Articles tagged with Hepatitis B
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A systematic review and meta-analysis of pegylated interferon treatment found HBsAg decline at week 24 to be the best predictor of functional cure, while on-treatment HBV RNA levels were most reliable for HBeAg loss. Novel virologic markers were less effective than traditional indicators.
The CDC recommends shared clinical decision-making for some childhood vaccinations, allowing parents to choose or skip certain vaccines. However, a survey found that many Americans are unclear about what this means and who can be included as health care providers in the discussion.
A national survey of adults found that three-quarters support vaccinating newborns against hepatitis B, but Republicans are less likely to recommend the vaccine. The survey also found that most respondents believe the vaccine protects against liver disease, and there is little evidence justifying delaying vaccination.
Revising newborn hepatitis B vaccination guidelines may lead to increased perinatal infections, according to infectious disease experts. The study estimates that revoking the policy could result in a significant number of new infections.
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
This study found that combining traditional Chinese medicine with peginterferon α-2b significantly reduces hepatitis B surface antigen, HBeAg, and HBV DNA levels. The addition of TCM also reduced myelosuppression in treatment-discontinuing patients.
Serum HBV RNA and HBcrAg have emerged as promising biomarkers for chronic hepatitis B, enabling better monitoring of disease progression, treatment response, and risk stratification. These markers provide a window into intrahepatic viral activity, correlating with clinical outcomes such as HCC development and liver fibrosis severity.
People with hepatitis B immunity induced by vaccination have a lower risk of developing diabetes of any kind. The study found that higher HBsAb levels were associated with greater reductions in diabetes risk.
A study found that in immune-tolerant HBV patients, a cumulative HBsAg/HBV DNA ratio below 1.791 is associated with a lower risk of disease progression, while those above this threshold face increased risk. Early antiviral treatment may improve clinical outcomes for these patients.
A 48-week interim analysis of tenofovir amibufenamide treatment found that 74.2% of patients achieved HBV DNA levels <20 IU/mL, demonstrating a favorable safety profile. The study suggests TMF treatment as a potential therapeutic option for chronic HBV-infected patients with normal ALT levels.
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
The European Union has launched a new toolkit to help eliminate viral hepatitis B and C in prisons across Europe. The toolkit provides practical tools and guidance for implementing interventions in prisons, with the goal of reducing transmission rates and promoting public health.
A nationwide study in Ukraine found substantial lifetime exposure to hepatitis B and C viruses, with significant ongoing circulation among the population. The study emphasizes the need for hepatitis B vaccination among infants and risk groups, as well as regular screening, treatment, and awareness-raising efforts.
The TherVacB vaccine aims to activate the natural immune response to eliminate the hepatitis B virus. In a new phase 1b/2a clinical trial, 81 patients will receive increasing doses of the vaccine components to determine its safety and effectiveness.
Despite reducing HBV prevalence from 9.72% to 5.86%, China still struggles with chronic infection, diagnosed cases, and treatment accessibility, particularly in rural areas. Innovative treatments and digital health tools hold promise for improving compliance and achieving functional cure.
A new study found that routine testing for multiple infectious diseases among migrants can identify key infections earlier, improving health outcomes and reducing onward transmission. The Leicester screening programme, which tested 4004 migrant patients, revealed new diagnoses of TB, Hepatitis B and C, and HIV.
This study explored the immune dynamics across different phases of HBV infection, identifying key factors influencing T cell function and liver priming. The research team uncovered distinct types of intrahepatic T lymphocytes and dual roles of DC-SIGN+ macrophages in modulating immune responses.
The EU/EEA is struggling to reach 2030 SDG targets for HIV, TB, viral hepatitis B and C, and STIs, with many countries not on track. Despite progress in some areas, significant data gaps hinder a complete assessment.
A Phase 3 clinical study found that adding hydronidone to entecavir resulted in significant reversal of liver fibrosis. The trial aimed to identify the antifibrotic effect and safety of hydronidone for CHB patients with significant liver fibrosis.
A study estimated the epidemiology of hepatitis D virus (HDV) in China, finding a prevalence of HDV antibody positivity among 4,936 patients with chronic HBV infection. The rate was 0.24%, with only one patient having both anti-HDV antibody and HDV RNA positivity.
A new rapid diagnostic test can accurately identify pregnant women with high levels of the hepatitis B virus, allowing for early detection and intervention. This breakthrough test could have a significant impact on hepatitis B management in low- and middle-income countries, reducing the spread of the infection.
