Articles tagged with Neurology
The Robert A. Winn Excellence in Clinical Trials Award Program is expanding its career development award to include neuropsychiatry researcher-physicians. This expansion aims to improve clinical trial enrollment and represent diverse patient populations affected by complex disorders.
The gut microbiota influences the central nervous system (CNS) through neural, immune, endocrine, and metabolic pathways. Dysregulation of this axis is linked to various neuropsychiatric and neurodegenerative disorders, including depression, schizophrenia, Alzheimer's disease, and Parkinson's disease.
A groundbreaking study has identified a molecular pathway in the brain crucial for working memory, revealing the Munc13-1 protein's role in temporarily strengthening synapses to retain information. Disruptions to this protein have been linked to neurodevelopmental disorders, highlighting its importance in healthy brain function.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
St. Jude Children's Research Hospital appoints Carsten Bönnemann, MD, to lead the newly created Department of Genomic and Translational Neuroscience, focusing on catastrophic neurological disorders. The department aims to develop genetic precision therapies and advance research into complex pediatric neurological conditions.
A study of 3,910 former college athletes found that those with three or more concussions had worse physical, mental, and cognitive health five years after graduation. Athletes with one to two concussions also showed signs of psychological distress, anxiety, and depression.
A prospective multicenter study found Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients. The therapy promotes durable aneurysm occlusion with minimal risks.
The American Academy of Neurology provides guidance on the use of wearable devices for neurological care, highlighting their benefits and limitations. Wearable devices can serve as screening tools for heart rate and cardiac arrhythmia, and can be helpful in disease management for epilepsy, but their use also carries risks and limitations.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
A mini-review synthesizes large-scale genomic findings to illuminate the polygenic architecture underlying common epilepsies. Rare genetic variants contribute to epilepsy risk, with shared biological pathways involving ion channel function and synaptic excitability
Patients with neurological diseases face profound questions about identity, purpose, and meaning, but neurologists often lack training and tools to address these concerns. A new paper offers practical strategies for incorporating spiritual assessment into routine neurological care.
A study in Taiwan found a positive association between maternal prenatal acetaminophen use and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) in offspring. However, associations were not observed in sibling-matched analyses, suggesting unaddressed sources of bias.
A study found that improving the gap between biological age and chronological age is associated with a lower risk of stroke and improved signs of damage in the brain. Participants who narrowed their biological age gaps were 23% less likely to have a stroke, while those with larger gaps had worse brain scans and higher risks.
A study found that people with changes in their activity patterns were more likely to have worsening disability and loss of brain volume than those whose patterns did not change. Wearable sensors measure physical activity, time spent sitting or inactive, and circadian rhythms.
Youth football is associated with nearly 1 in 5 traumatic brain injuries (TBIs) in children and young adults. Football players are also more likely to experience repeat TBIs, with 37% of cases occurring in athletes who participated in the sport.
A preliminary study found that short-term exposure to wildfire smoke was associated with a higher incidence and severity of stroke, particularly in patients with elevated ozone and particulate matter levels. The study suggests that public health interventions during wildfires are crucial for preventing strokes.
A recent study mapped brain injuries in individuals with acquired aphantasia and found that all cases were connected to the fusiform imagery node. This suggests a critical role for this region in maintaining visual imagination. The findings have implications for rehabilitation strategies and understanding of cognitive function.
A new study reveals how defective dopamine packaging in neurons triggers toxic processes, leading to Parkinson's disease symptoms. Researchers discovered that delivering energy via ATP can repair packaging and halt damage.
The ORIGIN study uses advanced molecular tools to identify risk factors and early warning signals in stored blood samples from up to 13,000 service members. By analyzing these data, researchers aim to predict and prevent diseases such as cancer, heart disease, and autoimmune disorders years before symptoms appear.
A UCF researcher is pursuing innovative approaches to treat diabetic neuropathy without relying on pain pills and anti-depressants. Dr. Jim Nichols is investigating overlooked mechanisms in the body that may show how insulin deficiency affects sensation in limbs.
A recent study found that standard therapy plus catheter ablation did not significantly reduce the risk of primary composite end point in patients with atrial fibrillation and a recent stroke history. The observed event rate was lower than anticipated, suggesting underpowered detection of clinically meaningful differences.
