Articles tagged with Cohort Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in the Journal of the American College of Cardiology found that alcohol abuse increases the risk of atrial fibrillation, heart attack and congestive heart failure, similar to other well-established risk factors. The researchers analyzed data from California residents with ambulatory surgery or emergency care and found...
A Geisinger-Regeneron genomics study found that Familial Hypercholesterolemia (FH) is more common than thought, with 1 in every 256 people carrying a disease-causing mutation. The study identified 35 mutations causing FH and found many patients were undertreated due to lack of genetic confirmation.
A healthy diet has been linked to a reduced risk of early death in patients with chronic kidney disease. The study analyzed 7 studies involving 15,285 participants and found that healthy dietary patterns were consistently associated with a 20-30% lower rate of mortality.
The study found that benzodiazepine and related drug use increased the risk of hip fracture by 43% in persons with Alzheimer's disease. Long-term hospital stays after hip fractures were also more common among those who used these drugs.
A RAND Corporation study found that 20% of US households view having a landline as the most important telecommunications choice. In contrast, mobile telephones dominate communications for most people, with 3.5 times more importance than landlines.
Researchers at MD Anderson Cancer Center have developed a new tool to predict lung cancer risk in never, light, and heavy smokers. By incorporating various risk factors, the model can better classify those in greatest need of lung cancer screening, thereby reducing unnecessary screenings and false positives.
The PLATINUM DIVERSITY trial found that women and minorities had higher rates of death and myocardial infarction after coronary stent procedures compared to white men. The study also highlighted the need for further research into the causes of these observed gradients of risk.
The largest study to investigate the effects of air pollution and traffic noise found that long-term exposure is linked to a greater incidence of high blood pressure. For every 5 μg/m3 of PM2.5, the risk of hypertension increased by 22% in people living in the most polluted areas.
A new RAND Corporation report reveals that Louisiana teachers are more likely to consult classroom resources and provide instruction aligned with their state standards. This success may offer lessons for other states on how to encourage teacher alignment.
A team of researchers found that widely accepted atrial fibrillation risk prediction algorithms do not accurately predict incidence when applied to electronic medical records. The study suggests that existing models may be incompatible with EMR data, leading to inconsistent predictions and potential misdiagnosis.
A comprehensive analysis of 77 studies found no difference in the work ethic between baby boomers, Generation X, and Millennials. The findings suggest that organizational initiatives targeting generational differences may be unwarranted.
A 13-year study found that nearly doubling ICU ventilation use among advanced-dementia patients did little to improve outcomes, raising concerns about late-life suffering and unnecessary care costs.
A phase I study of BAY 1163877 identified patients who will respond to the pan-FGFR inhibitor based on tumor mRNA expression, with notable activity seen in bladder cancer and adenoid cystic carcinoma. The drug was well-tolerated, revealing a toxicity profile better than other FGFR inhibitors under development.
A 10-year study found that moderate to high caffeine consumption was linked to a 36% reduced risk of dementia. The researchers analyzed data from over 6,400 postmenopausal women and adjusted for various risk factors.
A new study has associated genetic loci with bacterial species and metabolic signatures, revealing that human genes affect the microbiome. The study found associations between lactase variants and Bifidobacterium presence, as well as C-type lectin gene variants with immune system function.
Researchers found IDH gene mutations to be independently prognostic of overall and progression-free survival in grade II and III gliomas. CIC mutations also showed promise as prognostic markers, although more research is needed to confirm their effectiveness.
A new study challenges the traditional efficacy trial model by using real-world patients and GP practices to test COPD treatments. The Salford Lung Study found that a once-daily treatment regimen was associated with lower rates of exacerbations without increased risk of serious adverse events.
The Human Factors and Ergonomics Society will focus on human-centered issues in cyber operations, including situation awareness, vigilance, task-switching, and training. Presentations will address human factors gaps in cyber defense and explore persuasion principles in phishing emails.
A study of 6,120 Danish women found that high alcohol intake was associated with a slight decrease in fertility, while low to moderate consumption showed no effect. The authors recommend abstinence from alcohol during the fertile window until pregnancy is ruled out.
New research finds that men are more open to purchasing environmental products if their masculinity is boosted through branding. The study used various approaches, including affirming masculinity and changing product associations, to demonstrate the effectiveness of rebranding green products as masculine.
A recent study published in JAMA Cardiology found that HIV-infected adults with major depressive disorder (MDD) were more likely to experience a heart attack than those without MDD. The study, which included over 26,000 HIV-infected veterans, revealed a 30% increased risk of acute myocardial infarction (AMI) in those with MDD.
