Articles tagged with Cohort Studies
A new study has associated genetic loci with bacterial species and metabolic signatures, revealing that human genes affect the microbiome. The study found associations between lactase variants and Bifidobacterium presence, as well as C-type lectin gene variants with immune system function.
Researchers found IDH gene mutations to be independently prognostic of overall and progression-free survival in grade II and III gliomas. CIC mutations also showed promise as prognostic markers, although more research is needed to confirm their effectiveness.
A new study challenges the traditional efficacy trial model by using real-world patients and GP practices to test COPD treatments. The Salford Lung Study found that a once-daily treatment regimen was associated with lower rates of exacerbations without increased risk of serious adverse events.
The Human Factors and Ergonomics Society will focus on human-centered issues in cyber operations, including situation awareness, vigilance, task-switching, and training. Presentations will address human factors gaps in cyber defense and explore persuasion principles in phishing emails.
A study of 6,120 Danish women found that high alcohol intake was associated with a slight decrease in fertility, while low to moderate consumption showed no effect. The authors recommend abstinence from alcohol during the fertile window until pregnancy is ruled out.
New research finds that men are more open to purchasing environmental products if their masculinity is boosted through branding. The study used various approaches, including affirming masculinity and changing product associations, to demonstrate the effectiveness of rebranding green products as masculine.
A recent study published in JAMA Cardiology found that HIV-infected adults with major depressive disorder (MDD) were more likely to experience a heart attack than those without MDD. The study, which included over 26,000 HIV-infected veterans, revealed a 30% increased risk of acute myocardial infarction (AMI) in those with MDD.
A study of nearly 3,400 military veterans over 10 years found that those who misused opioid painkillers had a very high likelihood of also beginning to use heroin. Non-medical use of prescription painkillers was the biggest predictor of heroin use.
A study published in JAMA Surgery found that revascularization interventions improved walking comfort, distance, and symptoms in patients with moderate to severe IC compared to medical management. Revascularization significantly increased walking function and quality of life at 12 months.
A recent NIH survey found 79% of respondents willing to participate in the Precision Medicine Initiative Cohort Program, a nationwide research effort aimed at personalizing healthcare based on individual differences. The program, which aims to engage 1 million participants, shows promise for improving disease prevention and treatment.
A large study found that maintaining intermediate levels of high-density lipoprotein (HDL) cholesterol may help people live longer. The study, which included 1.7 million US male veterans, discovered a U-shaped relationship between HDL-C and mortality risk, with low and high levels being associated with higher risks.
A nationwide study suggests that heavy users of partisan media outlets are more likely to hold political misperceptions. The researchers found that the use of partisan media contributes to misperceptions above and beyond the influence of partisanship itself.
Researchers found an association between low physical activity and a higher risk for dementia in older individuals, with regular exercise potentially leading to higher brain volumes and reduced dementia risk. The protective effect was strongest in people aged 75 and older.
Research by Sam Houston State University reveals that restorative justice programs are more effective in reducing recidivism rates than traditional court processing. The study found that even minimal interventions had a significant impact on reducing re-offending rates.
Researchers from Hebrew SeniorLife Institute for Aging Research found that women with the most severe kyphosis had the greatest declines in lung function. Hyperkyphosis restricts lung expansion and causes difficulty breathing, leading to serious health problems.
A new study found that receiving treatment at Primary Stroke Centers (PSCs) led to significantly better survival rates for patients traveling less than 90 minutes. However, the benefit was nullified when travel time exceeded 90 minutes. The study used a cohort of Medicare beneficiaries with acute stroke admitted between 2010 and 2013.
A new study reveals a significant relationship between chronic periodontitis and lacunar infarct, two common diseases affecting the elderly. The study suggests that periodontitis may lead to systemic inflammation, increasing the risk of developing cerebrovascular diseases.
The Nurses' Health Study has made significant advances in risk prediction for cancer, while also guiding recommendations from the US Surgeon General on smoking's adverse health effects. The study's findings have led to changes in regulation, such as reduced heart disease and diabetes risk associated with trans fats.
A landmark study published in the International Journal of Cardiology found that stand-up comedians are more likely to die prematurely compared to comedy actors and dramatic actors. The study revealed a pattern of premature mortality among elite stand-up comedians, with those at the top being more likely to die at a younger age.
A cohort study of 24,623 men and 27,890 women found that habitual cycling was associated with a lower risk of developing type 2 diabetes. Participants who took up habitual cycling during the follow-up period were at 20% lower risk for T2D than non-cyclists.
