ImCheck's ICT01 selectively activates Vγ9Vδ2 T cells through all three isoforms of BTN3A, overcoming prior limitations. The therapy demonstrates anti-tumor activity in solid and hematologic cancer models.
SourceTrophic Communications·JournalScience Translational Medicine·TypeRandomized controlled/clinical trial·DateOct 20, 2021
Researchers identified a new cell type in human skin contributing to AD and psoriasis, highlighting potential therapeutic targets. The study revealed CD14+ type 3 dendritic cells co-producing IL1B and IL23A, essential for PSO pathogenesis.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalJournal of Experimental Medicine·TypeExperimental study·DateSep 17, 2021
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research at TUM has discovered that non-alcoholic steatohepatitis (NASH) is caused by auto-aggressive immune cells. These cells destroy liver tissue when exposed to inflammation signals and products of fat metabolism, leading to NASH. New therapies may be developed to target this destructive immune response.
SourceTechnical University of Munich (TUM)·JournalNature·DateMar 24, 2021
A new study reveals unique immune features of severe pediatric COVID-19, including increased activation of killer T cells and prolonged B cell frequencies. These findings may inform treatments for severe COVID-19 in children.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience Immunology·DateMar 2, 2021
A potential preventative treatment for Crohn's disease has been demonstrated using a triple-punch treatment to remove T memory cells and increase T regulatory cells, preventing colitis in both mouse models and patient cells. This treatment approach may offer a new immunotherapy to prevent or ameliorate inflammatory bowel disease.
SourceUniversity of Alabama at Birmingham·JournalScience Immunology·DateDec 21, 2020
Researchers developed DNA-based nanovaccines that stimulate killer T cell immunity, resulting in tumor control. The synthetic vaccines enhanced CD8 T cell activation and induced muscle cell apoptosis, attracting macrophage infiltration and activating immune responses.
SourceThe Wistar Institute·JournalCancer Immunology Research·DateSep 10, 2020
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A novel acidic niche in lymph nodes regulates T cell activation, suppressing effector functions that could damage the system. The findings highlight the importance of localized acidosis in shaping T cell biology.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalNature Communications·DateAug 18, 2020
Rice University researchers suggest that T cell relaxation time is key to immune response, explaining how invaders prompt the immune system. The approach helps explain why T cells can react so fast and selectively, despite self-ligand imposters outnumbering invaders by a factor of 100,000.
SourceRice University·JournalBiophysical Journal·DateJun 16, 2020
Researchers at Temple University Health System aim to understand immunological synapse formation and its impact on T-cell activation. They will focus on the role of molecules like STIM1 and septins in shaping immune responses.
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found that manipulating cellular metabolism can modulate the balance between pathogenic Th17 and regulatory T cells in chronic autoimmune disorders. A mouse model showed that inhibition of mitochondrial OXPHOS delays disease onset and reduces severity, promoting the generation of suppressive Treg cells.
SourceUniversity of Alabama at Birmingham·JournalCell Reports·DateFeb 25, 2020
Cancer cells use a camouflaging effect to escape the immune system by binding to SHP2 and PD1, activating a response switch-off mechanism. Researchers at the University of Freiburg and Leibniz University Hannover have identified this protein interaction as a target area for new treatments.
SourceUniversity of Freiburg·JournalScience Advances·DateJan 31, 2020
Researchers at UNC Lineberger Comprehensive Cancer Center have discovered a way to regulate co-stimulatory molecules in genetically engineered immune cells, allowing for the fine-tuning of CAR-T activity. This could lead to improved therapeutic strategies against blood cancers and potentially solid tumors.
SourceUNC Lineberger Comprehensive Cancer Center·JournalCancer Cell·DateJan 30, 2020
A study by Temple-led researchers describes a unique mechanism for coordinating calcium entrance and exit 'doors' on T cells, which helps them carry out their jobs and ensure normal immune function. The research offers new insight into calcium signaling that could help scientists better understand autoimmune and immunodeficiency diseases.
SourceTemple University Health System·JournalScience Signaling·DateOct 8, 2019
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers identified links between genetic variants and early activation of memory T cells, suggesting problems with regulating this process could lead to immune diseases. The study's findings could help narrow down the search for molecular pathways involved in immune diseases.
SourceWellcome Trust Sanger Institute·JournalNature Genetics·DateSep 23, 2019
Researchers found vitamin D affects dendritic cells' ability to activate T cells, hindering the activation process and reducing immune reactions. The study sheds light on how vitamin D deficiency may regulate the immune system and influence susceptibility to autoimmune diseases.