A study of nearly 3,400 military veterans over 10 years found that those who misused opioid painkillers had a very high likelihood of also beginning to use heroin. Non-medical use of prescription painkillers was the biggest predictor of heroin use.
A study published in JAMA Surgery found that revascularization interventions improved walking comfort, distance, and symptoms in patients with moderate to severe IC compared to medical management. Revascularization significantly increased walking function and quality of life at 12 months.
A recent NIH survey found 79% of respondents willing to participate in the Precision Medicine Initiative Cohort Program, a nationwide research effort aimed at personalizing healthcare based on individual differences. The program, which aims to engage 1 million participants, shows promise for improving disease prevention and treatment.
A large study found that maintaining intermediate levels of high-density lipoprotein (HDL) cholesterol may help people live longer. The study, which included 1.7 million US male veterans, discovered a U-shaped relationship between HDL-C and mortality risk, with low and high levels being associated with higher risks.
A nationwide study suggests that heavy users of partisan media outlets are more likely to hold political misperceptions. The researchers found that the use of partisan media contributes to misperceptions above and beyond the influence of partisanship itself.
Researchers found an association between low physical activity and a higher risk for dementia in older individuals, with regular exercise potentially leading to higher brain volumes and reduced dementia risk. The protective effect was strongest in people aged 75 and older.
Research by Sam Houston State University reveals that restorative justice programs are more effective in reducing recidivism rates than traditional court processing. The study found that even minimal interventions had a significant impact on reducing re-offending rates.
Researchers from Hebrew SeniorLife Institute for Aging Research found that women with the most severe kyphosis had the greatest declines in lung function. Hyperkyphosis restricts lung expansion and causes difficulty breathing, leading to serious health problems.
A new study found that receiving treatment at Primary Stroke Centers (PSCs) led to significantly better survival rates for patients traveling less than 90 minutes. However, the benefit was nullified when travel time exceeded 90 minutes. The study used a cohort of Medicare beneficiaries with acute stroke admitted between 2010 and 2013.
A new study reveals a significant relationship between chronic periodontitis and lacunar infarct, two common diseases affecting the elderly. The study suggests that periodontitis may lead to systemic inflammation, increasing the risk of developing cerebrovascular diseases.
The Nurses' Health Study has made significant advances in risk prediction for cancer, while also guiding recommendations from the US Surgeon General on smoking's adverse health effects. The study's findings have led to changes in regulation, such as reduced heart disease and diabetes risk associated with trans fats.
A landmark study published in the International Journal of Cardiology found that stand-up comedians are more likely to die prematurely compared to comedy actors and dramatic actors. The study revealed a pattern of premature mortality among elite stand-up comedians, with those at the top being more likely to die at a younger age.
A cohort study of 24,623 men and 27,890 women found that habitual cycling was associated with a lower risk of developing type 2 diabetes. Participants who took up habitual cycling during the follow-up period were at 20% lower risk for T2D than non-cyclists.
Researchers have developed a technique to help GPs and nurses identify young children most likely to have a UTI, enabling non-invasive urine sampling. The symptoms-and-signs-based clinical rule is superior to routine clinician diagnosis, reducing the need for unnecessary tests and increasing accurate diagnoses.
A study of 85 Gulf War veterans identified three types of white blood cells and six proteins in the blood that can help diagnose Gulf War Illness with 90% accuracy. The research found chronic inflammation as a key component of the illness, supporting the hypothesis that it is a well-defined chronic inflammatory disease.
The National Institutes of Health is launching a landmark longitudinal research effort, the Precision Medicine Cohort Program, with $55 million in funding. The program aims to engage 1 million or more U.S. participants to improve disease prevention and treatment based on individual differences in lifestyle, environment, and genetics.
A new study aims to identify the best method for collecting sexual orientation and gender identity data from patients in emergency departments. The EQUALITY Study found that non-verbal self-reporting is the preferred method among both patient and provider respondents, despite concerns about offending patients.
Research suggests that patients with MSA have lower levels of coenzyme Q10 (CoQ10) in their blood, regardless of COQ2 genotype. This finding may support the idea that CoQ10 supplementation could be beneficial for MSA patients. However, more studies are needed to confirm this hypothesis.
A protein-based risk score was developed and validated for predicting cardiovascular outcomes in patients with coronary heart disease. The score performed better than the Framingham secondary event risk model but provided modest discriminative accuracy.