A new hepatitis B vaccine, Heplisav-B, was compared to standard vaccines in a study of previously vaccinated individuals. The results showed that Heplisav-B was more effective at boosting immunity, with 99.4% achieving protective levels compared to 92.7% for standard vaccines.
A new study by Korea University researchers reveals that switching to besifovir may improve patient kidney and bone health for long-term hepatitis B treatment. The study showed that patients who switched to besifovir had higher estimated glomerular filtration rate indicating improved kidney function and higher hip and spine bone densit...
A large-scale analysis sheds light on the critical steps needed to combat the vertical transmission of chronic hepatitis B virus (HBV) in Africa. The study estimates that hepatitis B vertical transmission could be eliminated in Africa with increased coverage of birth dose vaccine and maternal antiviral therapy.
Researchers at Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine have discovered a vulnerability in the hepatitis B virus that could lead to new treatments. The study found a compound already in clinical trials against cancer that successfully disrupted the virus's ability to infect human liver cells.
The American Gastroenterological Association recommends antiviral drugs for patients at risk of hepatitis B reactivation due to immunosuppressive medications. Screening and tailored risk assessments can help identify vulnerable patients, who are at increased risk of liver damage, hospitalization, and death.
A real-world multicenter study evaluated the effectiveness and safety of tenofovir amibufenamide in treating chronic hepatitis B. The study found that TMF was comparable to TDF in terms of treatment effectiveness, with improved renal safety and no impact on lipid levels.
Researchers found that a lower CD4+/CD8+ T cell ratio after 12-24 weeks significantly predicted HBsAg clearance in IHCs treated with peginterferon alpha. Higher baseline percentages of CD3+CD8+ cells and lower CD4+/CD8+ ratios were also associated with improved outcomes.
A new hepatitis B vaccine, Heplisav-B, has been shown to be more effective than an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination. The study found that up to 99.4% of subjects received the new vaccine showed protective levels of antibodies.
This study analyzed liver cancer epidemiological trends attributed to hepatitis B and alcohol use, revealing substantial increases globally and in China. The burden varies by gender and age, with males and those aged 40-75 years bearing a higher risk.
Research analyzing European survey data from 113,884 men who have sex with men reveals that only 44% report being vaccinated against both hepatitis A and B. Strong public health support and creating an open environment are crucial to reduce outbreaks among MSM and eliminate hepatitis B.
A novel ratiometric fluorescent probe was synthesized to detect native human albumin (HA) activity in patients with hepatitis B cirrhosis and hepatocellular carcinoma. Native HA activity levels were significantly higher in low albumin groups, correlating with increased severity of liver disease.
A 48-week follow-up study found that TMF treatment did not significantly affect blood lipid profiles in patients with chronic hepatitis B. Lipid indices remained stable, regardless of baseline characteristics.
A study by Dr. Hee-Soon Juon found that those who felt stigmatized reported worse depression and physical health, despite greater knowledge of the disease not alleviating feelings of judgment.
The Chinese College of Interventionalists has introduced a consensus statement on TACE refractoriness in hepatocellular carcinoma, providing a framework for clinicians to identify and manage the condition. This move aims to optimize treatment strategies and improve patient outcomes, particularly in China where HCC incidence is high due...
A study analyzing 5.5 million EU/EEA infectious disease cases over 10 years found significant sex differences in notified male versus female cases for several diseases. The proportion of males ranged from 40-45% for pertussis and Shiga toxin-producing Escherichia coli infections to 75-80% for HIV/AIDS.
A new strategy for treating chronic hepatitis B virus infection in China advocates for early treatment of all patients with detectable HBV DNA or positive HBsAg. This approach aims to reduce liver-related diseases and improve patient outcomes.
A team of researchers has discovered a mechanism by which the liver's immune cells are suppressed in chronic hepatitis B, leading to organ damage. The 'sleep timer' function allows immune cells to weaken their activity over time, preventing them from proliferating excessively and causing further damage.
A study found that dopamine inhibits the expression of HBV surface and e antigens in HepG2 cells, increasing interferon-stimulated gene 15 expression. The JAK/STAT pathway was also activated, leading to decreased HBV DNA and antigen expression in a mouse model.
Hepatitis B virus (HBV) infects about 296 million people and kills 1 million annually. Researchers from Rockefeller University have revealed mechanisms that may lead to new treatments by targeting the pol protein's unique properties, including a 'tethering' mechanism that allows it to bind to specific RNAs.
