Articles tagged with Protein Synthesis
Scientists discovered that ribosomes struggle synthesizing transmembrane proteins, triggering quality control mechanisms to eliminate defective proteins. This new insight sheds light on a novel role of protein quality control at the ribosome, potentially leading to treatments for genetic diseases like cystic fibrosis.
Researchers have developed a tool to design synthetic disordered proteins, untangling their functionality. This innovation accelerates the exploration of biology's vast and underexplored area.
The study reveals how the encephalomyocarditis virus (EMCV) hijacks host ribosomes and translational factors to translate viral genes while blocking host gene translation. Targeting this mechanism could lead to new treatments for EMCV and similar viruses like poliovirus.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
Scientists identified a previously uncharacterized protein, SNOR, playing a significant role in awakening dormant yeast cells. The discovery sheds light on how microbes adapt to inhospitable environments and provides new insights into cellular quiescence.
Researchers found that eEF1A2 is significantly overexpressed in gallbladder cancer and correlates with advanced lymph node metastasis and poor patient survival. Targeting the EEF1AKMT4-eEF1A2 signaling axis may suppress translation-driven tumor growth and halt lymphatic spread.
Researchers have uncovered a new pathway to directly regulate glycogen levels in the body, offering potential therapeutic avenues for conditions like diabetes and heart disease. By studying ubiquitin's role in sugar storage, scientists have identified a new layer to a well-understood biochemical process.
Scientists at the University of Virginia Health System have developed a suite of AI-powered tools, called YuelDesign, YuelPocket and YuelBond, to transform how new drugs are created. These tools can design drug molecules tailored to fit their protein targets exactly, even accounting for protein flexibility.
An international research team led by Heidelberg University scientists discovered that the NAC complex binds to nascent protein building-blocks and initiates protein folding. This process prevents incomplete intermediate products from leading to incorrect folding, a common cause of neurodegenerative diseases.
Coronaviruses modify cellular machinery to produce viral proteins and spread rapidly. A study found that infection causes stress-induced changes in tRNAs, allowing coronaviruses to speed up protein production without generating new machinery. The modification of tRNAs is a promising candidate for developing broad-spectrum antiviral drugs.
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.
Researchers have found a way to harness the electrical energy generated by protein condensates, constantly shifting membrane-less organelles that govern cell function. This discovery could lead to bioelectrochemical devices for cleaning pollutants and fighting infection.
The NAC protein complex regulates protein synthesis by slowing down the early stages of protein formation to ensure a smooth process. This optimization allows for reduced risk of collision and coordinates subsequent folding and logistics processes.
Researchers have identified Tapt1 as a key gene in maintaining the balance between protein synthesis and degradation, crucial for normal brain development. The study reveals that Tapt1, along with its partner Suco, ensures proper neural stem cell proliferation and differentiation.
A research team led by the University of Minnesota Medical School will investigate alternative genetic decoding in single-celled organisms and identify readthrough-inducing drugs to treat genetic disorders caused by premature termination codons. The goal is to restore normal function of genes and proteins in cells, potentially helping ...
Janelia researchers have uncovered a complex interplay between the ER and lysosomes, with Lunapark stabilizing ER junctions and lysosomes regulating nearby translation. This finely tuned partnership links nutrient sensing and stress signaling to protein biogenesis.
Researchers have discovered a novel tubular structure within the symbiotic bacterium Profftella armatura found in the Asian citrus psyllid, challenging conventional views of bacteria. The discovery may lead to breakthroughs in pest control and the study of life's evolution.
Researchers at UCL successfully chemically linked amino acids to RNA under conditions that could have occurred on early Earth, a significant step towards understanding the origin of protein synthesis. The study demonstrates how RNA might have first come to control protein synthesis.
Researchers at the University of Illinois Chicago have uncovered the detailed chemical mechanism behind preventing premature protein release. The discovery sheds light on how cells execute protein production, one of life's most essential processes, and clarifies the role of the release factor.
A new study by Stanford researchers reveals that declining proteostasis in the brain leads to increased protein aggregation, which is linked to neurodegenerative diseases. The findings were made using the turquoise killifish model, and shed light on the fundamental molecular principles of aging.
