Hepatitis B
Articles tagged with Hepatitis B
Long-term dynamic virological response patterns and clinical outcomes in hepatitis B virus-related cirrhosis
Impact of removing the universal hepatitis B birth-dose vaccination in the US
Targeted birth-dose vaccine recommendation may increase neonatal HBV infections unless maternal screening improves or infant vaccination coverage increases. Universal screening and vaccination remain essential safeguards against these infections.
The cost of delaying childhood vaccination
A new study from Cornell University found that delaying the first dose of hepatitis B vaccine after birth leads to increased infections and higher healthcare costs. The longer the delay, the more severe the consequences for newborns, who are at high risk of developing chronic infections and premature death.
New study suggests reduced newborn hepatitis B vaccination coverage may increase infant infections
A recent study found that lower vaccination coverage among infants born to unscreened mothers is associated with a substantial increase in HBV infections. The researchers used simulation modeling to examine the impact of different levels of newborn vaccination coverage and maternal screening on HBV infection rates.
Economic impact of delaying the infant hepatitis B vaccination schedule
Brief delays in hepatitis B vaccine initiation result in substantial increases in virus infections, adverse health outcomes, and healthcare expenses. Economic evaluations reveal the significant financial burden of such delays on individuals and society.
Eight-year results from two randomized phase 3 trials of tenofovir alafenamide for chronic hepatitis B virus infection in China
This eight-year analysis showed that tenofovir alafenamide (TAF) maintained viral suppression, normalized alanine aminotransferase levels, and improved renal and bone safety in patients with CHB. The study's findings support the use of TAF as the preferred long-term treatment option for this population.
New clues to hepatitis B species restriction could help build a novel model for studying infection and testing therapies
Researchers have overturned decades-long assumptions about why HBV fails to infect mouse liver cells, pointing towards a new disease model. The study suggests that the problem lies in a late step during the viral entry process, which could be disrupted by certain mechanisms.
European Immunization Week 2026, For every generation, vaccines work: three countries reach 90% HPV vaccination target as Europe steps up action on cancer prevention
Three European countries reach 90% HPV vaccination coverage among girls by age 15, marking progress in cervical cancer prevention. HPV vaccination programmes show significant reductions in infections and precancerous lesions, with early administration increasing full protective potential.
Between 2.4 and 4.1 million people estimated to be living with chronic hepatitis B infection in Europe
The European Centre for Disease Prevention and Control estimates that between 2.4 and 4.1 million people in the EU/EEA are living with chronic hepatitis B infection. The prevalence varies significantly across countries, with the highest rates found in southern and eastern Europe.
Understanding pathogenesis of liver cirrhosis for improved clinical management
Researchers compare viral and MASLD cirrhosis pathogenic mechanisms, identifying shared pathways and diagnostic differences. The study aims to establish a framework for prevention, diagnosis, treatment, and monitoring of MASLD cirrhosis.
New study finds interferon therapy to be well-tolerated in compensated hepatitis B cirrhosis
A multicenter analysis of 920 patients with compensated cirrhosis found that interferon therapy was not associated with a higher risk of serious complications compared to standard treatment. Milder side effects were more common and required closer monitoring.
US newborn hepatitis B virus vaccination rates
A new study found that US newborn hepatitis B virus vaccination rates declined by over 10 percentage points in the last 2 years. This decline reverses 6 years of growth and is aligned with WHO and CDC coverage estimates through 2022.
Genotype-specific response to 144-week entecavir therapy for HBeAg-positive chronic hepatitis B with a particular focus on histological improvement
A prospective study of 49 treatment-naive CHB patients found that HBV genotype significantly influences liver histological response. Patients with genotype B showed higher histological improvement rates and greater inflammation resolution compared to those with genotype C.
Traditional and novel virologic markers for functional cure and HBeAg loss with pegylated interferon in chronic hepatitis B
A systematic review and meta-analysis of pegylated interferon treatment found HBsAg decline at week 24 to be the best predictor of functional cure, while on-treatment HBV RNA levels were most reliable for HBeAg loss. Novel virologic markers were less effective than traditional indicators.
CDC urges ‘shared decision-making’ on some childhood vaccines; many unclear about what that means
The CDC recommends shared clinical decision-making for some childhood vaccinations, allowing parents to choose or skip certain vaccines. However, a survey found that many Americans are unclear about what this means and who can be included as health care providers in the discussion.
