Articles tagged with Glucose
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A Salk Institute study found that depleting a mouse's microbiome with antibiotics reduces glucose levels and improves insulin sensitivity. The research suggests the microbiome plays a role in glucose regulation and may offer insights into treating type 2 diabetes.
Researchers found that increasing blood sugar levels improves memory and mood in older adults, making them more motivated to perform difficult tasks. This study suggests that short-term energy availability may be an important factor in older adults' motivation, leading to better cognitive engagement and confidence.
Researchers have developed a novel technique using genetically-encoded glucose biosensors to monitor Trypanosoma brucei parasite metabolism and identify molecules that disrupt glucose levels. This could lead to the development of therapeutics for African sleeping sickness, a disease causing fatal results in sub-Saharan Africa.
Researchers found that host plant quality determines whether brown planthoppers grow short wings or long wings, with higher glucose levels triggering the development of long-winged adults. This discovery could lead to new methods for controlling the insect, a major pest on rice in Asia.
Women with well-controlled type 1 diabetes often give birth to babies that are large for their gestational age, despite excellent glycemic control throughout pregnancy. Continuous glucose monitoring revealed elevated fetal weight and abdominal circumference percentages.
Researchers found that a dietary supplement derived from glucose increases muscle-force production in the Duchenne muscular dystrophy (DMD) mouse model by 50% after ten days. The study suggests that N-acetylglucosamine may preserve muscular strength and is an inexpensive product with potential as a treatment for DMD patients.
Researchers at Imperial College London have developed a more efficient enzyme that can break down plant-based biomass 30 times faster than current methods. This breakthrough could lead to cheaper and more environmentally friendly biofuel production, as well as more efficient plastic recycling.
Recent advances in cancer research focus on inhibiting key enzymes in glycolysis and glutaminolysis pathways to slow cancer cell proliferation. Several inhibitors are being tested in clinical trials, offering a promising new approach to combat cancer.
Researchers used super-resolution microscopy to study GLUT1 distribution on cell membranes, revealing clusters with an average diameter of ~250 nm. The transporter's clustering is linked to lipid rafts, actin cytoskeleton, and N-glycosylation.
Researchers found that combining elevated fasting glucose and HbA1c levels from a single blood sample is accurate for diagnosing diabetes. The new approach could prove useful in clinical practice by reducing patient visits and guiding treatment with HbA1c test results.
A recent study by a multi-institutional team identifies new linkages between quorum sensing activity and sugar metabolism in the gut, using AI-2 as an autoinducer secreted by various species of bacteria.
Researchers have found a link between bacteria metabolism and cell-to-cell communication, which could lead to the development of new drugs that block toxic molecules or prevent biofilm formation. By disrupting quorum sensing and biofilm forming in bacteria, these drugs may prevent infections such as urinary tract infections.
A recent study by UT Southwestern researchers reveals that the NAD+ molecule plays a crucial role in controlling genes essential for fat cell differentiation and cancer growth. The findings suggest that compartmentalized synthesis of NAD+ integrates cellular information to control gene expression, maintaining metabolic health.
Researchers are reevaluating lactate's role in metabolism and its potential as a treatment for various diseases. Lactate supplementation has been shown to speed recovery after injury or illness and is being explored as a tool to control blood sugar, fuel the brain, and manage inflammation.
Scientists used deep brain stimulation to regulate blood sugar metabolism and increase insulin sensitivity in patients with type 2 diabetes. The treatment showed promising results, reducing insulin requirements and boosting glucose tolerance.
A novel adipokine, WISP1, secreted by abdominal fat promotes insulin resistance and systemic inflammation. Researchers identified a link between poor oxygen supply and increased WISP1 production, which could lead to improved insulin action and alternative treatment approaches for obesity-related diseases.
Researchers at Salk Institute report a potential new approach for treating diabetes by protecting beta cells with vitamin D. The study identified a compound that enhances the activation of the vitamin D receptor, leading to improved survival of beta cells and normal glucose levels in mice.
A Monash University study has identified a lethal fungus that destroys the immune cell responsible for killing it by depleting its source of nutrients. The research found that Candida albicans competes with macrophages for glucose, leading to their death.
Researchers discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduces insulin effectiveness and glucose uptake in cells. In SDF-1 knockout mice, insulin-induced glucose uptake increased and insulin efficacy improved.
Bariatric surgery induces changes in alpha cells to produce beneficial GLP-1, combating insulin resistance and islet dysfunction associated with type 2 diabetes. Researchers aim to develop a drug mimicking this effect, making surgery's benefits more accessible.