A preliminary study found that people with drinking water from newer groundwater had a higher risk of developing Parkinson's disease. The study suggested that groundwater age and location may be potential environmental risk factors for the disease, with older groundwater from carbonate aquifers showing a protective effect.
Researchers investigated low-dose lithium as a potential treatment for mild cognitive impairment in a pilot clinical trial. The study found that none of the primary outcomes met the significance threshold, but effect size estimates suggest potential benefits for future trials.
A study found that people with chronic migraine who took glucagon-like peptide-1 receptor agonists (GLP-1) for other conditions had fewer emergency department visits and hospitalizations. GLP-1 drugs were also associated with lower need for medications used to stop and prevent migraine attacks.
A cross-sectional study of former American football players found prior participation to be associated with worse later-life cognitive and neuropsychiatric function. The findings support a dose-response association with years and level of play, providing context for clinicians and researchers assessing symptom risk among former players.
A recent study found that more parents are refusing vitamin K shots for their newborns, which can lead to avoidable brain injuries and lifelong brain problems. The study also found that babies who do not receive the vitamin K injection are 81 times more likely to develop a serious condition called vitamin K deficiency bleeding.
Researchers developed a single-item hoarding screen to quickly identify hoarding behaviors in patients with memory and brain disorders. The tool shows promise in flagging potentially serious hoarding behavior, especially in patients with behavioral variant frontotemporal dementia.
A study published by the American Academy of Neurology found that being an early bird and engaging in more physical activity are linked to a reduced risk of amyotrophic lateral sclerosis (ALS). After adjusting for various factors, researchers discovered that individuals who followed a sleep schedule that matched daylight hours and had ...
Researchers discovered higher levels of inflammation in football players were associated with worsened brain structure and related cognitive decline. The study, published in Neurology, also found associations between repeated head impacts and neurobehavioral dysregulation.
A new study published in Neurology found that currently smoking is associated with a lower risk of developing Parkinson’s disease, but quitting smoking was associated with a lower risk of death. Researchers also found that sustained quitters had a 17% lower risk of death compared to persistent smokers.
A study published in JAMA Neurology found that adhering to healthy dietary patterns, such as the DASH diet, is associated with lower subjective cognitive decline and better cognitive function. The findings highlight the importance of a balanced diet for maintaining long-term brain health.
The American Academy of Neurology is calling on federal lawmakers to support essential neuroscience research and address access issues. Neurologists are advocating for permanent telehealth flexibilities to ensure continuity of care and addressing ongoing Medicare payment cuts that reduce neurological care access.
A study published in Neurology found an association between prenatal lead exposure and lower performance on tests of thinking and memory skills in female participants, even decades later. The study analyzed baby teeth for lead levels and tested cognitive function, revealing a strong link between lead exposure and cognitive decline.
A study by University of Virginia Health System researchers found that Medicare Advantage patients had better access to preventive care and rehabilitation after a stroke, leading to faster recovery times. In contrast, traditional Medicare patients were less likely to receive these services due to prior authorization requirements.
A new theory asserts that associative learning depends less on repetition and more on time passing between rewards, explaining why students who cram don't perform well. The study's findings could shift the way we look at learning and addiction, potentially speeding up artificial intelligence by borrowing from this new approach.
A new national registry study found that people with traumatic brain injury (TBI) have an increased risk of work disability, which can recur years after the injury. The study included nearly 100,000 participants and found that even minor TBI injuries can affect long-term employment.
Researchers found that Parkinson's patients experience weight loss due to selective fat depletion, not muscle loss, driven by impaired carbohydrate-based energy production. This metabolic shift highlights a disorder of both the brain and body, driving disease progression.
A new study found that aligning overnight fasting with the body's natural sleep-wake rhythm improved cardiovascular and metabolic health. Participants who extended their fast by two hours and dimmed lights three hours before bedtime showed significant improvements in blood pressure, heart rate, and blood-sugar control.
Researchers have discovered a novel biomarker for fragile X syndrome in both human patients and mouse models, allowing for the comparison of brain wave patterns between species. This breakthrough enables the development of more effective treatments by enabling non-invasive treatment efficacy readouts across species.
Advanced 3D imaging reveals that vascular amyloid deposition follows a specific pattern, starting from surface vessels and spreading inward along connected pathways. The study provides new insights into the spatial organization of amyloid pathology in cerebral amyloid angiopathy.
