Articles tagged with Glucose
A group of neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus sense fluctuations in blood sugar levels and respond by rapidly decreasing or increasing their firing activities. This response can trigger changes in behavior to increase glucose levels, forming a feedback system that keeps blood glucose balance.
Researchers found that even small increases in blood glucose levels can cause significant changes in the behavior of insulin-producing beta cells, making them more vulnerable to autoimmunity and inflammation. This discovery may improve understanding of type 1 and type 2 diabetes and shed light on potential treatments.
A new study found that high blood glucose levels may trigger a severe inflammatory response in flu patients, leading to hospitalization or death. Glucose metabolism is believed to contribute to various COVID-19 outcomes as both influenza and COVID-19 can induce a cytokine storm.
People with type 2 diabetes and heart disease may benefit from newer therapies that combine glucose control with cardiovascular benefits. These treatments, such as SGLT2 inhibitors and GLP-1 receptor agonists, have been shown to reduce the risk of major cardiovascular events and improve outcomes for patients.
A large-scale study has identified protein network changes that could be developed into treatment targets and fluid biomarkers for Alzheimer's disease. The research found that sets of proteins regulating glucose metabolism are strongly associated with Alzheimer's pathology and cognitive impairment.
A study analyzing 6 million days of real-world data shows the MiniMed 670G system can maintain target glucose range of 70-180 mg/dL over 71% of the time. The AutoMode feature improves glycemic control, reducing low and high blood sugar episodes.
A study found that people with type 2 diabetes who have a lacunar stroke experience better cognitive function when their glucose levels are well-controlled. This association remains significant even after adjusting for other factors.
Researchers found reduced glucose metabolism in the brain stem and primary auditory cortex of patients with asymmetric hearing loss. Long duration of hearing impairment was associated with higher glucose metabolism on the contralateral side.
Research reveals glucose acts as a molecular switch regulating SIRT1's function, impacting gene expression and metabolic flexibility. Glucose modification affects organismal health, with both over-activation and under-activation linked to diseases.
A study published in PNAS reveals that neurobiological changes associated with aging can be seen at a younger age and may be prevented or reversed through dietary changes. Researchers found that consuming ketones, as opposed to glucose, stabilized brain networks and increased overall brain activity.
A recent review article reveals that marine cyanobacteria, such as Prochlorococcus and Synechococcus, can thrive on organic compounds from their environment. These findings are crucial for understanding cycles of essential elements like carbon, iron, phosphorus, and nitrogen.
A team of McGill University researchers has created an artificial pancreas system that significantly improves glucose control, enhancing quality of life for individuals with type 1 diabetes. The system, which combines insulin and pramlintide, has shown promising results in minimizing glucose highs and lows.
Researchers at USC Viterbi School of Engineering designed a new drug combination that mimics glucose deprivation in cancer cells, leading to their death. The combination may have fewer side effects than traditional chemotherapies and reduce the incidence of acquired resistance.
A new device can automatically manage glucose levels and deliver needed insulin quickly, eliminating the need for constant blood sugar checks and insulin injections. The adhesive patch, about the size of a quarter, has been successfully tested on mice and pigs, showing promise as a potential diabetes treatment.
Researchers developed a wearable device that monitors body chemistry to improve athletic performance and detect potential health problems, such as dehydration. The device can be used in military training and competitive sports, with applications including tracking athletic recovery.
A new study by the University of Alberta found that pregnant women with elevated fasting blood sugar levels are at a higher risk of complications, including large babies, high blood pressure, and preterm births. Despite receiving diabetes drug treatments, these women were more likely to experience adverse outcomes.
Researchers at the University of Illinois found that tasting or consuming sucralose can affect blood glucose and insulin levels, even in healthy individuals. The study suggests that sweetness should be consumed in moderation regardless of calories.
Researchers developed a small molecule drug CTPI-2 that targets Slc25a1 gene involved in lipid and glucose metabolism, preventing liver damage, obesity and glucose intolerance in mice. The study showed promising results, confirming the importance of this gene in fatty liver disease.
Researchers at the University of Warwick developed an AI technology that can detect hypoglycaemic events from raw ECG signals using wearable sensors with 82% reliability. This non-invasive method could replace fingerprick testing, particularly useful for pediatric patients.
Researchers developed an automated glucagon delivery system to treat post-bariatric hypoglycemia, reducing the risk of unpredictable low blood sugar levels. The closed-loop system, comprising a CGM and glucagon pump, provides patients with a safe and reliable treatment option.
