Articles tagged with Adenosine Triphosphate
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Scientists at Gladstone Institutes have performed a massive cellular energy audit to understand how cells regulate ATP levels. They identified genes and proteins that can be targeted to manipulate cellular energy and treat disease, including neurodegenerative disorders and cancer. The study reveals new pathways for boosting cellular en...
Researchers at UMass Amherst have developed an alternative energy source for muscle protein myosin, enabling controlled muscle activity and potentially treating conditions like cerebral palsy and chronic heart failure. The new energy source, Azobenzene triphosphate, has been shown to modulate myosin function and generate force and velo...
Researchers have identified a small mitochondrial uncoupler called BAM15 that decreases body fat mass in mice without affecting food intake or muscle mass. The molecule also shows promise in reducing insulin resistance and oxidative stress associated with obesity and related diseases.
A research team has created a system that uses light-reactive photo switches to control the formation and degradation of DNA building blocks. This allows for the creation of self-assembling structures with adaptable properties, opening up new possibilities for developing synthetic materials inspired by living organisms.
Researchers found a connection between HHV-6 exposure and ME/CFS symptoms, showing how efforts to boost immune system come at physiological cost. The study provides an explanation for the common observation that ME/CFS patients report fewer viral infections after developing the disease.
Researchers discovered a 'mild depolarization' of the inner mitochondrial membrane regulates mROS production and is key to the anti-ageing program. This mechanism falls apart in mice at 1 year but persists in naked mole rats up to 20 years, contributing to their exceptional longevity.
Researchers at Moscow Institute of Physics and Technology have identified quinone molecules in the C ring of ATP synthase, a molecular machine that produces energy-conserving compound ATP. The discovery opens up new avenues for understanding how cells store and utilize energy.
A scientist has described the details of an enzyme that mimics Maxwell's demon, enabling efficient energy transformation and cellular regulation. This discovery sheds light on how biological processes create information, a fundamental aspect of life.
A German-American research team has discovered a new metabolic pathway in the rumen microbiome of ruminants that allows the bacteria to adapt to extreme fluctuations in sodium content. This adaptation enables the production of ATP through two different respiratory circuits, one requiring sodium ions and the other using hydrogen ions.
Researchers have determined the atomic model of mitochondrial ATP synthase in a single-cell photosynthetic organism, Euglena gracilis. The study reveals new insights into the structure and function of this essential energy production machinery.
Researchers have identified a new bacteria-killing toxin that depletes cells of ATP, leading to bacterial death. This discovery holds potential for developing alternatives to antibiotics and addressing antimicrobial resistance.
Researchers discovered that inhibiting tanycytic TSPO increases energy expenditure and decreases appetite in high-fat diet-induced obese mice. This finding suggests a potential therapeutic strategy for treating metabolic diseases like obesity.
Researchers at the University of Groningen constructed a synthetic metabolic network for physicochemical homeostasis, producing ATP in synthetic vesicles. The system uses arginine and ornithine to maintain ionic balance and drive metabolic processes.
Researchers have discovered that microorganisms can shift from fermentation to respiration, producing more internal energy and reducing unwanted byproducts. This breakthrough enables the design of new, improved cell factories with enhanced efficiency.
Researchers have determined the first atomic structure of the V/A-ATPase family, a key energy machine in cells. The enzyme's structure reveals a turbine-like structure with two or three peripheral stalks and additional connecting protein subunits, enabling greater plasticity and flexibility in its rotation mechanism.
A biophysical study reveals that enzyme ABCE1 adopts multiple structural conformations during ribosome recycling, enabling it to dissociate ribosomal subunits. This process is crucial for the recycling of ribosomes after each round of translation.
The ABCE1 enzyme is essential for ribosome recycling, allowing cells to maintain protein quality and homeostasis. Its structure can adopt three conformations to boost recycling, influencing the interaction with ribosomes and ATP.
Keratoconus, an eye condition affecting 1 in 2,000, is caused by genetic and environmental factors, including UV light and vigorous eye rubbing. Researchers are exploring gene mutations, mitochondrial function and oxidative stress to develop new diagnostic tools and treatments.
Scientists at Tokyo Institute of Technology constructed simple artificial cells that can produce chemical energy to synthesize cell components. This breakthrough may shed light on how primordial cells used sunlight as an energy source early in life's history.
Washington State University researchers found the way plants respond to disease-causing organisms and how they protect themselves. The discovery provides a blueprint for breeding resistance to diseases or pests, enabling faster and more efficient development of crop protection strategies.
