Researchers highlight key phagocytosis checkpoints and 'do not eat me' signals as potential therapeutic targets for novel immunotherapies. The editorial summarizes challenges in targeting CD47 and potential solutions to overcome these obstacles.
A new study found that 2-bromopalmitate treatment reverses cell senescence in human vascular smooth muscle cells, reducing DNA damage markers and promoting cell proliferation. The research suggests a critical role for protein palmitoylation in regulating the senescent phenotype.
New vaccines are being explored as a promising approach to treating glioblastoma, a highly lethal brain cancer with limited treatment options. These vaccines have been generally well-tolerated and have shown promise in improving survival rates for GBM patients.
A new library of healthy participants' neuroimaging data has been created to aid in the diagnosis and treatment of traumatic brain injury (TBI). The Normative Neuroimaging Library consists of data from approximately 1900 individuals, providing a comprehensive dataset for clinicians and researchers.
Generative AI is revolutionizing oncological imaging by expanding datasets and improving image quality. This technology enables predictive oncology and personalized cancer screening, offering new hope in the fight against cancer.
Researchers suggest that hematopoietic stem and progenitor cells in the AML niche may retain an inflammatory memory, potentially leading to long-term functional consequences. This finding has significant implications for understanding the biology of acute myeloid leukemia (AML) and developing new cancer therapies.
A new editorial in Oncoscience explores the application of functional information to adapt radiation therapy to individual patients. This approach aims to reduce uncertainty and improve outcomes in cancer treatment by analyzing signal data uncertainty.
Researchers validate increase of specific t-Cys sites associated with aging in human proteome, suggesting potential role in age-related diseases. The study expands beyond classical proteinopathic paradigms, highlighting trioxidized cysteine as a key molecular mechanism underlying aging.
Researchers explore AI's role in addressing challenges in immunotherapy, developing new biomarkers for precise disease characterization and predicting treatment response. A comprehensive review applied AI/radiomics to cross-sectional imaging, showcasing the current landscape in IO treatment.
The MIT Press is accepting applications for its shift+OPEN initiative, which provides funding and support to convert subscription-based journals to diamond open access. Selected journals will receive three-year funding, professional publishing services, and sustainable funding model development support.
The European Societies and European Journal of Cultural and Political Sociology journals will transition to diamond open access with the MIT Press, starting in 2025. The move is driven by the growing acceptance of open access in academic fields and the European Union's new requirements.
The MIT Press is expanding its shift+OPEN initiative with a $275,000 NSF grant to flip two high-impact subscription-based journals to diamond OA. The program aims to accelerate STEM and HSS research by providing barrier-free access to scholarly works.
The EU project CRAFT-OA aims to strengthen institutional publishing using Diamond Open Access model across Europe. The project will enable local platforms and service providers to expand their content services with the aim of networking them with other information systems in science.
A new case study explores the early years of BioOne and SPIE's nonprofit platform partnership, highlighting its potential to reduce costs and enhance strategic development. The authors share key lessons learned, including the importance of regular communication and reciprocal service-level agreements.
Researchers found that overexpressing matriptase reduced myeloma cell proliferation and inhibited migration. Matriptase also blocked Src kinase activation, supporting its potential as a tumor suppressor in multiple myeloma. The study provides new insights into the role of matriptase in hematological malignancies.
Researchers at the University of Surrey have introduced an upgraded version of their augmented reality book technology, allowing users to trigger digital content with a gesture. The new 3G model enables sustainable hybrid solutions for various book genres, including education and travel, offering a deeper understanding of written topics.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
The MIT Press has released a white paper on its Direct to Open (D2O) model, a collective framework for supporting open access monographs. The report examines the context and logic behind the model's design, which balances private benefits with mission-aligned support for open business models.
The MIT Press has partnered with Jisc to provide central licensing and invoicing for Direct to Open, a framework that moves books from a market-based model to a library-supported open access model. Libraries committing to D2O before September 30 will earn exclusive benefits, including term access to an archive of gated titles.