Articles tagged with Gene Regulation
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Scientists have identified an autoinflammatory disease called Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI) linked to mutations in the LYN gene. The research suggests that Lyn kinase may be a potential therapeutic target for drugs treating non-syndromic small vessel vasculitis and inflammation-induced liver fibrosis.
Researchers have discovered the critical role of linker histone protein H1 in plant immune responses to bacterial and fungal infections. The study found that mutant plants with knocked-out H1 isoforms exhibited higher defense gene expression and resistance to infection, but lacked priming ability.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
Researchers at University of Cologne discovered a way to improve DNA repair in body cells, making them resilient towards DNA damage. This can help prevent aging and cancer development, with potential applications for treating human patients.
Researchers at Texas A&M University have developed the first molecular therapeutic for Angelman syndrome, a devastating neurogenetic disorder. The therapy targets an evolutionarily conserved region in the UBE3A-AS transcript and has shown promising results in clinical trials.
A study published in Nature Immunology found that female mouse and human NK cells have more of a specific epigenetic regulator called UTX, which boosts anti-viral function while repressing NK cell numbers. This suggests that therapies need to be tailored to individual differences, including sex.
Researchers at USTC discovered a dynamic map of chromatin accessibility during mitosis, revealing important bookmarking factors. The study found that certain chromatin regions remained open throughout mitosis and were enriched in rapidly reactivated genes.
Children with Down syndrome are highly vulnerable to developing aggressive leukaemia due to a defect in the RUNX1 gene, which regulates blood cell formation. Researchers have identified a specific variant of the gene that promotes leukaemia development and discovered potential therapeutic approaches to correct this malfunction.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have observed quasiparticles in a classical system made of microparticles driven by viscous flow. The hydrodynamic forces among the particles create pair excitations that propagate through the crystal, stimulating the creation of new pairs.
A new study found that neutral maternal behavior at 12 months correlates with an epigenetic change in children related to stress response. The researchers analyzed data from a cohort of mother-infant pairs and found a small increase in methylation on the NR3C1 gene, which regulates the body's response to stress.
Researchers found epigenetic changes in post-COVID patients, including genes associated with taste and smell, as well as cell metabolism. These findings may lead to the development of new diagnostic tools for this and similar diseases.
A study published in PNAS reveals how environmental signals interact with genetic information to influence brain cell health and survival. The research highlights a protein called TNK2 that tunes dopamine levels, finding mutations lead to Parkinson's degeneration.
A team of researchers from the University of Minnesota Medical School identified approximately 100 genes associated with fat deposition in women. One gene, SNX10, was found to be strongly associated with cholesterol and triglycerides, which has implications for cardiovascular health.
Researchers from HKU School of Biological Sciences reveal the important role of SCT Receptor in regulating drinking behaviour under thirst. The study demonstrates how SCTR participates in SFO to regulate thirst and provides new insights into gut-brain axis regulation.
Researchers from Rice University have developed a new approach to control gene expression using proteolysis targeting chimeras (PROTACs). By reengineering the PROTAC molecular infrastructure, they demonstrated the ability to achieve chemically induced dimerization (CID), allowing for precise control over gene activation in specific loc...
Researchers have discovered that cocaine addiction is associated with faster brain aging, with changes in DNA methylation in the prefrontal cortex contributing to this effect. The study, which analyzed cryo-preserved brains of deceased male donors, found that cells in this region appeared biologically older in individuals with CUD.
Researchers at The Hospital for Sick Children have discovered that dysregulation of energy production is an early sign of heart failure. They found that lysine demethylase 8 (Kdm8) helps maintain balanced energy use, but its suppression leads to changes in metabolism.
A study analyzed gene expression data from 46 different human tissues to understand the impact of circadian and circannual cycles on human health. The research revealed that certain genes have strong diurnal or seasonal preferences, which could inform effective diagnostic and therapeutic strategies.
Researchers have elucidated a mechanism that makes tiny plant stem cells destined to give rise to stomata, cellular valves of plants. The discovery reveals two DNA codes and regulator proteins working together to lock in the fate of a plant cell.
Researchers discovered that certain microorganisms dominate burned soil after a wildfire, with some species increasing in abundance and others consuming charcoal. This finding could help revive megafire dead zones and provide insights into the human microbiome's response to stress.
