Articles tagged with Adult Neurogenesis
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Researchers found that voluntary running exercise mitigates cafeteria diet-induced behavioral changes via hormonal and microbial pathways. The study revealed specific metabolites, such as anserine and indole-3-carboxylate, were decreased by the cafeteria diet but partially restored by exercise.
A study found that memories acquired while awake are stored in a more permanent form during REM sleep, requiring the reactivation of only three adult-born neurons involved in memory formation. This process is synchronized with theta rhythm activity and essential for proper memory function.
Researchers identified a family of RNA molecules, B2-SINEs, that stimulate growth in peripheral nerves and brain neurons after injury. These findings may lead to new treatments for nerve injuries and neurodegenerative diseases.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
Researchers found that removing the choroid plexus leads to a reduction of newly born immature neurons and fewer repairing damage caused by a stroke. The study suggests that the choroid plexus keeps regenerative cells ready to deploy to injured areas in animal models.
Researchers found that removing the choroid plexus led to a reduction in newly born immature neurons, which are essential for repairing damage caused by stroke. The study suggests that the choroid plexus may be necessary to retain these cells and facilitate brain repair after injury.
Research using mice models of Alzheimer's disease found that deep brain stimulation activated only a small population of new neurons, restoring cognitive and non-cognitive functions. The study also identified protein pathways involved in improved memory performance and plaque clearance.
Research at the University of Massachusetts Amherst shows that circadian disruption from jet lag can harm adult neurogenesis, which supports learning and memory. The study found that the Cryptochrome 1 gene regulates this process and that misalignment can lead to adverse health effects such as dementia and mental illness.
A new study from the Netherlands Institute for Neuroscience proposes a roadmap to solve the controversy surrounding the human brain's ability to regenerate. Researchers critically discussed and re-analyzed previously published single-cell transcriptomics datasets, revealing that markers used in mouse studies may not be suitable for hum...
Researchers at UNIGE and UNIL have discovered the importance of cell metabolism in reactivating quiescent neural stem cells, increasing new neurons in adult mice. This breakthrough could lead to potential treatments for conditions like depression and neurodegenerative diseases.
Scientists at Heidelberg University have identified a second stem cell population in the mouse brain, which is primarily involved in producing new neurons in the olfactory bulb. This discovery refutes the single stem cell type theory and suggests that both apical and basal stem cells are responsible for adult neurogenesis.
Researchers at UNC School of Medicine used optogenetic techniques to stimulate specific brain cells, increasing production of neural stem cells and neurons relevant to memory and emotion processing. This promoted neurogenesis, altering anxiety-like behaviors in mice.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
Researchers discovered that old neurons can block neurogenesis in mice, highlighting excessive senescence as a driving factor behind aging. By destroying senescent cells, the study showed enhanced hippocampal neurogenesis and cognitive function in middle-aged mice.
Researchers from the Netherlands Institute for Neuroscience have discovered a small molecule that can be used to rejuvenate the brain and counteract memory loss in Alzheimer's disease. The molecule, microRNA-132, regulates adult hippocampal neurogenesis and is required for the neurogenic process in the adult hippocampus.
A study from King's College London found that intermittent fasting increased Klotho gene expression and promoted adult hippocampal neurogenesis in mice, leading to improved long-term memory retention. The researchers hope to replicate the study with human participants to further explore the effects of IF.
Researchers found that quercetin and dihydroxybezoic acid from apples stimulate neurogenesis, generating new neurons and protecting against cell death. The effects on learning and memory are comparable to those seen after physical exercise.
New research reveals that prenatal alcohol exposure impairs adult hippocampal neurogenesis in mice, while adult-generated neurons may contribute to recovery from alcohol dependence. The study suggests that targeting adult neurogenesis could lead to more effective treatment of alcohol use disorders.
St Petersburg University researchers found that lack of TAAR5 leads to higher dopamine neurons and increased adult neurogenesis, potentially treating neurodegenerative disorders like Parkinson's disease. TAAR5 is present in neurogenic areas and regulates adult neurogenesis.
Researchers found that adult-born neurons in rats continue to grow and develop for a longer period than those born during infancy. The study suggests that these mature neurons may have distinct functions, contributing to brain flexibility and plasticity. Adult neurogenesis can occur even after the decline of this process in adulthood.
Neurogenesis has been shown to have an additional role beyond learning and memory, with adult neural stem cells involved in regeneration. In a study published in JNeurosci, mice were exposed to a toxic substance that damaged the dentate gyrus, but recovered almost fully through neurogenesis.
Researchers found that seizures associated with Alzheimer's disease accelerate neurogenesis in adult brains, but administering anti-seizure medication restored normal dynamics and improved cognitive function. The findings suggest a possible explanation for the controversy surrounding neurogenesis in Alzheimer's patients.
University of British Columbia professor Jason Snyder reviews the conflicting reports on adult neurogenesis in humans, pointing to methodological differences as a major issue. He argues that there is evidence for low rates of neurogenesis in specific brain regions, particularly the hippocampus.
