Articles tagged with Genes
Researchers have assembled a near-complete genome map of northern wild rice (Zizania palustris), spanning 1.41 Gb with 47,804 predicted genes. This improved genome provides critical insights into the plant's unique adaptations and traits, supporting future breeding and sustainable cultivation.
Researchers found genetic adaptations underlying survival in hot and dry environments, revealing how natural selection enabled the Turkana to thrive in extreme conditions. The study identified key genes, including STC1, that play vital roles in conserving water and protecting kidneys from waste.
Researchers found genetic adaptations in response to micronutrient shortages and surpluses, particularly in regions with iodine-poor soils. The study provides insights into the impact of micronutrient availability on human evolution, highlighting potential vulnerabilities to deficiencies as climate change affects soil nutrient levels.
Researchers identified genes associated with breastfeeding disorders and postpartum breast cancer in the mammary gland, revealing potential new targets for investigation. The study provides a detailed atlas of genetic expression for the adult developmental cycle of the mammary gland.
The Gabriella Miller Kids First Pediatric Research Program has released its 36th study, introducing significant new data updates to two existing studies. These advances aim to uncover the genetic foundations of childhood cancers and congenital conditions. With over 110,000 data files available, researchers can explore publicly accessib...
Researchers discovered that languages from different continents and populations become more similar after contact, with rates of borrowing ranging from 4-9%. The team found that linguistic features are not consistently transferable, challenging long-held assumptions about language learning.
Researchers have identified shared gene signatures and key mechanisms underlying the progression from chronic liver cirrhosis to acute-on-chronic liver failure. Metabolic dysfunction, including altered glycolysis and gluconeogenesis pathways, plays a central role in both conditions.
Researchers have identified a group of proteins known as the GATOR1 complex as essential tumour suppressors that play critical roles in preventing lymphoma development. Disruption of these genes promotes lymphoma development and existing drugs targeting the same cellular pathways were highly effective at slowing growth.
Aging is harsh on the hippocampus, a region responsible for learning and memory. Researchers at UCSF identified protein FTL1, which slows cognitive decline in mice by increasing metabolism. Treating with a compound that stimulates metabolism prevents these effects. The study offers hope for therapies to block FTL1's impact.
Researchers at Salk Institute launched a machine learning framework called ShortStop to explore overlooked DNA regions and discover microproteins with potential roles in disease. The tool identified 210 new microprotein candidates in lung cancer data, including one validated target for therapeutic treatment.
A new genomic study has identified 178 de novo genes in peaches, which have evolved from noncoding DNA regions. These genes are expressed in reproductive tissues and contribute to important biological functions, shedding light on how novel genes can arise, diversify, and become essential parts of plant growth and evolution.
A large-scale genetic study found ten new regions associated with the ability to detect specific odours, with three showing sex-specific effects. The research also uncovered a link between the risk of Alzheimer's disease and the sense of smell, highlighting the interconnectedness of these senses.
A new study by University of South Australia researchers uses genetic recall to explore links between multiple sclerosis (MS) and the Epstein-Barr virus. The study aims to identify early warning signs or biomarkers for MS, enabling early detection and intervention.
Researchers at The University of Osaka have developed a novel technology to unzip DNA's double helix structure, allowing for efficient and accurate genetic testing. The device uses a nano-sized platinum coil and precise heating to minimize DNA damage and read information from the DNA molecule.
New research reveals that body size and caste in ants are coupled, with genetics determining the threshold for becoming a queen. Genes influence size and modify the size at which queen-like traits emerge, affecting the probability of becoming a queen.
A new study reveals B cell-derived ELL2 as a promising biomarker for diagnosing and predicting the prognosis of sepsis. The research identified three subtypes with significantly different prognoses, which were consistently reproduced across all cohorts.
A team of researchers has discovered the regulation of de novo genes in fruit flies, finding that transcription factors and genomic neighbors play a crucial role in switching these genes on. The study also reveals that de novo genes often share regulatory elements with adjacent genes, suggesting a mechanism of co-regulation.
Researchers at Florida Atlantic University have secured two key grants to investigate targeting the MBLAC1 gene as a new approach to treat glioblastoma, a very aggressive and fast-growing type of brain cancer. The project aims to advance innovative projects that could make a meaningful impact on cancer therapy.
Researchers mapped human cell cycle gene activity and found recently evolved transcription factors play a crucial role in regulating the process. Disabling these genes caused cells to struggle with DNA copying and division timing.