Scientists have developed a technique to detect RNA structures in live cells, shedding light on the role of G-quadruplexes in neurodegenerative diseases. The method uses fluorescent spectroscopy and resolves existing limitations in studying these structures in real-time.
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
Researchers discovered that non-vascular bryophytes like Marchantia polymorpha adapt their architecture in response to shade, using phytochromes to regulate branching. The study found a liverwort-specific microRNA and SPL gene controlling meristem function, differing from vascular plants.
Researchers found that SIRT6 maintains mitochondrial function through transcription regulation of mitochondrial genes. Without SIRT6, mitochondrial gene expression is down-regulated, leading to increased ROS production and impaired ATP generation, similar to changes observed in aging and neurodegenerative diseases.
The study reveals that repeated mutations in the sarZ gene lead to increased severity of MRSA blood stream infections, and that surface protein ClfB plays a critical role in pathogenesis. The findings provide insights into the factors contributing to MRSA virulence and may help uncover new treatment approaches.
Researchers at Baylor College of Medicine discovered a novel mechanism of gene expression regulation involving enhancers and promoters. They found that enhancers and promoters are tightly interconnected through a process called enhancer-promoter entanglement, which affects transcription.
Researchers at RIKEN Center for Integrative Medical Sciences discover genes and individual variations associated with atrial fibrillation, predicting stroke and mortality risk. They also uncover a potential treatment target, ERRg, involved in the pathogenesis of atrial fibrillation.
In a mouse model of laser-induced CNV, RORα expression was highly increased in the choroidal/RPE complex post-laser, while loss or inhibition of RORα worsened CNV with increased lesion size and vascular leakage. RORα negatively regulates pathological CNV development by modulating angiogenic response and inflammatory environment.
Researchers have identified a new genetic pathway involved in regulating sleep from fruit flies to humans. The Pig-Q gene is associated with sleep regulation in both humans and animals, providing a novel insight into the genetics of insomnia.
A recent study has revealed a novel cold domesticated repair mechanism for DNA damage in rice, providing elite modules for improving chilling tolerance. The discovery of GCG codon repeats in the first exon of COLD11, a DNA repair protein, has opened the way for fine regulation of rice chilling tolerance with a single site.
Researchers found a new role for enzymes regulating genome function, which is linked to diseases such as brain tumors, blood cancers, and Kleefstra syndrome. The discovery could help understand these diseases and develop new treatments.
UC San Diego researchers have developed a simple quantitative formula to interpret how cells regulate transcription and translation processes. This breakthrough provides insight into how cells process environmental information and modulate behavior, enabling the precise manipulation of protein levels. The study's findings have signific...
Scientists at IRB Barcelona have detailed the atomic scale mechanism of action for FoxH1, a key transcription factor in embryonic development and cancer. The study reveals an unusual binding mechanism to compacted DNA, shedding light on its role in disease progression.
Researchers discovered that cabbage white butterfly caterpillars use two complementary enzymes for detoxification, allowing them to adapt to various cruciferous plants. The NSP and MA enzymes differ in their capacity to process different glucosinolates, enabling the caterpillars to fine-tune their detoxification mechanisms.
A recent study has unveiled how nucleotide excision repair (NER) is controlled at the molecular level, shedding light on its role in cancer treatment. The research revealed that TFIIH uses XPG to stimulate motor activity and locate damaged DNA, licensing XPG nuclease activity to excise it.
G-Quadruplex DNA structures play a crucial role in regulating genes and cell processes, but their visualization is challenging due to the dynamic nature of double standard DNA. Fluorescence-active small molecule probes have emerged as a real-time visualization method, enabling researchers to detect G-quadruplexes with high selectivity.
Researchers at the Salk Institute have identified mechanisms that activate oncogenes in cancer cells, providing insights into predicting and treating the disease. The study found that structural variants in DNA can impact gene expression, leading to cancer, but most variants have no effect.
A recent study reveals that the SD6/ICE2 molecular module regulates seed dormancy in rice, controlling abscisic acid homeostasis. By editing this gene, researchers improved pre-harvest sprouting resistance in both rice and wheat, offering a promising strategy for improving crop yields.