The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B patients. Favorable effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.
A new study reveals that chronic hepatitis B is globally undertreated, especially among women and Asian minorities in the West. The research highlights the need for targeted outreach to reduce new infections and deaths, with oral antiviral therapy being a lifesaving but underutilized treatment option.
A multicenter retrospective cohort study found that combining entecavir with Fuzheng Huayu reduced the cumulative incidence of hepatocellular carcinoma in patients with compensated chronic hepatitis B cirrhosis. The antifibrotic property of FZHY may be attributed to its beneficial effects on this population.
Studies found a negative relationship between HBV replication and liver inflammation in HBeAg-positive patients with high viral DNA levels, which shifted to positive relationships for those with low DNA levels or HBeAg-negative status. This interaction suggests a complex relationship between viral replication and liver damage progression.
Researchers identify a promising strategy for combating hepatitis B virus (HBV) by boosting the effects of immune cells called stem cell memory T cells (TSCMs). In a mouse model, introducing TSCMs from patients into mice resulted in the elimination of HBV-infected liver cells.
Scientists used Delta's GPU-based architecture to study the life cycle of the Hepatitis B virus, revealing how it binds human proteins called importins. The research provides a platform for developing inhibitors that could block this interaction and prevent the virus from accessing the nucleus.
Researchers discovered a connection between hepatitis B and C viruses and multiple myeloma, finding that antiviral treatment can improve outcomes. The study suggests that early detection of these infections may lead to better treatment and survival rates for patients with this cancer.
A comprehensive study finds that continuous antiviral therapy significantly reduces the risk of liver nodules and cirrhosis in HBeAg-negative CHB patients. Patients with high HBV DNA levels also show a significant decrease in liver cirrhosis risk with ongoing treatment.
A novel method using functional resilience assesses liver conditions through clinical blood tests, achieving a macro-averaged precision of 84.74%. This approach reduces the need for excessive imaging exams and optimizes medical resource utilization.
Researchers found that hepatitis C treatment improved response to hepatitis B vaccine in individuals who previously didn't respond. The study recommends checking for hepatitis B immune protection and offering vaccination after treatment.
Researchers have developed an approach to studying HBV in the lab, allowing for a sharper view of its behaviors and characteristics during its life cycle. This breakthrough could lead to improved drug treatments and potentially even a cure for hepatitis B.
A Danish study has validated a dried blood spot test that can detect HIV, hepatitis B, and hepatitis C from a single drop of blood. The test uses existing hospital equipment and is suitable for places where needle-based testing is not practical or feasible.
Researchers found that after 96 weeks, some patients achieved loss of detectable HBsAg and reduced liver inflammation levels, indicating functional cure. The study suggests that discontinuing long-term antiviral therapy may be more effective than continuing it for certain patients.
A study published in Journal of Hepatology found that some patients with chronic hepatitis B can achieve sustained immune control by discontinuing antiviral therapy after four years. This suggests a potential cure for the disease, which affects an estimated 350 million people worldwide.
The study sheds light on Beethoven's health problems, including progressive hearing loss and chronic gastrointestinal complaints. Genetic risk factors for liver disease were identified, and evidence of a hepatitis B virus infection was found in the composer's final months.
Researchers analyzed DNA from Beethoven's hair to shed light on his chronic health problems, including progressive hearing loss. They found genetic risk factors for liver disease and evidence of a hepatitis B virus infection, which likely contributed to his death.
Three real-world studies published in the Journal of Hepatology and JHEP Reports demonstrate that bulevirtide is well-tolerated and safe for treating chronic hepatitis delta. Long-term suppressive therapy with BLV monotherapy has the potential to reduce viral replication and improve liver function in difficult-to-treat patients.
A new set of guidelines has been established to quantify hepatitis B virus DNA in infected liver cells, crucial for preclinical and clinical evaluation of therapeutic strategies. The standards were developed based on a study that identified the importance of sample type-tailored methods for accurate measurement.
Research reveals that commonly used antiretroviral drugs TAF and TDF directly impact mitochondria's energy production in immune cells. The study suggests a larger energy reduction when combined with other antiretrovirals, sparking concerns about potential long-term effects on human cells.
A study published in Journal of Hepatology found that efficient priming of HBV-specific CD4 T cells is crucial for the success of therapeutic hepatitis B vaccination. The researchers developed a novel heterologous prime-boost vaccine, TherVacB, which induced antiviral efficacy in preclinical mouse models.