Articles tagged with Ovarian Cancer
A study by Queen Mary University researchers investigated how women at high risk of ovarian cancer make choices about possible preventive surgery. Women who have BRCA1 and BRCA2 genetic mutations have a higher lifetime risk of ovarian cancer, and may choose to undergo surgery to reduce their risk.
A new study from the University of Minnesota Medical School found that Pap test samples can detect proteins also present in ovarian cancer tumor tissues. This discovery suggests potential biomarker candidates for early detection of ovarian cancer, which currently has no early warning system.
The European Union has funded a project to develop diagnostic tools and combination treatments for ovarian cancer using AI. The research aims to identify patients whose cancer is not responding to current treatments and discover effective, personalized therapies.
Researchers found that antibodies produced by B cells predominantly have the IgA subtype, which inhibits RAS signaling, sensitizing tumor cells to T cell-mediated killing. This study provides insights into how immune components regulate ovarian cancer progression and offers new approaches for targeted immunotherapies.
This study elucidates the molecular mechanism of 2-methoxyestradiol (2MeOE2) inducing apoptosis in ovarian tumors through PKCδ signaling. The findings suggest that 2MeOE2 activates PKCδ, leading to γH2Ax expression and apoptotic histone modifications, thereby driving apoptosis in ovarian cancer cells.
Researchers discovered that ovarian cancer cells undergo structural changes in their mitochondria to survive and proliferate in the peritoneal cavity. This adaptation enables aggressive cancerous cells to grow and spread, making it harder to detect and treat. Understanding these cellular adaptations could lead to new targeted therapies.
Mutations in the ARID1A gene increase glutamine metabolism in ovarian cancer cells, which can be blocked to target ARID1A-mutant tumors. Glutaminase inhibitors like CB-839 show promise as a standalone or combination therapy for clear cell ovarian carcinoma.
A new advanced computing technique enables doctors to take fewer, more accurate tumour biopsies by combining computed tomography (CT) scans with ultrasound images. This method captures the patchwork of different cancer cell types within a tumour, critical for selecting the best treatment.
A comprehensive study of over 250,000 women found oral contraceptives significantly reduce the risk of ovarian and endometrial cancer, with benefits persisting even years after use ends. The findings contradict previous associations with increased breast cancer risk.
Researchers at Tel Aviv University developed a CRISPR-Cas9 system that specifically targets cancer cells, destroying them by genetic manipulation. The system improved the average life expectancy of mice with glioblastoma tumors by 30% and increased overall survival rate in metastatic ovarian cancer mice model by 80%.
A new study published in JNCI: Journal of the National Cancer Institute indicates that receiving assisted reproductive technology does not increase the risk women have for developing ovarian cancer. While fertility treatments may slightly increase borderline ovarian tumor risk, this association appears to be due to underlying patient c...
Population-wide screening of 30-year-old women resulted in 75 fewer cancer cases per 100,000 women, with a gain of 288 quality-adjusted-life-years compared to 97 for women aged 45.
Scientists have created a 3D tumour model for ovarian cancer, which can mimic the way tumour cells grow and respond to chemotherapy drugs. The new model has the potential to improve understanding and treatment of the disease.
This observational study examines survival rates and chemotherapy use before surgery in US women with advanced ovarian cancer between 2004-2016. The study found improvements in treatment and survival rates over time, with more patients receiving chemotherapy before surgery.
Researchers from CU published a paper on ovarian cancer tumor composition changes during chemotherapy, revealing potential biomarkers for therapeutic response. The team aims to improve prediction of patient response to chemotherapy using multi-spectral immunohistochemistry and transcriptomics.
Researchers at the University of Turku developed a rapid point-of-care diagnostic test to detect ovarian cancer from blood samples in 30 minutes. The new test shows improved sensitivity and accuracy compared to conventional CA125 diagnostics.
Scientists at Cornell University's veterinary college have identified the genetic drivers of ovarian cancer, a deadly disease that kills more women than any other cancer. The study reveals that ovarian surface stem cells are more susceptible to mutations, while certain genes can inhibit cancer initiation.
Researchers found GATA3 and APOBEC3B overexpressed in adrenocortical carcinoma, regulating cell proliferation and DNA damage. Their expression levels are linked to patient survival, providing novel insights into ACC prognosis.
Researchers found a slight increase in risk of ovarian cancer and some types of breast cancer among women who used permanent hair dyes. Natural hair color was also associated with an increased risk of certain cancers, while the use of darker hair dye colors may be linked to higher concentrations of ingredients.
Researchers have identified a metabolic vulnerability in cells that may represent a therapeutic target for treating small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). A new treatment agent has been shown to starve cancer cells by eliminating arginine, an amino acid necessary for protein production.