Researchers at KAUST have developed a plastic biosensor that can power itself using glucose, enabling continuous monitoring of key health indicators like blood sugar levels. The device uses an electron-transporting polymer and glucose oxidase enzyme to drive its circuitry, offering an ideal alternative to current implantable devices.
Researchers are testing whether changing brain's fuel source from glucose to ketones could potentially save neurons and neural networks over time. The study, funded by a $2.5 million grant, aims to understand how ketones affect brain cells and connectivity in the face of insulin resistance.
A new Tel Aviv University study finds that consuming a starch-rich breakfast early in the morning and a small dinner may improve glycemic control among type 2 diabetics, reducing the need for insulin injections. The researchers' 3M-diet was shown to have significant benefits, including weight loss and improved sugar levels.
Researchers found that adjusting CGM alarm settings can inform patients about high or low blood sugar events early, enabling timely treatments. The study suggests simpler adjustments to these thresholds could lead to better management of hypo- and hyperglycemia for people with type 1 diabetes.
Researchers at Stevens Institute of Technology developed a meal-detection system that can accurately calculate carbohydrate intake in real-time, allowing for faster insulin administration. The system's estimates are remarkably accurate, outperforming previous systems by up to 17 grams.
Researchers at American Heart Association Scientific Sessions reveal that e-cigarettes pose significant cardiovascular threats. Contrary to popular belief, e-cigarettes do not appear to be a healthier alternative to traditional cigarettes regarding heart health.
Scientists develop optogenetic approach to control glucose levels in diabetic mice, achieving improved tolerance and regulation of glucose without pharmacological intervention. The light-switchable cells can produce more than two- to three-fold the typical level of insulin in response to glucose levels.
Researchers have developed a pacifier-based biosensor that tracks real-time glucose levels in saliva, allowing for non-invasive monitoring of newborns. The device could help diagnose and treat diabetes in infants, providing an alternative to continuous glucose monitoring currently only available in hospitals.
Researchers identified a single glucose-sensing neuron that controls insulin and glucagon hormone balance in flies, maintaining ideal glucose homeostasis. Silencing this neuron led to hyperglycemia, similar to diabetes in humans, supporting its critical role in regulating sugar levels.
Researchers link high glucose levels to impaired circadian clock function in obesity, which may drive cardiovascular disease. Intermittent fasting and clock repair drugs show promise in restoring normal circadian rhythms and improving cardiovascular health.
Research reveals a connection between Alzheimer's disease and metabolic disturbances, including glucose resistance and abnormal sleep patterns. Introducing ApoE2 into cells expressing ApoE4 may reduce metabolic deficiencies, supporting cellular functions and energy metabolism in the brain.
A new report suggests that immune cells process glucose differently in living organisms, with implications for therapeutic development and a more complete understanding of immune cell function. The study's findings could lead to breakthroughs in diagnostic and treatment strategies.
Researchers found that high fructose diets specifically inhibit the liver's ability to metabolize fat, while glucose improves fat-burning function. High fructose diets damage liver mitochondria, leading to an increase in fatty liver disease risk and metabolic syndrome.
A novel gene therapy treatment has shown promising results in patients with glycogen storage disease, allowing them to discontinue their reliance on cornstarch and experience normal blood glucose levels. Patients have reported significant improvements in energy, muscle strength, and overall quality of life.
A new study suggests that high glucose levels increase enzymatic precursor lysyl oxidase propeptide (LOX-PP), promoting cell death and contributing to retinal vascular cell loss. LOX-PP may be a therapeutic target for developing novel treatments for diabetic retinopathy.
Researchers at UNIGE found that the liver can produce glucose independently of hormonal signals, challenging the long-held belief about its role in glucose regulation. This autonomous glucose production may contribute to the development of type 2 diabetes in patients with a fatty liver syndrome.
An international team of scientists has discovered a potential drug that may prevent neuronal death through glucose metabolism modification. The new drug shows promise in treating conditions such as Amyotrophic lateral sclerosis, Alzheimer's disease, and traumatic brain injury.
A new study at the University of Kentucky reveals that mitochondrial changes, rather than glucose, drive chronic inflammation in type 2 diabetes. This finding challenges the long-held assumption that glucose is the primary cause of inflammation in the disease.
