Articles tagged with Glucose
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A new study led by University of Manchester biologists reveals how glucose levels in the lungs control immune responses during inflammation. The research found that blocking sugar receptors may reduce inflammation in chronic conditions, while inhalation therapy could enhance immune response against some infections.
Researchers create green fluorescent protein-based biosensors to probe energy metabolism in living cells, enabling multicolor imaging and visualization of multiple molecules. The sensors achieve up to a seven-fold increase in fluorescent brightness in response to glucose concentrations.
A new UBC study found that consuming just one dose of carbohydrates while on a high-fat, low-carbohydrate diet can damage blood vessels. The researchers recruited nine healthy young males and had them consume a glucose drink before and after a seven-day keto diet, revealing biomarkers in the blood suggesting vessel wall damage.
Hagfish hearts can pump for 36 hours without oxygen, a phenomenon that could inspire new strategies for protecting the human heart during anoxia. Researchers found that glycerol enhances heart contraction during anoxia, raising questions about its role in hagfish physiology.
A new automated drug delivery system can detect impending low blood sugar and deliver glucagon to prevent severe hypoglycemia in patients with post-bariatric hypoglycemia. The study found the system was effective in improving blood glucose levels after meals and reducing severe hypoglycemia.
A new study presented at ENDO 2019 found that the A1c test used to diagnose diabetes tends to underestimate its prevalence. The test missed detecting 73% of diabetes cases compared to the oral glucose tolerance test, highlighting its limitations.
A study found that mild sleep apnea in pregnant women was associated with higher blood sugar levels and an increased risk of childhood obesity. The researchers suggest that addressing sleep apnea may help improve maternal and infant outcomes.
Researchers found that SGLT-2 inhibitors induce a fasting state by causing the body to lose glucose, triggering weight loss and reduced fatty liver disease. The medication also activates beneficial metabolic pathways similar to those seen during fasting or calorie restriction.
Researchers found that split sleep schedules with short night duration but longer afternoon nap improved alertness, vigilance, working memory, and mood compared to continuous sleep. In contrast, continuous sleep schedules were better for glucose tolerance, but this doesn't necessarily mean a higher risk of diabetes later in life.
Researcher Jianhai Du finds that tumor cells hijack glucose metabolism to fuel cancer growth, while retina cells use it to renew photoreceptor membranes. MPC1 protein plays a critical role in regulating glucose uptake in both cell types.
Researchers at TIFR have identified molecular mechanisms that allow the liver to adapt to nutrient intake after fasting. These 'fed-microRNAs' inhibit protein synthesis, maintaining blood glucose levels. The study's findings offer potential therapeutic targets for metabolic diseases.
A Texas A&M-led study reveals that estrogen can decrease insulin resistance and glucose production, reducing Type 2 diabetes incidences. The study highlights the importance of estrogen receptor signaling and Foxo1-mediated gluconeogenesis in regulating glucose homeostasis.
A large clinical study found that intensive glucose management after stroke did not improve functional outcomes and increased the risk of low blood sugar. The results provide a clear answer to the long-held debate on blood sugar control after stroke.
A multicenter trial of 1,151 patients found that IV insulin intensive glucose control did not improve functional outcomes at 90 days compared to standard subcutaneous insulin injections. Intense glucose therapy also increased the risk of hypoglycemia and required more resources.
A Massachusetts General Hospital research team has identified intestinal immune cells that slow down metabolism, increasing fat storage. These cells, which guide immune cells to the gut, also regulate systemic metabolism by reducing a protein called GLP-1.
A new study from the University of Eastern Finland reveals that linoleic acid's impact on human inflammatory response is influenced by genetic variations. The study, which analyzed over 1,300 middle-aged men, found that different FADS1 gene variants resulted in varying effects on fasting glucose levels and inflammation.
Researchers found that patients with biochemical hypoglycemia are at increased risk of severe hypoglycemic events. The study analyzed the DCCT data set and used two levels of biochemical hypoglycemia to determine the relationship to severe hypoglycemic events.
A new UCLA study overturns the long-held belief that cancer cells are glycolytic, consuming more glucose than normal cells. Instead, researchers found that squamous cell skin cancers can use alternative nutrients like glutamine to fuel their growth.
Yeast cells produce ethanol as a 'safety valve' when their metabolic operation reaches a critical level. This discovery also explains the Warburg effect in cancer cells, where energy is wasted by producing lactate.
