Articles tagged with Eye Diseases
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
Researchers at the National Eye Institute have discovered a novel genetic eye disease, a type of macular dystrophy that affects central vision. The disease is linked to mutations in the TIMP3 gene, which regulates retinal blood flow and is secreted from the retinal pigment epithelium.
Researchers used stem-cell models to uncover hidden genetic markers of glaucoma, a leading cause of permanent blindness. The study identified 312 genetic variants associated with retinal cells and 97 genetic clusters linked to damage caused by glaucoma.
The 24th International Conference on Oxidative Stress Reduction, Redox Homeostasis & Antioxidants, shed light on the latest redox field innovations and the future of redox medicine. Keynote speaker Prof. Helmut Sies discussed stringently selective modulation of enzymatic oxidant sources and sinks in redox nanomedicine.
Researchers investigated the effects of treatment with exogenous Humanin G on inflammation markers in AMD and normal retinal cells. The study found reduced levels of inflammatory proteins in AMD plasma and treated cybrids, highlighting the positive effects of Humanin G.
A groundbreaking study has discovered that the cornea produces a delicate immune response to fight viral infections without damaging vision. Long-living memory T cells have been found patrolling and fighting viral infections in the cornea, upending previous thought on T cell presence in healthy corneas.
Researchers at West Virginia University are studying the mechanisms behind Alzheimer's disease and PTSD, using animal models to investigate how stressful events affect brain cells. They aim to understand the role of estrogen and high-cholesterol diet in developing the disease.
Academic researchers will present newest discoveries on redox in aging, immunity, ocular disorders, and fertility. The conference highlights the mechanisms of redox control like Nrf2 signaling pathway.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
A new study maps the distinct differences among cells in the retina's retinal pigment epithelium (RPE), which nourishes and supports photoreceptors. The research identifies five subpopulations with varying levels of disease sensitivity, opening doors to more precise cell and gene therapies for specific degenerative eye diseases.
The new COBRE grant will help WVU recruit researchers and clinician-scientists to develop innovative solutions for preventing and treating incurable vision problems. The project aims to reduce visual disparities in West Virginia by understanding the complex combination of factors that contribute to these problems.
Scientists at Osaka University created 3D human stem cell-derived lacrimal gland organoids that mimic the human tear duct. The organoids exhibited organization and branching patterns characteristic of the human lacrimal gland, demonstrating potential as a platform for regenerative therapies for dry eye syndrome.
A recent study published in Stem Cell Reports found that sleep deprivation negatively affects corneal stem cells, leading to increased rates of cell multiplication and reduced tear film antioxidants. This can result in serious effects on corneal health, such as thinning and ruffling of the cornea.
Researchers have developed a non-invasive imaging method to examine conjunctival goblet cells (CGCs) in live rabbit eyes, which are similar to human eyes. The study found that CGC density decreased with dry eye disease (DED) and recovered over time.
A new study by USC researchers uses focused ultrasound technology to stimulate the retina of blind rats, demonstrating the potential for a non-surgical solution to restore sight. The technology generates sound waves that activate neurons and send signals to the brain, bypassing traditional light-based stimulation.
A study published in Ophthalmology identified the genetic spectrum behind foveal hypoplasia, a rare condition affecting vision development. The research combined data from over 900 cases across the globe and revealed relationships between genetic defects and the degree of arrested foveal development.
Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
A new collaboration between UW Oshkosh and Fauna Bio aims to translate animal disease resistance into human treatments. The partnership will enable researchers to study emerging animal models, such as the 13-lined ground squirrel, to develop novel therapeutic programs.
A new University of Houston study finds racial and ethnic disparities in diabetic eye care, with Whites more likely to receive regular exams than minorities. The study also reveals that Hispanics have the highest prevalence of diabetic eye complications.
Researchers detect Sars-CoV-2 mRNA in human retina organoids, indicating infection of retinal cells. The virus also replicates in these cell types, with implications for 'Long Covid' pathologies.
Researchers developed a new OCT method called Spatio-Temporal Optical Coherence Tomography (STOC-T) to improve the accuracy of eye disease diagnoses. This method uses multimode optical fibers to reduce noise, enabling clearer images of the choroid and other vital parts of the eye.