A new two-stage surgical protocol delays the induced menopause caused by ovary removal, providing some ovarian cancer risk reduction while avoiding detrimental consequences. The study found that 69% of premenopausal women at high risk of ovarian cancer were interested in this alternative option.
Researchers developed a tumour gene test that accurately predicts ovarian cancer survival, outperforming age and cancer stage. The test identifies high-risk patients for personalized treatment options.
A CUNY ISPH study reveals that ovarian cancer grows and evolves continuously, with mixtures of subclones accumulating mutations. The findings challenge previous simplistic models of discrete subtypes, offering a clearer picture of tumor heterogeneity.
Researchers discovered a way to target cancer cells by blocking functions of Flap Endonuclease 1 (FEN1), which is involved in DNA replication and repair. The approach preferentially killed BRCA1 and BRCA2 mutant cancer cell lines, with normal cells recovering from FEN1 inhibition.
L-Grb2 antisense oligodeoxynucleotide (L-Grb2) has promising antitumor activity in preclinical models of ovarian and uterine carcinoma, reducing angiogenesis and increasing apoptosis. L-Grb2's therapeutic efficacy suggests a potential new target for cancer treatment.
A global study led by Queen Mary University of London found that screening entire populations for breast and ovarian cancer genes can prevent millions more cases than current clinical practice. The research shows that cost-effective genetic testing can be implemented in high and upper-middle income countries to save lives.
A study by TGen has identified a drug, SP-2577, which can enable the immune system to attack ovarian cancer. The drug, also known as Seclidemstat, was developed to inhibit LSD1, a protein that is abundant in SCCOHT ovarian cancer.
Researchers utilized a computational method to analyze the CDR3 regions of T-cell receptors from high-grade serous ovarian cancers. The study found that patients with low T-cell infiltration but diverse or focused repertoires had clinical outcomes similar to highly-infiltrated tumors. The authors identified the degree of divergence bet...
Researchers developed a new test, PrOTYPE, to classify high-grade serous ovarian cancer into four molecular subtypes. This test allows clinicians to tailor treatments to individual patients' tumours with over 95% accuracy.
A study published in Oncotarget reports that adoptive cell therapy in combination with checkpoint inhibitors improves T cell fold expansion and increases CD8 T cell tumor reactivity in patients with late-stage metastatic ovarian cancer. The authors suggest that combination immunotherapy may be a way forward for this purpose.
Researchers found that ovarian cancer patients with a modified BRCA1 gene do not respond better to platinum chemotherapy or have a better prognosis than those with the normal functioning gene. However, they did live longer on these treatments compared to those without any gene modifications.
A new clinical trial has validated a remote genetic counseling approach, enabling women to assess their cancer risk from the comfort of their own homes. The study showed that skipping personalized counseling did not increase patients' distress and may lead to increased access for genetic testing.
A phase III clinical trial found that the addition of cediranib to olaparib and standard platinum-based chemotherapy did not improve progression-free survival outcomes, but showed similar activity in patients. The study suggests potential for non-platinum based alternatives in certain biomarker subgroups.
A study by the Hubrecht Institute found that oviduct cells are more prone to develop into tumors than ovarian surface epithelium cells. This suggests a possible shift in treatment approach, with earlier removal of fallopian tubes considered as a preventive measure for high-risk patients.
A new study found that personalized ovarian cancer risk prediction reduces cancer worry and anxiety in women. Participants who received the personalized risk estimate were more likely to take preventative action and reduce their risk of developing ovarian cancer.
Researchers have confirmed biological hallmarks of survival in tumor cells and identified two processes linked to high-grade serous carcinoma. Proteomics analysis reveals details about protein communication and function in cancerous cells, providing insights into the 'broken' machinery behind ovarian cancer.
A study published in PLOS ONE found that endosalpingiosis (ES) and other gynecological lesions occur at a higher rate than previously thought, even among women without cancer. The researchers suggest that ES is not directly linked to cancer development, contrary to initial suspicions.
Researchers at MD Anderson Cancer Center and Ipsen Biopharmaceuticals have developed a novel drug, IPN60090, a glutaminase inhibitor for lung and ovarian cancers. The Phase I clinical trial shows promising results, particularly for patients with KEAP1/NRF2 mutations or low ASNS levels.
Researchers have discovered a new approach to overcome chemotherapy resistance in clear cell ovarian cancer by using low doses of 2-deoxy-D-glucose. The treatment has shown significant improvement in laboratory models and is expected to be safer for patients with reduced side effects.
Researchers have discovered that cancer cells use fats as an energy source when detached from their point of origin, and that limiting access to a specific enzyme may starve them of this resource. The study suggests that an existing drug could be repurposed to treat chemo-resistant ovarian cancer.
