Articles tagged with Immune Regulation
Researchers at the Wyss Institute have created a new treatment for traumatic brain injury (TBI) that leverages macrophages to deliver localized anti-inflammatory treatment. The approach reduced lesion size by 56% and significantly decreased local inflammation levels in pigs, offering a promising new direction for TBI treatment.
Researchers discovered a novel therapeutic target BAMBI that suppresses immune cells, reducing the effectiveness of radiation therapy and inducing therapy resistance in cancer patients. BAMBI's expression is associated with improved survival rates, suggesting it as a promising approach to overcome radiation therapy resistance.
AG5, a novel non-steroidal anti-inflammatory, has been developed by a multidisciplinary team to inhibit the cytokine storm like corticosteroids but preserve innate immunity. It has shown promise in animal models of inflammation and is expected to be useful in treating chronic inflammatory diseases.
Researchers used machine learning to guide high-throughput experimental screening of small molecules, finding ones that improve vaccine response and reduce inflammation. The team discovered a molecule that outperforms the best immunomodulators on the market, with potential applications in cancer treatment.
A team of researchers developed a vaccine that stimulates regulatory T cells to suppress harmful immune cells, prolonging allograft survival in mice. This discovery identifies an analogous pathway in humans, suggesting potential treatment for autoimmune disorders and organ transplant patients.
Researchers discovered a malaria protein, PfAP2-P, that plays a key regulatory role in immune evasion and parasite development. This protein acts as an activator of proteins required for the parasite to exit infected red blood cells and invade new ones.
A study found that specific proteins in breast milk correlate with the abundance of certain gut microbes in infants, potentially playing a role in early immune and metabolic development. The research suggests a regulatory function of these proteins on the immune function of the gut microbiome in humans.
Researchers found that plant-to-plant interactions can modulate disease susceptibility in both wheat and rice, with 23 same-species mixtures showing a significant effect. This phenomenon, known as Neighbor-Modulated Susceptibility, may be used to design varietal mixtures with embedded crop protection.
Researchers have deciphered a biochemical mechanism explaining how cortisone preparations mediate inflammation-resolving effects in human immune cells. Cortisone influences enzymes involved in the formation of inflammation-resolving messenger substances, inducing resolvins early but impairing function later.
A multidisciplinary team of scientists has revealed the existence of a brain circuit involved in sensing and regulating inflammation. The circuit detects inflammatory hormones in the blood and organizes the immune response through the vagal complex and parabrachial nucleus.
Researchers found that CD4+ T cells initiate fat wasting, while CD8+ T cells induce muscle wasting, which surprisingly helps the mice fight infection and survive. The study sheds light on the complex relationship between immune cells and wasting responses.
A preclinical study has uncovered the role of Y chromosome gene KDM5D in regulating anti-tumor immune responses and promoting metastasis in male patients with KRAS-mutated colorectal cancer. The study reveals that mutant KRAS drives upregulation of KDM5D, leading to reduced cell adhesion and immune recognition by the immune system.
Research identifies beneficial changes in immune system during pregnancy, which can lead to new treatment strategies for MS. Women with MS experience a 70% decrease in relapses during the last third of pregnancy, possibly due to epigenetic changes and hormone regulation.
Researchers found variability in IgA levels between blood and gut samples, suggesting IgA regulates commensal microbes to prevent immune dysregulation. Patients with normal fecal IgA were less likely to develop symptoms, while those deficient in both blood and fecal IgA showed elevated inflammatory cytokines.
Researchers found that apoE4 poorly binds factor H, a regulatory factor of immunity, leading to amyloid-β oligomerization and neuroinflammation. This could be a potential solution to preventing Alzheimer's disease, with further research needed to find a bridging molecule.
A study published in Microorganisms shows that melatonin can aggravate Crohn's disease and ulcerative colitis by disrupting the balance of gut microbiota. The hormone, commonly used to improve sleep, had negative effects on bowel inflammation in laboratory mice, depending on their microbiota profile.
Maynooth University research finds that the obesity treatment drug GLP-1 can restore the body's natural cancer-killing defences by boosting NK cell function. The study shows independent benefits of GLP-1 on cancer risk, beyond its weight loss effects.
Researchers at NIH have characterized idiopathic CD4 lymphocytopenia, a rare immune deficiency that affects the body's ability to fight off infections. People with severe cases of ICL are at higher risk of acquiring or developing multiple diseases, including cancers and autoimmune disorders.
