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New imaging system maps retinal oxygen in unprecedented detail

A new dual-imaging system simultaneously maps retinal structure and capillary oxygen levels in live mice, allowing researchers to study vision-threatening diseases like glaucoma and diabetic retinopathy. This non-invasive approach offers a powerful tool for elucidating local capillary values and tracking changes in retinal oxygenation.

Breathing in 4D: Optical technique maps airway wall elasticity during bronchoscopy

Scientists developed a new 4D optical coherence tomography technique that measures airway wall elasticity in under 42 seconds, enabling detailed assessment of respiratory tissue mechanics. This faster approach may help diagnose and monitor upper airway disorders, assess injury, and guide treatment decisions.

SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateAug 14, 2025

Dual-mode optical imaging system offers new noninvasive approach to skin cancer diagnosis

Researchers develop compact, noninvasive imaging system combining LC-OCT and Raman microspectroscopy to examine skin cancer structures and chemical composition. The AI model achieves high classification accuracy for basal cell carcinoma and other types, offering new insights into cancer development and behavior.

SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateJul 30, 2025

Polarized light imaging enhances accuracy of deep brain stimulation

A new study explores catheter-based polarization-sensitive optical coherence tomography (PS-OCT) as a tool for improving the precision of electrode placement in deep brain stimulation. PS-OCT provides high-resolution intraoperative visualization of deep brain structures, distinguishing between white and gray matter more clearly than MRI.

Retinal clues to mental health

A recent study by the University of Zurich examined the connection between retinal nerve connections and schizophrenia. The researchers found that individuals with a higher genetic risk for schizophrenia tend to have thinner retinas, which can be detected using non-invasive retinal measurements.

SourceUniversity of Zurich·JournalNature Mental Health·TypeExperimental study·DateApr 22, 2025

Optical imaging technique offers more precise diagnosis of sleep apnea

A recent study has explored a new imaging approach that uses swept-source optical coherence tomography to visualize the upper airway with high precision. By integrating computational fluid dynamics, researchers were able to identify areas of turbulence and pinpoint obstruction sites, leading to more accurate diagnoses and treatment pla...

SourceSPIE--International Society for Optics and Photonics·JournalBiophotonics Discovery·DateJan 7, 2025

Noninvasive choroidal vessel analysis via deep learning: A new approach to choroidal optical coherence tomography angiography

Researchers developed a novel noninvasive choroidal angiography method using deep learning, enabling layer-wise visualization and evaluation of choroidal vessels. The approach employs an advanced segmentation model to handle varying quality of OCT B-scans, offering a promising tool for clinical applications.

SourceHealth Data Science·JournalHealth Data Science·DateNov 4, 2024

Comparison of the “late catch-up” phenomenon between BuMA Supreme and XIENCE stents through serial optical coherence tomography at 1–2 month and 2 year follow-ups: A multicenter study

The multicenter study found that the BuMA Supreme stent showed faster re-endothelization with no 'late catch-up' phenomenon compared to the XIENCE stent. This results in decreased dual antiplatelet therapy duration, potentially benefiting patients with coronary artery disease and high bleeding risk.

SourceCompuscript Ltd·JournalCardiovascular Innovations and Applications·DateApr 23, 2024

New method for detecting blood circulation problems in brain capillaries

Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.

New imaging technique measures elasticity of multiple eye components simultaneously

A new imaging technique, multifocal acoustic radiation force-based reverberant optical coherence elastography (RevOCE), has been developed to measure the elasticity of multiple eye components simultaneously. This approach offers high resolution measurements of the stiffness of eye structures and could revolutionize how we study ocular ...

SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateSep 12, 2023

Technology advance lays groundwork for OCT eye imaging at home

Researchers have developed a custom OCT setup that incorporates a vertical cavity surface emitting laser (VCSEL) diode, which could increase access to OCT imaging and help catch eye problems early. The system performed well in imaging the eye of a healthy volunteer and showed potential for use in biometric eye scanner systems.

SourceOptica·JournalOptics Letters·DateJun 1, 2023

Eye imaging technology breaks through skin by crossing beams

Duke researchers developed a method to increase the depth of view of optical coherence tomography (OCT), allowing for clear images from beyond a millimeter beneath the skin's surface. The new technique, known as dual-axis OCT, tilts the light source and detector to collect more scattered light from deep tissues.

SourceDuke University·JournalBiomedical Optics Express·TypeExperimental study·DateDec 1, 2021

3D polarization-sensitive OCT imaging of collagen organization within organ systems

Researchers developed a novel PSOCT method, polarization state tracing (PST), to image depth-resolved collagen organization within living tissues without damaging the sample. This allows for accurate clinical diagnosis and image-guided surgery, targeting precision medicine.

Dynamic full-field optical coherence tomography: 3D live-imaging of retinal organoids

Researchers developed a new imaging modality for in-development retinal organoids using D-FFOCT, which offers high spatial and temporal resolutions. The technique allows for the creation of highly contrasted images of almost transparent samples without labels, enabling long-term study of sample development.

Nanometer-scale growth of cone cells tracked in living human eye

Researchers at Indiana University have developed a method to measure microscopic changes in cone cells using optical coherence tomography (OCT) phase differences. They found the outer segments of cone cells grow at a rate of about 150 nanometers per hour, which is significantly faster than human hair growth.

SourceOptica·JournalBiomedical Optics Express·DateDec 20, 2011