Researchers at Temple University Health System will test whether inhibiting a specific protein can stimulate new neuron growth. The goal is to understand the significance of reduced adult neurogenesis in Alzheimer's disease and potentially develop novel therapies.
Researchers found that physical activity increases hippocampal capacity by promoting neurogenesis, which clears out old memories. This process helps maintain memory capacity throughout life, particularly for those with Alzheimer's disease.
New research from University of California - San Francisco scientists shows that the human hippocampus no longer produces new neurons after childhood. This finding presents a challenge to previous studies suggesting neurogenesis could help treat brain diseases.
University of Wisconsin-Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell, revealing four stages of gene activation. The study found hints about the origin of Alzheimer's, Parkinson's diseases and autism, suggesting a link between stem cell impairment and complex disorders.
Adult brain neurogenesis is increased by sustained aerobic exercise, particularly in genetically predisposed rats, indicating a potential improvement in learning abilities. The study suggests that aerobic exercise, but not high-intensity interval training or resistance training, enhances hippocampal neurogenesis.
Researchers found that integration of new neurons in the adult brain is compromised in depressed patients, particularly in the olfactory bulb. This discovery provides an important step towards understanding the mechanisms of depression.
Researchers found that Ginkgo biloba treatment improved recovery and reduced brain damage after inducing experimental stroke in mice. The treatment also enhanced neurogenesis due to increased protein expression of hemeoxygenase 1, an antioxidant gene involved in neurogenesis.
Transplantation of adipose-derived stem cells (ADSCs) into APP/PS1 transgenic AD model mice promoted neurogenesis in the subgranular and subventricular zones. This improved cognitive function and reduced oxidative stress, providing evidence for AD treatment with ADSCs.
Researchers have discovered a unique pattern of neurogenesis in the adult human brain, particularly in the striatum region. New neurons are generated here, which could potentially be useful for developing novel therapies for neurological diseases.
Researchers found that fluoxetine stimulates the production of new neurons from neural progenitor cells in the adult cortex. This process coincides with a reduction in apoptotic cell death following ischemia, highlighting the potential neuroprotective response induced by this antidepressant drug.
Researchers found that a high-fat diet encourages more eating and fat storage by spurring new neurons in the hypothalamus, a key area for regulating hunger and body weight. This neurogenesis is critical in regulating weight gain and fat storage.
A study suggests deleting a protein that regulates nerve cell growth can increase new nerve cells and speed up antidepressant effects, potentially offering a novel therapeutic approach for depression. The research found that mice without this protein showed improved symptoms of depression and anxiety even without medication.
A study by NIH-funded researchers has found that boosting adult neurogenesis in the hippocampus improves pattern recognition abilities, similar to those seen in younger brains. However, combining this with exercise was necessary for antidepressant-like effects to emerge.
Researchers at Columbia University have developed a new way to stimulate neuron production in the adult mouse brain, improving cognitive functions. The study suggests that stimulating neurogenesis may contribute to treatment of anxiety disorders, including PTSD and panic disorder, by enhancing pattern separation.
Recent studies published in Cell Transplantation suggest a link between exercise, brain cell regrowth, and improved mental health. Exercise has been shown to promote neurogenesis, which may help counteract stress-related disorders and improve mood and cognition.
Researchers found that fragile X protein (FMRP) regulates adult neurogenesis, a process crucial for learning and memory. FMRP dysregulation leads to defective neural maturation and reduced new neurons, contributing to learning disabilities associated with fragile X syndrome.
Researchers at UT Southwestern Medical Center found that blocking new growth of specific brain nerve cells increases vulnerability for cocaine addiction and relapse. Increasing adult neurogenesis may prevent addiction before it starts, potentially improving the length and quality of life for millions of drug abusers.
Research reveals new neurons produced in cerebellum of young and adult rabbits, expanding understanding of mammalian neurogenesis. This breakthrough opens new avenues for brain repair and regeneration research in humans.
Scientists have discovered a method to track neural progenitor cells in the adult human brain, opening new avenues for diagnosis and treatment of neurological disorders. The breakthrough uses magnetic resonance spectroscopy (MRS) to detect proteins produced by these cells.
A Princeton University study found that brain cell growth in adult monkeys begins to decline soon after reaching adulthood, but it does not have to stop altogether. The team's research suggests that stimulating the human brain to generate neural cells more rapidly may be possible through methods such as exercise and socialization.
Researchers have discovered a positive correlation between medical marijuana use and increased adult neurogenesis, a process that can modify behavior. Cannabinoids are believed to play a key role in this process, making them a promising area of study for mental health treatment.
Scientists at NIMH have discovered newborn neurons in adult rat cortex that communicate via GABA, suggesting potential new treatments for depression and anxiety. The discovery adds to the scientific debate over adult neurogenesis and has implications for understanding brain disorders such as Alzheimer's and schizophrenia.