Articles tagged with Dna Sequencing
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study highlights the potential of living cell banks to contribute to global conservation priorities. Cryo-banked samples provide crucial genetic diversity and reintroduction opportunities to increase adaptability and resilience in threatened species.
Researchers have developed a new method to control the movement of individual DNA molecules through a nanopore, allowing for higher accuracy in sequencing and analysis. This breakthrough has the potential to improve diagnostic and sequencing applications, including peptide sequencing.
Researchers developed a CRISPR/Cas9-based gene drive system targeting the Drosophila suzukii doublesex gene, resulting in female sterility and high transmission rates. Mathematical modeling predicts efficient population suppression with low release ratios.
Researchers found that only 6.8% of cancer patients underwent genetic testing within two years of diagnosis, with lower rates among Black, Hispanic, and Asian patients. The low rates are attributed to lack of integration of test results into cancer management and prevention.
A recent study found significant differences in the gut microbiome of female southern white rhinos that reproduced successfully versus those that did not. The researchers identified a particular genus of microbes that may be limiting reproductive success in captive breeding programs.
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
A new international study reconstructs the legacy of Chile's largest indigenous community, the Mapuche, through genetics and linguistics. The research reveals distinct Mapuche lineages originated locally and have remained in relative isolation, punctuated by episodes of contact with other South American populations.
A recent study by Carolyn Elya reveals the molecular mechanisms behind summiting behavior in infected fruit flies. The researchers discovered that hormonal axes mediate this behavior, and that fungal cells invade the fly's brains during summiting.
Researchers use chromosome structure to determine that comb jellies were the first lineage to branch off from the animal tree, followed by sponges. This finding sheds light on how animals arose and evolved into the diverse species we see today.
A new study using ancient DNA from northern and central Mexico reveals population continuity despite drastic environmental change, providing new insights into the region's demographic history. The research also identifies two 'ghost' populations contributing to pre-Hispanic populations, revealing a complex demographic landscape.
A new study led by Mass General Brigham researchers found that 88% of rare disease experts agree on the benefits of genomic sequencing in newborn screening. The experts recommended screening for over 600 genetic conditions, including those associated with hemophilia and retinoblastoma.
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
A new clinical RNA sequencing platform at SickKids is helping researchers understand complex genetic conditions and improve diagnosis for patients with rare diseases. The platform has been validated to be used in the clinical space, providing valuable diagnostic information that complements genome sequencing.
Researchers have identified a new cell state in embryonic airway development, which may lead to new approaches for treating chronic respiratory diseases. The discovery highlights the crucial role of cellular heterogeneity in shaping airway biology.
A revolutionary investigation has shed light on pioneering female migrants who arrived in Orkney during the Bronze Age. Ancient DNA analysis revealed a major influx of non-local people, dominated by women, challenging previous assumptions about the archipelago's influence during this period.
A study of bird poop reveals a unique relationship between birds and their microbiomes, which differ from those found in mammals. The researchers found that the types of bacteria present in the birds' gut microbiomes change over short time periods, rather than being tied to specific host species.
A new study links shorter telomeres to multiple changes in the brain associated with dementia, including reduced grey matter volume and a thicker cerebral cortex. Longer telomeres were found to be protective, reducing the risk of dementia but not stroke or Parkinson's disease.
Research found that inbreeding is a major factor contributing to the decline of the endangered Southern Resident killer whale population. The study, published in Nature Ecology and Evolution, indicates that inbred individuals have lower survival rates and birth rates compared to those with lower levels of inbreeding.
Researchers developed a novel machine-learning algorithm that analyzes a person's entire transcriptome to create an 'atlas' of pediatric cancer. The platform refines cancer diagnoses for 85% of pediatric cancer patients, identifying 455 subtypes of cancer and revealing subtle differences within subtypes.
A genomic study of 180 indigenous Africans provides new insights into human history, biology, and population diversity. The research sheds light on the origin of modern humans, African population history, and local adaptation, including traits such as skin color, heart development, and immunity.
A decade-long international study has linked genetic changes in kidney cancer to patient outcomes, identifying four groups of patients based on specific genes. The findings suggest that tumour DNA sequencing may provide a more effective way to predict patient risk of kidney cancer recurrence.