Researchers at Dana-Farber Cancer Institute have identified two factors that predict which ovarian cancer patients will not benefit from a combination of immune checkpoint and PARP inhibitors. Patients with specific gene mutations or vigorous immune responses to the cancer are more likely to respond to the therapy.
A genetic study found that long-term statin use may be associated with a 40% reduction in ovarian cancer risk in the general population and those with BRCA1/2 gene faults. The research used Mendelian randomization to analyze thousands of people's genetic data.
Researchers developed a simple blood test that measures the body's immune response to improve ovarian cancer diagnosis. The test uses an immune marker for inflammation and cancer markers to detect epithelial ovarian cancer in blood, with results validated across two separate human trial cohorts.
Researchers at MUSC and UCSD found that autophagy genes work against tumors in certain types of ovarian cancer. The study validated the role of BECN1 and LC3B as tumor suppressors, shedding light on their potential as targets for treatment.
Researchers at the University of Oxford have identified six previously unknown cell types in human Fallopian tubes using single-cell RNA sequencing, which may lead to a screening tool for ovarian cancer. The discovery sheds new light on the complexity of ovarian cancers and could lead to personalized treatments.
A Phase 2 clinical trial demonstrated improved localization and complete removal of small and peripheral lesions in 12% of patients. The treatment, OTL38, targets adenocarcinomas of the lung and has received fast-track designation for both lung and ovarian cancer indications.
Scientists discovered that over 20% of mutations occur in early stages of tumor development, with some changes taking place years or even decades before cancer is diagnosed. These early genetic alterations can be identified using a new method developed by researchers at the Francis Crick Institute.
A new MRI tool has been developed and shown to be 90% accurate in distinguishing between malignant and benign ovarian cysts. This could lead to earlier treatment and improved outcomes for women with ovarian cancer, reducing the need for invasive surgery.
A study found that APLN overexpression correlates with worsened prognosis in ovarian cancer patients treated with bevacizumab. The researchers also identified a distinct gene signature associated with resistance development, paving the way for new treatment strategies.
Researchers pooled data from four large studies involving 250,000 women to investigate the association between powder use and ovarian cancer risk. The study found a statistically significant increase in ovarian cancer risk among women who used powder in their genital area.
Researchers have identified a new therapeutic strategy to combat chemotherapy resistance in ovarian cancer by targeting the NAD+ metabolic pathway. Combining cisplatin treatment with pharmacological inhibition of NAMPT suppresses the outgrowth of resistant cancer cells and prolongs survival in a preclinical model.
Researchers at the University of Texas MD Anderson Cancer Center found that secondary tumor-reduction surgery followed by chemotherapy did not result in longer survival than chemotherapy alone. The study involved 240 patients with platinum-sensitive recurrent ovarian cancer and showed that complete tumor resection was associated with i...
Nami Therapeutics develops nanoparticles for targeted drug delivery, offering increased efficacy and reduced toxicity. The platform selectively targets ovarian cancer metastasis in the peritoneal cavity, improving survival rates.
A new study found that a blood test for CA125 levels can detect ovarian cancer in women with suspicious symptoms, with 10% of those with high levels diagnosed with the disease. The test also revealed higher risks of other cancers, such as pancreatic and lung cancer, among older women
A laboratory study found that fibrosis, a natural stiffening of the ovaries, occurs with age and may be linked to ovarian cancer. Metformin, a diabetes drug, was shown to halt this process in some cases.
A new treatment using niraparib after conventional chemotherapy improves progression-free survival and reduces risk of relapse or death in patients with advanced ovarian cancer. The study, led by Dr. Antonio González Martín, found a significant reduction in risk of relapse, especially in patients with homologous recombination deficiency.
A new trial shows that adding a PARP inhibitor to bevacizumab improves ovarian cancer patients' chances of responding to chemotherapy. The study found median progression-free survival of 22.1 months in the olaparib arm, compared to 16.6 months in the placebo group.
A Phase III trial validates the benefit of veliparib for patients with newly diagnosed, metastatic high-grade serous ovarian cancer. The combination therapy achieved a PFS of 23.5 months, compared to 17.3 months for the control arm.
Cancer survival in the UK has improved since 1995, with significant increases in one-year and five-year survival rates for various cancers. Despite this progress, the UK still lags behind other high-income countries in cancer survival.
Survival rates for seven cancers have improved in Australia, Canada, and Norway compared to New Zealand, Denmark, Ireland, and the UK. The largest gains were seen in patients under 75 years old with poor prognosis cancers. Improvements in cancer control suggest progress has been made in these countries.