Scientists discovered that inhibiting microRNA-141-3p can reduce chronic inflammation, muscle loss, and bone degradation in aged mice. By blocking this tiny RNA, researchers found improvements in the spleen's immune response, lower levels of pro-inflammatory proteins, and a more youthful profile in bones and muscles.
A recent study led by Children's Hospital of Philadelphia identifies two different regulatory T cell populations, one related to autoimmunity and the other to protective immunity. The findings could pave the way for new treatments that target the immune system selectively.
Researchers at the University of Chicago have found that adding small molecules called immunomodulators to vaccine adjuvants can regulate the body's response to vaccines, reducing negative side effects. The study increased antibody response in flu vaccine models and reduced inflammation in typhoid vaccine models.
Studies found that certain T cells in human blood can produce acetylcholine, regulating blood pressure and inflammation. Higher levels of these immune cells were associated with reduced risk of death in seriously ill patients.
Researchers have discovered the critical role of linker histone protein H1 in plant immune responses to bacterial and fungal infections. The study found that mutant plants with knocked-out H1 isoforms exhibited higher defense gene expression and resistance to infection, but lacked priming ability.
A new study found a protein that regulates macrophage function, clearing residues from regenerating muscle and recovering regenerative capacity in aged mice. The discovery holds promise for regenerative medicine and aging, potentially improving the success of current stem-cell based therapies.
A study published in Nature Immunology found that female mouse and human NK cells have more of a specific epigenetic regulator called UTX, which boosts anti-viral function while repressing NK cell numbers. This suggests that therapies need to be tailored to individual differences, including sex.
Researchers at Hokkaido University discovered itaconate's modulatory effect on T helper and T regulatory cells, potentially leading to new treatments for autoimmune diseases. The study found that itaconate inhibits Th17 cell differentiation and promotes Treg cell development, reducing disease symptoms in mice models.
Researchers at the University of Virginia Health System have identified a vital contributor to hyperactive immune responses and neuroinflammation in multiple sclerosis. Blocking this regulator alleviated harmful inflammation in lab mice, suggesting a potential therapeutic target for new treatments.
A new study discovered that maternal γδ T cells influence the transfer of microorganisms during birth and nursing, impacting lung immune response in newborns. This discovery highlights the role of gut microbiota in modulating lung immunity and has implications for understanding the first breath response.
Researchers from Tokyo University of Science discovered β-damascone, a natural aroma compound found in rose fragrance, modulates dendritic cell functions and reduces inflammatory cytokine production. The study showed β-damascone inhibits antigen-dependent activation and Th1 cell development, as well as ear inflammation in mice models.
Researchers explore CEACAM1, CEACAM5, and CEACAM6's pathological significance in cancer biology and immunology. The review highlights their interactions with pathogens and potential avenues for cancer therapy.
Researchers have discovered a new group of immune cells called NKRM cells that limit immune responses in tissues and prevent autoimmunity. This discovery may lead to new treatments for conditions like Sjogren's Syndrome and chronic inflammatory diseases.
A new study found that excessive salt intake disrupts the energy metabolism of regulatory T cells, leading to dysfunction. This may have implications for autoimmune and cardiovascular diseases. The research suggests that sodium can alter gene expression and trigger malfunctions in mitochondrial energy generation.
New UCLA research finds that tobacco smoking and vaping can predispose healthy young people to increased inflammation and severe COVID-19. The study, published in Journal of Molecular Medicine, found higher levels of key proteins in plasma from smokers and vapers compared to non-smokers.
Researchers highlight CD200's role in regulating immunosuppressive tumor microenvironments and propose alternative strategies for its neutralization. Unbiased genomic- and proteomic-based approaches may help clarify CD200 expression regulation across various human cancers.
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
Researchers analyzed how immunological memory gets generated and maintained to understand its role in cancer and inflammatory diseases. They found that increased inflammation can actually reduce immunological memory, highlighting the need for regulation.
Researchers have created a humanized mouse model that can predict the best match for a living organ donor and detect early signs of transplant rejection. The model uses a combination of HLA-G and B regulatory cells to identify patients who may need less immunosuppressive therapy.
Scientists from Trinity College Dublin discovered that Interleukin-37 activates the immune system, contrary to earlier theories. This finding has significant implications for understanding and treating autoimmune disorders and inflammation.
Researchers found that vitamin D deficiency increases the risk of dynapenia, an age-associated loss of muscle strength, by 70-78%. Vitamin D supplementation was shown to reduce this risk. The study analyzed data from over 3,000 individuals aged 50 and over, highlighting the importance of vitamin D for maintaining muscle strength.
