Articles tagged with Glucose
A new study develops hydrogels that release glucagon as glucose levels drop, potentially preventing severe hypoglycemic episodes. The technology aims to stabilize blood glucose levels long enough for parents to get medical attention in emergency situations.
A new method developed by Institute for Systems Biology allows researchers to show how fatty acids are absorbed by single cells. The study reveals that fatty acid uptake is differentially regulated by two downstream effectors of the mTOR pathway in brain cancer cells, uncovering a novel combination therapy to block tumor growth.
A new study by Pendulum Therapeutics presents proprietary probiotic formulations that may improve glucose control in patients with Type 2 Diabetes. The research shows that Pendulum Glucose Control increases circulating butyrate and ursodeoxycholic acid, supporting the mechanism for improvement in glucose control.
Researchers discovered a brain mechanism that regulates whole-body glucose balance without altering body weight, indicating a promising therapeutic target for type 2 diabetes. By modulating this mechanism, it may be possible to regulate blood sugar levels in obese individuals with diabetes without requiring weight loss.
Researchers found dapagliflozin reduced the risk of progressive kidney disease by half in FSGS patients over a 2.4-year period, with good tolerability and safety. The medication stabilizes renal function and improves clinical outcomes in patients with type 2 diabetes and concomitant kidney damage.
The study found that continuous glucose monitors reduced emergency department visits and hospitalizations for hypoglycemia, improving blood sugar control in selected insulin-treated type 2 diabetes patients. The monitors also showed comparable results to a new diabetes medication in terms of blood sugar control.
Researchers investigated the effect of real-time continuous glucose monitoring on glycemic control among patients with insulin-treated diabetes. The study found that this technology improved blood sugar control, allowing for more effective management of the condition.
University of Kentucky researchers found that brain glycogen contains 25% glucosamine, a crucial sugar for protein decoration. This discovery has implications for understanding neurological diseases, including Lafora disease and glycogen storage disorders.
A new study in zebrafish reveals that tumors can alter the metabolism of healthy tissues, which could lead to new cancer treatments. The research found that melanoma consumes more glucose than other tissues, but surprisingly, this has no impact on circulating glucose levels.
A study by the American College of Cardiology found that people with prediabetes are at a significantly higher risk of heart attacks and strokes compared to those with normal blood sugar levels. The researchers suggest that preventing prediabetes from the start may be the best approach, rather than just focusing on preventing diabetes.
Researchers have developed a personalized sweat sensor that accurately estimates blood glucose levels without the need for finger pricks. The device uses a polyvinyl alcohol hydrogel and electrochemical sensors to measure glucose in sweat, providing an accurate estimate of blood sugar levels with an accuracy rate of over 95%.
A study by Sansum Diabetes Research Institute and Rice University found wearable devices that continuously monitor blood sugar levels provide new insights into the progression of Type 2 diabetes among at-risk Hispanic/Latino adults. The results point to new directions for improved diabetes care, particularly in underserved populations.
Researchers found that certain gut microbes, specifically Asaia bogorensis, increase the risk of malaria parasite infection in mosquitoes by raising gut pH levels. Feeding mosquitoes a sugar diet promotes the proliferation of this bacterial species, which enhances parasite infection.
A recent study by Vanderbilt researchers reveals that non-cancer cells in a tumor, primarily immune cells called macrophages, have the highest glucose uptake, upending traditional models of cancer metabolism. This finding could lead to new therapies and imaging strategies.
A new study by Brigham Young University researchers found widespread glucose metabolism impairment in Alzheimer's Disease brains, while ketolytic metabolism remained relatively intact. The study proposes that dietary and lifestyle changes could slow cognitive decline associated with the disease.
Researchers found that mice lacking Rev-erb gene exhibit characteristics similar to dawn phenomenon in type 2 diabetes. The study suggests that altered daily rhythm of Rev-erb gene expression may underlie the condition. Further investigations may lead to therapies.
The Omnipod 5 System shows significant average improvements in hemoglobin A1c and time spent within the recommended target glucose range. Children also experience improved blood sugar control after using the device.
Hospitalized COVID-19 patients with high blood sugar are more likely to require aggressive therapies and experience kidney injury, according to a new study. Patients with diabetes have a higher risk of ICU admission and in-hospital death when their blood glucose levels exceed certain thresholds.
A study found that the gut microbiome can predict changes in glucose regulation, particularly related to insulin levels and secretion. The study suggests that certain microbes may be useful for predicting disease progression and informs future research.
A study found that maternal cardiovascular health during pregnancy is associated with the later cardiovascular health of their offspring in adolescence. The research examined various factors such as body mass index, blood pressure, and cholesterol levels.