Researchers have developed a gene therapy that restores night vision in dogs with congenital stationary night blindness (CSNB), a condition affecting the ON bipolar cells. The treatment enables dogs to navigate mazes in dim light and has a lasting therapeutic effect, paving the way for potential human treatments.
A study found that telemedicine and community screening for diabetic retinopathy are highly cost-effective in rural and urban China. The results suggest that adopting telemedicine screening programs at the national primary care level is economically reasonable.
Researchers at UC Berkeley discover that Antabuse helps improve sight in mice with retinal degeneration by reducing hyperactive retinal cells. The treatment may one day lead to better therapies for humans with inherited diseases like retinitis pigmentosa.
Researchers discovered that fusing Müller glia with adult stem cells can differentiate into ganglion cells, a type of neuron essential for vision. This finding brings hope for recovering the retina's regenerative capacity in humans.
AAVMC awards Dr. Barry T. Rouse with the Excellence in Research Award for his outstanding contributions to viral immunology and immunopathology research. With over $20 million in NIH funding, he has published more than 425 papers and mentored almost 80 post-doctoral fellows.
A new peer-reviewed study confirms MiSight 1 day contact lenses slow eye growth and halt myopia progression in 90% of children, with no loss of effectiveness over time. The longest-running soft contact lens study among children demonstrates sustained efficacy for nearly all children, regardless of age or initial refractive error.
A recent study published in JAMA Ophthalmology found that depression is associated with more severe dry eye disease symptoms and overall signs. The analysis of data from a randomized clinical trial revealed this significant connection among 535 participants.
A study led by Kyoto University researchers found that modulating hormone levels can improve meibomian gland disorder, a common cause of dry eyes. Topical administration of nicotinamide mononucleotide (NMN) boosted NAD levels and rebooted 3-HSD activity in mutant mice, alleviating dryness.
Researchers developed smart contact lenses that emit far-red light to treat diabetic retinopathy. The study showed the lenses prevented retinopathy in diabetic animal models, demonstrating their safety and effectiveness.
Researchers found that mitochondria act as microlenses to focus light on outer segments where it's converted into nerve signals, shedding new light on the retina's optical properties. This discovery has potential clinical implications for detecting retinal diseases.
A new study published in The Lancet Planetary Health found that improved eye health services are associated with moving closer to achieving seven SDGs. Multiple direct connections were discovered between eye health services and increased productivity, household expenditure, income, education, and equality.
Researchers from Trinity College Dublin have pinpointed a key driver gene, SARM1, that contributes to impaired vision and blindness. Deleting this gene shows promise in preserving vision, suggesting targeted therapies may offer long-lasting preservation of sight for various ocular conditions.
Researchers developed a method to diagnose atherosclerosis using self-learning software and eye photos. The algorithm accurately identified vascular changes in patients with peripheral arterial disease, even in early stages without symptoms.
A new study will focus on the biological mechanisms causing cataracts, potentially leading to new treatments. The research team, led by Nicholas Delamere, PhD, will investigate the role of protein ion channels TRPV1 and TRPV4 in age-related lens cell changes.
A comprehensive study investigates the metabolism of four drugs in rabbit eyes, revealing different enzyme profiles from liver metabolism. The findings provide valuable information for advancing ophthalmic drug development.
Researchers at UCI discovered that AdipoR1 protein deficiency leads to ceramide accumulation in the retina, causing progressive photoreceptor cell death. A pharmacological treatment combining desipramine and L-cycloserine reduced ceramide levels, protecting photoreceptors and improving vision.
A new AI-based method has been developed to evaluate patients with Stargardt disease, a leading cause of childhood blindness. The study found that the severity of vision loss can be classified into different phenotypes based on genetic variants, and provided sensitive structural outcome measures for therapeutic trials.
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers found that a third of patients with wet age-related macular degeneration can safely stop eye injection therapy without further vision loss. Patients who stopped treatment showed better visual acuity, gain of vision, and less fluid in their retina compared to those requiring continued injections.
A study published in Nutrients found that consuming a small serving of dried goji berries five times a week for 90 days increased lutein and zeaxanthin levels in healthy participants' eyes. This increase provides antioxidant protection and filters out harmful blue light, potentially delaying age-related vision loss.
