Articles tagged with Autophagy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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A team of researchers at Osaka University has discovered a novel autophagy-dependent secretory system that facilitates the secretion of inflammatory cytokines like interleukin-1 beta and leaderless proteins such as ferritin. This finding opens new therapeutic avenues for diseases related to autophagy.
Researchers at UT Southwestern Medical Center have discovered a receptor on the inner mitochondrial membrane plays a crucial role in guiding autophagosomes to damaged mitochondria for destruction. The process, called mitophagy, is essential for cellular health and preventing diseases like cancer and neurodegenerative disorders.
Researchers found that autophagy degrades Cep63 to regulate centrosome number, preventing genomic instability. Cells deficient in autophagy have extra centrosomes, highlighting the role of autophagy in maintaining genomic stability.
A new study by Temple researchers shows that the BAG3 protein helps protect the heart from damage caused by reperfusion injury. By increasing BAG3 expression, cells can clear out damaged components and prevent cell death pathways.
Research suggests that inhibiting autophagy can improve chemotherapy's immune-targeting effects without compromising overall immune system function. In mouse models, autophagy inhibitors did not disrupt the immune response to tumors during chemotherapy.
Researchers at the University of Vienna have made a groundbreaking discovery on how cells regulate autophagy, a vital process for maintaining cellular balance. The study shows that autophagy is tightly controlled in space and time by two independent coordinators, which enables the activation of autophagy when precise requirements are met.
Scientists from Daegu Gyeongbuk Institute of Science and Technology have identified a key enzyme in regulating our appetite, revealing how low glucose levels activate AMPK to control food intake. This breakthrough provides new insights into the complex mechanisms governing our eating behavior.
Researchers have identified the ATG5 protein as a key regulator of metastatic capacity in melanomas. The study found that patients with partial loss of the ATG5 gene have a worse prognosis, developing metastasis and resistance to drugs.
Researchers have identified a critical protein associated with Alzheimer's disease symptoms, suggesting a new target for therapy. The study shows that increasing p62 levels may reverse the effects of damaging plaques in the brain through autophagy.
Scientists have dissected the autophagy process in unprecedented molecular detail using live imaging and super resolution microscopy. The study reveals how the first autophagy structure forms and clarifies protein and membrane associations leading to its development into a fully-fledged autophagosome.
Researchers have found that AGGF1 promotes therapeutic angiogenesis through autophagy, increasing the number of mice that survive after acute heart attacks. Treatment with AGGF1 also improves cardiac functions and reduces scarring in the heart.
A new generation of drugs that prevent cancer and Alzheimer's are in development thanks to research from the University of Warwick. The university has identified over 700 previously undiscovered proteins related to autophagy, a cellular process that declines with age.
Cells have two disposal systems: proteasomes, which handle smaller proteins, and autophagy, a process that removes larger complexes. Researchers discovered a smart bin liner-like system in autophagy, involving Cue5 receptors and Hsp42 chaperones.
A recent study from the Neuromed Institute reveals that two previously separate processes converge into a single cell component, the autophagoproteasome. This discovery provides a new understanding of autophagy, a critical mechanism for cellular renewal and waste removal.
By inducing autophagy, researchers at Drexel University and Yale University decreased lung injury in mice exposed to high oxygen levels, offering a potential solution for preventing chronic lung conditions like Bronchopulmonary Dysplasia (BPD) in premature infants.
Research from Sanford Burnham Prebys Medical Discovery Institute shows that cell recycling in the intestine is crucial for healthy aging, leading to longer lifespans.
Researchers at Tokyo Institute of Technology have discovered the molecular mechanism behind autophagy initiation, revealing that Atg13 forms a supramolecular complex with other proteins. This breakthrough may lead to the development of therapeutic treatments for diseases such as neurodegeneration and cancer.
Researchers at MUSC discovered that Dab2 is a molecular switch regulating autophagy or apoptosis in tumor cells. Maintaining Dab2 levels blocks autophagy and promotes cell death, enhancing chemotherapeutic agent efficacy. In vivo studies showed Dab2 reduces tumor metastasis and increases drug-induced cell death.
Researchers at Linköping University have discovered that stimulating autophagy can be harmful when trying to treat tuberculosis, highlighting the need for new treatment alternatives. Strengthening immune defense cells like macrophages and dendritic cells may hold promise in controlling tubercule bacilli.
A study at IRB Barcelona discovered that Mitofusin 2 is required to preserve healthy muscles in mice, with its loss associated with muscle wastage and sarcopenia. The protein could serve as a therapeutic target to ameliorate sarcopenia in the elderly.