Researchers have developed a technique to help GPs and nurses identify young children most likely to have a UTI, enabling non-invasive urine sampling. The symptoms-and-signs-based clinical rule is superior to routine clinician diagnosis, reducing the need for unnecessary tests and increasing accurate diagnoses.
A study of 85 Gulf War veterans identified three types of white blood cells and six proteins in the blood that can help diagnose Gulf War Illness with 90% accuracy. The research found chronic inflammation as a key component of the illness, supporting the hypothesis that it is a well-defined chronic inflammatory disease.
The National Institutes of Health is launching a landmark longitudinal research effort, the Precision Medicine Cohort Program, with $55 million in funding. The program aims to engage 1 million or more U.S. participants to improve disease prevention and treatment based on individual differences in lifestyle, environment, and genetics.
A new study aims to identify the best method for collecting sexual orientation and gender identity data from patients in emergency departments. The EQUALITY Study found that non-verbal self-reporting is the preferred method among both patient and provider respondents, despite concerns about offending patients.
Research suggests that patients with MSA have lower levels of coenzyme Q10 (CoQ10) in their blood, regardless of COQ2 genotype. This finding may support the idea that CoQ10 supplementation could be beneficial for MSA patients. However, more studies are needed to confirm this hypothesis.
A protein-based risk score was developed and validated for predicting cardiovascular outcomes in patients with coronary heart disease. The score performed better than the Framingham secondary event risk model but provided modest discriminative accuracy.
A heart monitor implant has been shown to detect potentially fatal cardiac arrhythmias in patients with systemic sclerosis, a serious immune disease. The device can store ECG data automatically and pick up various heart rhythm abnormalities in over half of the cohort of SSc patients.
A recent study found that approximately one-third of women taking oral bisphosphonates continue to be at elevated risk for bone fracture. Despite the medication being effective in reducing fracture risk, various factors such as other medical conditions and fall-related problems contribute to this increased risk.
A new study finds that EU-15 citizens increasingly identify as European, with the proportion rising to 61% in 2013. The study also shows that younger cohorts are more likely to have multiple identities, which will continue to increase as they replace older generations.
A study published in Journal of the American Geriatrics Society found that doctors and non-doctors in the US experience similar levels of hospital care and intensive care unit stays at the end of life. More than 46% of doctors enrolled in hospice care compared to 43.2% of non-doctors, suggesting a shift towards more palliative care.
A new study published in the journal Sleep found that US military members who reported insomnia symptoms or short sleep durations were less resilient than those with healthy sleep hygiene. The study also showed that poor sleepers are more likely to leave the military early and are less likely to deploy.
A study of over 3,500 patients with CKD found a significant association between high urinary sodium excretion and an increased risk of cardiovascular disease. The researchers discovered that moderate sodium reduction may lower CVD risk in these patients.
Research from UC Berkeley and Northwestern University suggests that outbursts of anger predict cardiovascular problems, while shutting down emotionally or 'stonewalling' raises the risk of musculoskeletal ailments. The study monitored couples' behaviors over 20 years, finding a stronger link for husbands but also correlations in wives.
Researchers investigated late mortality rates among sepsis survivors and found a high rate of death within two years. The study suggests that pre-existing health conditions do not explain the increased risk of late death after sepsis, implying that treatments may be more effective than previously thought.
CHF patients with predominant central sleep apnea (CSA) are at higher risk for death and unplanned hospitalization, particularly those in the most severe NYHA class. ASV therapy has been shown to be effective in treating CSA, but its impact on mortality rates remains unclear.
Researchers analyze high-risk individuals and track their HIV status to understand the evolution of symptoms and signs during acute infection. The study reveals a correlation between peak viremia and set-point viremia, establishing a critical window for intervention strategies.
A new study has found a significant association between prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) and lower birth weight. Infants exposed to SSRIs for two or more trimesters weighed 205 grams less than those not exposed, on average.
A new study published in Neurobiology of Aging found that shift workers performed worse on a cognitive test compared to non-shift workers. Those who had quit shift work for more than five years showed similar results to non-shift workers.
Researchers at Brigham and Women's Hospital found a significant association between eating four or more servings of boiled, baked, mashed potatoes or French fries per week and an increased risk of high blood pressure. Replacing potato consumption with non-starchy vegetables was associated with a lower risk of hypertension.
Untreated obstructive sleep apnea (OSA) is associated with a significant increase in major adverse cardiac and cerebrovascular events, including cardiovascular death, heart attack, stroke, and unplanned revascularization. Patients with OSA have a 1.57 times higher risk of these events compared to those without OSA.
