in preventing recurrence of uveitis and improving quality of life. The study aims to identify which patients with uveitis benefit most from this medication, both in terms of vision and treatment side effects.
Scientists at RCSI University of Medicine and Health Sciences have discovered a potential new treatment for Sjögren's Syndrome, a disease that causes severe dry eyes and mouth. By reducing the levels of microRNA-744, they were able to reduce inflammation and damage to the eye.
A new study found that very low doses of Avastin are effective in preventing blindness in preterm infants. The treatment was tested on 59 preterm infants with type 1 ROP and showed success in improving vision with minimal side effects.
Researchers discovered a key mechanism behind eye vessel leakiness in diseases like age-related macular degeneration and diabetic retinopathy. By targeting this specific step, they hope to develop new treatments that can selectively block leak-inducing effects without harming nerve and blood-vessel cells.
Research found that the physical characteristics of charismatic invasive species, such as body size and coloration, contribute to their appeal and can lead to increased human interaction and difficulty in management. Conversely, other species that are considered problematic may be viewed less favorably due to cultural perceptions.
Researchers discovered a potential new method to detect age-related macular degeneration using tetracycline staining and fluorescence lifetime imaging microscopy. Tiny deposits of lipids, proteins, and minerals under the retina can be visualized with this technique, offering enhanced early detection.
A multi-disciplinary team has identified a protein called SARM1 as a potential therapeutic target for treating retinal degeneration. This discovery may provide a new approach to slowing the progression of blinding diseases such as AMD and retinitis pigmentosa.
A recent analysis found that adherence to the Mediterranean diet correlates with higher cognitive function and slower cognitive decline. High fish and vegetable consumption had the greatest protective effect on cognition.
Researchers at Hokkaido University discovered a lipid gradient in tears that helps form and maintain the tear film's inner liquid layer and outer lipid layer. This finding could lead to new treatments for dry eye disease by targeting the lipid layer.
A retrospective observational study of ophthalmologists' experiences with familial amyloid polyneuropathies (FAP) reveals the challenges of treating this rare disease, particularly in maintaining eyesight despite liver transplants. The study aims to share knowledge and best practices with other researchers and doctors worldwide.
A new FDA-approved medication has been shown to effectively treat thyroid eye disease in patients of all ages and genders, regardless of their smoking status. According to a study, teprotumumab reduces inflammation and tissue buildup behind the eye, leading to improved symptoms and quality of life.
Scientists from Osaka University created a new cellular model of the human eye using hiPSCs, enabling them to isolate specific cells involved in eye development and study related diseases. The novel model uses PITX2, a key protein during eye development, to track cell expression and differentiate between eye cells.
A study published in Neurology found that 82% of people with Parkinson's reported one or more eye problems, compared to 48% without the disease. Eye problems often interfered with daily life for 68% of those with Parkinson's, affecting activities like driving and reading.
A study by University of Helsinki researchers identified a gene variant in the regulatory region of the retina responsible for canine blindness in Miniature Schnauzers. The finding provides valuable insights into retinal biology and offers a new model for understanding related diseases, such as retinitis pigmentosa.
OCU400, a novel gene therapy product candidate, demonstrates efficacy in rescuing photoreceptors from degeneration by resetting retinal homeostasis. The treatment has the potential to be broadly effective across genetically diverse IRDs, offering hope for millions of people worldwide affected by inherited retinal degenerations.
Neuroscientists at the University of South Florida have developed a method to regulate eye pressure, which is sufficient to cause and explain glaucoma. The new technique enables direct knowledge and control of eye pressure, removing experimental variability and enabling systematic studies.
A new minimally invasive treatment has shown significant improvement in symptoms and quality of life for patients with thyroid eye disease. The drug, teprotumumab, blocks inflammatory autoimmune pathophysiology and has the potential to alter the course of the disease.
A new protein called factor H-related protein 4 (FHR-4) has been linked to age-related macular degeneration. Higher levels of FHR-4 in the blood may indicate increased risk of developing the disease, which affects over 1.5 million people in the UK.
A team at Massachusetts Eye and Ear has identified GPR108, a G protein-coupled receptor, as a molecular 'lock' necessary for most adeno-associated virus (AAV) vectors to gain access to cells. This discovery may enable scientists to better explain, predict, and ultimately direct AAV gene transfers to specific tissues.
A special issue of Restorative Neurology and Neuroscience reports remarkable progress in treating conditions of partial blindness. Research explores various aspects of vision loss due to diseases like glaucoma or optic neuropathy, with a focus on stop-cell death and induce regeneration to restore vision.
In mouse studies, a 'methylation clock' on the ELOVL2 gene ticked toward impaired vision with decreased gene expression, but boosting expression rescued age-related decline in visual function. The study highlights ELOVL2's regulatory role in producing essential fatty acids for healthy retinal function.
A recent study by the University of Gothenburg found that many 70-year-olds in Sweden overestimate their eyesight, but can still see considerably better with glasses or power correction. The study also highlights the importance of regular eye exams to detect visual impairment and age-related diseases.
Researchers at UNH have reported the first structural model of PDE6 enzyme and its activating protein, offering clues for new therapeutic interventions to manage retinal diseases. The study's findings could lead to improved treatments for genetically inherited eye diseases like retinitis pigmentosa and night blindness.
Researchers at the University of Illinois Chicago will conduct 3,000 eye exams among Latinos living in Chicago and Miami to study common eye conditions like glaucoma and macular degeneration. The goal is to identify patterns or causes of disease that can be prevented or slowed with treatment.
A new study estimates heritability and maps relationships among thousands of diseases using electronic health record data. Disease prevalence curves show early onset vs late onset patterns, revealing genetic links between diseases. The team identifies new patterns, including parasitic infections aligning with noninfectious diseases.
A recent study published in the European Heart Journal has identified a potential mechanism linking long-term exposure to environmental noise and cardiovascular disease. The research found that high noise levels lead to activation of the amygdala, a deep brain structure, triggering changes that increase the risk of heart attack, stroke...
Researchers suggest a thermally induced fluid mixing approach could improve the delivery of anti-vascular endothelial growth factor agents to target tissue. This technique may reduce the amount of drug injected into the vitreous and increase effective treatment outcomes for patients with macular degeneration.
A new screening approach for retinopathy of prematurity (ROP) has been developed, adding slow weight gain to existing criteria. The method was tested in a large prospective study and found to correctly predict ROP cases while reducing unnecessary examinations by nearly a third.