Researchers aim to develop strategies to protect the kidneys from permanent damage caused by cisplatin, a common chemotherapy agent used to treat various cancers. They investigate two pathways: p53 and PKCδ, which contribute to kidney cell death during treatment.
Researchers at the University of Chicago found that inhibiting autophagy, a cellular housekeeping process, effectively blocks tumor cell migration and breast cancer metastasis in tumor models. Autophagy is essential for tumor metastasis, and its inhibition can be an effective approach to block metastatic dissemination.
Researchers found that defects in LC3-associated phagocytosis (LAP) may contribute to systemic lupus erythematosus (SLE), the most common form of lupus. LAP ensures proper digestion and disposal of dead cells, which was found to be impaired in SLE-prone mice.
Researchers at Washington State University are investigating new drugs to treat neurological disorders related to autophagic dysfunction. The goal is to selectively activate autophagy, recruiting 'housekeepers' to the brain and potentially regenerating the system.
The Autophagy Regulatory Network database provides integrated and systems-level source for autophagy research, containing data on over 14,000 proteins. The new edition of the guidelines offers recommendations for best practices in autophagy monitoring, measurement, and diagnosis.
Researchers discovered a rare genetic mutation in Turkish children with ataxia, which caused a significant impact on the brain's autophagy process. This finding has important implications for understanding and treating neurological disorders, such as ataxia and developmental delays.
Researchers at Johns Hopkins Medicine have discovered that cocaine triggers autophagy, a process that causes brain cells to digest themselves. A compound called CGP3466B has been shown to prevent this damage in mouse nerve cells.
The newly established Collaborative Research Centre on selective autophagy aims to improve therapy for diverse diseases by targeting autophagy at the molecular and cellular level. Researchers will study autophagy in complex organisms, including humans, to understand its role in pathophysiology and develop new therapies.
QUT scientists uncover the secrets of Aussie 'resurrection' grass, a native species that can survive droughts by selectively culling its own cells. The research reveals sugar manipulation and autophagy as key survival mechanisms, potentially leading to the development of stress-tolerant crops like chickpea.
Researchers have found a potential treatment strategy for glycogen storage disease Ia by inducing autophagy in liver cells, which reduces fat and glycogen levels. A drug called rapamycin stimulates autophagy and improves liver size and function in animal models.
Autophagy has been shown to work in the cell nucleus, playing a role in guarding against the start of cancer. By degrading unwanted cellular bits and pieces, autophagy helps prevent cancerous growth, but its improper activation during normal aging leads to premature aging and age-related diseases.
Researchers have identified GATA4 as a key transcription factor that activates cellular senescence. This process is characterized by a pro-inflammatory response and the production of secreted inflammatory cytokines. The study reveals that GATA4 is normally suppressed by autophagy, but its accumulation promotes senescence.
A multidisciplinary team is designing a mathematical model for autophagy in lung cancer to develop novel cancer treatment strategies. The model will be used to systematically evaluate therapeutic strategies and identify the most promising ones, which can then be evaluated experimentally.
Cancer cells can be made vulnerable to autophagy shutdown by combining an FLT3 inhibitor with an autophagy blocker. This combination prevents cancer cells from metabolizing glucose and mobilizing stored nutrients, leading to cell death. The study provides evidence that this approach could be a new way to treat various types of cancer.
Scientists at the NIH discovered that PINK1 triggers an intricate process called mitophagy, which breaks down and removes damaged mitochondria from cells. This discovery suggests a new avenue for treating diseases like ALS and Parkinson's by boosting the disposal of damaged mitochondria.
Researchers discovered that Schwann cells digest damaged myelin internally through autophagy, clearing 40-50% of the myelin within 5-7 days. This mechanism enables significant nerve repair in the peripheral nervous system, contrasting with the CNS where oligodendrocytes fail to clear myelin.
Inflamed kidney cells produce an enzyme that consumes tryptophan, activating a stress response and inducing autophagy to clear damaged protein. The IDO-GCN2 pathway provides natural protection against inflammation-induced kidney damage, offering new potential treatment targets.
Researchers discovered that actin polymerization powered by the Arp2/3 complex is essential for forming and moving autophagosomes. The formation of 'actin comet tails' propels these compartments toward lysosomes for final processing, enabling cells to recycle misfolded proteins and damaged organelles.
Researchers identify a new autophagy receptor, FAM134B, which ensures proper breakdown and disposal of dysfunctional endoplasmic reticulum. Mutations in FAM134B cause rare hereditary disease HSAN II, highlighting the importance of autophagy in cellular quality control.
Researchers have identified the Clec16a gene as a regulator of T cell education, which is central to the development of autoimmunity. The study shows that turning off the gene protects mice from developing diabetes, suggesting its role in preventing autoimmune diseases.