Research reveals that trypanosomes use gluconeogenesis and glycerol metabolism to produce ATP and synthesize glucose, challenging the long-held assumption of exclusive reliance on glycolysis. This metabolic flexibility is essential for adaptation to environmental conditions and survival in mammalian host tissues.
Researchers found that dietary sugars, particularly fructose and glucose, decrease the abundance of a protein called Roc required for Bacteroides thetaiotaomicron colonization. A resistant strain engineered by researchers outcompeted the wild-type strain in mice fed high-sugar diets.
Researchers at WSU have developed a 3D-printed glucose biosensor that outperforms traditional methods in terms of stability and sensitivity. The new technology uses direct-ink-writing and reduces waste, making it more cost-effective and customizable for individual patients.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
A lab study funded by Cancer Research UK and Worldwide Cancer Research found that mannose can slow tumour growth and enhance the effects of chemotherapy in mice with multiple types of cancer. The researchers discovered a dosage of mannose that could block enough glucose to slow tumour growth in mice without affecting normal tissues.
Researchers at Clemson University have discovered a key role for glucose in the parasite's life cycle, potentially leading to new treatments for African sleeping sickness. The study sheds light on how the parasite adapts to its environment and can inform strategies to defuse outbreaks.
Researchers identified a gene mutation in SGLT1 that helps protect against spikes in glucose levels, resulting in lower incidence of obesity, diabetes, death, and heart failure. The study's findings suggest potential therapeutic targets for metabolic disease.
Scientists from the University of Bristol have designed a new synthetic glucose binding molecule platform that brings us closer to developing the world's first glucose-responsive insulin. This innovation could eliminate hypoglycemia and provide better metabolic control for people living with diabetes.
Researchers found that hot-water immersion improved inflammatory markers and blood sugar levels in overweight men. A two-week treatment period showed a reduction of fasting blood sugar and insulin levels as well as improved low-grade inflammation.
A new streamlined method by the Endocrine Society helps people with diabetes use CGM data to refine insulin doses and improve blood glucose control. The approach, based on trend arrows in Abbott FreeStyle Libre systems, provides simplified calculations for users.
Scientists at UCLA have identified sodium glucose transporter 2 (SGLT2) as a key mechanism in lung cancer cell growth, which could lead to earlier diagnosis and treatment. The study found that SGLT2 is predominantly used by lung cancer cells to transport glucose, even in pre-malignant lesions.
An investigation by The BMJ found that tens of thousands of UK patients with type 1 diabetes are being denied access to flash glucose monitoring devices due to a postcode lottery. Despite NHS guidance, only 3-5% of patients have access to the devices, compared to 20-25% recommended by clinical commissioning groups.
Eating daily servings of nuts has been associated with lower risk of weight gain and obesity, as well as improved glucose and insulin responses. A one-ounce serving of nuts or peanut butter can be substituted for less healthy foods to prevent slow weight gain over time.
Research reveals chronic stress impairs spatial memory through altered glucose metabolism, with susceptible individuals showing cognitive impairments.
A new study found that fasting hyperglucagonemia in type 2 diabetes is associated with higher waist-to-hip ratio, poor glycemic control, and increased insulin concentrations. Visceral fat deposition may play a role in the development of this condition.
A research group led by Professor Sanna Lehtonen found that metformin directly binds to the lipid phosphatase SHIP2, increasing glucose uptake in muscle cells and protecting kidneys from damage. This discovery highlights SHIP2 as a drug target for regulating glucose metabolism and cell death.
Researchers found that switching to real-time continuous glucose monitoring (RT-CGM) significantly reduced time spent in hypoglycemia among adults with type 1 diabetes at high risk of hypoglycemia. The study also showed that continuing RT-CGM for an additional 8 weeks maintained the benefits of this option
A new study reveals that protein kinase C epsilon (PKCε) is acting from fat tissue to worsen disease, pointing to a new function in this dynamic organ. Fat tissue reveals striking differences in cell shape and size in the presence and absence of PKCε.
A study by Joslin Diabetes Center shows that alanine can activate AMPK, increasing energy production and lowering glucose levels. This finding suggests a new potential way to modify glucose metabolism in the body.
Researchers at MU and MIT developed a noninvasive technology to monitor blood glucose levels without needles or finger pricking. The device uses Raman spectroscopy to detect glucose molecules in the skin, achieving accuracy comparable to traditional finger prick tests.
Researchers identified a gene mutation linked to lower risk of diabetes, obesity, heart failure, and death. Selectively blocking the SGLT-1 receptor could slow down glucose uptake to prevent or treat cardiometabolic disease.