Researchers at Medical University of South Carolina identified nicotinamide adenine dinucleotide (NAD) as a compound that restores mitochondrial function and energy production in Mitochondrial DNA Depletion Syndromes (MTDPS) liver-like cells. NAD was found to increase ATP levels by activating a transcription cascade that results in inc...
Researchers found that mature plant chloroplasts isolate ATP production, while young leaves allow for temporary import of ATP to support development. This strategy optimizes energy efficiency in plants.
UMass Amherst researchers are developing a synthetic compound to power skeletal and cardiac muscle contractions during stress. This alternative energy source aims to improve heart function during a heart attack and maintain skeletal muscle function during fatigue, which is a debilitating symptom of many common diseases.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that cancer cells redirect energy production when lactate dehydrogenase is inhibited, instead relying on glutamine to sustain growth and survival. This discovery identifies a potential new target for melanoma treatment by targeting the ATF4-signaling pathway.
Chronic diseases are linked to disrupted healing cycles caused by cellular miscommunication, preventing the completion of the natural healing process. This blocks the cycle, leading to persistent conditions like cancer, diabetes, and neurological disorders.
Researchers at Gladstone Institutes identify 156 genes affecting ATP levels in cells, shedding light on cellular energy production. The findings could lead to the development of new therapies for diseases such as mitochondrial disorders, heart disease, and neurodegenerative diseases.
A recent study sequenced the genome of a Pacific tidepool crustacean and found that mitochondrial genes differ widely between populations. Hybrid offspring suffer from lowered fitness due to incompatibility. The research suggests that rapid mitochondrial evolution may be an early stage of one species becoming multiple species.
A study at Summit Health found that nearly all hospital room checklist surfaces passed testing for biological residues, but markers and erasers tested positive for ATP. The findings emphasize the need for accurate checklists to include frequently touched items like writing instruments.
The study reveals that ATP binding induces ClpB ring formation and hydrolysis causes significant structural changes between round, spiral, and twisted-half-spiral conformations. The results clarify individual roles of AAA1 and AAA2 domains in the disaggregation reaction.
Researchers at UMass Amherst have developed a molecular switch that uses light to control the release of compounds. The system consists of a thin membrane made up of chemical bonds, which can be compromised by the movement of a single chemical bond to allow the compounds to react with each other.
Researchers at Rosalind Franklin University have solved the complete structure of mitochondrial ATP synthase using cryo-electron microscopy, revealing secrets about energy production in cells. The discovery provides evidence for inhibiting enzymes and sheds light on disease-causing mutations.
Researchers used a novel, multi-scale modeling method to demonstrate that tensegrity principles govern the spatial arrangement and physical forces experienced by components of living cells. This approach revealed how tensegrity-based changes in molecular shape drive cellular motion and generate tensional forces.
Researchers develop MARIO, a fluorescent probe that measures magnesium ion concentration, showing its critical role in chromosome condensation. The study provides a new mechanism for chromosome organization and may help understand diseases like cancer.
Researchers discover J147, an Alzheimer's treatment that reverses aging by targeting ATP synthase, a protein found in mitochondria. The compound has shown promising results in treating Alzheimer's and potentially other age-associated diseases.
Scientists used fluorescent tagging to track movement of two enzymes in glycolytic pathway, revealing that aldolase chemotaxed up the reactant gradient produced by the functioning of the first three enzymes. This suggests a possible role for chemotaxis in enzyme cluster assembly, such as metabolons.
Researchers at Tohoku University have introduced a novel intermolecular surface force that explains the actomyosin driving mechanism. The discovery sheds new light on muscle contraction, highlighting a previously unexplained aspect of the myosin power stroke model.
Mice subjected to a calorie-restricted diet experienced improved skin and hair health, including increased fur production and reduced body fat. Skin vascularization also changed, with more blood vessels and increased blood flow to skin cells.
The Southwest Telehealth Resource Center, funded by a $975,000 grant, assists healthcare providers in Arizona, New Mexico, Colorado, Utah, and Nevada in connecting with rural patients. The center provides training, technical assistance, and business planning support to help start-up and existing telehealth programs expand their services.
A Rice University-led study shows that kinesins ignore weak forces as they transport cargo in cells, with lead kinesins carrying 90% of the load. The research provides molecular-level details of how kinesins respond to external forces and confirms earlier experiments on team-based motor proteins.
Researchers developed a model predicting heart cells' ability to produce ATP and stay alive under low oxygen conditions. The study found that even severely depleted regions of the heart can maintain ATP levels using energy reserves until oxygen approaches zero, but eventually crash when backup reserves shut down.