A recent study by Ludwig Institute for Cancer Research has made a significant breakthrough in understanding the molecular mechanisms behind Parkinson's disease. The researchers discovered that disruption of a developmental mechanism, Lmx1b, leads to the death of dopamine-producing neurons, resulting in the symptoms of PD.
A new approach to combating tuberculosis aims to harness the body's natural anti-microbial process, autophagy, to target Mycobacterium tuberculosis. Autophagy is being researched for its potential role in various diseases, including heart disease and neurodegenerative disorders.
Mutations in calcium channel genes disrupt autophagy in neurons, leading to neurodegeneration. Calcium channels play a key role in regulating autophagic vesicle fusion with lysosomes, maintaining neuronal homeostasis.
Scientists have discovered a new role for voltage-gated calcium channels (VGCCs) in neurons, which play a critical role in cellular 'garbage disposal' processes. VGCCs are found not only on the synaptic membrane but also in lysosomes, where they facilitate lysosomal fusion and autophagy.
A team of Singapore-based scientists identified a new signalling pathway regulating cancer internal diet. The therapy combines an old anti-malarial drug with CK1α inhibition, effectively treating colon and bladder cancers. Researchers hope to develop more potent inhibitors for this treatment.
Researchers at Johannes Gutenberg Universitaet Mainz identified RAB3GAP complex as a key factor in autophagy, a process that breaks down cellular proteins and organelles. This discovery may enable innovative approaches to treat neurodegenerative diseases like Alzheimer's.
Researchers at The Scripps Research Institute have identified a new cellular pathway affected in cystinosis, which could lead to new drug treatments for reducing or preventing renal failure. The study found that concentrations of LAMP2A, a lysosomal surface protein, were down by 50-80% in cystinotic cells.
HIV-associated neurocognitive disorders affect 10-50% of aging patients, causing cognitive impairment and daily challenges. Researchers found that the tat protein disrupts autophagy, a critical disposal process, in neurons.
Researchers found that autophagy, a cellular recycling process, helps eliminate a molecule called A20 that blocks the immune response. By removing A20, autophagy allows for a quick release of emergency signals, boosting anti-fungal immunity.
Researchers found that inactive EGFR is involved in autophagy, a process where cells consume nonessential contents to survive. Cancer cells use this process to thrive under stressful conditions. Combining drugs that block autophagy with those that inactivate EGFR could be an effective way to treat cancers
Researchers found that FKBP51 regulates acute and chronic effects of antidepressants via autophagic pathways in mice and humans. Autophagy markers correlate with antidepressant treatment response in patients with depression.
Researchers found that autophagy plays a central role in mediating the non-specific immune effects of BCG, leading to trained immunity. Monocytes from individuals with specific variants of the ATG2B gene respond with trained immunity, supporting the hypothesis that autophagy is clinically relevant.
Researchers found that autophagy, a cellular recycling mechanism, helps activate muscle stem cells by inducing metabolic shifts and coping with increased biosynthesis demands. Inhibited autophagy delayed stem cell activation, highlighting SIRT1's regulatory role in this process.
Scientists at Brigham Young University have discovered two proteins that trigger autophagy in cancer cells, offering a potential therapeutic avenue for targeted treatment. The study's unique approach led to the identification of a protein pair responsible for switching on autophagy under stress conditions.
Researchers at UC San Diego identified microRNA let-7 as a key player in managing cell survival and growth. The molecule controls autophagy through the amino acid sensing pathway, which has emerged as the most potent activator of mTORC1 complex activity.
Researchers identified a gene called AMPK that can slow the aging process throughout the entire body when activated remotely in key organ systems. Activating AMPK in fruit flies increased their lifespans by about 30 percent and kept them healthier longer.
Researchers at Virginia Commonwealth University Massey Cancer Center have developed a novel cancer therapy that leverages the autophagy defense mechanism to induce cell death in multiple myeloma cells. By targeting the p62 protein, the therapy disrupts autophagy and triggers apoptosis, resulting in increased effectiveness compared to t...
A study found that children with autism have a surplus of synapses in the brain due to a slowdown in synaptic pruning during development. The researchers discovered that administering a drug called rapamycin can improve autistic-like behaviors in mice, even when given after the behaviors have appeared.
Researchers found that autophagy is activated in the hippocampus of vascular dementia model rats, leading to neuronal injury. Inhibiting autophagy has shown neuroprotective effects, suggesting it as a novel pathway and target for drug treatment of vascular dementia.
Research suggests that autophagy may be both beneficial and detrimental to neuronal survival after stroke. The study proposes that autophagy has dual effects on neuronal survival, highlighting the need for further investigation into its therapeutic potential.