Researchers developed a technique to peer inside the nucleolus and reveal its hidden system of creation, allowing them to watch RNA molecule movement and track protein-making machine assembly. The new method uses advanced imaging and genomics techniques without destroying the cell, providing a precise spatial and temporal map.
The histone modification H3K4me3 is crucial for chromosome and spindle stabilization, normal oocyte development, and embryonic competence. Removing H3K4me3 leads to destabilized spindles, impaired embryonic development, and decreased fertility.
A novel mechanism linking fetal anemia to disrupted intracellular iron distribution has been identified due to impaired mitochondrial protein synthesis. Mitochondrial tRNA modification enzyme Mto1 plays a crucial role in efficient protein synthesis and maintaining proper iron homeostasis.
The Protein Society recognizes five award winners in 2025 for their groundbreaking research in protein science and technology. Professor Jan Steyaert receives the Christian B. Anfinsen Award for pioneering nanobody technology, while Dr. Brian Kuhlman wins the Emil Thomas Kaiser Award for novel protein design and structural modeling.
Scientists at Nagoya University have developed a new mRNA technology that can produce up to 200 times more protein than traditional methods. This breakthrough enables the creation of healthy proteins to treat illnesses or toxic proteins to kill unwanted cells.
Researchers at KAIST developed CamBio, a biotemplating method utilizing specific intracellular proteins to create functional nanostructures with high tunability. The method enables the selective synthesis of nanostructures from biological samples, showing improved performance in surface-enhanced Raman spectroscopy substrate detection.
A recent study revises our understanding of the universal genetic code's evolution, suggesting that early life preferred smaller amino acids over larger ones. The researchers found that amino acids with aromatic ring structures were incorporated into the code later than previously thought, offering clues about other extinct genetic codes.
A novel 'reporter' molecule has been developed to detect ER-related problems during protein synthesis, offering simplicity and robustness against environmental fluctuations. The tool uses a firefly luciferase-based system to identify defects in protein translocation and disulfide bond formation.
Researchers at Linköping University have developed a new version of AlphaFold that can predict the shape of very large and complex protein structures, integrating experimental data. This breakthrough aims to improve the development of new proteins for medical drugs.
A research team has developed a simplified synthesis method for organic fluorophores using formaldehyde, reducing molecular size and increasing atomic efficiency. The new technique can also be applied to in vivo environments, showing promise for life sciences research and diagnostics applications.
A groundbreaking study reveals how TRMT10A deficiency disrupts protein synthesis, synaptic structure, and function in the brain, leading to impaired cognitive abilities. Researchers found a significant decrease in specific tRNA levels, particularly those essential for initiating protein synthesis.
Researchers analyzed young and aged dermal fibroblasts, finding a significant decrease in protein secretion with age. The study also revealed an increase of over 60% in cytoplasmic protein accumulation, highlighting the cytoskeleton's crucial role in skin aging.
Researchers have discovered that ribosomes play a crucial role in protein folding, directing folding pathways by impacting energy and stability. This discovery reveals the structural basis of how ribosomes affect protein folding, offering new insights into diseases such as cancers.
Researchers at Toyohashi University of Technology discovered a compound called diaphorin that promotes protein synthesis in vitro using Escherichia coli-derived components. The study found that diaphorin targets bacterial gene expression systems, improving the growth and substance production ability of E. coli.
Researchers have gained new insights into how a specific enzyme, HydF, facilitates the production of hydrogen from algae enzymes. The study reveals the importance of amino acids in anchoring and synthesizing a crucial ligand for hydrogen turnover.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers have identified spermidine as a key molecule that helps Salmonella survive inside macrophages by shielding it from oxidative stress. Targeting spermidine production with an FDA-approved drug, DFMO, may weaken the bacteria's ability to cause infection and improve survival rates in mice.
Researchers identify TRMT10C enzyme causing methylation of ND5 mRNA, leading to mitochondrial dysfunction and reduced energy supply to the brain. Impairment of complex I in the respiratory chain contributes to Alzheimer's disease pathology.
Researchers at TTUHSC are studying a new approach to inhibit STAT3, a protein associated with 70% of human tumors. Disrupting STAT3 synthesis on ribosomes could lead to new cancer treatments.
A new study published in the Journal of Nutrition found that consuming whole food omnivorous meals with lean beef resulted in significantly higher muscle protein synthesis rates compared to isocaloric and isonitrogenous vegan meals. The research, conducted on healthy older adults, demonstrated a 47% increase in muscle protein synthesis...
