Articles tagged with Virology
Researchers identified four therapeutic monoclonal antibody candidates that neutralized a range of SARS-CoV-2 variants. Prolonged exposure to the virus triggered somatic hypermutations, equipping these antibodies with an extensive binding interface.
A new study published in Science Advances has found that certain antibodies against the Epstein-Barr virus can mistakenly target the brain and spinal cord, causing damage in multiple sclerosis patients. The research reveals a potential link between EBV infection and MS, with implications for personalized therapies.
A Phase 3 trial found that mailing HPV self-collection kits and scheduling assistance increased cervical cancer screenings among under-screened, underserved women. The study demonstrated the effectiveness of this approach in breaking down access barriers to screening.
A study found bats in disrupted ecosystems are more frequently infected with coronaviruses, linked to chronic stress and loss of resources. Land use changes such as agriculture, deforestation, and energy production increase the risk of bat infection.
A study by Osaka Metropolitan University found that users of heated tobacco products had a higher rate of COVID-19 infections and severe cases requiring hospitalization or oxygen. Researchers analyzed data from 30,130 participants and discovered a significant association between heated tobacco product use and increased risk of SARS-CoV...
The CoDe tool enables precise edits to genetic codes, making vaccines safer and more effective. It can also modulate gene expression in small sections, aiding vaccine design and basic research.
Researchers suggest a four-part framework to identify animal viruses that may infect humans, focusing on viruses from repeat offender families and those with known human compatibility. By studying these viruses early, scientists can develop diagnostic tools and treatments, and be better prepared to combat future pandemics.
Researchers identified 7 key symptoms of long COVID, including heart issues and joint pain, in a study of 52,461 patients. The findings could help healthcare providers diagnose and treat the condition more effectively.
Researchers found that measles virus mutations in its fusion protein allow it to infect nerve cells, leading to subacute sclerosing panencephalitis. The team's discovery sheds light on the evolutionary mechanisms of viruses like coronaviruses and herpesviruses.
Researchers developed a translational step forward in treating brain tumors using intraventricular immunovirotherapy, which has shown safety and efficacy in recent clinical trials. This approach uses oncolytic herpes simplex virus type-1 to target high-grade glioma with promising results.
Experts call for a nuanced discussion around gain of function research, highlighting its benefits for human health and its potential to reduce future disease outbreaks. The authors emphasize the need for evidence-based policies that balance safety concerns with the importance of this research in protecting humanity from viral threats.
Researchers have shed new light on viral genome replication machinery, revealing its intricate structure at atomic resolution. The study, published in PNAS, provides essential insights into the assembly, dynamic operation, and potential therapeutic targets of this complex machine.
Researchers found that high levels of mucosal IgA antibodies in the airways protect against SARS-CoV-2 infection for at least eight months, with a 90% lower risk of re-infection. Participants with prior infections generated stronger mucosal immune responses to Omicron breakthrough infections.
A new study found that COVID-19 primarily affected patients with a moderate to critical course, often with comorbidities, whereas many had mild courses despite metastatic melanoma and systemic therapy, recommending continued treatment whenever possible.
A study found that Ezo red foxes and Japanese raccoon dogs infected with HPAI virus had different outcomes due to varying diets. The fox died, while the raccoon dog survived but suffered damage to its eyes. The findings suggest that monitoring programs should be expanded to understand HPAI ecology and identify risk factors.
A team of researchers at the University of Nebraska-Lincoln has discovered that certain microorganisms, such as Halteria, can eat high numbers of chloroviruses, which are known to infect green algae. This finding suggests that virovory, a virus-only diet, can support physiological growth and even population growth in an organism.
Researchers have unveiled the mechanism behind monkeypox virus genome replication using cryo-microscopy. The findings could guide the development of antiviral drugs and may aid in preventing future outbreaks.
Researchers found that lncRNA MVIH is overexpressed in cervical cancer tumors and associated with younger age, lymph node metastasis, tumor invasion depth, and squamous cell type. This suggests its potential as a diagnostic biomarker for cervical cancer.
Researchers develop a new method to track disease-carrying mosquitoes by ingesting harmless DNA particles, providing unique fingerprints of information. This innovative approach has the potential to revolutionize mosquito-borne disease surveillance and tracking, offering insights into mosquito movement and hotspots.
A study found that individuals with blood group Rh(D) have a higher risk of contracting parvovirus, which causes fifth disease. The study screened over 160,000 blood donors in Germany and found all infected persons belonged to the Rh(D) blood group.