A new study published in Nature Communications suggests that maintaining high levels of adenosine in rats with damaged ACLs prevents osteoarthritis. Adenosine replacement therapy could potentially delay the onset of osteoarthritis and joint replacements.
Researchers have identified a novel adenosine receptor gene, A2c, that mediates the appetizing smell of fish food in zebrafish and other aquatic vertebrates. This receptor is highly sensitive to ATP and related compounds, triggering foraging behaviors.
A new microfluidic platform helps researchers understand how red blood cells recover their shape after deformation, shedding light on diseases like sepsis and malaria. The system reveals that cells hold less fuel under stress, contrary to intuition.
Researchers at Tohoku University used large-scale hybrid quantum-classical simulations to explain ATP hydrolysis energy. They discovered the microscopic mechanism of AHE release in water, finding that electronic-state stabilization and hydration free energy compensate for each other.
Researchers captured the first steps of human DNA replication in unprecedented detail, revealing how proteins orchestrate the process. The study sheds light on crucial mechanisms, including ATP usage and protein interactions, which may help prevent diseases like Meier-Gorlin Syndrome.
A study found that current reprocessing techniques for flexible endoscopes are not consistently effective, with organic residues often remaining. Visual inspections and cleaning verification tests are necessary to ensure all endoscopes are free of damage and debris before reuse.
Scientists have identified functions for three previously unknown mitochondrial proteins, shedding light on complex I deficiencies and coenzyme Q production. The discoveries may lead to therapies for inborn errors of metabolism and other diseases associated with mitochondria.
A new molecular model of lithium's bioactive form suggests the drug works by forming an 'intimate association' with magnesium and phosphates in the brain. This interaction may prolong signaling pathways in neurons, contributing to its mood-stabilizing effects.
The study reveals that the calcium pump uses energy from ATP to transport calcium ions into the cell, a process crucial for muscle function and heart health. This insight could lead to the development of new drugs targeting this enzyme to alleviate ionic imbalances associated with disease.
A multi-disciplinary team of researchers has identified a pivotal role for sphingomyelin in driving inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction. This study provides new insights into the underlying mechanisms of diabetic kidney disease and may lead to the development of novel treatments.
Researchers found that inhibiting calcium transfer to mitochondria selectively kills cancer cells by inducing bioenergetic crisis and autophagy. Providing metabolic substrates rescues the lethal effect, suggesting that cell death is caused by compromised bioenergetics.
A team of researchers led by Prof. Nicolau has created a model bio-supercomputer that processes information quickly and accurately using parallel networks, powered by proteins present in all living cells. The device uses much less energy than traditional electronic supercomputers, making it more sustainable.
Researchers harness molecular machinery of living systems to power integrated circuit from ATP, enabling new artificial systems with both biological and solid-state components. The system produces an electrical potential harvested by the IC in the presence of ATP.
A pilot study reveals clinical workstations can be a reservoir for multidrug-resistant organisms (MDROs) in hospitals. ATP testing identified MDROs on high-touch objects like chairs, clipboards, and keyboards more effectively than microbial swabbing.
Researchers at Lomonosov Moscow State University developed a novel approach to study electron transport chain in living mitochondria using SERS. They successfully observed changes in cytochrome c structure during ATP synthesis and were able to initiate and stop electron transport. This method provides new insights into mitochondrial fu...
Researchers found that impairments in mitochondria can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease. The study revealed the energy threshold needed to support synaptic vesicle cycling, highlighting the importance of mitochondrial function in brain cells.
A recent study found that adding adenosine triphosphate to pulmonary vein isolation treatment for atrial fibrillation did not significantly reduce late recurrences of the condition. The study, which included 2,113 patients, used ATP to identify and address potential gaps in electrical conduction around the pulmonary veins.
The new ACC/AHA guidelines for statin eligibility better predict cardiovascular risk by considering coronary artery plaque levels. The guidelines were found to identify adults at higher risk more accurately than previous guidelines, leading to a potential reduction of 41,000 to 63,000 cardiovascular events over 10 years.
The 2013 ACC/AHA guidelines outperform the 2004 ATP III guidelines in identifying increased risk of cardiovascular disease and subclinical coronary artery disease. Statin treatment eligibility is higher among those applying the new guidelines, leading to a significant reduction in CVD events.
Fireflies produce light through a chemical reaction involving luciferin and ATP, but intermediate steps were unclear. Researchers explored enzyme luciferase, finding that a single electron transfer occurs during the final step, suggesting a unifying feature of bioluminescence.