A Japanese study found that increased fasting glucose, higher BMI, and impaired insulin sensitivity were detectable up to 10 years before the diagnosis of diabetes as well as prediabetes. The study suggests that elevated metabolic markers for diabetes may be detectable more than 20 years before its diagnosis.
A new study reveals that low-calorie sweeteners can change the types of bacteria found in the gut, leading to impaired regulation of glucose levels. The research found a significant reduction in beneficial bacterial species and an increase in opportunistic gut bacteria.
Scientists have discovered new compounds in whole grains that may improve glucose metabolism and reduce the risk of type 2 diabetes. The findings suggest that a high intake of whole grains increases levels of betaine compounds, which are associated with improved glucose metabolism and lower post-meal glucose levels.
A study found that a high-fat, high-sugar diet may accumulate fat around the uterus of female rats, potentially impairing future fertility. Researchers observed no change in glucose tolerance or insulin sensitivity compared to control animals.
Research reveals that women with versus without prediabetes experience significantly larger adverse differences in cardiometabolic health compared to men. Women with prediabetes had higher blood pressure, worse cholesterol profiles, and increased inflammation before the onset of type 2 diabetes.
Researchers found significant reductions in mean glucose and other glycemic factors when adding dapagliflozin to metformin or insulin in patients with type 2 diabetes. Greater improvements were seen in patients taking metformin compared to insulin.
Leukemia undercuts normal cells' ability to consume glucose, leading to a diabetic-like condition that favors cancer growth. Researchers have identified key strategies, including manipulating insulin production and gut bacteria, which can be targeted with low-tech therapies like serotonin supplementation.
QUT researchers have discovered a drug that prevents laminitis in ponies with equine metabolic syndrome. The drug, velagliflozin, works by causing the kidneys to excrete more glucose in the urine, taking pressure off the pancreas and lowering insulin levels.
Researchers at the University of Guelph found that a sudden drop in glucose levels can have a lasting effect on mood. The study, published in Psychopharmacology, examined the impact of hypoglycemia on emotional behavior in rats.
A synthetic organelle created in a lab modelled membraneless organelles found to drive efficient sugar processing by balancing substrate and enzyme interactions. Researchers at Georgia Institute of Technology used this setup to explore cellular biochemistry, discovering unexpected nuances in organelle chemistry.
A $200,000 Pew grant will support research into how dietary nutrients affect gut microbes and glucose sensing in zebrafish. The study aims to uncover the mechanisms behind this interaction and identify new strategies to combat disorders like diabetes and obesity.
Untreated gestational diabetes after pregnancy is associated with development of glucose metabolism disorders in mothers, but not childhood overweight/obesity. The study found that new criteria for gestational diabetes diagnosis may be relevant in assessing maternal risk.
Researchers at the University of Colorado Anschutz Medical Campus have discovered that T cells elicited from subunit vaccines can reproduce without glucose, supporting their expansion and potentially defeating cancerous tumors. This finding has major implications for the development of immunotherapies for cancer patients.
Scientists at the University of Bristol have developed protocell communities that can exhibit cooperative and antagonistic behavior by responding to a chemical signal. The study demonstrates a new approach to creating synthetic soft materials with life-like properties.
Researchers developed a novel approach using glucose to assess how kidney cancer tumors use glucose. The study found that ccRCC tumors process glucose differently than most tissues, providing a potential target for new treatments.
Researchers at Gladstone Institutes discovered how to improve the survival of CD8 T cells, which can combat tumors and chronic infections. The study found that deleting two specific molecules enhances the survival of effector cells and yields more protective memory cells.
Researchers have successfully assembled enzyme-powered artificial cells that can oscillate in water column using catalase-generated gas bubbles. The protocells use glucose oxidase as a fuel source, enabling buoyant motion and self-sorting capabilities.
A study found that eating white button mushrooms can alter the gut microbiome, producing short-chain fatty acids that regulate glucose production in the liver. This research holds promise for developing new diabetes treatments and prevention strategies.
Continuous glucose monitoring in healthy participants showed that large fluctuations in blood glucose occur more commonly than expected. Researchers identified three distinct glucose behaviors: low, moderate, and severe, with certain foods causing significant spikes. The study aims to provide actionable advice to shift individuals towa...
A new Stanford study finds that healthy individuals often experience significant fluctuations in blood sugar levels, similar to those seen in people with diabetes. The researchers used continuous glucose monitoring devices to track participants' glucose levels over two weeks and identified distinct 'glucotypes' based on spike intensity.