Cell and gene therapy across 35 years
A bibliometric analysis of global advances in cell and gene therapy reveals uneven progress, with US and China leading the field. Japan's contributions are significant but lack qualitative influence.
Impact Factors
Articles tagged with Impact Factors
Sage Policy Profiles adds new free feature connecting researchers to policy opportunities
The new feature in Sage Policy Profiles matches researchers with live policy engagement opportunities based on their research, biography, and countries of interest. Over 26,000 researchers have used the tool to discover their policy impact since its launch.
Digital Science awards 2025 Catalyst Grants to two teams visualizing the future of research
Two US-based teams, FigureTwo and Syntheos, have won Digital Science's 2025 Catalyst Grant for their innovative data visualization projects. FigureTwo transforms static figures into interactive visuals, while Syntheos maps ideas across research communities to show impact.
Article-level metrics would provide more recognition to most researchers than journal-level metrics
A study compares article-level metrics with journal-level metrics, finding that most influential papers are published in lower-tier journals. Article-level data provides more recognition to most researchers than journal-level metrics.
Social scientists say societal impact is the ultimate goal, finds global survey
A global survey of over 1,800 social science researchers reveals a significant disconnect between their goals to benefit society and the incentive structures that govern their careers. The study highlights the need for universities, funders, and publishers to foster research that prioritizes societal impact.
The UJI reflects on the scientific evaluation system and presents its team's vision
The UJI survey highlights issues with quantitative indicators, such as publication numbers and citations, that often overlook quality, social relevance, and working conditions. The university is addressing these concerns through its commitment to improving the scientific evaluation system.
The health impact of wildfires in Los Angeles County and Maui
Research shows that the 2025 Los Angeles wildfires resulted in an estimated 440 excess deaths, while the 2023 Maui wildfires led to immediate increases in suicide and overdose deaths. Higher social support was linked to improved mental health outcomes but did not buffer physiological effects.
Maximum Academic Press marks milestone: 8 journals awarded their first impact factor
Eight MAP journals have earned their first Journal Citation Reports (JCR) impact factors, demonstrating the strength of Maximum Academic Press's interdisciplinary community. The recognition is attributed to the editorial teams' dedication, peer-review processes' rigor, and published research's relevance to the academic community.
Parental technology use in a child’s presence and health and development in the early years
A study found that parental technology use in a child's presence was negatively associated with cognitive and psychosocial outcomes, as well as screen time among young children. The effect sizes were small, highlighting the need for further research on potential impacts on physical activity, sleep, and motor skills.
JMIR Aging launches new section focused on advance care planning for older adults
The journal will publish research exploring digital health and advance care planning for older adults, including caregiver integration and technological innovation support. JMIR Aging boasts a strong impact in the field, with a Journal Impact Factor of 5.0 and a CiteScore of 6.5.
Does teamwork fulfill the goal of project-based learning?
A study by Associate Professor Mitsuko Tanaka found that a good group work environment significantly increases motivation among English language learners, regardless of individual factors. The research suggests that educators should prioritize environmental preparation for successful project-based learning outcomes.
White-collar crimes: ‘Fall from grace’ and the stigma of reentry into society
A Florida Atlantic University study reveals that middle-class white-collar offenders face unique challenges during reentry into society, including stigma, anxiety, and fear of public exposure. Despite these challenges, they tend to secure employment and stable housing more easily than non-white-collar offenders.
GHG concentration and emissions vary seasonally and alongside human behaviors in estuaries
A two-year study found that anthropogenic activities significantly impact methane and nitrous oxide levels in the Pearl River Estuary. Seasonal variations also play a role, with reduced concentrations observed during COVID-19 lockdowns.
Miracle, or marginal gain?
A study by MIT economists suggests that industrial policy has a relatively limited impact on GDP growth, with average long-run gains of 1.08% in favorable circumstances. The research indicates that local consumer demand can curb the impact of industrial policy, putting a ceiling on directed growth.
JMIR Aging achieves top ranking, accepted into prestigious science citation indexes
JMIR Aging has achieved top ranking, with a Journal Impact Factor of 5.0, making it the #1 ranked journal in the 'Gerontology' category. The inclusion in SCIE and SSCI underscores its exceptional quality and impact.