A new multivalent mRNA vaccine candidate has shown promising results in mice and ferrets, producing high levels of cross-reactive antibodies and offering protection against various influenza strains. The approach differs from previous universal flu vaccines by including antigens specific to each subtype.
Three circulating omicron subvariants have shown improved resistance to vaccine- and infection-generated neutralizing antibodies. BQ.1 and BQ.1.1 are dominating US infections, while BA.2.75.2 is the best at evading neutralizing antibodies.
Researchers at La Jolla Institute for Immunology have developed a new therapy for Lassa fever using a trio of rare human antibodies that can block viral infection. The therapy, called Arevirumab-3, was tested in non-human primates and proved 100% effective in treating the disease.
Recent advancements in pig-to-human transplants have demonstrated potential as a solution to the dire transplant organ shortage, with over 100,000 people awaiting transplants. Further research is needed to address challenges such as navigating ethical concerns and reducing organ rejection, but trials should continue in humans.
The Independent Task Force Report emphasizes the need for a One Health approach to prevent or respond adequately to the next pandemic. Key findings highlight the importance of 'Smart Surveillance' to identify high-threat pathogens and invest in R&D for innovative diagnostics, antiviral strategies, and therapeutic research.
Researchers developed a highly effective and safe Zika vaccine technology that prevents systemic infection in pregnant mice and stimulates an immunogenic reaction. The vaccine was tested in various mouse models, proving safe and protective against the virus.
Researchers at the University of Maryland Baltimore County have discovered that some viruses can sense their environment and
Researchers at Cleveland Clinic's FRIC found that cytoskeleton disruption is a key signal for the body to respond to viruses. This discovery has potential implications for developing new anti-viral vaccines and treatments.
Researchers developed an AI method to predict how well new COVID-19 variants infect human cells and evade antibodies. The system can analyze a million mutated variants, enabling the development of next-generation antibody therapies and vaccines that provide broader protection against potential future variants.
A US study found that health facilities in metropolitan areas with a high proportion of Black citizens were less likely to administer COVID-19 vaccines, indicating potential vaccine access barriers. The study suggests disparities in vaccine distribution across the country.
Scientists uncover ancient herpes DNA, revealing the virus's prehistoric origins around 5,000 years ago. The discovery suggests a link between the emergence of facial herpes and cultural practices like romantic and sexual kissing in Europe during the Bronze Age.
Researchers used virus-like particles to identify mutations in Omicron that make it more infectious and escape antibodies. The study found that mutations in the nucleocapsid protein are crucial for enhancing spread, highlighting potential new vaccine targets.
Researchers at the Institut Pasteur and CNRS studied SARS-CoV-2 replication in bat cells, finding that viral infection triggers a powerful immune response that prevents the virus from replicating. The study uses real-time imaging techniques to visualize the speed of cell infection and the formation of syncytia.
Researchers at Osaka Metropolitan University identified four proteins in saliva that bind to and inhibit SARS-CoV-2 entry, including neutrophil elastase and histone H2A. These findings may lead to the development of methods to prevent or treat COVID-19 infection.
New research found that coinfection with influenza A virus can significantly suppress SARS-CoV-2 replication in the lung. This effect can persist even after clearance of influenza A virus, suggesting potential factors that restrict SARS-CoV-2 growth.
Researchers report that apratoxin S4, an anticancer drug candidate, can interfere with viral replication in human cells. The compound was effective against multiple viruses, including SARS-CoV-2, influenza A, and Zika virus. Further studies are needed to confirm its potential as a broadly acting antiviral.
A UC San Diego study suggests COVID-19 rebound symptoms after taking Paxlovid are likely caused by insufficient drug exposure, not resistance or impaired immunity. The study found the virus remained sensitive to the drug and no relevant mutations were detected.
Researchers discovered that nano-sized electrostatic atomized water particles damage SARS-CoV-2 viral envelope, protein, and RNA, reducing its infectivity. The particles' reactive oxygen species (ROS) are responsible for this damage, posing a promising alternative disinfection method.
A new study published in mSystems demonstrates that a surface sampling method can detect SARS-CoV-2 RNA on surfaces, improving environmental surveillance in public health labs.
A new analysis reveals that marine RNA viruses predominantly infect protist and fungal hosts, including plankton, and sort into four distinct ecological zones. The study found that RNA viruses have a large influence on the ocean ecosystem, affecting processes like photosynthesis and ocean carbon flux.