Researchers identified genetic variants associated with susceptibility to Epizootic Hemorrhagic Disease (EHD) in white-tailed deer. The study found that deer with specific mutations are less susceptible to the disease, which has been on the rise in northern Illinois and neighboring states.
A new study links genetic changes in kidney cancer to patient outcomes, identifying four groups of patients based on mutation presence. This research may lead to more effective prediction of recurrence risk and personalized treatment for thousands of patients annually.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
Researchers confirmed the first cases of canine distemper virus in tigers and leopards in Nepal, which can cause fatal neurological disease. The study found that 11% of tigers and 30% of leopards had antibodies to CDV, indicating prior infection with the virus.
A study by University of Gothenburg researchers identifies two distinct types of cod, 'offshore cod' and 'coastal cod', genetically adapted to different environments. The coastal cod remain in the fjords, but their adult stage is uncertain, with possible spawning locations still unknown.
A recent NTU Singapore study reconstructed the history of The Sundaland using paleogeography and population genetics to show that rapid sea-level rise drove early settlers to migrate, increasing genetic diversity. This finding provides insight into how climate change can profoundly impact human populations.
Researchers have solved an 80-year-old medical mystery that causes kidney damage in children and can be fatal in babies. They discovered a gene mutation is the primary cause, but found that around 10% of patients without the mutation still experience symptoms.
Researchers at the University of Adelaide analyzed DNA samples from over 100 retailers across South Australia and found four threatened shark species being sold as flake. The study highlights the need for clearer national guidelines or labelling laws to build trust across the supply chain.
Researchers identify vulnerable cell populations in the striatum, which contributes to loss of motor control and early mood disorders. Damage to striosomes may be responsible for mood disorders, while degeneration of matrix neurons likely contributes to motor decline.
Researchers analyzed over 600 genome sequences to chart the complex history of Y. pestis, the bacterium that causes plague. They found an unstable molecular clock and identified five populations throughout history, including ancient pandemic lineages.
Researchers advocate for descendant community involvement in ancient DNA research to ensure benefits and risks are shared fairly. Without such guidance, the science can be exploitative, perpetuating colonial practices and harming modern Indigenous groups.
A study in Serrana, Brazil showed that mass vaccination reduced severe cases and death rates even while gamma and delta variants were circulating. Vaccination coverage reached 80% of the target population.
The study found that the Erfurt Jewish community was more genetically diverse than modern-day Ashkenazi Jews, with at least two distinct groups. The research team discovered that the founder event, which makes all Ashkenazi Jews today descendants of a small population, happened before the 14th century.
A study using DNA analysis of a sacrificial spider monkey at Teotihuacàn, Mexico, reveals the earliest evidence of primate captivity and translocation in the Americas. The research provides insight into ancient trade networks and suggests that the spider monkey was a diplomatic gift between Teotihuacàn and the Maya civilization.
Researchers have identified genetic variants associated with natural resistance to SARS-CoV-2, including a gene linked to mucin production. These findings may help develop vaccines and treatments for viral diseases by understanding the mechanisms underlying immune responses.
A new web-based tool called Taxonium is helping scientists track the evolution of SARS-CoV-2 and other viruses by analyzing massive genetic datasets. The analysis reveals that COVID-19 variants worldwide are repeatedly evolving the same mutations, suggesting a convergent evolutionary process.
Researchers developed STAARpipeline to analyze rare genetic variants, enabling comprehensive analysis of noncoding variants. The tool found significant associations in gene-centric and non-gene-centric analyses, advancing genetic research.
A study published in European Journal of Nuclear Medicine and Molecular Imaging identified specific genetic markers associated with high risk of head and neck cancer. The research used DNA sequencing, artificial intelligence, and positron emission tomography to analyze cellular characteristics of tumors. These markers can facilitate mo...
Researchers at Rice University have developed a procedure to quantify unintended changes that accompany on-target CRISPR-Cas9 gene editing, potentially threatening the efficacy and safety of therapies. The new method uses single-molecule sequencing with unique molecular identifiers to detect large deletions, insertions, and chromosomal...
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
A new genetic test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, improving the accuracy of diagnoses compared to current guidelines. The test distinguishes between different types of cysts with higher accuracy than traditional forms of surveillance and current pancreatic cyst guidelines.
