A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
SourceBroad Institute of MIT and Harvard·JournalCell·TypeComputational simulation/modeling·DateAug 5, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers analyzed 430 lung squamous tumors and identified mutations in genes such as TP53, CDKN2A, and FGFR1. The study found that 13.5% of patients with druggable mutations had lower median overall survival.
SourceImpact Journals LLC·JournalOncotarget·DateJun 2, 2021
Research identifies novel E6 inhibitors with potential for targeted therapy in HPV-positive head and neck squamous cell carcinomas. The study reveals the key role of E6 in tumor formation and growth, highlighting its importance as a strategic approach for HPV-positive HNSCC treatment.
SourceImpact Journals LLC·JournalOncotarget·DateJun 2, 2021
A study characterized genomic and neoantigen evolution between primary and first recurrence tumors in 23 HNSCC patients, identifying shared genes with predicted neoantigens. Patients with these shared neoantigens tend to have increased duration of survival with disease.
SourceImpact Journals LLC·JournalOncotarget·DateMar 17, 2021
Researchers are using AI to improve treatment outcomes for patients with oral squamous cell carcinomas by predicting which patients need chemotherapy, radiation, or surgery. The project aims to develop a more precise and personalized approach to cancer care.
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A new method uses conductive polymer spray ionization mass spectrometry and machine learning to detect changes in metabolites in saliva samples from 373 volunteers. The diagnostic accuracy of the method is reported at 86.7%, suggesting a potential point-of-care test for oral squamous cell carcinoma.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateJun 29, 2020
Researchers characterized bacteriome, mycobiome, and mycobiome-bacteriome interactions of oral wash in Head and neck squamous cell carcinoma patients, finding distinct differences compared to healthy controls. Unique interactions between fungal and bacterial communities may serve as potential screening tool for HNSCC.
SourceImpact Journals LLC·JournalOncotarget·DateJun 23, 2020
A research team led by University of Würzburg scientists has found a way to inactivate the cancer protein NP63, which is crucial for squamous cell carcinoma growth. By using a preclinical inhibitor, they were able to switch off NP63's parking ticket remover and stop tumor cells from growing.
SourceUniversity of Würzburg·JournalEMBO Molecular Medicine·DateMar 10, 2020
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that Clostridium perfringens enterotoxin induces CLDN4 nuclear translocation, enhancing epithelial-mesenchymal transition, stemness, and invasive ability in oral squamous cell carcinoma cells. The complex of YAP1, CLDN4, and zona occludens-2 was formed by CPE treatment, suppressing YAP1 phosphorylation and activating it.
SourceImpact Journals LLC·JournalOncotarget·DateFeb 4, 2020
Researchers found a new long non-coding RNA, PRECSIT, that regulates the growth and invasion of squamous cell carcinoma in skin. PRECSIT's expression is linked to the tumor suppressor gene p53, promoting cancer progression via STAT3 signaling.
SourceUniversity of Turku·JournalAmerican Journal Of Pathology·DateFeb 4, 2020
Researchers analyzed the virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis, finding correlations between specific viruses and clinical outcomes. The study suggests that certain viral signatures may impact tumor biology and behavior, offering potential avenues for future research and treatment.
SourceImpact Journals LLC·JournalOncotarget·DateJan 27, 2020
The GW Cancer Center is conducting a phase II clinical trial examining the safety and effectiveness of Libtayo in reducing tumor size and preventing recurrence in high-risk cutaneous squamous cell carcinoma. The study aims to enroll over 75 participants and build on preliminary results from similar trials.
A large Norwegian study of nearly 160,000 women found a significant association between cumulative exposure to indoor tanning and the development of squamous cell carcinoma. The findings suggest that even short-term indoor tanning can increase cancer risk, emphasizing the importance of sun protection measures.
SourceJAMA Network·JournalJAMA Dermatology·DateOct 2, 2019
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
The GW Cancer Center is conducting a randomized, placebo-controlled phase III trial to investigate cemiplimab's safety and effectiveness in preventing recurrence and metastasis in high-risk cutaneous squamous cell carcinoma. The study aims to enroll over 400 participants worldwide.
A new study reports that cervical adenocarcinoma incidence rates are increasing in non-Hispanic whites, particularly among women aged 40-49 and 50-59. This trend underscores the need for intensified efforts to improve screening utilization and HPV vaccination.
SourceAmerican Cancer Society·JournalPreventive Medicine·DateApr 17, 2019
A combination of topical creams reduces precancerous skin lesions and lowers the risk of developing squamous cell carcinoma. The therapy combines 5-fluorouracil with calcipotriol, activating the immune system's T cells to attack tumor cells.
American University researchers identify Tpl2 gene's role in squamous cell carcinoma, revealing potential therapeutic target for advanced cancers. The study shows that blocking the MET receptor reduces tumors by 60%, offering new hope for treatments.
