Articles tagged with Induced Pluripotent Stem Cells
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A new study has identified optimized immunosuppressive strategies that allow transplanted iPSC-CMs to survive without immune rejection in non-human primates. The researchers found a triple-drug regimen consisting of methylprednisolone, calcineurin inhibitors, and mycophenolate mofetil reliably prevents acute immune rejection.
A team at UC San Diego is developing functional, patient-specific livers using 3D bioprinting and stem cell technology. The goal is to create 'made-to-order' livers grown from a patient's own cells, offering a safe alternative to transplantation that eliminates the need for donor organs.
Researchers at Kobe University developed a method to preserve iPS cells directly in their culture dishes using D-proline as a cryoprotectant. This allows for easy automation of the process, reducing costs and increasing efficiency in regenerative medicine and drug discovery research. The breakthrough enables the direct freezing, thawin...
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
The new approach uses lab-grown heart tissue made from reprogrammed adult stem cells, delivered through a tiny incision. In preclinical testing, the stem cell patch restored heart function and improved healing, offering a new way to repair damaged hearts.
Researchers at Sanford Burnham Prebys have developed a new method to generate more and potent skeletal muscle progenitor cells. The study found that blocking the activity of Janus kinase 2 (JAK2) yields a twofold increase in cell yield, while also delivering more mature and effective cells for regenerative medicine treatment.
Stem cell transplantation has been shown to reverse stroke damage in mice by regenerating neurons and restoring motor functions. The treatment also improved blood-brain barrier integrity, reduced inflammation, and promoted new blood vessel formation.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
Researchers found that increased levels of EPS8 drive pathological protein aggregation and neurodegeneration in worms and human cell models. By reducing EPS8 activity, they prevented toxic protein accumulation and preserved neuronal function.
Researchers at Wyss Institute develop in vitro method to induce meiosis in human cells, enabling replication of critical step in egg and sperm cell development. The breakthrough could lead to modeling defects and creating healthy gametes for individuals with infertility.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers have created a more efficient and controlled method to produce lab-grown inner ear hair cells, offering new hope for hearing loss research. The innovative approach uses a doxycycline-inducible transcription factor system, significantly increasing efficiency and reducing time compared to existing methods.
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Researchers at Harvard University's Wyss Institute have successfully created human microglia cells in a dish, using induced pluripotent stem cells, within four days. This breakthrough enables new avenues for brain disease-focused research and potential therapeutic perspectives.
A new method captures totipotency using a short-term high-dose treatment of Pladienolide B, reprogramming classical mouse embryonic stem cells into transient totipotent blastomere-like stem cells. These cells exhibit remarkable developmental potential and self-organize into blastoid structures mimicking early embryonic development.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
Researchers have successfully developed lab-grown pig retinal organoids, which shared similarities with human retinal organoids. The study offers a promising approach to combatting retinal disease by testing 'human-equivalent' photoreceptors in pigs.
A research team at the University of Cologne has identified a specific form of the tau protein, 1N4R, responsible for mediating toxic effects of protein clumps in human brain cells. This breakthrough understanding could lead to new treatments for Alzheimer's disease.
Dr. Gordon Keller's groundbreaking research on directed differentiation of human pluripotent stem cells has illuminated the path to transforming human health. His lab's world-first discovery and pioneering efforts have pushed the boundaries of what is possible, offering hope for regenerating heart, liver, and blood cells.
Scientists discovered a novel method to activate extraembryonic trophoblast potentials in conventional human pluripotent stem cells through transient treatment of epigenetic regulators. This approach holds promise for advancing understanding and treatment of diseases related to placental development.
The ISSCR International Symposium will commemorate the 20th anniversary of iPSC discovery, highlighting breakthrough achievements and new research advances. The event aims to celebrate the transformative power of scientific curiosity and its potential to unlock cures for previously untreatable diseases.
Researchers found that injecting infarcted pig hearts with specially bioengineered cells significantly decreased the infarct area and improved heart function. The therapy worked by stimulating the proliferation of endogenous pig cardiomyocytes, which had previously been unable to divide in adult hearts.
Researchers at the University of Montreal have successfully transplanted human retinal sheets into minipigs with damaged macula, resulting in signs of restored vision. The method uses hypoimmunogenic human retinal sheets and has shown promise in treating severe photoreceptor degeneration.
Researchers identified critical proteins involved in animal stem cell regulation, including SOX and POU transcription factors, which existed in single-celled organisms over 700 million years ago. These ancient proteins retained functional properties that enabled them to induce stem cell reprogramming in mouse cells.
An international team of researchers successfully created a mouse using genetic tools from a unicellular organism, challenging the notion that these genes evolved exclusively within animals. The study uses ancient genetic tools to reprogram mouse cells into pluripotent stem cells.
Researchers have successfully transplanted human stem cell-derived heart cells into monkeys with a rare heart condition, offering a potential treatment for congenital heart defects. The study demonstrated the safety and integration of these cells into the host myocardium, paving the way for future clinical applications.
Researchers at Kumamoto University have achieved a groundbreaking advancement in stem cell biology by reproducing the developmental process of hematopoietic stem cells in vitro. This culture system enhances our understanding of HSC development and has the potential to be instrumental in stem cell therapy and blood disease treatments.
Researchers at Johns Hopkins University mapped variation in human stem cells, revealing unique developmental patterns and gene expression traits that modify conserved steps. The findings may aid personalized regenerative therapies and advance understanding of cellular variation in humans.
A team at Medical University of South Carolina identified a pathway to reduce fat accumulation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). They used a novel stem cell platform and screened 1,100 compounds to find five that more than halved fat droplets on treated liver cells.