A phase I clinical trial enrolls adults with type 1 or 2 diabetes to test the accuracy of a non-invasive tattoo sensor that measures glucose levels through sweat. The technology has the potential to break down barriers to regular blood glucose monitoring, improving patient management and quality of life.
A non-invasive adhesive patch has been created to measure glucose levels through the skin without a finger-prick blood test. The patch can accurately track glucose levels across several hours and does not require calibration with a blood sample.
The study investigates the susceptibility of TSNPRs to H2O2 etching, revealing that small-sized TSNPRs capping with citrate show great interest for glucose sensing. The research offers an ultrahigh sensitive analytical platform for point-of-care diagnostics.
A new study suggests that poor dental health may be a sign of increased risk for diabetes. The research found a progressive positive relationship between worsening glucose tolerance and the number of missing teeth among adults in the US.
A new study from Israel found that a diet with three meals per day, including a high-energy breakfast, promotes weight loss and improves diabetes control in obese type 2 diabetes patients. The study showed significant reductions in glucose levels, insulin dosage, and hunger.
A new UCLA-led study finds that the Great Recession was associated with increased blood pressure and glucose levels, particularly among older homeowners and those still in the workforce. The study analyzed data from the Multi-Ethnic Study of Atherosclerosis and suggests that economic crises can have measurable effects on public health.
The new smart contact lens can detect glucose levels in tears using built-in pliable electronics and wireless antenna. It offers a pain-free way to measure blood sugar levels, potentially reducing compliance issues among diabetic patients.
Researchers found higher levels of leisure-time physical activity linked to lower diabetes risk in Chinese adults with impaired fasting glucose. A 12-25% reduction in diabetes risk was observed with increased physical activity levels, highlighting the urgent need for promoting physical activity as a strategy for diabetes prevention.
Researchers found a connection between oxygen deprivation in bone cells and abnormally heavy bones, as well as low glucose levels. This discovery may lead to new treatments for conditions like osteoporosis, diabetes, and obesity.
A ketone ester supplement has been shown to lower blood sugar levels in healthy individuals by reducing spikes in sugar consumption. The study used a single drink containing 75 grams of sugar and found that the ketone drink reduced the blood sugar spike compared to a placebo.
The Eversense implanted continuous glucose monitoring system has been proven to be safe and highly accurate in patients with type 1 and 2 diabetes. The system achieved an average absolute relative difference of 4%, exceeding regulatory requirements for approval.
Salk researchers have identified how the liver rapidly responds to food by storing pre-RNA molecules involved in glucose and fat metabolism. This finding could help better understand metabolism and some forms of diabetes.
A peptide called catestatin has been shown to improve glucose and insulin tolerance and reduce body weight in obese mice. CST treatment also inhibited liver inflammation and reduced fatty liver.
A new study has shown that an individualized approach to nutritional ketosis combined with remote monitoring via a mobile application can sustainably and safely reverse Type 2 diabetes. The treatment resulted in significant improvements, including a 12% weight loss and a reversal of diabetes progression in 94% of patients.
Researchers have successfully palliated kidney disease in mice by removing protein tyrosine phosphatase 1B from renal podocytes. Mice with this modification displayed improved glucose tolerance and insulin sensitivity, alleviating some consequences of diabetes.
A team of Japanese researchers has identified Sirt2 as a key player in regulating hepatic glucose uptake, which is impaired in obesity and type 2 diabetes. The study found that Sirt2 regulates the dissociation of glucokinase from its regulatory protein, GKRP, through post-translational modifications.
Researchers developed an ultra-thin, flexible sensor that can track glucose levels in tears and sweat for improved diabetes monitoring. The biosensor detects a range of glucose concentrations and is flexible enough to be incorporated into contact lenses or watches.
A new report describes a soft, flexible contact lens that monitors glucose levels in tears through wireless circuits, glucose sensors, and displays. The device can deliver real-time sensing results and alerts users if glucose levels are too high, offering potential for pre-diabetes screening and daily monitoring.
Researchers have demonstrated that electronic modulation of the carotid sinus nerve can restore insulin sensitivity and glucose homeostasis in diabetic rats. The treatment has been shown to be reversible without significant adverse effects. This study provides a promising new approach for managing type 2 diabetes.