SourceUniversity of Edinburgh·JournalFrontiers in Immunology·DateApr 17, 2019
A study by CU Anschutz researchers found that men who have sex with men have unique gut microbiomes that drive immune activation and may increase their risk of HIV infection. The study suggests a direct link between microbiome composition and immune activation in HIV-negative and HIV-positive MSM.
SourceUniversity of Colorado Anschutz Medical Campus·JournalPLOS Pathogens·DateApr 10, 2019
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A study found that gut microbes from high HIV-risk men who have sex with men drive immune activation in mice and HIV infection in cells. The researchers suggest that the gut microbiome might be a risk factor for HIV transmission in these individuals.
Researchers found that certain Gαs-coupled receptor agonists, including adrenaline and prostaglandin E2 and D2, prevent T cells from activating their integrins after recognizing their target. Sleep helps to decrease these molecules' levels, leading to higher integrin activation in T cells.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·DateFeb 12, 2019
Researchers at MD Anderson Cancer Center have discovered a link between FGL2 protein and glioblastoma progression. FGL2, known for suppressing the immune system, is highly expressed in GBM and can be eliminated by knocking it out, eliminating tumor progression in mice with intact immune systems.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Communications·DateJan 25, 2019
Research suggests that weakened metabolism of immune T cells, specifically one-carbon metabolism, may contribute to age-related immunity loss. Adding small-molecule compounds that boost T cell performance could potentially restore immune function.
SourceHarvard Medical School·JournalProceedings of the National Academy of Sciences·DateDec 13, 2018
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Researchers observed age-related changes in T cell mitochondrial size and respiratory capacity. Supplementing aged mice with formate and glycine improved T cell survival and growth, suggesting potential therapeutic strategies for boosting immune responses in older individuals.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateDec 10, 2018
Researchers at Tokyo Institute of Technology discover CLIP-170's critical role in T cell activation by relocating the microtubule-organizing center (MTOC) to the cell surface. This process is essential for immune response initiation and could lead to improved cancer immunotherapy.
SourceTokyo Institute of Technology·JournalScientific Reports·DateDec 6, 2018
Researchers studying a rare skin disorder called DEB found that loss of collagen VII affected the cellular microenvironment, leading to abnormal mRNA and protein turnover. Meanwhile, another study used novel proteomics to characterize changes in O-GlcNAc modification sites on proteins involved in T cell activation.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalMolecular & Cellular Proteomics·DateMar 12, 2018
Researchers at University of Utah Health identified a mechanism that activates T cells, a key component of the immune system, in patients with persistent Lyme arthritis. This activation mechanism triggers inflammation and arthritis by producing inflammatory molecules that accumulate around the joints.
SourceUniversity of Utah Health·JournalThe Journal of Immunology·DateFeb 5, 2018
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Scientists have discovered that T cell activation leads to a depletion of amino acids in the blood, which in turn affects neurotransmitters serotonin and dopamine, causing anxiety and fear responses. In mice without PD-1 receptor, they found behavioral changes dominated by anxiety and exacerbated fear responses.
Researchers found that PCSK9 inhibition can reverse the effects of oxidised LDL on immune activation, leading to an anti-inflammatory state that may directly influence atherosclerosis and cardiovascular disease. This new mechanism is independent of lowering LDL cholesterol.
Research reveals that cellular stress enhances Th17 cell activation, increasing the risk of autoimmune diseases such as arthritis and multiple sclerosis. Inhibiting cellular stress may hold promise for reducing disease symptoms by preserving other T cell responses.
SourceInstituto de Medicina Molecular·JournalCell Reports·DateJun 13, 2017
Researchers developed an artificial structure that can switch on immune cells to target and destroy cancer cells. The system mimics the cell membrane of antigen-presenting cells, which are responsible for activating immune responses against cancer.
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at Brigham and Women's Hospital identified a distinct gene module for T cell dysfunction, contributing to chronic disease states like cancer and chronic viral infections. A transcription factor, Gata-3, was found to play a crucial role in T cell dysfunction, offering new avenues for targeted therapy.
