Articles tagged with Parasitic Diseases
A VUB study has mapped the immune system's response to brain infections, revealing that resident macrophages play a key role in defending against pathogens. The researchers found that blood-derived immune cells can eliminate parasites, but may retain 'memory' of past infections, altering their ability to respond to future insults.
A WVU biomedical engineer is working on a rapid diagnostic tool that can detect tick-borne infections such as Lyme disease via a blood sample on a single chip. The tool uses dielectrophoresis and machine-learning to detect diseases within one to two weeks after onset, reducing the risk of hospitalization and chronic conditions.
A new, shorter combination treatment has been shown to be effective in treating visceral leishmaniasis in Eastern Africa. The treatment, which combines miltefosine and paromomycin, is safer and reduces hospitalization time by 18%, eliminating the need for painful daily injections.
Researchers from Ludwig-Maximilians-Universität München have deciphered a crucial signaling mechanism that enables trypanosomes to reach the salivary glands of tsetse flies. By understanding this process, scientists can develop new methods to prevent transmission of African sleeping sickness.
Research reveals that 32 species of animals, including prawns, crabs, and lizards, can act as carriers of the rat lungworm parasite, which can cause serious illness and death. The study aims to raise awareness about paratenic hosts and prevent infection by avoiding eating raw or infected animals.
A study of medieval Cambridge's Augustinian friary and local cemetery found that friars were almost twice as likely to be infected by intestinal parasites. The researchers suggest that the high infection rates among friars may have been due to their practice of manuring vegetable gardens with human faeces.
Cognitive impairment can lead to population declines, particularly for species relying on learning and memory. Infections can impact cognitive abilities differently across animals, depending on their survival strategy and pathogen manifestation.
Researchers found that different lineages of Cryptosporidium parvum are increasingly exchanging their DNA, which helps the parasite evolve faster and potentially result in more virulent strains. The study suggests that globalization and close contact with animals increase the rate of genetic exchange.
A new digital PCR technique helps identify mutations in malaria parasites that evade detection by rapid tests, reducing false negatives. This allows for more accurate selection of diagnostic tests tailored to specific regions.
Researchers found no association between social behavior and parasite infection in Asian elephants, despite studying three key aspects of their social life. The study suggests that social benefits may outweigh the costs of sociality for these animals.
Researchers found that flower shape is a key predictor of parasite transmission to bees, with wider, shorter flowers increasing the risk. The study suggests that identifying floral traits and species associated with lower parasite transmission rates could help create pollinator habitats with reduced disease risk.
A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.
A WHO-supported series has collected 13,700 new database records on mosquito-borne diseases, providing valuable resource for studying and containing infectious diseases. The data can be used to train machine-learning models for vector detection and classification, improving global human health.
A new analysis of ancient faeces found at Durrington Walls has uncovered evidence of parasitic worms, suggesting the inhabitants feasted on cattle and fed leftovers to their dogs. The findings indicate that people ate raw or undercooked internal organs from infected animals, resulting in parasite eggs passing through the body.
A study led by Washington University in St. Louis found that nonlethal parasitic infections reduce herbivory rates and trigger trophic cascades impacting plant communities. The research used a mathematical model and global meta-analysis to highlight the ecological consequences of common parasitic infections in wild animals.
Two fatal cases of airport malaria were reported in Belgium, highlighting the need for healthcare awareness near airports. The most likely route of transmission was through an imported infectious exotic Anopheles mosquito that was possibly brought via the international airport or military airport.
Research reveals high rates of parasitic worm infections in ancient British populations, particularly during the Roman and Medieval periods. The study sheds light on the lives and habits of past populations, providing insights into public health measures.
A new study by University of Waterloo researchers highlights the need for a multi-faceted approach to prevent infections from becoming harder to treat due to antimicrobial resistance.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
A study led by the University of Minnesota Medical School found that exposure to helminths can stimulate the immune system and reduce predisposition for inflammatory bowel disease. The research revealed a unique glycosylation mechanism, O-GlcNAcylation, which activates epithelial cells to orchestrate an anti-helminth response.
Researchers have discovered that P. malariae, a malaria parasite infecting humans, originated in African apes before evolving to infect people. This breakthrough reveals the evolutionary links between the two species and sheds light on how the parasite adapted to infect humans.
Researchers discover that common herbicides can kill the Toxoplasma gondii parasite without harming human cells. The compounds work by inhibiting heme biosynthesis, a promising approach for treating toxoplasmosis.