A new study from the University of Eastern Finland found that camelina oil reduces overall and LDL cholesterol levels in individuals with impaired glucose metabolism. Camelina oil, rich in alpha-linolenic acid, showed a positive effect on blood cholesterol levels but had no similar effects for fatty or lean fish.
A stress protein found in muscle has been linked to diabetes promotion, but blocking it with inhibitors could prevent glucose intolerance. FKBP51-protein inhibitors are being developed for clinical trials to treat diabetes and metabolic diseases.
Researchers at UCLA discovered that high glucose levels in pregnant women can lead to premature heart cell maturation, increasing the risk of congenital heart disease. The study found that targeting the pentose phosphate pathway could help generate more mature cells for regenerating heart tissue.
Researchers from Ural Federal University and Russian Academy of Sciences developed new methods to treat type 1 diabetes by using anti-diabetic chemical compounds. The study showed that these compounds can help reduce glucose levels and increase insulin production in lab rats with diabetes.
Engineers at UC San Diego developed a smartphone case and app that allows patients to record and track their blood glucose readings anywhere. The device, called GlucPhone, uses reusable sensors and wireless transmission for accurate measurements.
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
Scientists studied how intestinal epithelial stem cells respond to varying glucose levels, discovering a switch from renewal to growth mode triggered by higher glucose. This finding has implications for understanding cancer cell proliferation and developing new therapeutic strategies.
Experts developed a streamlined approach to using Dexcom G5 Mobile Continuous Glucose Monitor (CGM) trend arrow data. The new tool helps individuals with diabetes adjust insulin doses more accurately, reducing dangerous fluctuations and long-term complications.
Researchers have identified a new blood-sugar marker, fructosamine, that can predict patients at highest risk of complications after joint surgery. The test detects changes in glucose control faster than current markers, which could help prevent life-threatening post-surgery complications.
A genetic variant in ankyrin-B gene causes cells to store more fat, leading to obesity. This variant is carried by millions of Americans and can be identified through family history and physiological traits.
Researchers discover that CDK8 plays a critical role in allowing cancer cells to use glucose for energy. Blocking CDK8 activity combined with glycolysis inhibitors slows cancer cell growth more effectively than either approach alone.
Researchers found a connection between abnormal glucose breakdown in the brain and the severity of Alzheimer's symptoms, with lower glycolysis rates and higher brain glucose levels correlated to more severe pathology. The study suggests that targeting glycolysis defects could lead to new treatments for Alzheimer's disease.
A study published in the Journal of Human Evolution found that humans do not have uniquely expensive brains, challenging a major dogma in human evolution studies. Researchers measured the cross-sectional area of cranial arteries and brain glucose uptake to compare brain costs across 22 species.
A two-week high-intensity interval training (HIIT) program reduced glucose metabolism in all areas of the brain in physically inactive individuals with prediabetes or type 2 diabetes. HIIT improved whole-body insulin sensitivity, and moderate exercise also showed similar benefits.
Scientists at Columbia University Irving Medical Center have identified several compounds that selectively inhibit FOXO1, improving insulin sensitivity and reducing glucose production in the liver. These findings offer a promising approach to developing new, safer treatments for diabetes.
Researchers at the University of Pennsylvania School of Medicine conducted a randomized control trial showing that providing small financial incentives can motivate young people to engage in daily glucose monitoring. Participants who received $60 monthly credits were nearly three times more likely to achieve daily goals, but overall gl...
A new Yale study reveals decreased brain glucose levels in individuals with obesity and type 2 diabetes compared to lean individuals. This finding might explain the underlying mechanisms of disordered eating behavior and an increased risk of Alzheimer's disease among obese and diabetic individuals. The researchers suggest that impaired...
Researchers at NYU School of Medicine discovered that calcium flow into cells controls the activation of genes involved in glucose metabolism, enabling T cells to multiply. The study's findings have implications for autoimmune diseases and may lead to new treatments.
Researchers at Joslin Diabetes Center found that mice on a fatty diet who consumed high levels of fructose suffered worse metabolic effects compared to those given similar calories of glucose. The study highlighted the increased production of an enzyme called Khk, which is specifically important in fructose metabolism.
Researchers at Charité found that retinol saturase plays a role in adaptive processes in liver cells, increasing with body weight and reducing negative metabolic effects associated with excess glucose exposure. The enzyme's inactivation may offer a new approach to treating metabolic liver disease and its related issues.
The new model predicts how glucose-responsive insulin (GRI) will affect patients' blood sugar levels based on chemical traits. The MIT team identified several strong GRI candidates and plans to test them in animals.