Articles tagged with Genes
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
Scientists have identified the DOMINANT AWN INHIBITOR (DAI) gene in sorghum, which regulates the absence and shortening of awns. The gene encodes a protein that negatively regulates awn formation as a transcription factor, with implications for breeding modern awnless cultivars.
A study led by Brigham and Women's Hospital investigators has revealed that alpha-synuclein plays a dual role in Parkinson's disease, interacting with both vesicles and P-body structures. This new understanding may lead to targeted treatments for the disease, with ongoing genetic studies aiming to identify optimal therapeutic targets.
Researchers identify genetic determinants of immune phenotypes in type 1 diabetes, highlighting 11 genes as potential candidates for new treatments. Genetic variants affecting T-cell composition and cytokine production were found to be significantly involved in the disease.
Researchers at UC San Francisco have identified five genes that enable efficient sleep, contrasting with current thinking that lack of sleep accelerates neurodegeneration. These genes may confer protections against neurological disease and improve sleep quality, paving the way for new treatments.
Scientists have discovered the orf137 gene responsible for male sterility in tomato plants, enabling the development of an efficient F1 hybrid breeding system. The study also demonstrates targeted mutagenesis and homologous recombination mechanisms underlying this trait.
Researchers discovered a population of Colorado blue columbines that have lost their petals and nectar spurs due to a single gene mutation. The finding supports the punctuated equilibrium hypothesis, suggesting that adaptation can occur in large jumps rather than gradual changes over extended timespans.
Researchers developed a new method to complete genetic data gaps using haplotype blocks, improving breeding efficiency in plants. The approach has shown comparable quality to collecting more information from DNA strands, reducing costs in animal and plant breeding.
Researchers from Hiroshima University analyzed 839 collections of genetic material to identify common features of oxidative stress. They found two genes, CRIP1 and CRIP3, downregulated during oxidative stress, suggesting a relationship with zinc homeostasis. The study also identified shared biological processes between the two types of...
Researchers found that patients with a rare genetic condition may develop chronic inflammatory bone diseases due to an impaired response to interferon gamma. The study suggests that this impairment leads to excessive osteoclast proliferation and increased bone resorption, causing multifocal osteomyelitis.
Researchers found that high levels of complement protein Ba are a reliable indicator of transplant-associated thrombotic microangiopathy development, contrary to previous reports. The study's findings provide hope for developing prophylactic treatments to prevent the disease.
A study published in Nature Communications found that microRNA-455 helps regulate cartilage homeostasis and slows cartilage degeneration in osteoarthritis. By targeting the gene hypoxia-inducible factor-2α, miR-455 treatment inhibits cartilage breakdown.
Researchers at Tokyo Medical and Dental University identified a microRNA molecule that can silence specific cancer-promoting genes, overcoming resistance to certain drugs. The study found that the miRNA target multiple genes and pathways simultaneously, making its impact potent.