Researchers developed a modular flow platform to safely execute SuFEx click chemistry, generating toxic sulfuryl fluoride in a controlled manner. The system facilitates rapid functionalization of small molecules, peptides, and proteins.
Scientists identify pyroglutamination, a spontaneous chemical change, in peptide synthesis, leading to an amyloidal structure and potential implications for neurodegenerative diseases like Alzheimer's and Parkinson's. The process favors aggregation of molecules, forming plaques that interrupt neuronal flow.
Researchers have discovered a novel enzyme family related to bacterial pathogenicity in Gram-negative bacteria. The study revealed that enzymes involved in OPG synthesis and regulation play crucial roles in bacterial infection capability.
Researchers at University of California - Riverside uncover COVID's Achilles heel - its dependence on key human proteins. By understanding how the virus interacts with human cells, a new class of antiviral medication may be developed to block replication and treatment.
The protein leverage hypothesis proposes that a decrease in protein intake due to modern diets drives increased energy consumption. Research supports this idea, showing how protein appetite interacts with processed foods and life stage changes to increase the risk of obesity.
A research team at Ritsumeikan University has identified the elusive ApiT gene in celery, crucial for apiin synthesis. The discovery may pave the way for efficient biosynthesis of apiin, a compound with potential health benefits and medicinal uses.
A novel study found that consuming two oz-eq portions of animal-based versus plant-based protein foods results in different EAA bioavailability. The study, conducted by scientists at Purdue University, included young and older adults, with no differences in EAA bioavailability between age groups.
The Bioaction project leverages bacteria as allies in promoting tissue regeneration, offering a paradigm shift in addressing infections. By developing functional bio-hydrogels, the project aims to accelerate healing and stimulate bone growth, reducing reliance on extended antibiotic therapies.
Scientists at Tokyo Institute of Technology have engineered protein crystals in bacteria to produce hybrid solid catalysts for artificial photosynthesis. These catalysts exhibit high activity and stability, with the potential to convert CO2 into formate upon exposure to light.
Researchers at Hokkaido University unveil unprecedented carrier protein-mediated ring-forming step in actinopyridazone biosynthesis. The dihydropyridazinone ring is formed through a novel machinery involving Apy3, Apy4, and Apy6 proteins.
Researchers have developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This 'Purecap' technique extracted up to 100% pure Cap2-type mRNA, which showed improved protein production and lower immunostimulatory activity.
Scientists have identified a molecular control centre responsible for processing newly formed proteins correctly when they leave the cell's protein factories. The ribosomal gatekeeper NAC ensures the excision of methionine from specific proteins, preventing cell death.
Scientists at Tohoku University found that boric acid catalyzes polypeptide synthesis under neutral and acidic conditions, producing up to 39 monomer-long glycine polypeptides. This discovery challenges previous studies suggesting neutral conditions hinder peptide synthesis.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
A protein complex formed of HuR and YB1 is crucial for messenger RNA stability during muscle-fiber formation. Further research could help scientists influence protein synthesis and develop novel therapeutics for muscle-related pathologies.
Regulatory T cells suppress self-reactive T cells by controlling protein synthesis, maintaining immune tolerance and preventing autoimmunity. A small molecule inhibitor called RocA also shows promise in mitigating inflammatory responses.
Researchers at La Jolla Institute for Immunology have discovered that OGT regulates mTOR, a key protein for mitochondrial powerhouses, keeping cells healthy. The study may lead to important medical advances in understanding cancers, diabetes, and cardiovascular disease.
Researchers at Hokkaido University developed a novel branched ionizable lipid that significantly increases the efficiency of mRNA delivery by LNPs. The new lipid, CL4F 8-6, was found to enhance protein expression in mice and achieve stable formulations.
Researchers discovered a link between reduced protein synthesis and Feingold syndrome type 1, a rare genetic disorder. The study suggests that a nutritional supplement may help reverse this decrease, potentially alleviating intestinal symptoms in patients with the condition.
Researchers observe atomic-level structural changes in bacterial ribosomes and their response to antibiotics, shedding light on mechanisms of action and potential off-target effects. The study provides new insights into the complex interactions between ribosomes and other cellular complexes.