Although public overwhelmingly supports hepatitis B vaccine for a newborn, partisan differences exist
A national survey of adults found that three-quarters support vaccinating newborns against hepatitis B, but Republicans are less likely to recommend the vaccine. The survey also found that most respondents believe the vaccine protects against liver disease, and there is little evidence justifying delaying vaccination.
Universal hepatitis B vaccination at birth – risks of revising the recommendation
Revising newborn hepatitis B vaccination guidelines may lead to increased perinatal infections, according to infectious disease experts. The study estimates that revoking the policy could result in a significant number of new infections.
Experts urge continued hepatitis B vaccine birth doses for newborns
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
Traditional Chinese medicine combined with peginterferon α-2b in chronic hepatitis B
This study found that combining traditional Chinese medicine with peginterferon α-2b significantly reduces hepatitis B surface antigen, HBeAg, and HBV DNA levels. The addition of TCM also reduced myelosuppression in treatment-discontinuing patients.
Emerging serum biomarkers for chronic hepatitis B: Focus on serum HBV RNA and HBcrAg
Serum HBV RNA and HBcrAg have emerged as promising biomarkers for chronic hepatitis B, enabling better monitoring of disease progression, treatment response, and risk stratification. These markers provide a window into intrahepatic viral activity, correlating with clinical outcomes such as HCC development and liver fibrosis severity.
Study suggests link between hepatitis B immunity and lower risk of developing diabetes
People with hepatitis B immunity induced by vaccination have a lower risk of developing diabetes of any kind. The study found that higher HBsAb levels were associated with greater reductions in diabetes risk.
Cumulative hepatitis B surface antigen/hepatitis B virus DNA ratio in immune-tolerant hepatitis B patients
A study found that in immune-tolerant HBV patients, a cumulative HBsAg/HBV DNA ratio below 1.791 is associated with a lower risk of disease progression, while those above this threshold face increased risk. Early antiviral treatment may improve clinical outcomes for these patients.
Interim analysis of 48-week tenofovir amibufenamide treatment in chronic hepatitis B patients with normal alanine aminotransferase levels
A 48-week interim analysis of tenofovir amibufenamide treatment found that 74.2% of patients achieved HBV DNA levels <20 IU/mL, demonstrating a favorable safety profile. The study suggests TMF treatment as a potential therapeutic option for chronic HBV-infected patients with normal ALT levels.
Reducing the global burden of liver cancer: Recommendations from The Lancet commission
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
New European toolkit launched by EU agencies to help eliminate viral hepatitis B and C in prisons
The European Union has launched a new toolkit to help eliminate viral hepatitis B and C in prisons across Europe. The toolkit provides practical tools and guidance for implementing interventions in prisons, with the goal of reducing transmission rates and promoting public health.
New study in Ukraine indicates significant lifetime exposure and ongoing transmission of hepatitis B and C viruses among the general population
A nationwide study in Ukraine found substantial lifetime exposure to hepatitis B and C viruses, with significant ongoing circulation among the population. The study emphasizes the need for hepatitis B vaccination among infants and risk groups, as well as regular screening, treatment, and awareness-raising efforts.
Therapeutic vaccine for chronic hepatitis B enters first clinical trial in patients
The TherVacB vaccine aims to activate the natural immune response to eliminate the hepatitis B virus. In a new phase 1b/2a clinical trial, 81 patients will receive increasing doses of the vaccine components to determine its safety and effectiveness.
Epidemiology, achievements, and challenges in the elimination of hepatitis B in China
Despite reducing HBV prevalence from 9.72% to 5.86%, China still struggles with chronic infection, diagnosed cases, and treatment accessibility, particularly in rural areas. Innovative treatments and digital health tools hold promise for improving compliance and achieving functional cure.
Multiple testing for infectious diseases key to cutting onward transmission
A new study found that routine testing for multiple infectious diseases among migrants can identify key infections earlier, improving health outcomes and reducing onward transmission. The Leicester screening programme, which tested 4004 migrant patients, revealed new diagnoses of TB, Hepatitis B and C, and HIV.
Chinese researchers reveal core cellular network modulating immune phenotype switching in hepatitis B
This study explored the immune dynamics across different phases of HBV infection, identifying key factors influencing T cell function and liver priming. The research team uncovered distinct types of intrahepatic T lymphocytes and dual roles of DC-SIGN+ macrophages in modulating immune responses.