Researchers have successfully synthesized a new allohexaploid wheat, Triticum kiharae, by hybridizing Timopheevii wheat and goat-grass. This approach allows for the simultaneous introgression of genetic variations from wild relatives into common wheat, potentially enhancing its intraspecific genomic diversity.
Researchers found that low-cost genetic testing methods can effectively detect BRCA2 and HOXB13 mutations linked to increased prostate cancer risk. These findings support the adoption of precision medicine in prostate cancer care, enabling better diagnosis and personalized treatment plans.
Researchers identified a gene mutation that disrupts iron absorption in patients with Crohn's disease, leading to persistent anemia. The study sheds light on how genetic risk factors for IBD can compound patient symptoms by interfering with nutrient absorption.
A study published in PLOS One reveals that cats' purring behavior is linked to genetic variation, specifically the short-type androgen receptor gene. Cats with this gene exhibit higher owner-assessed purring scores than those with the long-type gene.
As women age, more genes on their X chromosomes escape silencing, potentially influencing disease. This epigenetic change may explain sex-based differences in age-related diseases.
Scientists have identified a brain molecule called NEAT1 that appears to play a central role in triggering light sensitivity (photophobia) during migraines. By disrupting the normal balance of nerve signaling and pain regulation, NEAT1 makes nerves more sensitive to light.
Researchers have discovered a selfish X chromosome in fruit flies that manipulates inheritance in both males' sperm and females' eggs. The supergene's unique structure allows it to expand and accumulate repetitive DNA sequences contributing to its ability to cheat during female reproduction.
Researchers at UC San Diego found that HPV DNA hybridizes with human DNA genes in oropharyngeal cancer cells, forming ecDNA that promotes tumor growth. This study suggests that selectively targeting ecDNA-disrupting therapeutics could slow tumor growth while leaving normal cells intact.
A research team identified a new gene called TaMs6 that controls male fertility in wheat, enabling the development of hybrid wheat varieties. The study found that TaMs6 regulates lipid metabolism and is expressed during critical stages of pollen formation, making it essential for producing fertile pollen.
Researchers have identified an epigenetic mechanism underlying hemizygote-dependent super-early flowering in soybean transformants. The study reveals that a specific gene expression system can be designed to respond to genetic dosage through epigenetic elements, offering new tools for precise regulation of flowering and maturation.
Research reveals pregnancy-induced immune shifts affecting disease susceptibility and delivery outcomes, with adaptations in T cells, B cells, and monocytes identified across stages.
Scientists discovered a protective variant of the HAQ-STING gene that prevents COPA Syndrome. This finding opens the door to a new gene therapy for the condition, which currently has no cure.
A research team led by Hidemasa Bono mapped the genomes of susceptible and resistant bed bug strains, revealing new insights into the development of pyrethroid resistance. The study identified 729 resistance-specific mutations in protein-coding genes related to DNA damage response, cell cycle regulation, and lysosome functions.
A team of biologists at UT Arlington has discovered a new species of gecko, Pseudogonatodes fuscofortunatus, with distinct skeletal features and genetic data. The discovery highlights the unique characteristics of this tiny lizard, found in the Paria Peninsula of Venezuela.
A new AI tool called PIONEER has been developed to predict protein-protein interaction mutations in hundreds of diseases, including dozens of cancers. The tool allows researchers to navigate the interactome for over 10,500 diseases and identify potential drug targets.
Researchers found specific gene mutations in barley affect starch synthesis, forming elongated starch granules with altered properties. Mutations disrupt enzymes, altering glucose chain formation and branching.
The ASHG 2024 Annual Meeting will showcase the latest research in human genetics and genomics. The event will feature a Presidential Symposium on Mendelian traits and a Distinguished Speakers Symposium on the promise of human genetics and genomics, among other sessions.
The study reveals hormone-dependent molecular mechanisms that cause sexual dimorphism in chicken feathers, including the role of thyroid hormone activation/inactivation system. The findings also shed light on the cultural significance of chickens in Japanese society and its impact on promoting social cohesion.
Researchers at UC San Diego have developed a faster and more affordable method to study chromatin organization, which influences gene activation and cell function. The droplet Hi-C technique has been successfully deployed to analyze chromatin organization in mouse brain cells and human tumors.
Researchers create a novel paradigm for adding non-canonical amino acids to proteins by using four RNA nucleotides instead of the traditional three. This approach allows for efficient and targeted incorporation of new building blocks into specific sites in target proteins, enabling the creation of tailored proteins with unique functions.