Researchers found the moths originated from the Baja Peninsula and Arizona, with a new subspecies discovered in western North America. The study recommends using synthetic pheromones to control the invasive pest.
A recent genetic study has found that three-quarters of the Early Medieval population in Eastern England was comprised of migrants originating from Continental regions bordering the North Sea. These migrants intermarried with local populations, but integration varied greatly from region to region.
Researchers at Stockholm University solved the mystery of the supergene responsible for distylous flowers with differing lengths of male and female sexual organs. The study reveals that the supergene itself varied in length, with a dominant form containing about 260,000 base pairs of DNA.
Scientists at the University of Freiburg have successfully characterized epigenetic modifications using nanopore analysis. The technique allows for rapid detection of protein fragments with varying levels of acetylation, enabling more accurate diagnosis and treatment of diseases like cancer.
The University of Guam is conducting a four-person research team's study on the genetics of corals from the Northern Mariana Islands to understand coral population connections, diversity, and adaptations. The study aims to identify potential reserves for declining reefs and assess the impact of warming waters.
A new DNA extraction technique has enabled researchers to analyze genetically diverse mollusc species from museum collections, shedding light on their evolutionary history and informing conservation management. The method's success opens up novel research avenues, particularly for endangered or never-before-seen-alive molluscs.
A new study found nearly half of Florida panther mutations originated from Texas and Central American pumas, bringing both good and bad genetic material. Researchers emphasize the need to monitor genetic health due to potential risks, especially with small population sizes. Genetic screening for future introductions may be necessary.
Researchers developed a new quantitative RT-qPCR assay to detect and quantify the Omicron variant of SARS-CoV-2 in wastewater. The assay revealed that Omicron displaced Delta as the dominant variant within just 3 weeks in an Italian population.
Scientists analyzed UK bumblebee populations and found evidence of increasing stress due to climate change, with higher asymmetry in wing shapes linked to hotter and wetter years. The study used ancient DNA methods to determine genetic diversity loss and adaptability of bee genomes over time.
A new study by Johns Hopkins Medicine researchers reveals a promising genetic method for identifying hundreds of disease agents using next-generation sequencing. The Respiratory Pathogen Infectious Diseases/Antimicrobial Resistance Panel (RPIP) system shows near-comparability to traditional diagnostics in identifying pathogens.
Researchers at Gladstone Institutes developed a tool called Retro-Cascorder, which logs a cell's genetic activity for days at a time. This allows scientists to create living biosensors that can record changes to their environment.
Researchers used Guardant NGS to analyze nearly 17,000 lung cancer samples and found MET amplification in 1.2% of cases, with 20.8% having overlapping oncogenic drivers. The study suggests that high gene copy numbers and smaller amplified regions can be used to enrich for the true MET-sensitive population.
A centuries-old tooth found on a Caribbean island yielded ancient DNA from a domesticated American horse, which was later discovered to be the oldest sequenced specimen in the Americas. The DNA analysis linked the horses to Spanish explorers who brought them to the mid-Atlantic region in the 16th century.
A team of researchers developed a clonal barcoding approach to track live cancer cells, enabling the detection and isolation of precise clones responsible for tumor formation and early metastases. This technology has the potential to be applied to other cell-based studies, providing valuable insights into biological processes.
Genomic data reveals two distinct species of scrub jays: A. sumichrasti, endemic to southern Mexico, and A. texana, found only in Texas. The study's findings support the recognition of these new species based on phenotypic, behavioral, and genetic differences.
Researchers have discovered a selfish genetic element, known as Segregation Distorter (SD), that skews genetic inheritance. SD has caused dramatic changes in chromosome organization and genetic diversity, leading to the accumulation of deleterious mutations.
Researchers have discovered rare colonies of Rock Doves, the wild ancestors of common domestic and feral pigeons, on secluded Scottish and Irish islands. The findings provide valuable insights into how the domestic pigeon came to be, with varying degrees of interbreeding between the two forms of the species.
Researchers at New York University have created artificial Hox genes using synthetic DNA technology and genomic engineering in stem cells. The findings confirm that clusters of Hox genes help cells learn and remember where they are in the body, with no other genes needed to be present.