Making the next five years count: Europe not on track to reach 2030 Sustainable Development Goal targets on HIV, TB, viral hepatitis B and C and STIs
The EU/EEA is struggling to reach 2030 SDG targets for HIV, TB, viral hepatitis B and C, and STIs, with many countries not on track. Despite progress in some areas, significant data gaps hinder a complete assessment.
Hydronidone for the treatment of liver fibrosis associated with chronic hepatitis B
A Phase 3 clinical study found that adding hydronidone to entecavir resulted in significant reversal of liver fibrosis. The trial aimed to identify the antifibrotic effect and safety of hydronidone for CHB patients with significant liver fibrosis.
Prevalence of hepatitis D virus antibody positivity in Chinese patients with chronic hepatitis B virus infection
A study estimated the epidemiology of hepatitis D virus (HDV) in China, finding a prevalence of HDV antibody positivity among 4,936 patients with chronic HBV infection. The rate was 0.24%, with only one patient having both anti-HDV antibody and HDV RNA positivity.
Hepatitis B: new rapid diagnostic test to halt mother-to-child transmission
A new rapid diagnostic test can accurately identify pregnant women with high levels of the hepatitis B virus, allowing for early detection and intervention. This breakthrough test could have a significant impact on hepatitis B management in low- and middle-income countries, reducing the spread of the infection.
Newer hepatitis B vaccine shows promise as booster for health care workers
A new hepatitis B vaccine, Heplisav-B, was compared to standard vaccines in a study of previously vaccinated individuals. The results showed that Heplisav-B was more effective at boosting immunity, with 99.4% achieving protective levels compared to 92.7% for standard vaccines.
New study by Korea University researchers reveals a safer alternative for long-term hepatitis B treatment
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
Interventions identified to eliminate transmission of hepatitis B in Africa
A large-scale analysis sheds light on the critical steps needed to combat the vertical transmission of chronic hepatitis B virus (HBV) in Africa. The study estimates that hepatitis B vertical transmission could be eliminated in Africa with increased coverage of birth dose vaccine and maternal antiviral therapy.
Digging into a decades-old hepatitis B mystery suggests a new potential treatment
Researchers at Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine have discovered a vulnerability in the hepatitis B virus that could lead to new treatments. The study found a compound already in clinical trials against cancer that successfully disrupted the virus's ability to infect human liver cells.
Hepatitis B is a problem for a growing number of patients on immunosuppressive medications
The American Gastroenterological Association recommends antiviral drugs for patients at risk of hepatitis B reactivation due to immunosuppressive medications. Screening and tailored risk assessments can help identify vulnerable patients, who are at increased risk of liver damage, hospitalization, and death.
Effectiveness and safety of tenofovir amibufenamide in the treatment of chronic hepatitis B: A real-world, multicenter study
A real-world multicenter study evaluated the effectiveness and safety of tenofovir amibufenamide in treating chronic hepatitis B. The study found that TMF was comparable to TDF in terms of treatment effectiveness, with improved renal safety and no impact on lipid levels.
Peripheral blood CD4+/CD8+ t cell ratio predicts HBsAg clearance in inactive HBsAg carriers treated with peginterferon alpha
Researchers found that a lower CD4+/CD8+ T cell ratio after 12-24 weeks significantly predicted HBsAg clearance in IHCs treated with peginterferon alpha. Higher baseline percentages of CD3+CD8+ cells and lower CD4+/CD8+ ratios were also associated with improved outcomes.
Updated Hep B vaccine more effective for people with HIV
A new hepatitis B vaccine, Heplisav-B, has been shown to be more effective than an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination. The study found that up to 99.4% of subjects received the new vaccine showed protective levels of antibodies.
Burden of liver cancer attributable to hepatitis B and alcohol globally, in China, and for five sociodemographic index regions from 1990 to 2021
This study analyzed liver cancer epidemiological trends attributed to hepatitis B and alcohol use, revealing substantial increases globally and in China. The burden varies by gender and age, with males and those aged 40-75 years bearing a higher risk.
Men who have sex with men in Europe still vulnerable to hepatitis A and B, highlighting need for public health action and support
Research analyzing European survey data from 113,884 men who have sex with men reveals that only 44% report being vaccinated against both hepatitis A and B. Strong public health support and creating an open environment are crucial to reduce outbreaks among MSM and eliminate hepatitis B.
A novel probe technology for detecting native albumin activity as a biomarker in patients with hepatitis B-related cirrhosis and hepatocellular carcinoma and its clinical applications
A novel ratiometric fluorescent probe was synthesized to detect native human albumin (HA) activity in patients with hepatitis B cirrhosis and hepatocellular carcinoma. Native HA activity levels were significantly higher in low albumin groups, correlating with increased severity of liver disease.