SourceAmerican University·JournalOncogenesis·DateJan 13, 2019
Patients with metastatic non-small cell lung cancer (NSCLC) treated at academic centers had higher 2-year survival rates than those treated at community-based centers. The study found significant differences in survival outcomes based on facility type, histology, and molecular profile.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateOct 10, 2018
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A study published in Cell Reports has identified Np63a as a driver of squamous cell carcinoma growth and found that activating tumor suppressor genes TGFB2 and RHOA can halt this process. This discovery provides a promising pathway for developing new cancer treatments.
SourceUniversity of Colorado Anschutz Medical Campus·JournalCell Reports·DateSep 18, 2018
Researchers identified APOBEC enzymes as major contributors to the development of aggressive skin cancer in patients with Butterfly Syndrome. The discovery reveals a mechanism that instigates tissue damage-driven cancers and provides new therapeutic strategies.
SourceThomas Jefferson University·JournalScience Translational Medicine·DateAug 27, 2018
Two targeted therapies, MLN128 and CB-839, individually target the metabolism of key nutrients glucose and glutamine, respectively, to treat squamous cell carcinomas of the lung. Researchers found that when used in combination, these drugs could reduce tumor growth in aggressive lung cancer.
SourceUniversity of California - Los Angeles Health Sciences·JournalCancer Cell·DateApr 12, 2018
Researchers investigated molecular mechanisms behind squamous cell carcinoma, revealing NUP62's role in regulating ΔNp63α nuclear transport. This mechanism is crucial for maintaining SCC cells' undifferentiated status and proliferation.
SourceKanazawa University·JournalEMBO Reports·DateDec 19, 2017
A recent analysis of published studies found that higher alcohol intake increases the risk of basal cell carcinoma by 7% and cutaneous squamous cell carcinoma by 11% for every 10 gram increase per day. The study suggests that limiting alcohol consumption may help reduce skin cancer risk.
SourceWiley·JournalBritish Journal of Dermatology·DateJul 31, 2017
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers found that squamous cell carcinoma diagnoses increased by 263% and basal cell carcinomas by 145% between 2000-2010. Women in specific age groups experienced the greatest increase in basal cell carcinoma diagnoses, while men's diagnosis trends varied across time periods.
SourceMayo Clinic·JournalMayo Clinic Proceedings·DateMay 15, 2017
Researchers at UCLA have discovered that targeting cancer stem cells and killing tumor mass with chemotherapy drugs results in better outcomes for patients with head and neck squamous cell carcinoma. The study also found that cancer stem cells cause cervical lymph node metastasis.
SourceUniversity of California - Los Angeles·JournalCell Stem Cell·DateMar 9, 2017
A new study reveals a strong association between human papillomavirus (HPV) types and the risk of head and neck squamous cell carcinoma (HNSCC). Detection of HPV-16 in the oral cavity significantly increases the risk of oropharyngeal squamous cell carcinoma, highlighting the role of HPV in HNSCC.
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Research from University of Eastern Finland finds SIP1 protein expression indicates advanced tumour stage, high recurrence risk, and poor prognosis. The study identifies SIP1 as a potential new prognostic factor for clinical use.
SourceUniversity of Eastern Finland·JournalJournal of Histology and Histopathology·DateNov 14, 2014
Low preoperative serum squamous cell carcinoma antigen levels and absence of tumor invasion into the pleura or blood vessels are independent prognostic factors for patients with peripheral squamous cell carcinomas of the lung. These factors are associated with longer overall survival and reduced disease recurrence.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateOct 24, 2014
A phase III trial demonstrated that afatinib significantly improved progression-free survival compared to methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The study showed a 20% reduction in risk of progression or death, with patients experiencing less pain over time.
SourceEuropean Society for Medical Oncology·JournalAnnals of Oncology·DateSep 27, 2014
A genetic mutation caused by ultraviolet light is linked to millions of human skin cancers, according to Stanford researchers. The mutation occurs in the KNSTRN gene and can cause genomic catastrophe, leading to cutaneous squamous cell carcinomas.
SourceStanford Medicine·JournalNature Genetics·DateSep 7, 2014
Researchers have identified a link between HPV detection and improved survival rates in patients with oropharyngeal squamous cell carcinoma (OPSCC). A specific pattern of DNA modifications associated with HPV was found to be correlated with better outcomes in OPSCC patients.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateMay 1, 2013
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A Kaiser Permanente study found basal cell and squamous cell carcinomas occur more than twice as often among HIV-positive individuals compared to those who are HIV-negative. The risk for these cancers is consistent with the growing evidence about this population's increased risk for a broad range of cancers.
SourceKaiser Permanente·JournalJNCI Journal of the National Cancer Institute·DateJan 29, 2013
A new study confirms a link between indoor tanning and non-melanoma skin cancer, particularly among those exposed before age 25. The research estimates that indoor tanning accounts for hundreds of thousands of new cases each year in the US alone.
A meta-analysis and review of medical literature found a clear association between smoking and an increased risk of cutaneous squamous cell carcinoma. The study, which included data from 11 countries, showed a 52% significant increase in odds for current or ever smokers.