A study published in Nature suggests that limiting tumor cells' glucose consumption could improve immunotherapy efficacy by freeing up energy for immune cells. This approach may help overcome resistance to checkpoint blockade therapies, which have varying success rates.
A large study found that older adults with moderately elevated blood sugar levels do not frequently develop full-blown diabetes. Instead, many improve their blood glucose levels or die from other causes, suggesting that the 'prediabetes' diagnosis is less useful in this age group.
Research using magnetic resonance spectroscopy reveals that SGLT2 inhibitors trigger a balance between glucose loss and new production in the liver, affecting metabolism in several organs. The study provides insight into the acute impact of these drugs on lipid and energy metabolism.
Researchers discovered pancreatic beta cells secrete miR-29 family members to promote insulin resistance and enhance hepatic glucose output. This finding reveals a new mechanism linking obesity-induced insulin resistance in type 2 diabetes's pathogenesis.
Researchers identified pancreatic β cell-derived exosomal miR-29 family as a new mechanism that regulates glucose homeostasis through liver. Exosomal miR-29s negatively regulate insulin signalling pathway via targeting p85 α, attenuating the suppression of insulin on glucose output.
Researchers found that better glucose uptake in the brain compensates for age-related deterioration, leading to longer life. Improved neuronal glucose uptake also coupled with dietary restrictions showed enhanced lifespans.
The American Diabetes Association has lowered the target HbA1C levels for children with type-1 diabetes to less than 7% to reduce acute and long-term organ damage. The new guidelines aim to improve immediate and long-term health outcomes, fewer complications, and reduced mortality rates in T1D children.
Researchers at Oregon State University found that specific beneficial microbes can improve glucose metabolism and reduce obesity risk in mice fed a western diet. The study identified four bacterial species with potential therapeutic applications for type 2 diabetes, opening new avenues for probiotic treatments.
A recent study published by The Endocrine Society found that consuming drinks with sucrose can lead to lower levels of appetite-regulating hormones compared to glucose. The researchers discovered that individual characteristics, such as body weight and sex, also affect hormone responses to different types of sugar.
Researchers at Texas A&M University have designed a hydrogel membrane with fine-toothed molecular combs that can prevent leakage of small molecules while allowing glucose to freely diffuse in and out. The membrane, made from poly(N-isopropylacrylamide), could be used to form biosensors for monitoring sugar levels in diabetics.
A new study from the University of Eastern Finland found that consuming blackcurrants after a meal can attenuate the rise and fall of blood glucose levels. The beneficial effect is attributed to berry-derived polyphenolic compounds, specifically anthocyanins, which slow down glucose absorption and reduce oxidative stress.
Researchers have developed a self-repairing gelatin-based film that can mend cracks in minutes and preserve electrical functionality. The film, which incorporates glucose, can be used to enhance the durability of touchscreen and flexible display devices.
Researchers used a trans-omic approach to map the total landscape of diabetes regulation in mice. They found that obese mice lack rapid responses to glucose and instead use slower methods like changing gene expression.
A standardized 'Artificial Pancreas (AP) Dashboard' is proposed to improve glycemic control and reduce hypoglycemia in insulin requiring patients with diabetes. The dashboard provides a single-page report of seven main components, including glucose metrics, insulin management, and user experience.
Researchers developed a microneedle-based technique to extract dermal interstitial fluid, which could provide valuable information for routine clinical monitoring and diagnostic testing. The study found that ISF contains unique compounds not found in blood samples, offering potential insights into skin exposure to products and pesticides.
A University of Gothenburg study found that continuous glucose monitoring (CGM) has favorable effects over several years, including a 4 mmol/mol decrease in average blood glucose levels and a 70% reduction in episodes with low blood sugar levels. Patients also reported improved comfort and reduced anxiety.
A new computer vision app developed by University of Cambridge engineers allows easier monitoring of blood glucose levels in people with diabetes. The app uses a smartphone camera to read glucose meter data, eliminating the need for manual input or internet connectivity.
A study found that consuming lactisole-supplemented sucrose increased energy intake and reduced serotonin levels in male subjects, suggesting a role for the sweet taste receptor in satiety regulation. The effect was not observed with glucose supplementation.
A new agreement establishes a clear guideline for exercising safely with type 1 diabetes, covering carbohydrate consumption and safe glucose thresholds. The guidance is tailored for healthcare professionals to help patients manage blood sugar levels during physical activity.
Researchers have developed a simple, environmentally friendly process to produce well-defined linear and star-shaped polymers with ultrahigh molecular weights from nonconjugated monomers. The photoenzymatic RAFT polymerization method offers outstanding control over composition, molecular weight, and architecture.