A recent study published in Neurology suggests that individuals with traumatic brain injuries (TBI) are more likely to qualify for work disability, regardless of the severity of their injury. The study found that people with TBI had a higher likelihood of having work disability during a five-year follow-up period.
A small observational study found that most women with macromastia who experienced frequent headaches screened positive for migraine rather than tension-type headache. After surgery, participants reported fewer and less severe headaches, with improvements lasting over a year.
A new study found that individuals with higher levels of lifelong learning developed Alzheimer's disease five years later than those with the lowest level of learning. Higher lifetime enrichment was also associated with a 38% lower risk of Alzheimer's disease and a 36% lower risk of mild cognitive impairment. The study suggests that pu...
A Phase III clinical trial found that neuroprotective medication loberamisal improved brain cell recovery in stroke patients treated within 48 hours. The study, conducted at 32 centers in China, compared loberamisal to a placebo and showed significant benefits.
A new treatment combining restricted arm use with intensive physical therapy improved function and skills on the weak side in infants with perinatal arterial ischemic stroke. While results were promising, differences in responses among children highlight the need for further research.
A new AI-powered model can read a brain MRI and diagnose neurological conditions with up to 97.5% accuracy, predicting treatment urgency and automating alerts for immediate medical attention. The technology has the potential to transform neuroimaging at health systems across the US, reducing workload and improving patient outcomes.
Researchers have found that adding daily asundexian to antiplatelet therapy can reduce the risk of a second ischemic stroke without increasing bleeding risks. The study, which included over 12,300 stroke survivors, suggests that asundexian could be widely used for patients who have had non-cardioembolic strokes or TIA.
A new study highlights the clinical relevance of brain functional connectome uniqueness in identifying biomarkers for major depressive disorder. Researchers found that patients with MDD displayed reduced FC uniqueness, especially in frontoparietal and sensorimotor networks.
Researchers have developed a long, needle-thin brain electrode with channels that enables neural signal recording and precisely targeted medication delivery across different brain regions. The technology has primarily been developed for basic research but may be important for future treatments in epilepsy and other neurological diseases.
Researchers found that certain types of CD8+ killer T cells are more abundant in people with MS and target the EBV virus, indicating the virus may trigger an immune response leading to progressive neurological damage. The study suggests that interfering with EBV could have a significant impact on other autoimmune diseases.
A rare case of hyperammonemic encephalopathy caused by 5-fluorouracil (5-FU) chemotherapy has been reported, highlighting the importance of monitoring neurological symptoms in patients receiving 5-FU. The patient's symptoms resolved after stopping 5-FU and administering lactulose and intravenous fluids.
A recent study published in Neurology Open Access found that following a Mediterranean diet is associated with a reduced risk of stroke among women. The study, which involved over 105,000 participants, showed that the diet was linked to lower rates of ischemic and hemorrhagic strokes, as well as overall stroke risk.
Researchers found a synthetic protein, recombinant factor VIIa, can reduce bleeding in patients with a 'spot sign' on CT brain imaging who are treated within 90 minutes of stroke onset. These patients also experienced better outcomes and reduced ICH growth.
A new study has found that improving blood flow to the brain by opening narrowed carotid arteries does not improve cognitive skills. The CREST-2 trial compared treatments and found no difference in thinking or memory over time among participants who received stenting, surgery, or intensive medical therapy.
A new study identifies the somato-cognitive action network (SCAN) as responsible for Parkinson's disease symptoms, which can be treated with non-invasive transcranial magnetic stimulation. Targeting this network improves symptoms more than twice as much as treatments targeting nearby brain areas.
Researchers found that adding alteplase to thrombectomy can significantly increase the chances of an excellent recovery in patients with large-artery ischemic strokes. The CHOICE2 trial showed improved outcomes in patients who received clot-busting medication after successful thrombectomy.
A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
The American Heart Association has awarded 11 exceptional scientists in stroke and brain health, including Bruce Ovbiagele, Pooja Khatri, and Raghu Vemuganti, for their groundbreaking research findings and contributions to the field. The recipients will be recognized at the International Stroke Conference 2026.
A new study by McGill University researchers offers a potential solution for infant hydrocephalus, a life-threatening condition that affects 1 in 1,000 newborns. RNA therapy has been shown to prevent the condition in mice models, with a promising impact on treating genetically caused hydrocephalus.