SourceJAMA Network·JournalArchives of Dermatology·DateJun 18, 2012
Researchers at Fred Hutchinson Cancer Center have discovered a new drug target for squamous cell carcinoma, the second most common form of skin cancer. The protein alpha-catenin acts as a tumor suppressor and regulates cell proliferation by controlling Yap1 activity in cancer cells.
SourceFred Hutchinson Cancer Center·JournalScience Signaling·DateMay 19, 2011
Sharing educational materials with kidney transplant recipients increased their likelihood of performing self-examinations and detecting skin cancers, according to a randomized controlled trial. The intervention also improved knowledge and attitudes towards skin cancer risk, leading to more follow-up appointments with dermatologists.
SourceJAMA Network·JournalArchives of Dermatology·DateFeb 21, 2011
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A new international multidisciplinary classification of lung adenocarcinoma has been published by three top lung associations. The classification takes a comprehensive approach, incorporating advances in genetics, clinical information, and molecular studies to improve diagnosis and treatment.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateFeb 1, 2011
A study published in the Journal of the National Cancer Institute found that celecoxib, a widely used arthritis drug, significantly reduces non-melanoma skin cancers. The medication achieved a 68% reduction in basal cell carcinomas and a 58% reduction in squamous cell carcinomas among high-risk patients.
SourceUniversity of Rochester Medical Center·JournalJNCI Journal of the National Cancer Institute·DateDec 2, 2010
A study has identified the BRF2 oncogene as specifically associated with lung squamous cell carcinoma, potentially serving as an identification marker and novel therapeutic target. Genetic analysis found frequent activation of BRF2 in pre-invasive stages of the disease, suggesting its role in tumorigenesis.
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study comparing preoperative and postoperative chemoradiotherapy to surgery alone in patients with resectable esophageal squamous cell carcinoma found significant differences in overall survival and progression-free survival. Perioperative chemoradiotherapy maximizes long-term survival, but increases toxicity.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateApr 9, 2010
According to a study published in Archives of Dermatology, regular use of non-steroidal anti-inflammatory drugs (NSAIDs) is not associated with an increased risk of squamous cell skin cancer. The study found that NSAID users were not at a higher risk for squamous cell carcinoma regardless of duration or dose.
SourceJAMA Network·JournalArchives of Dermatology·DateFeb 15, 2010
A study of 312 heart transplant patients found that nearly half developed skin cancer during a 19-year follow-up period. The majority of these cancers were squamous cell carcinomas, with risk factors including age, other types of cancer, and immunosuppressive medication use.
SourceJAMA Network·JournalArchives of Dermatology·DateDec 21, 2009
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers found that E-cadherin and N-cadherin expression is correlated with invasion and aggravation of esophageal squamous cell carcinoma. The down-regulation of N-cadherin decreases invasiveness of esophageal squamous cell carcinoma cells in vitro.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateFeb 19, 2009
A study found an association between HPV antibodies and squamous cell carcinoma risk, with patients diagnosed with squamous cell carcinoma more frequently testing positive for beta type HPVs. Lifestyle habits, such as sun exposure and smoking, were not significantly linked to skin cancer development.
SourceThe Geisel School of Medicine at Dartmouth·JournalJNCI Journal of the National Cancer Institute·DateMar 14, 2006
The study found a significant increase in nonmelanoma skin cancer incidence among young adults, with rates rising by 13.4% for women and 22.9% for men between 1976-1979. Squamous cell carcinoma incidence also increased significantly over the study period, emphasizing the need to focus on prevention.
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Combination therapy of radiotherapy and cetuximab significantly improves loco-regional control, median survival, and overall survival rates in patients with loco-regionally advanced squamous cell carcinoma of the oropharynx, hypopharynx, or larynx. The treatment also showed minimal enhancement of toxicity compared to radiotherapy alone.
SourceECCO-the European CanCer Organisation·DateOct 26, 2004
Patients with massive skin cancers can now experience significant improvement in function, appearance, and quality of life after undergoing free tissue transfer surgery. This innovative technique, pioneered by OHSU researchers, has revolutionized the care of patients with this condition.
SourceOregon Health & Science University·JournalArchives of Facial Plastic Surgery·DateMar 4, 2004
A statewide study found that people who used tanning lamps were 2.5 times more likely to develop squamous cell carcinoma and 1.5 times more likely to develop basal cell carcinoma than non-users. The risk of these skin cancers increased with younger age at use.
SourceThe Geisel School of Medicine at Dartmouth·JournalJNCI Journal of the National Cancer Institute·DateFeb 5, 2002
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new study found that individuals who used tanning devices were 2.5 times more likely to develop squamous cell carcinoma and 1.5 times more likely to develop basal cell carcinoma compared to those who did not use them. The risk of these cancers increased with the age at which participants started using tanning devices.
SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateFeb 5, 2002