Researchers at Iowa State University have discovered a potential breakthrough in producing lab-grown blood stem cells by pausing the initial activation of inflammatory signals. This allows for the production of hundreds of functional stem cells, which could replace bone marrow transplants for blood disorders such as leukemia and anemia.
Researchers at Osaka Metropolitan University have successfully generated high-quality feline induced pluripotent stem cells (iPSCs) without a genetic footprint. These cells exhibit properties similar to human iPSCs and can differentiate into various cell types, making them a promising tool for veterinary regenerative medicine research.
Melbourne researchers have developed a breakthrough in creating lab-grown human blood stem cells, which can be used to treat childhood blood disorders. The cells closely mimic those found in the human embryo and can create specific matched blood cells for transplantation, reducing complications and addressing donor shortages.
Researchers have discovered that SARS-CoV-2 can infect more types of lung cells than previously thought, including those without known viral receptors. The study also found that the lung can independently muster an inflammatory antiviral response without immune system help when exposed to the virus.
Researchers develop a model of heart disease by tricking stem cells to behave like mature heart cells with a mutation that causes hypertrophic cardiomyopathy. The study reveals the connection between mechanical stress and electrical function in hearts, shedding light on why genetic mutations can cause arrhythmias.
A study using induced pluripotent stem cells has revealed that inflammation triggered by retrotransposons and interferon signaling causes atherosclerosis in Werner syndrome patients. The researchers propose targeting the interferon signaling pathway as a potential treatment for reducing stroke and heart attacks.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
The study, published in Cell Stem Cell, improves the growth of nephron progenitor cells (NPCs) using a chemical cocktail, enabling sustained growth in a simple 2-dimensional format. The breakthrough has potential for advancing kidney research and discovering new treatments.
A Japanese research team from Shinshu University has successfully tested a novel approach to regenerative heart therapy using human induced pluripotent stem cells. The strategy involves injecting cardiac spheroids into damaged hearts, resulting in improved blood pumping capability and minimal arrhythmias in primate models.
JAX researchers develop platform to mimic genetic diversity in humans, allowing for precise modeling of disease mechanisms and therapeutic targets. The platform enables direct comparison between mouse and human cells, providing molecular insights into autism, intellectual disability, and other neurodevelopmental disorders.
Researchers have identified a link between CCHS and the ubiquitin transfer system, revealing that aberrant interaction with this system disrupts normal neural protein degradation, leading to cell death. This discovery could pave the way for significant advances in disease therapeutics.
Researchers successfully created a rat-derived lung in mouse model using reverse-blastocyst complementation and tetraploid-based organ complementation. The study identified crucial factors required for functional lung formation, including fibroblast growth factor 10 (Fgf10) and its interaction with Fgfr2b.
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
A study from the University of Wisconsin-Madison and Academia Sinica of Taiwan has successfully combined lab-grown cardiomyocytes with stem-cell-derived endothelial cells to regenerate damaged heart muscle after a heart attack. This combination therapy holds promise for tackling arrhythmia and could lead to improved clinical applications.
Researchers created a new CRISPR-based gene therapy tool using locally sourced, human-derived proteins that can activate silent or insufficiently expressed genes. The DREAM tool mimics the natural ability of human cells to turn on specific genes in response to mechanical cues.
A breakthrough technique has been developed by University of Oxford researchers to repair brain injuries using 3D printing. Neural cells can be printed to mimic the architecture of the cerebral cortex, showing structural and functional integration with host tissue.
A study suggests that Brazil's unique genetic diversity could provide the necessary number of stem cell lines to cover 95% of the world's population. Researchers estimate that at least 559 distinct cell lines would be required for this goal, and Brazil could contribute considerably to a global iPS cell bank.
Researchers from the Center for Regenerative Medicine at Boston University School of Medicine have discovered a novel approach for engrafting engineered cells into injured lung tissue. They successfully reconstituted the stem cell compartment of injured airways and alveoli using cells engineered from pluripotent stem cells, resulting i...
Researchers have made key discoveries in a new stem cell-based therapy for Parkinson’s disease, using patients’ own cells to replace lost neurons. The approach, called an autologous therapy, has shown promise in reversing symptoms of the disease in rat models and holds potential for clinical trials with improved success rates.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
This study demonstrates the potential of cell therapy using genome-edited iPS cells secreting therapeutic molecules, such as mNAGA, to supply GLA activity in vivo. Transplantation of these cells improved GLA activity in the liver, but not in other organs, and future enhancements are possible through genome editing.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
Researchers at the Francis Crick Institute have discovered a key role for autophagy in controlling intracellular infections like TB. By boosting this natural process, they hope to create new treatments that can combat antibiotic-resistant bacteria.
Researchers found that a plakophilin-2 mutation leads to increased desmosomal protein degradation in ACM hearts, causing structural and functional changes. Studying human heart samples and mice models confirmed the role of protein degradation in ACM development.
Researchers identified a new mutation in the desmoplakin gene that leads to cardiac disease arrhythmogenic cardiomyopathy (ACM). The mutation affects heart muscle cell connections and ion channel function, highlighting the importance of desmosomes in maintaining healthy heart function.
Scientists have successfully transformed blood cells into sperm precursors in marmoset embryos using a step-by-step process. The study, published in eLife, opens up new avenues for studying primate biology and developing novel assisted reproductive technologies.
Researchers have generated induced pluripotent stem cells from bats, gaining insights into the relationship between bats and viruses. The study may also shed light on bats' remarkable defenses against aging and cancer.
A new study has identified distinct patterns of circular RNA expression in human ALS muscle tissue, which display disease-specific gradients and could inform about neuromuscular molecular programs in ALS. The research reveals that specific circRNAs are elevated in ALS muscle biopsies but reduced in spinal cord samples from ALS patients.