SourceBrigham and Women's Hospital·JournalCell·DateSep 8, 2016
Researchers at Helmholtz Zentrum München have identified two variants of the protein MALT1, which are regulated by posttranscriptional splicing and affect the immune response. The study found that stronger activation of T cells is associated with the MALT1A variant, while the MALT1B variant results in a weaker response.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature Communications·DateApr 12, 2016
Researchers propose that bacteria in the gut activate immune cells against proteins in the eye, leading to autoimmune uveitis. A study on mice found that eliminating gut bacteria delayed disease onset and severity, suggesting a potential therapeutic target for this condition.
SourceNIH/National Eye Institute·JournalImmunity·DateAug 18, 2015
Research finds gut microbes produce a molecule mimicking retinal protein, activating T cells responsible for autoimmune uveitis. The study offers a novel mechanism explaining how tissue-specific autoimmune diseases can arise from responses to gut microbes at a distal site in the body.
Higher levels of HMGB1, a 'danger' molecule fueling inflammation and blood pressure, may contribute to male hypertension. A new study suggests targeting HMGB1 could help prevent T cell activation and lower blood pressure.
SourceMedical College of Georgia at Augusta University·DateFeb 13, 2015
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at the La Jolla Institute for Allergy and Immunology report that Nuclear Factor of Activated T cells (NFAT) plays a key role in CD8 T cell exhaustion, leading to impaired immune responses. The study identifies NFAT as a molecular hub that orchestrates T cell activation and exhaustion.
SourceLa Jolla Institute for Immunology·JournalImmunity·DateFeb 12, 2015
Researchers discover enzyme SPPL3 activates T cells without cutting proteins, providing new insight into immune system control. The findings could also shed more light on presenilin functions and related Alzheimer's disease.
SourceJohns Hopkins Medicine·JournalMolecular and Cellular Biology·DateDec 29, 2014
Researchers discovered that integrin loss in dendritic cells leads to increased signaling through the GM-CSF receptor, reprogramming them into a mature phenotype. This activation triggers T cell immune response, offering insights into designing targeted therapies for autoimmunity and cancer treatments.
SourceUniversity of Helsinki·JournalNature Communications·DateOct 29, 2014
Researchers at the University of California, San Diego School of Medicine have discovered that T-cells are activated by a pain receptor called TRPV1 channel. The study shows that this receptor helps regulate intestinal inflammation in mice, suggesting a potential new target for treating certain autoimmune disorders.
SourceUniversity of California - San Diego·JournalNature Immunology·DateOct 5, 2014
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers discover a molecule that causes atherosclerosis also activates white blood cells called T cells in mice, worsening autoimmune disease symptoms. This finding sheds light on the link between autoimmunity and atherosclerosis, potentially leading to improved treatments.
Researchers at Rockefeller University Press develop a novel two-pronged approach to combat glioblastoma, a highly aggressive form of brain cancer. By combining interleukin-12 with a CTLA-4 blocking drug, the cocktail successfully eradicated tumors in mice, showing promise for future treatment.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·DateNov 25, 2013
Researchers at Howard Hughes Medical Institute discovered that the pool of inactive HIV viruses in a patient's body is larger than expected, with some retaining the ability to become active even after treatment. This finding suggests that targeting the inactive viruses, known as proviruses, is crucial for achieving a complete cure.
SourceHoward Hughes Medical Institute·JournalCell·DateOct 24, 2013
Scientists have developed two new indicator molecules that can visualize the activation of auto-aggressive T cells in the body, shedding light on the autoimmune disease multiple sclerosis. The indicators enable researchers to track T cell activity and activation patterns in real-time, offering new avenues for drug development.
SourceMax-Planck-Gesellschaft·JournalJournal of Clinical Investigation·DateMay 24, 2013
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers have identified a novel genetic mechanism underlying idiopathic CD4 lymphopenia, an immunodeficiency characterized by low levels of CD4 T cells. The mutation affects Unc119's ability to activate T cells and reduce Lck signaling, leading to impaired T cell proliferation.
Researchers at La Jolla Institute have identified a previously unknown molecular interaction between protein kinase C theta and CD28 that is essential for T lymphocyte activation. This discovery opens up a novel therapeutic avenue for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis by blocking the cellular inter...
SourceLa Jolla Institute for Immunology·JournalNature Immunology·DateOct 2, 2011
Researchers at The Wistar Institute have found that the protein Foxp1 actively maintains T cells in a 'quiescent state,' allowing them to work without antigenic triggers. Removing Foxp1 enables T cells to proliferate and become activated, which could lead to new treatments for diseases like cancer.