A new mechanism has been discovered that decorates the end tails of RNA molecules in a parasite causing sleeping sickness, preventing their degradation and potentially increasing virulence. This fundamental discovery opens new avenues for treatment strategies for this disease, as well as other RNA-based infections/diseases.
A novel class of bed net that kills mosquitoes resistant to traditional insecticides by making them unable to move or fly significantly reduces malaria infection in children. The study found a 43% reduction in malaria prevalence and 44% reduction in clinical episodes over two years.
Researchers found that Chagas trypanosomes change the bacterial community in predatory bugs' intestines, leading to a decrease in diversity and an increase in certain pathogenic bacteria. The study also identified four bacteria species crucial for bug survival, which could be used to develop defensive substances against the parasite.
A new analysis from Emory University reveals a significant increase in the parasitism rate of monarch butterflies over 50 years, with the O.E. parasite infecting up to 10% of eastern monarch populations. The rise in infection rates may endanger the mass migration of monarchs, threatening their survival.
A new study by Emory University finds that schistosome transmission can be highest when freshwater snail populations are low. Snails competing for resources may lead to lower infectivity rates, contrary to typical pesticide-based control methods.
Scientists at UCR have discovered a new species of nematode parasite that infects and kills tarantulas, exhibiting strange behaviors like walking on tiptoe and loss of fang control. The parasite, Tarantobelus jeffdanielsi, is named after actor Jeff Daniels, who saved fictional spiders in the 1990 film Arachnophobia.
Researchers have discovered that living filtration membranes made from kombucha cultures can resist fouling and maintain faster filtering rates compared to conventional polymer membranes. This breakthrough could lead to an inexpensive, biodegradable, and effective way to treat water, tackling issues such as biofilm formation and clogging.
Two independent teams of researchers have found the molecular mechanism of action of praziquantel, the only approved drug to treat schistosomiasis. The drug binds to a specific type of channel in the cell membrane, causing calcium ions influx and resulting in worm paralysis and death.
Researchers have solved the mystery of how praziquantel works, a key to treating schistosomiasis. The discovery highlights new opportunities for drug development and may help combat this debilitating disease affecting over a billion people worldwide.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
Researchers at UT Southwestern Medical Center have discovered a potential cure for strongyloidiasis, a deadly tropical disease caused by Strongyloides stercoralis. Combining dafachronic acid and ivermectin increased survival rates to 85% in animal models, offering a new therapeutic target for parasitic nematode diseases.
A collaborative research study found Cryptosporidium prevalence to be 20-25% across Belgium, France, and the Netherlands, posing a serious threat to dairy cattle and human life. The parasite is concerning due to its ability to become infectious in chlorine, increasing the risk of infection through traditional methods.
Researchers have made progress towards a new diagnostic test for schistosomiasis, which could help interrupt transmission and eventually eliminate the disease. The test targets proteins produced by the parasite and can detect even low-intensity infections.
A new study by Royal Holloway University of London found that glyphosate has no significant effect on bumble bee mortality, reproduction, or sucrose consumption. The research also suggests that the pesticide does not make parasite infections more intense at environmentally realistic concentrations.
Researchers have developed a database of parasite-host interactions among ancient ocean animals, shedding light on the evolution of biodiversity and the impact of parasitism on ecosystems. The study suggests that parasites can positively stabilize coastal ecosystems, making them more stable despite individual harm to hosts.
A new study reveals that mice infected with bacteria or parasites develop a unique tolerance mechanism to shield their enteric neurons from death. This finding has potential clinical implications for conditions like irritable bowel syndrome, where neuronal loss can lead to severe gastrointestinal disease.
A breakthrough oral vaccine candidate has been developed to prevent hookworm infection, which affects half a billion people worldwide. The vaccine triggers a strong immune response and reduces worm numbers by up to 94% in mice trials.
A study by the University of Georgia's Center for the Ecology of Infectious Diseases identified contaminated water as the most common driver of large-scale zoonotic disease outbreaks. The researchers analyzed over 4,400 outbreaks and found that unusual weather patterns and changes in vector abundance were also significant contributors.
Researchers find hookworms resistant to multiple drugs used to treat them, with high prevalence in racing greyhounds. The study's results highlight the importance of regular deworming and caution against dog parks as potential breeding grounds for drug-resistant parasites.