Anti-hepatitis b virus treatment with tenofovir amibufenamide has no impact on blood lipids: A real-world, prospective, 48-week follow-up study
A 48-week follow-up study found that TMF treatment did not significantly affect blood lipid profiles in patients with chronic hepatitis B. Lipid indices remained stable, regardless of baseline characteristics.
How stigma affects Asian Americans living with hepatitis B
A study by Dr. Hee-Soon Juon found that those who felt stigmatized reported worse depression and physical health, despite greater knowledge of the disease not alleviating feelings of judgment.
Chinese Medical Journal study reframes guidelines for transarterial chemoembolization refractoriness in hepatocellular carcinoma treatment
The Chinese College of Interventionalists has introduced a consensus statement on TACE refractoriness in hepatocellular carcinoma, providing a framework for clinicians to identify and manage the condition. This move aims to optimize treatment strategies and improve patient outcomes, particularly in China where HCC incidence is high due...
Study highlights sex differences in notified infectious disease cases across Europe
A study analyzing 5.5 million EU/EEA infectious disease cases over 10 years found significant sex differences in notified male versus female cases for several diseases. The proportion of males ranged from 40-45% for pertussis and Shiga toxin-producing Escherichia coli infections to 75-80% for HIV/AIDS.
“Treat-all” strategy for patients with chronic hepatitis b virus infection in China: Are we there yet?
A new strategy for treating chronic hepatitis B virus infection in China advocates for early treatment of all patients with detectable HBV DNA or positive HBsAg. This approach aims to reduce liver-related diseases and improve patient outcomes.
Hepatitis B: "Sleep timer" for immune cells discovered
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
Dopamine inhibits the expression of hepatitis b virus surface and e antigens by activating the JAK/STAT pathway and upregulating interferon-stimulated gene 15 expression
A study found that dopamine inhibits the expression of HBV surface and e antigens in HepG2 cells, increasing interferon-stimulated gene 15 expression. The JAK/STAT pathway was also activated, leading to decreased HBV DNA and antigen expression in a mouse model.
Researchers may have found an Achilles heel for Hepatitis B
Hepatitis B virus (HBV) infects about 296 million people and kills 1 million annually. Researchers from Rockefeller University have revealed mechanisms that may lead to new treatments by targeting the pol protein's unique properties, including a 'tethering' mechanism that allows it to bind to specific RNAs.
Five-year treatment with tenofovir alafenamide achieves high rates of viral suppression, alanine aminotransferase normalization, and favorable bone and renal safety in Chinese chronic hepatitis B patients
The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B patients. Favorable effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.
Hepatitis B is globally underassessed and undertreated, especially among women and Asian minorities in the West
A new study reveals that chronic hepatitis B is globally undertreated, especially among women and Asian minorities in the West. The research highlights the need for targeted outreach to reduce new infections and deaths, with oral antiviral therapy being a lifesaving but underutilized treatment option.
Beneficial effects of traditional Cinese medicine Fuzheng Huayu on the occurrence of hepatocellular carcinoma in patients with compensated chronic hepatitis b cirrhosis receiving entecavir
A multicenter retrospective cohort study found that combining entecavir with Fuzheng Huayu reduced the cumulative incidence of hepatocellular carcinoma in patients with compensated chronic hepatitis B cirrhosis. The antifibrotic property of FZHY may be attributed to its beneficial effects on this population.
The relationship between viral replication and the severity of hepatic necroinflammatory damage changed before HBeAg loss in patients with chronic hepatitis B virus infection
Studies found a negative relationship between HBV replication and liver inflammation in HBeAg-positive patients with high viral DNA levels, which shifted to positive relationships for those with low DNA levels or HBeAg-negative status. This interaction suggests a complex relationship between viral replication and liver damage progression.
Could novel immune cell therapy combat hepatitis B infections?
Researchers identify a promising strategy for combating hepatitis B virus (HBV) by boosting the effects of immune cells called stem cell memory T cells (TSCMs). In a mouse model, introducing TSCMs from patients into mice resulted in the elimination of HBV-infected liver cells.
Simulating tiny invaders
Scientists used Delta's GPU-based architecture to study the life cycle of the Hepatitis B virus, revealing how it binds human proteins called importins. The research provides a platform for developing inhibitors that could block this interaction and prevent the virus from accessing the nucleus.