Articles tagged with Drug Development
A study found that glucose-6-phosphate dehydrogenase (G6PD) is critical to embryonic development, increasing the risk of prenatal and postnatal death. The deficiency also increases the incidence of birth defects in fetuses exposed to oxidative stress.
Scientists at Duke University Medical Center discovered a biological mechanism in mice that prolongs morphine's painkilling effects by eliminating a protein switch called beta-arrestin 2. This finding may lead to the development of new drugs that enhance morphine's action and reduce side effects.
Research suggests that poverty has a greater impact on the mental development of children exposed to cocaine before birth, even when controlling for IQ scores and preschool attendance. Children who had been exposed to cocaine performed no worse than low-income children without cocaine exposure in problem-solving tests.
A new pediatric cancer program in El Salvador has shown remarkable success, achieving remission and cure rates of over 80% for children with acute lymphoblastic leukemia. This model program, developed by St. Jude Children's Research Hospital, aims to improve survival rates for children with cancer worldwide.
World leaders discuss economic, ethical and human rights issues underlying healthcare resource allocation for HIV/AIDS. The meeting highlights the need for better balance of resources between prevention and treatment, as well as access to essential drugs and treatments.
Scientists at Vanderbilt University Medical Center have identified a new target for drugs that inhibit tumor angiogenesis. Thromboxane A2 receptor antagonists show promise in blocking endothelial cell migration and preventing blood vessel formation associated with tumors.
A new report from Dr. Anthony-Samuel LaMantia suggests a possible neuro-developmental theory of schizophrenia linked to altered brain development during the first three months of pregnancy. Abnormalities in retinoic acid signaling pathways may contribute to the development of schizophrenia.
A study of 12,330 men and women aged 45-64 found that those with high levels of white blood cells, albumin, or fibrinogen were at higher risk of developing diabetes. The research suggests that inflammation may play a central role in the development of Type 2 diabetes.
Researchers at Vanderbilt University Medical Center have identified a critical molecular link between endothelial cells and the development of new blood vessels. This discovery could lead to more targeted treatments for heart disease and cancer with fewer side effects.
A new drug has been developed to target E.coli infections, reducing the risk of kidney damage by half in trials. The drug, developed by Synsorb Biotech, works by mimicking the receptors on gut cells to which the bacterium's deadly 'shiga' toxin binds, allowing it to mop up the toxin undigested.
A study at Brown University found that 'bad' brain experiences can lead to stronger connections and improved brain function during infancy. Researchers tested the effect of eyelid closure versus blocking electrical activity in one eye on neural connections, finding that eyelid closure caused more severe weakening.
Researchers found that DES exposure suppresses a gene crucial for normal reproductive tract development in mice, leading to changes similar to those seen in women exposed to DES before birth. These changes can result in infertility and an increased risk of developing clear cell adenocarcinoma of the vagina or cervix at a young age.
The Robert Wood Johnson Foundation awards Wake Forest University School of Medicine a $1.9 million grant to develop a national technical assistance program for adult day centers, building on successful programs from 1987 and 1992.
Researchers are studying the genetic mechanisms of Nostoc commune, a microorganism that can survive in dry conditions for hundreds or thousands of years. The goal is to understand how it protects itself from heat, desiccation, and UV radiation, with potential applications for stabilizing other living cells.
Dr. Brundtland highlights the importance of addressing social determinants of health, such as education and poverty reduction, to build healthy populations in healthy communities. She stresses the need for multi-sectoral action and collaboration with other agencies to tackle pressing public health needs.
A study found that women with longstanding hypertension are more likely to develop preeclampsia if they have a history of high blood pressure and protein in the urine early in pregnancy. Women who developed preeclampsia were also more likely to experience complications such as premature birth and low birth weight.
Dr. David Noever's project aims to classify tiny life forms on Earth and in Mars samples using shape analysis, leveraging AI and neural networks. The 'D'Arcy Machine', a network of volunteer computers, will help process the massive dataset.
Researchers found that blocking beta-adrenergic receptor kinase (BARK) can prevent heart failure in mice genetically engineered to develop the disease. The study suggests a fundamental abnormality in the beta-adrenergic receptor system is at the root of causing heart failure.
Researchers found that women with the p53Arg gene variation are seven times more likely to develop cervical cancer due to HPV infection. The study suggests that this genetic variation may confer a strong susceptibility to skin cancers linked to HPV and ultra-violet radiation exposure.
The Cystic Fibrosis Foundation has selected seven top care centers to participate in an innovative Therapeutics Development Center network. This model will enable researchers to quickly translate laboratory discoveries into new therapies, with the goal of developing life-saving treatments for cystic fibrosis.
Researchers have developed new 'green' materials derived from chlorophyll, which can be used to overcome limitations of photodynamic therapy (PDT) for treating bulky solid tumors. These materials can kill cancer cells in tissue culture and mice while minimizing side effects.
Harvard Medical School researchers have isolated a gene, Crx, that plays a key role in photoreceptor development. The findings suggest that Crx could help prevent blindness in people with retinal disease by regulating the expression of genes unique to photoreceptors.
The Sandia-developed explosives-detection portal uses chemical preconcentrator technology to identify passengers with recent exposure to explosive chemicals. The portal has been tested on over 2,000 passengers to gauge acceptance and performance.
A recent study led by Professor Susan Fisher of the University of California at San Francisco found that low oxygen levels regulate cell proliferation in early pregnancy, controlling placental development. The team also discovered a process similar to cancerous growth occurs when cells invade healthy tissue under low-oxygen conditions.
A recent study suggests that many people have unrealistic views of the power of hypnosis, with 28% of warned subjects and 44% of non-warned subjects developing false memories. Researchers warn that warnings are only partially effective in preventing pseudomemories.
Researchers at Pacific Northwest National Laboratory have developed two portable detection systems that can identify strategic metals used to make nuclear weapons. The Material Identification System uses eddy current technology to detect metals, while the Ultrasonic Pulse Echo instrument uses ultrasound to characterize container contents.
The new guidelines rank treatment options using data from 69 experts, recommending cognitive-behavioral therapy (CBT) as the primary first-line treatment. The guidelines also suggest starting medication before adding CBT for severe patients, and recommend a trial of clomipramine after failed SSRI trials.
Newborn ferrets' brains develop visual abilities through internal patterns of electrical activity before birth, suggesting an interaction between nature and nurture in brain development. The study found that stimulating the optic nerves disrupted this process, leading to altered neural responses.
A new technology has been developed to address the need for Rh immune globulin, a treatment for pregnant women with Rh-Factor Incompatibility. The approach uses phage display to isolate anti-Rh antibodies from whole cells, offering a promising solution to this long-standing problem.
Researchers found that men with high homocysteine levels and Factor V Leiden were three times more likely to develop venous blood clots. A 20-fold increased risk was seen in those with both conditions.
Researchers have created a mouse model that mimics Familial Combined Hyperlipidemia (FCHL), a disorder causing high cholesterol and triglycerides, leading to premature heart disease. The study suggests APOC3 genetic variations underlie the disease, offering new hope for drug development.
A new company in Florida plans to introduce its revolutionary wheelchair, powered by Oak Ridge National Laboratory's (ORN L) innovative technology. The TransRovr features omnidirectional movement and a three-piece modular construction, allowing for enhanced ergonomics and convenience.