A new coronavirus has been identified in Swedish bank voles, with the virus found in 3.4% of voles between 2015 and 2017. Researchers from Uppsala University discovered the 'Grimsö Virus' in red-backed voles caught around Grimsö in Örebro County.
Researchers at Hiroshima University have discovered a new non-radioactive compound that can be used to stain and image viruses in clear detail using TEM. The Preyssler-type phosphotungstate molecule is a good alternative to radioactive uranyl acetate, providing easy-to-use and stable results.
A new study analyzing 8 cohorts of COVID-19 patients found that antibody responses in previously infected individuals were relatively stable, providing protection from reinfection unless the new infection was the Omicron variant. Vaccination also boosted protection, with rapid immune responses observed even after a single vaccine dose.
Researchers found that a single mRNA vaccine booster shot can provide the same level of protection as three doses, making it a promising investment for resource-poor countries. The study suggests that this strategy could benefit billions of people worldwide and help combat emerging COVID-19 variants.
Research found that SARS-CoV-2 relies on human transmembrane proteins, especially IFITM2, to replicate efficiently and produce infectious viruses. Antibodies targeting IFITM2 can protect lung cells from infection, suggesting a promising therapeutic approach by targeting host factors instead of viral ones.
A global survey of ocean RNA sequences has identified thousands of previously unknown RNA viruses, doubling the number of orthornavirans. The study reveals new insights into the evolution of RNA viruses, including a 'missing link' in retroelement evolution.
A recent Cornell University study reveals that white-tailed deer can shed and transmit the COVID-19 virus for up to five days following infection. The virus replicates in the deer's respiratory tract, lymphoid tissues, and central nervous system, making them a potential reservoir for the virus in nature.
A study found that double vaccinated individuals generate a potent and broad neutralizing antibody response after a delta breakthrough infection. This response provides protection against current variants of concern, including omicron.
Researchers examined Kappa and Delta variant structures using cryo-EM, finding Delta's spike protein binds stronger with human ACE2 receptor. This explains the rapid global dominance of the Delta variant. The study provides insight into COVID-19 variants' evolution.
The authors argue that lethal mutagenesis, which introduces errors into viral genetic code, could be an important antiviral strategy. However, its long-term effects on human health are unclear and require further study.
Researchers detect four cryptic variants of SARS-CoV-2 in NYC wastewater samples, suggesting possible animal origins. The variants' mutations could help identify the next variant of concern for COVID-19.
A new smartphone app and lab kit can rapidly detect COVID-19 and flu viruses, providing a platform for inexpensive home-based testing. The system uses a smartphone's camera to measure a chemical reaction, achieving accurate diagnosis in 25 minutes at a fraction of the cost of current diagnostic methods.
Researchers have identified two new compounds that can inhibit the replication of human herpesviruses by targeting specific enzymes. This breakthrough offers new opportunities for developing agents against herpesviruses, which are currently difficult to treat effectively.
Acute COVID-19 infection can lead to various neurological symptoms, including confusion, stroke, and depression, which persist months after infection. The authors propose possible mechanisms, such as vascular and immune dysfunction, that may give rise to these symptoms and trigger future neurodegenerative diseases.
A new study found that a third dose of the BNT162b2 vaccine increases protection against the Omicron variant by 23-fold. The data suggest that a third dose augments antibody-based immunity against Omicron.
Northwestern University scientists have identified a key mechanism used by the Zika virus to evade the antiviral response of host cells. The study reveals how the virus suppresses interferon signaling to gain access to cells, providing a new target for antiviral therapeutics.
The use of self-spreading viruses in wildlife management and vaccine development poses significant risks due to their unpredictable nature. International institutions must be leveraged to address concerns and promote responsible research practices.
Researchers at the University of Louisville School of Dentistry found that oral bacteria like Porphyromonas gingivalis can suppress the production and effectiveness of proteins that protect humans from viral infection. This suppression increases vulnerability to infection, allowing viruses to enter the body more easily.
A new study reveals that SARS-CoV-2 limits viral particle release and instead spreads through cell-to-cell transmission, enabling efficient infection without the need for antibodies. This stealthy transmission method makes it challenging for the host immune system to target and neutralize the virus.
Researchers at NIST developed new standards and calibrations for optical microscopes, enabling accurate measurement of microdroplet volumes smaller than 100 trillionths of a liter. They combined microscopy with gravimetry to verify results, linking their findings to fundamental constants of nature.