A new study finds that discrimination influences the central and enteric nervous systems, altering the bidirectional signaling between the brain and gut microbiome. This leads to changes in systemic inflammation, emotional arousal, and psychological symptoms across different racial and ethnic groups.
Researchers at Johns Hopkins Medicine discovered that regulating the electrical charge on the inner side of the cell membrane can activate pathways responsible for cell movement. This finding has potential implications for understanding cancer cell migration and immune cell function.
Researchers from Kumamoto University reveal how hematopoietic stem and progenitor cells orchestrate intestinal tissue repair through microbial signals. The study found that acute gut inflammation triggers the activation and expansion of immune progenitor cells, which migrate to lymph nodes to promote tissue repair.
Researchers at UNIGE and LMU discovered that immune system's anti-tumour activity peaks in the morning. Tumours implanted at night grew faster than those implanted in the afternoon. Administering immunotherapy treatments early morning significantly enhanced their effectiveness, suggesting a new strategy for cancer treatment.
Researchers at KAUST have discovered a key protein that acts as a master switch for plant immunity, suggesting a simpler way to develop more resilient crops. The protein, OXI1, triggers the production of immune-promoting molecules, but its overactivity can harm plants.
Researchers found an imbalance in an important immune system signaling pathway associated with severe COVID-19. They detected dysregulation of the immune system mediated by ATP, leading to a pro-inflammatory state and potentially fatal systemic inflammation.
The study reveals that coronin proteins regulate T cell population size by promoting survival signals when cells are not too crowded. This mechanism is evolutionarily conserved in both humans and slime molds, opening up new avenues for research.
Researchers have discovered that mutations in mitochondrial-related genes can trigger hyperinflammation, leading to diseases such as Crohn's disease and tuberculosis. The study found that these mutations lead to a new type of cell death called necroptosis, which causes an aggressive inflammatory immune response.
Researchers at Cleveland Clinic are exploring the role of inflammatory cytokines in cancer treatment, with a focus on developing personalized therapies. The five-year grant will help identify potential windows for therapy and optimize treatment strategies for individual cancers.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
A comprehensive study reveals SARS-CoV-2 viral-to-human protein interaction network, showing how the virus hijacks human proteins. Researchers identified 23 candidate drugs, including an FDA-approved beta-blocker that shows promise in inhibiting viral infection.
Researchers at the University of Arizona have identified a protein called Ait1 that regulates cell growth in yeasts. This discovery presents new targets for developing antifungal drugs that can attack disease-causing yeasts while sparing human immune cells.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
A new study suggests that growing up with dogs and in large families may lower the risk of inflammatory bowel disease. Exposure to dogs, particularly between ages 5-15, was linked to healthy gut permeability and a balanced immune response, which may help protect against Crohn's disease.
A team of researchers developed a novel chip-based infection model to study invasive aspergillosis, a mold infection that affects the lungs. The model allows for live microscopic observation of damage caused by fungal hyphae and the response of immune cells.
Scientists have identified a new immune process that regulates inflammation in human fat, which may help manage obesity. The research found that specific immune cells can work together in fat tissue to cause weight gain and obesity.
Researchers discovered that Candida albicans stimulates human immune cells to release microRNAs, triggering increased fungal growth. The fungus exploits human immune defenses by releasing signal molecules recognized by special immune cells.
Scientists at Washington State University have discovered a novel theory that the innate immune system can respond differently to specific pathogens. This quality, known as immunological specificity, is driven by the nervous system and could provide a basis for finetuning an experimental treatment to fight infection.
A study published by Arizona State University found that survivors of Hurricane Maria experienced accelerated aging in their immune systems, with molecular changes indicating a 7-8 year acceleration in human lifespan. The research used rhesus macaques as a model to explore the effects of extreme weather events on biological aging.
Antibodies that mimic the SARS-CoV-2 virus may explain lingering symptoms of long-haul COVID-19 and rare vaccine side effects like allergic reactions and blood-clotting. This theory, based on classic immunological concepts, suggests a cascade of immune responses that can lead to adverse effects.
A new AAV-delivered gene therapy strategy uses immunomodulation to reduce inflammation and improve efficacy. By incorporating TLR9-inhibitory sequences into the AAV genome, researchers have enhanced expression of transgenes in mice, suggesting potential for higher efficacy.