Researchers led by Prof. Maciej Wojtkowski create two-photon excited fluorescence scanning laser ophthalmoscope (TPEF-SLO) to observe molecules supporting visual pigments in retinal cells in real-time. The device allows for non-invasive assessment of metabolic processes and biochemical markers, leading to new insights into eye diseases.
Researchers at WVU are studying the Musashi proteins to understand their role in retinal degeneration and develop a universal therapy. By investigating protein translation and gene suppression, they hope to identify potential pathways to boost protein production and slow vision loss.
Researchers developed a color-coded test that quickly signals whether medical nanoparticles deliver their cargo into target cells. The tool, tested in mouse cells and living mice, assesses nanoparticle formulations on their ability to escape cellular defenses and reach the cell's interior.
Patients with eye conditions from racial minority groups report feeling less respected by healthcare professionals compared to their non-Hispanic white counterparts. The study highlights the importance of addressing cultural disparities in healthcare settings.
Researchers are exploring how an engineered adeno-associated virus (AAV) can compensate for missing protein or swap out genetic mutations that cause vision problems. AAV has been found to be beneficial and is being used as a tool to deliver genes that work as they should.
The Nixon Visions Foundation has given a significant gift to support studies of the PRPH2 gene linked to macular dystrophy and boost stem cell research aimed at developing early diagnosis and a cure for this devastating genetic eye disease. Researchers hope to make a tremendous impact on people with this inherited eye disease.
Researchers developed a dish-based model that replicates the characteristics of dry age-related macular degeneration, allowing them to screen over 1,200 drugs for their ability to slow or halt disease progression. Two drugs, Aminocaproic acid and L745, showed promise in inhibiting key phenotypes associated with AMD.
A study led by LSU Health found how late-onset retinal degeneration develops and identified a surprising potential therapeutic, metformin. The research suggests that an enzyme called AMPK activates the protein CTRP5 to regulate fatty acid metabolism and energy stability.
A NIH study has identified a molecular link between a gene mutation and late-onset retinal degeneration, a rare eye disease. The researchers found that the diabetes drug metformin and gene therapy may be effective treatments for the condition, which can cause abnormal blood vessel growth and deposits of apolipoprotein E.
Researchers found immune cells in lens trying to fix damage and responding to long-lasting inflammation. Immune cells integrate into lens capsule, increasing invasion with disease progression, contradicting decades of scientific understanding.
Researchers found that subjects who underwent cataract surgery had a nearly 30% lower risk of developing dementia compared to those who did not. The results persisted for at least a decade after surgery and were associated with lower risk of Alzheimer disease dementia specifically.
Researchers created a disease map of genes involved in eye disorders, shedding light on how individual cells respond to external factors like injury. The study paves the way for regenerative medicine and cell replacement therapies for eye diseases.
The HyVIS project is a four-year European initiative that will develop bionic synapses for retinal prostheses, exploiting residual neuronal functionality to restore sensitivity to light. The approach involves plasmonic nanocannals and intelligent polymers to release neurotransmitters in response to light stimuli.
Duke researchers developed a method to increase the depth of view of optical coherence tomography (OCT), allowing for clear images from beyond a millimeter beneath the skin's surface. The new technique, known as dual-axis OCT, tilts the light source and detector to collect more scattered light from deep tissues.
Researchers genetically mapped the cell types of the mouse iris, revealing four new cell types and mapping genetic changes that occur when the iris dilates. This research may help connect genetic similarities between mice and humans, offering clues for developing new diagnostic tests and treatments for eye diseases.
Researchers found that three minutes of morning exposure to 670nm deep red light improved color contrast vision by 17% and the effects lasted for at least a week. The study built on previous findings that daily longwave deep red light exposure boosts energy-producing mitochondria cells in the retina.
Researchers found that CD146 expression is linked to retinal neovascularization in laser-induced CNV models. Anti-CD146 therapy showed promise in reducing neovascularization and improving vision outcomes.
Researchers at West Virginia University have received FDA approval for a new drug to treat uveal melanoma, a rare form of eye cancer. The drug, MTI-201, targets specific biomarkers in diseased cells, allowing for more precise treatment with minimal damage to healthy cells.
Researchers have discovered that a low-dose oral compound, HBI-002, can safely reduce oxidative stress and inflammation in the retina, common causes of diabetic retinopathy. The study suggests that small amounts of carbon monoxide may help protect vision in diabetes patients.