The NSF is funding projects that utilize the International Space Station (ISS) National Laboratory to advance tissue engineering and mechanobiology research. This solicitation aims to further drug discovery and therapeutic development through space-based research, with potential impacts on regenerative medicine and disease diagnosis.
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
A new study found that early-life experiences can alter gene expression in fruit flies, leading to improved health and extended lifespan. The researchers discovered that changes in chromatin packaging persisted across the lifespan, counteracting normal aging processes.
Researchers at Hokkaido University discovered a novel sex-determination mechanism in the Amami spiny rat, a species lacking the Y chromosome and Sry gene. The mechanism involves the upregulation of Sox9 gene on chromosome 3, induced by a new regulatory element similar to Enh14.
Using an AI, researchers successfully designed synthetic DNA that controls protein production in cells. The technology can speed up the development of vaccines, drugs for severe diseases, and alternative food proteins.
Researchers at Kyoto University discovered METTL16's role in DNA repair and erythropoiesis, a process generating 200 billion new red blood cells daily. Tiny methyl groups on specific mRNAs play a pivotal role in this process, involving mechanisms mediated by RNA-binding proteins.
A team of Duke researchers identified a group of human DNA sequences regulating genes that seem to have evolved rapidly after our family line split from that of the chimpanzees. These changes were fine-tuned over time and appear in brain development, digestion and immunity.
Researchers identified USP7 as a novel cyclin F-interacting protein that stabilizes cyclin F protein. The study also found that USP7 regulates cyclin F mRNA, with pharmacological inhibition resulting in downregulation of cyclin F mRNA.
Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
Research reveals TBX3 as a fate determinant controlling hypothalamic KNDy neuron development and puberty onset. Multiple TBX3 mutants fail to form phase-separated condensates, leading to delayed puberty in UMS patients.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
Researchers discover chemical inhibitor TIS108 significantly lowers Striga infestation without affecting plant growth or grain yield. The study shows canonical strigolactones contribute to seed germination in root parasitic weeds and play a major role in stimulating invasion by Striga.
Researchers discovered a link between reduced protein synthesis and Feingold syndrome type 1, a rare genetic disorder. The study suggests that a nutritional supplement may help reverse this decrease, potentially alleviating intestinal symptoms in patients with the condition.
A Dartmouth study reveals that disruptions in the mTORC1 pathway can rescue neuronal overgrowth and synapse function dysregulated by Pten loss, potentially offering new treatments for autism spectrum disorders. The research team also found that administering Rapamycin to children showed some benefit to symptoms of autism.
A team of Cornell scientists discovered that certain genes have their transcription regulatory factors already in place, but in a latent state. This 'poised' state allows these genes to rapidly respond to environmental changes, like the presence of bread sugars.
A study found that the HASTER lncRNA promoter regulates the activity of the HNF1A gene, which causes diabetes. This discovery paves the way for new therapeutic strategies by manipulating this regulatory element.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
Researchers found evidence supporting a new theory on how chromosome recombination is regulated during sexual reproduction. By manipulating protein expressions in the model plant Arabidopsis thaliana, they discovered that boosting HEI10 levels significantly increased crossovers, while disrupting ZYP1 expression had a similar effect.
New research reveals how non-coding DNA accommodates a basic plan for butterfly wing patterns while allowing evolution of diverse patterns. Regulatory elements work like switches to turn up or down patterns, supporting an ancient color pattern ground plan.
Researchers have identified microRNA-7 as a non-classic genetic risk factor for hereditary obesity. The molecule affects energy balance and appetite regulation in humans and mice, highlighting the need to examine non-genetic factors in gene-based studies. This discovery may lead to new therapeutic approaches for treating obesity.
The study reveals how the activating partner PI5P interacts with two different regions of regulatory protein UHRF1, showing its role in modulating complex proteins. This finding could breathe new life into the search for UHRF1-directed medicines.
Scientists have developed a new method to study human brain development by growing millimetre-sized three-dimensional tissues called organoids from pluripotent stem cells. The researchers characterized the cells in molecular-genetic terms, creating a kind of map showing the molecular fingerprint of each cell within the organoid.