A research team at Hiroshima University developed an analytical pipeline to identify unexploited genes associated with Parkinson's disease and oxidative stress. The study revealed two novel candidate genes, NUPR1 and UHRF2, which were absent from current gene-disease associations databases.
Researchers predict that circular RNAs will play a crucial role in cancer diagnosis and treatment, enabling innovative diagnostic and therapeutic developments. The study highlights the potential of circRNAs as biomarkers, therapy targets, and even immune response inducers against cancer cells.
A cross-sectional study found that men from disadvantaged neighborhoods had higher stress-related gene expression in their prostate tumors. This association suggests a potential link between neighborhood factors and aggressive prostate cancer.
Hybrids between two manakin species in Panama have remained relatively stable over the past 30 years, with minimal changes in genomic markers. The phenotypic transition zone also shows stability, with only one trait having shifted location, suggesting a potential selection for green bellies.
A research team from Göttingen University has discovered that antisense RNA (asRNA) plays a crucial role in cell transport, allowing cells to accelerate gene expression and produce proteins quickly in response to environmental stress or harm. This new understanding sheds light on the function of asRNAs and their potential link to disea...
A comprehensive molecular portrait of KRAS has been established, revealing its key role in pancreatic cancer progression and resistance to treatment. The study identifies ERK as a critical regulator of KRAS activity, with implications for developing targeted therapies.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers analyzed the genome of Corylus chinensis to understand its demographic history and adaptive potential. They found species-specific gene families involved in adaptation and identified diverged genetic lineages with southwest-northern differentiation patterns.
A study utilizing RNA-Seq and single-cell RNA-Seq data identified key transposable elements (TEs) linked to myocarditis. These findings reveal a significant role for TEs in modulating immune responses, providing new insights into cardiomyopathy's pathogenesis.
Researchers at Hiroshima University identified 14 genes that are up-regulated and eight genes that are down-regulated when responding to five specific abiotic stresses, including drought, salinity, and cold. These findings provide new insights into the molecular mechanisms underlying plant responses to environmental stressors.
A study found specific genetic mutations, including a previously reported mutation and a novel variant, linked to DJS. The mutations disrupt the liver's ability to eliminate waste products, leading to a buildup of bilirubin.
Researchers at the Francis Crick Institute have identified the first prehistoric person with mosaic Turner syndrome, characterized by one X chromosome instead of two. The study also found the earliest known incidence of Jacob's syndrome, Klinefelter syndrome, and an infant with Down Syndrome in ancient DNA samples.
Researchers from National University of Singapore have synthesised a redesigned yeast chromosome XV, comprising 1.05 million base pairs. The novel technology, CRISPR/Cas9-mediated mitotic recombination with endoreduplication (CRIMiRE), speeds up the assembly process, allowing for rapid reconfiguration of the synthetic chromosome.
A new study confirms the presence of deadly Vibrio bacteria in Florida's coastal waters following Hurricane Ian. The research, led by University of Maryland senior author Rita Colwell, found high levels of pathogenic Vibrio parahaemolyticus and Vibrio vulnificus, particularly in oyster samples from Lee County.
A recent study classified clubmosses into seven primary clades and nineteen genera, with twelve newly described genera. This classification offers advantages for analysis, communication, and conservation of these ancient vascular plants.
Scientists successfully transfer a longevity gene from naked mole rats to mice, resulting in improved health and a 4.4% increase in median lifespan. The gene enhances cellular repair and protection, reducing inflammation and cancer risk, paving the way for potential human longevity benefits.
Researchers at Nara Institute of Science and Technology identified the WOX13 gene as a key negative regulator of shoot regeneration in plants. The study found that WOX13 inhibits a subset of shoot meristem regulators while directly activating cell wall modifier genes involved in cell expansion and differentiation.
Researchers have discovered that gene editing technologies may introduce unintended mutations and damage to DNA in early human embryos. The study found that most cells repair breaks in the DNA using non-homologous end joining, which can lead to additional genetic abnormalities.
Researchers analyzed 557 subjects to link genetic variations, brain structure, and behavior to intelligence test performance. They found specific brain areas where gene variations influence brain characteristics, which in turn affect intelligence.
Researchers at NIH's National Human Genome Research Institute identified a gene, KTD1, that provides resistance to the K28 toxin in yeast. This discovery sheds light on the molecular mechanisms underlying toxin resistance and has implications for understanding human toxin resistance.
Researchers have solved an 80-year-old medical mystery that causes kidney damage in children and can be fatal in babies. They discovered a gene mutation is the primary cause, but found that around 10% of patients without the mutation still experience symptoms.