A heart monitor implant has been shown to detect potentially fatal cardiac arrhythmias in patients with systemic sclerosis, a serious immune disease. The device can store ECG data automatically and pick up various heart rhythm abnormalities in over half of the cohort of SSc patients.
A recent study found that approximately one-third of women taking oral bisphosphonates continue to be at elevated risk for bone fracture. Despite the medication being effective in reducing fracture risk, various factors such as other medical conditions and fall-related problems contribute to this increased risk.
A new study finds that EU-15 citizens increasingly identify as European, with the proportion rising to 61% in 2013. The study also shows that younger cohorts are more likely to have multiple identities, which will continue to increase as they replace older generations.
A study published in Journal of the American Geriatrics Society found that doctors and non-doctors in the US experience similar levels of hospital care and intensive care unit stays at the end of life. More than 46% of doctors enrolled in hospice care compared to 43.2% of non-doctors, suggesting a shift towards more palliative care.
A new study published in the journal Sleep found that US military members who reported insomnia symptoms or short sleep durations were less resilient than those with healthy sleep hygiene. The study also showed that poor sleepers are more likely to leave the military early and are less likely to deploy.
A study of over 3,500 patients with CKD found a significant association between high urinary sodium excretion and an increased risk of cardiovascular disease. The researchers discovered that moderate sodium reduction may lower CVD risk in these patients.
Research from UC Berkeley and Northwestern University suggests that outbursts of anger predict cardiovascular problems, while shutting down emotionally or 'stonewalling' raises the risk of musculoskeletal ailments. The study monitored couples' behaviors over 20 years, finding a stronger link for husbands but also correlations in wives.
Researchers investigated late mortality rates among sepsis survivors and found a high rate of death within two years. The study suggests that pre-existing health conditions do not explain the increased risk of late death after sepsis, implying that treatments may be more effective than previously thought.
CHF patients with predominant central sleep apnea (CSA) are at higher risk for death and unplanned hospitalization, particularly those in the most severe NYHA class. ASV therapy has been shown to be effective in treating CSA, but its impact on mortality rates remains unclear.
Researchers analyze high-risk individuals and track their HIV status to understand the evolution of symptoms and signs during acute infection. The study reveals a correlation between peak viremia and set-point viremia, establishing a critical window for intervention strategies.
A new study has found a significant association between prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) and lower birth weight. Infants exposed to SSRIs for two or more trimesters weighed 205 grams less than those not exposed, on average.
A new study published in Neurobiology of Aging found that shift workers performed worse on a cognitive test compared to non-shift workers. Those who had quit shift work for more than five years showed similar results to non-shift workers.
Researchers at Brigham and Women's Hospital found a significant association between eating four or more servings of boiled, baked, mashed potatoes or French fries per week and an increased risk of high blood pressure. Replacing potato consumption with non-starchy vegetables was associated with a lower risk of hypertension.
Untreated obstructive sleep apnea (OSA) is associated with a significant increase in major adverse cardiac and cerebrovascular events, including cardiovascular death, heart attack, stroke, and unplanned revascularization. Patients with OSA have a 1.57 times higher risk of these events compared to those without OSA.
Researchers found that patients with ARDS were more likely to have ILA, and those with ILA on CT imaging prior to ARDS development had a greater risk of in-hospital mortality. This suggests ILA may be a risk factor for ARDS.
A study of over 300 Iraq and Afghanistan veterans found that nearly 50% met the criteria for mild to moderate CMI, with common symptoms including fatigue, joint pain, and difficulty remembering. The study suggests a link between deployment and CMI, but notes limitations in the research and recommends further investigation.
A comprehensive assessment of dengue fever's economic impact found the global cost to be substantial at $8.9 billion annually, exceeding several other major infectious diseases. The study provides valuable insights for governments and donors in making informed decisions about dengue programs.
A new study published in Hypertension found that arterial stiffening can be detected in early adulthood, particularly in ethnic minority groups, and is associated with physical inactivity, stress from racism, and high blood pressure. Regular physical activity was linked to lower arterial stiffness, emphasizing the importance of exercis...
A new NYU Steinhardt study reveals growing income-based gaps in college attendance and completion, but decreasing gaps in high school graduation rates. The research suggests that rising income inequality may be making it harder for low-income students to get ahead, particularly in accessing four-year colleges.
A large-scale study found that a difference of 5mm Hg in systolic blood pressure measurements between the two arms was associated with almost double the risk of death from heart-related disease over an eight-year period. This suggests that measuring blood pressure in both arms is crucial for identifying individuals at higher risk of ca...