SourceThe Wistar Institute·JournalNature Immunology·DateMay 5, 2011
Researchers at the University of Gothenburg have discovered that superantigens, produced by staphylococcus bacteria, can activate the immune system in more ways than previously thought. This complex interaction may be behind several illnesses, including long-term wound infections and autoimmune disorders.
SourceUniversity of Gothenburg·JournalNature Communications·DateNov 28, 2010
Researchers at Scripps Research Institute have discovered the underlying mechanisms that activate gamma delta T cells in the skin and other organs. These cells play a unique role in recognizing damage or disease in epithelial tissues, and their activation is crucial for wound healing.
SourceScripps Research Institute·JournalScience·DateSep 2, 2010
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers found that minocycline effectively targets and reduces HIV replication in immune cells, providing an additional layer of defense against the virus. The antibiotic may improve current treatment regimens for HIV-infected patients when used in combination with HAART.
SourceJohns Hopkins Medicine·JournalThe Journal of Infectious Diseases·DateMar 19, 2010
A new TB booster vaccine has been shown to improve resistance to tuberculosis in previously vaccinated adults, according to a study published by the American Thoracic Society.
SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateMar 16, 2010
Scientists have discovered that Vitamin D is essential for activating killer cells in the immune system. Without sufficient vitamin D, T cells cannot detect and fight off serious infections. The researchers found that T cells rely on vitamin D to activate and that a lack of vitamin D can lead to immune suppression.
SourceUniversity of Copenhagen·JournalNature Immunology·DateMar 7, 2010
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers found that periodontal pathogens activate HIV-1 promoters in T-cells, monocytes/macrophages, and dendritic cells. TLR2 and TLR9 play a key role in this response.
SourceInternational Association for Dental, Oral, and Craniofacial Research·JournalJournal of Dental Research·DateMar 5, 2010
A new study reveals that HLA B*35-Px molecules cripple killer T cell responses, allowing HIV to progress more rapidly. This finding highlights the importance of inhibitory dendritic cell receptors in HIV-1 vaccine and therapy design.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·DateDec 14, 2009
A team of researchers has created a mouse model with key features of HIV infection, shedding light on the disease's mechanisms. The mouse exhibits symptoms similar to those of immunodeficiency virus infection, but with notable differences that highlight its limitations as a model for human disease.
SourceBMC (BioMed Central)·JournalJournal of Biology·DateNov 30, 2009
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A new study published in the Journal of Leukocyte Biology found that zinc activates a key protein on T cells needed to fight infections. Zinc supplementation has been shown to reduce the duration and severity of various illnesses, including childhood diarrhea and lower respiratory infections.
SourceFederation of American Societies for Experimental Biology·JournalJournal of Leukocyte Biology·DateJul 30, 2009
Research team finds that women's immune system activates more strongly in response to HIV-1, leading to higher levels of CD8+ T cell activation and faster disease progression. The study suggests that targeting this pathway may lead to new treatment strategies.
SourceMassachusetts General Hospital·JournalNature Medicine·DateJul 13, 2009
Researchers at Yale University have created nanowire sensors that can detect specific antigens and identify diseases with high sensitivity and specificity. The system uses immune cell activation to generate a current in the nanowires, allowing it to detect as few as 200 activated cells.
B cells can activate themselves in autoimmune diseases without T cell assistance, leading to a 'vicious cycle' of chronic disease. This finding may explain why treatments targeting T cells have been less effective and newer B cell-targeted therapies show promise.
SourceYale University·JournalImmunology·DateAug 7, 2008
Researchers at Helmholtz Munich have found that ubiquitin attaches to Malt1 protein in T cells upon antigen stimulation, regulating immune defense. This process is reversible and helps prevent over-activation of T cells, a common cause of chronic diseases.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalThe EMBO Journal·DateOct 19, 2007
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers found that a viral protein helps monkeys resist AIDS symptoms, but HIV-1 lacks this protective function, leading to increased immune activation and disease progression. The study suggests that treatments mimicking the primate immune system might offer a new approach to HIV therapy.
Research reveals that human T cells lack expression of certain 'Siglec' molecules, which regulate T cell activation in nonhuman primates. This absence may contribute to the disparity in disease susceptibility between humans and great apes. The study highlights the potential for Siglecs to act as a 'brake' on T cell activation.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateMay 1, 2006
Scientists have discovered a specific signaling pathway, PKA, that is crucial for T-cell activation and immune function. In microgravity, this pathway fails to respond to pathogens, leading to severe T-cell suppression.
SourceUniversity of California - San Francisco·DateOct 12, 2005