Researchers analyzed 83 randomized controlled trials involving 121,070 people with and without diabetes. They found that increasing long-chain omega-3 fats had little or no effect on likelihood of diabetes diagnosis or glucose metabolism. In contrast, higher doses of long-chain omega-3 may have negative effects on diabetes risk.
A ketogenic diet has been shown to inhibit the growth of squamous cell carcinoma tumors in mice with lung cancer. The study also found a correlation between high blood glucose levels and poor survival among patients with squamous cell carcinoma.
Researchers found that whole body vibration increases levels of Alistipes, a bacterium producing short chain fatty acids that decrease inflammation. This shift also improves the balance between macrophages promoting and suppressing inflammation.
Researchers at Ben-Gurion University discovered Mankai duckweed provides significant health benefits, including glycemic control and high protein content. The study showed that Mankai shake consumption reduced glucose peak levels and morning fasting glucose levels compared to a yogurt shake equivalent.
Scientists have designed gold nanoparticles to mimic bacterial swarming behavior, creating a collective movement towards glucose gradients. The artificially created nanoswimmers exhibit chemotactic behavior, similar to bacteria, and demonstrate the potential for studying collective intelligence on the nanoscale.
Retinitis pigmentosa (RP) is caused by the starvation of photoreceptors due to disrupted glucose transport. Research led by UofL's Douglas C. Dean and Wei Wang found similar metabolic changes in lung cancer.
A nationwide study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that high blood sugar levels significantly increase the risk of pancreatic cancer. The study suggests that early detection of hyperglycemia and lifestyle modifications to improve glucose profiles may help lower this risk.
A new NIH-funded study suggests that standard treatment of blood sugar levels after acute ischemic stroke is more effective than aggressive methods in improving patient outcomes. The study found that intensive glucose management increased the risk of hypoglycemia and required higher levels of care.
A study of over 900,000 VA patients found that routine blood tests with random plasma glucose levels below 200 mg/dL can accurately predict the development of diabetes. Patients with high glucose levels are more likely to be diagnosed with diabetes in the future, making this test a valuable tool for early intervention and prevention.
Scientists developed permanent dermal sensors that can be applied as artistic tattoos to detect changes in blood pH and metabolite levels. The sensors, based on colorimetric chemical reactions, were tested on pig skin patches, showing accurate detection of biomarkers.
Researchers at the Feinstein Institutes have discovered how the vagus nerve relays signals from the periphery to the brain to regulate glucose levels. This finding could lead to new ways of measuring blood glucose levels and may uncover a new approach to managing diabetes.
A new study found that exposure to blue light at night can raise blood sugar levels and increase sugar consumption in male rats. The researchers suggest limiting screen time at night or using apps and night mode features to mitigate this effect.
Researchers at Joslin Diabetes Center have identified a protein found in the eye that protects against and potentially treats diabetic eye disease. Retinol Binding Protein 3 (RBP3) prevents the development of diabetic retinopathy, and introducing it early can reverse the effects of the complication in rodent models.
A new study by University of Arizona researchers suggests that ALS patients may benefit from more glucose, as it can help increase energy production and improve cellular function. The findings, published in eLife, reveal that when ALS-affected neurons are given more glucose, they are able to survive longer and function better.
Scientists at the University of Illinois found that three phenolic compounds in cocoa bean shells can repair damaged mitochondria, block inflammation, and restore insulin sensitivity in white fat cells. The study suggests that consuming these compounds could prevent mitochondrial dysfunction in adipose tissue.
Scientists at Linköping University have created artificial muscles that harness energy from glucose and oxygen, mimicking biological muscle movement. The innovation uses enzymes to convert chemical energy into electrical energy, enabling the creation of implantable and autonomous microrobots.
Researchers discovered a modified enzyme produced by fungus Trichoderma harzianum that increases glucose release from biomass for fermentation. The modified protein proved 300% more efficient than the wild-type enzyme in terms of glucose release, making it suitable for industrial application.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
Researchers from University of Warwick modelled effects of high blood glucose on human endothelial cells, revealing a key mechanism in blood vessel damage. The study identifies increased hexokinase-2 activity and methylglyoxal formation as drivers of metabolic dysfunction and inflammation.
A gene mutation that became more common in humans after cooking and farming emerged as a potential adaptation to modern high-carb diets. The variant is associated with improved blood sugar regulation and may have helped ancient humans manage food scarcity.
A study by UCSF researchers found that high blood pressure and elevated blood sugar can cause heart block, a common form of arrhythmia. Lifestyle changes and monitoring could eliminate the need for pacemakers.