Researchers found a strong correlation between glycoalbumin levels in tears and blood, suggesting potential for non-invasive diabetes monitoring. The study of 100 subjects with diabetes indicates that tear analysis could provide a reliable alternative to current invasive methods.
Among individuals with type 1 diabetes, those who stopped working during lockdown experienced improved blood sugar levels. This improvement was attributed to reduced opportunities for exercise and heightened psychological stress being replaced by a more regular lifestyle and increased focus on diabetes management.
A new study from the University of California, Davis links combining fructose and glucose in high fructose corn syrup to increased risk factors for heart disease. The researchers found that the interaction between the two sugars had a more significant impact on health risks than previously thought.
Researchers at Temple University Health System have identified a new mechanism for promoting neuron regeneration after spinal cord injury, involving the metabolic switch associated with glucose metabolism in glial cells. The study found that upregulating glycolysis in glial cells can stimulate axon growth and improve functional recovery.
Researchers have developed a painless and biodegradable patch using microneedles to diagnose conditions like prediabetes. The patch combines porous microneedles with paper-based sensors for accurate glucose monitoring.
A non-fasting blood test, hemoglobin A1c (HbA1c), can accurately identify youth at risk for type 2 diabetes and heart disease. The study suggests using HbA1c more frequently to screen youth for diabetes and related health risks.
A study by Tufts University researchers found that estrogen can have a disruptive effect on glucose metabolism in females, but not males, when a specific protein is absent. The study identified a key protein in the brain that mediates these effects and provides insight into the differences between men and women in their risk of diabetes.
A genomic signature associates with differential expression of glucose transporters and hexokinase proteins in prostate cancers with low PSMA expression. This allows for improved uptake of 18F-FDG compared to PSMA-targeted radioligands, making it an attractive imaging tool for neuroendocrine prostate cancer patients.
Scientists develop a strategy to synthesize biomolecule-metalorganic frameworks with high bioactivity by adding peptides as modulators. These biohybrids can mimic cellular cascades and function as optical glucose sensors, offering potential for industrial applications.
Researchers developed a vaccine targeting aged immune cells, which accumulated in fat tissues of obese individuals and caused chronic inflammation. Vaccination improved glucose metabolism, insulin resistance, and overall organ function in obese mice by removing senescent T cells.
Researchers at Penn State and Xiangtan University developed a device that analyzes sweat for biomarkers like pH and glucose to monitor health conditions. The single-opening device reduces evaporation and allows for on-the-spot analysis using a colorimetric approach.
Researchers design a disposable, double-sided film that attaches to the underside of a smartwatch, detecting biomarker molecules in sweat to monitor body chemistry. The system can track glucose and lactate levels, providing real-time insights into metabolic health.
A six-month clinical trial found that continuous glucose monitoring devices can significantly reduce hypoglycemia and severe hypoglycemic events in older adults with type 1 diabetes. The study also showed improved overall glucose control without worsening glycemic outcomes.
Emerging evidence suggests COVID-19 may trigger new-onset diabetes in healthy people and exacerbate pre-existing conditions. The Global Registry aims to understand the relationship between COVID-19 and diabetes, informing treatment strategies.
The study shows that the FreeStyle Libre 14 day system is estimated to save roughly 50% in average costs associated with severe hypoglycemia for people with type 1 and type 2 diabetes. Annual cost savings are 61% and 63% lower compared to traditional fingerstick testing.
Research by Liao Chen reveals significant differences between simple and realistic models of aquaporins and glucose transporters, leading to a better understanding of their biological functions. The study's findings have implications for diseases such as de Vivo's syndrome and multiple forms of cancer.
A new study developed a non-invasive molecular imaging approach using dynamic MRI to measure glucose level changes in the brain lymphatic system. This method helps identify Alzheimer's disease at early stages, allowing treatments to start promptly. The technique uses glucose as a 'tracer' and is compatible with existing MRI machines, m...
A new study found that telehealth monitoring and technology can lead to better outcomes for patients with type 1 diabetes during the COVID-19 pandemic. By allowing for frequent insulin dose adjustments and improving glucose values, telehealth helped avoid hospital admissions for diabetic ketoacidosis.
A study published in Hepatology reveals that Annexin A6 is essential for liver regeneration after a transplant or hepatic surgery. The protein helps maintain glucose homeostasis, allowing the liver to recover and restore its functions.
A miniaturized Bluetooth device can detect glucose and fructose molecules in fermentation processes over days, enabling the study of metabolites and disease. The device has an accuracy above 98% and can transmit data wirelessly for up to 24 hours.