Researchers found that patients with ARDS were more likely to have ILA, and those with ILA on CT imaging prior to ARDS development had a greater risk of in-hospital mortality. This suggests ILA may be a risk factor for ARDS.
A study of over 300 Iraq and Afghanistan veterans found that nearly 50% met the criteria for mild to moderate CMI, with common symptoms including fatigue, joint pain, and difficulty remembering. The study suggests a link between deployment and CMI, but notes limitations in the research and recommends further investigation.
A comprehensive assessment of dengue fever's economic impact found the global cost to be substantial at $8.9 billion annually, exceeding several other major infectious diseases. The study provides valuable insights for governments and donors in making informed decisions about dengue programs.
A new study published in Hypertension found that arterial stiffening can be detected in early adulthood, particularly in ethnic minority groups, and is associated with physical inactivity, stress from racism, and high blood pressure. Regular physical activity was linked to lower arterial stiffness, emphasizing the importance of exercis...
A new NYU Steinhardt study reveals growing income-based gaps in college attendance and completion, but decreasing gaps in high school graduation rates. The research suggests that rising income inequality may be making it harder for low-income students to get ahead, particularly in accessing four-year colleges.
A large-scale study found that a difference of 5mm Hg in systolic blood pressure measurements between the two arms was associated with almost double the risk of death from heart-related disease over an eight-year period. This suggests that measuring blood pressure in both arms is crucial for identifying individuals at higher risk of ca...
A late-breaking abstract at the European Lung Cancer Conference presented findings on osimertinib's effectiveness as first-line treatment for EGFR mutated non-small-cell lung cancer. The study showed a high overall response rate and prolonged progression-free survival, suggesting that osimertinib may alter the biology of the disease.
A new study finds that early treatment for post-traumatic stress disorder (PTSD) significantly reduces symptoms, but does not prevent long-term suffering. The research suggests that prolonged exposure and cognitive therapy can shorten the recovery time, but may not reduce PTSD prevalence.
Researchers at Rush University Medical Center are conducting a five-year randomized trial to test the MIND diet's effects on cognitive decline and Alzheimer's disease incidence. The study will enroll 600 individuals aged 65+ and evaluate the diet's impact on brain structure, cognition, and health outcomes.
A rare study of attitudes to death and dying amongst the very old reveals that this group is willing to discuss their end-of-life care, but rarely does so. The research found that most older people feel ready to die and would prefer a peaceful, pain-free passing.
A study found that the prevalence of treated diabetes increased from 5.2% to 7.7% in the US, while estimated spending for insulin per patient rose from $231 to $736 between 2002 and 2013. Insulin prices skyrocketed, with average prices increasing by 197% over the same period.
New research from South Korea suggests that higher dietary calcium intake may lower the risk of cardiovascular disease in older people, but not stroke and fracture risk. In a population with low calcium intake, higher dietary calcium was significantly associated with decreased risk of CVD.
The study suggests that PSA screening should be extended and higher biopsy thresholds used to preserve benefits while controlling harm and costs, potentially making it a more cost-effective strategy.
Researchers found that physical activity among children is lower in autumn and winter compared to spring and summer. The study highlights the need for increased active opportunities during the colder months to support children's health and development.
Researchers found that 56% of elective resections for uncomplicated diverticulitis occurred after fewer than 3 episodes, suggesting a need for further investigation into appropriate care guidelines. The study included 87,461 patients and analyzed inpatient, outpatient, and antibiotic claims.
A study published in JAMA Surgery found that gastric bypass surgery significantly reduced mortality rates in patients aged older than 35 years. The lack of mortality benefit for younger patients was attributed to a higher number of externally caused deaths, mainly among women.
Two Penn professors, Dorothy Roberts and Sarah Tishkoff, co-authored a piece in Science journal arguing that the use of genetic concepts of race is problematic and harmful. They recommend using terms like ancestry and population instead.
A new study published in PLOS Medicine found that Parkinson's patients experience a higher risk of injurious falls and hip fractures up to 30 years before diagnosis. This suggests early signs of balance issues may be an indicator of the disease.
Research published in Diabetologia reveals that each extra hour of daily sedentary time is associated with a 22% increased risk of developing type 2 diabetes. Participants with type 2 diabetes spent more time sedentary, highlighting the importance of reducing sedentary behavior in diabetes prevention.
A study found that both short and long sleep durations in pregnancy are associated with extreme gestational weight gain. Poor sleep has been linked to adverse pregnancy outcomes, and the study provides a potential mechanism for this association.