A new study led by Rachel Penczykowski investigates the hydra effect in water fleas, where parasite infections trigger a counterintuitive increase in population density. The researchers found that infected water fleas consume less algae, leading to an abundance of resources for uninfected individuals.
A team of researchers has discovered a new group of coral-infecting microbes called Corallicolida. Despite lacking photosynthetic genes, they express chlorophyll genes and may still play a role in their host cells. The authors propose that Corallicolida could be an ancient parasite that lost its photosynthetic machinery.
Researchers at Kanazawa University have identified a new vaccine platform that targets liver cells to induce anti-malaria immunity. The AAV8 vaccine platform was found to be more effective in eliciting a T cell-mediated response in the liver, providing sterile protection against malaria in a murine model.
A recent study has identified a nematode attractant in flax seeds, which can be used to develop sustainable and environmentally-friendly agriculture methods. The attractant, consisting of cell wall polysaccharides, is found to contain L-galactose sidechains that are critical for nematode attraction.
A new study published in the New England Journal of Medicine found that a combination of seasonal vaccination with RTS,S/AS01 E and antimalarial drugs significantly reduces clinical episodes, hospital admissions, and deaths from malaria. The results show a 70% reduction in these outcomes compared to current interventions.
A new study led by ISGlobal has identified a gene called PfAP2-HS that allows the malaria parasite to defend itself from febrile temperatures and other adverse conditions within the host. The study found that this gene activates a protective response against high temperatures, helping the parasite survive in the host's environment.
Researchers found that parasitic hairworms in praying mantis infected with parasites are attracted to horizontally polarized light and enter the water. This manipulation of host behavior is a remarkable example of how parasites can alter their hosts' morphology and behavior for their own benefit.
Research from the University of Colorado Boulder reveals that Toxoplasma-infected hyena cubs are more bold and approach lions from closer distances, leading to a higher risk of death. The parasite has a direct and detrimental impact on hyena fitness.
A new study reveals that a changing parasite is behind the intensification of oyster disease in the Chesapeake Bay region. The emergence of a more virulent form of Perkinsus marinus, caused by evolutionary pressures from a non-native parasite MSX, led to a sharp increase in disease prevalence and deadliness.
Ant workers infected with a tapeworm live significantly longer than uninfected nest-mates, resembling the lifespan of ant queens. The parasites alter expression of ant genes and release antioxidants, contributing to their extended lifespan.
A recent study found that conservation efforts have led to an increase in mountain gorilla population densities, which may raise their risk of infectious diseases. The research also discovered striking geographic differences in parasite infections across the entire range of the mountain gorilla.
A study by Brandi Wren found that monkeys carrying whipworm parasites exhibit reduced social grooming and cuddling, implying a link between infections and behavioral changes. This research opens new avenues for understanding animal behavior and human health, particularly in the context of social distancing and contagion.
Researchers can use eDNA and eRNA analysis to determine the presence of human and wildlife pathogens, providing timely insights into disease spread. This approach has been successfully used to track large-scale outbreaks of COVID-19, allowing for proactive measures to be taken.
A study by Universities of Cape Town and Bonn found that helminth-infected mice developed severe symptoms after infection with a genital herpes virus. This remote effect is thought to be caused by misdirected immune response, where eosinophil granulocytes accumulate in the vagina and secrete cell-damaging enzymes.
A recent study warns that moving endangered species to new locations can accidentally spread diseases and parasites, putting populations at risk of collapse. The researchers recommend stricter quarantine periods and relocation strategies to mitigate this risk.
Researchers have uncovered a molecular reason why faecal transplants are effective in treating C. diff infections, suggesting new therapeutic targets. The study identified specific microRNAs that contribute to disease pathogenesis and protect bowel cells from bacterial toxins.
A new laboratory study has identified five herbal medicines with potent activity against Babesia duncani, a malaria-like parasite causing babesiosis. The herbal medicines included Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Alchornea cordifolia, and Polygonum cuspidatum.
A new study finds that the high cost of antiparasitic drugs used to treat hookworm and other soil-transmitted parasites is driving up patient costs and decreasing the quality of care. In rural areas, these diseases are more prevalent, and patients often receive inadequate treatment.
Researchers have confirmed that parasites can parasitize newly-recorded snail species in Thailand, posing a risk of food-borne zoonotic diseases. The study highlights the need for further research on the biodiversity and biology of these snails to improve public health understanding.