Journal of the Royal Society of Medicine ranked in global top ten medical journals
The Journal of the Royal Society of Medicine has been ranked as one of the world's top ten general medicine journals by Clarivate's Journal Citation Reports. With an Impact Factor of 16.3, the journal has seen a significant increase from its 2018 figure of 3.538.
Researchers aim to spark action to address rising homelessness among older people
A new study provides a clear definition of late-life homelessness, which is shaped by age-based structures, social relations, and intersecting forms of oppression. The researchers argue that policy makers and professionals need a comprehensive understanding of this issue to effectively address it.
Smaller, more specific academic journals have more sway over policy
A new study by Duke University researchers reveals that smaller, specialized science publications have a disproportionate impact on conservation efforts. The team found that journals focused on specific regions or organisms were often cited more frequently by federal agencies than high-impact journals.
Research alert: Cannabis use linked to workplace absenteeism
A recent analysis found that cannabis use and cannabis use disorder are associated with increased workplace absenteeism. The study, published in the American Journal of Preventive Medicine, showed that even infrequent cannabis use can lead to more workdays missed due to illness or injury.
New insights into neural circuit imaging: A comparison of one-photon and two-photon techniques
A recent study by Harvard University researchers compares the effectiveness of one-photon (1P) versus two-photon (2P) voltage imaging in neural circuits. The study found that 2P excitation requires approximately 10,000 times more illumination power per cell compared to 1P excitation, posing significant challenges for 2P voltage imaging.
Work-related stress may increase the risk of an irregular heart rhythm
A new study found that job strain and effort-reward imbalance at work increase the risk of developing atrial fibrillation, an abnormal heart rhythm. The research suggests that recognizing and addressing psychosocial stressors at work can foster healthy environments.
Co-analysis of methylation platforms for signatures of biological aging in the domestic dog
A new study published in Aging explores the potential of three large DNA methylation datasets to identify biological age signals in dogs. The researchers found that biological age methylation clocks are affected by population stratification and require heavy parameterization to achieve effective predictions.
Roles of PEDF in exercise-induced suppression of senescence and its impact on lung pathology in mice
The study found that exercise increased PEDF levels in skeletal muscles and suppressed senescence markers in the lungs. PEDF also reduced senescence markers in multiple tissues and attenuated decline in respiratory function in pulmonary emphysema mouse model, suggesting its potential as a therapeutic agent for age-related diseases.
Aging retinal pigmented epithelium: Omics-based insights into vision decline
Researchers discuss the critical role of the retinal pigmented epithelium in human vision and its susceptibility to aging. The study highlights the importance of understanding molecular and cellular mechanisms driving age-related pathological changes in vision decline.
Senescent cell-derived vaccines: A new concept towards an immune response against cancer and aging?
Researchers describe a new concept for an immune response against cancer and aging using senescent cell-derived vaccines. The vaccines aim to stimulate the immune system against cancer cells and slow down or reverse aging-related diseases.
Global consensus for sarcopenia
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
Mitophagy and cancer: BNIP3/BNIP3L’s role in stemness, ATP production, proliferation, and cell migration
Researchers have developed a model to enrich sub-populations of cancer cells with high basal levels of mitophagy, promoting CSC features such as self-renewal, proliferation, and drug-resistance. This study highlights the importance of BNIP3/BNIP3L in maintaining cancer stem cell properties.
The aging brain and peripheral vascular dysfunction
A new review paper explores the mechanistic links between peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. The study suggests that targeting fundamental aging mechanisms may be a promising strategy to reduce dementia risk.
Depression, antidepressants, epigenetic age acceleration, and mortality in postmenopausal women
A new study reveals that depression and antidepressant use are associated with an increased risk of all-cause mortality in postmenopausal women. Epigenetic age acceleration, measured by GrimAge DNA methylation age acceleration, partially mediates the relationship between antidepressant use and increased mortality risk.
Serine racemase expression in the brain during aging in male and female rats
Researchers found a significant reduction in serine racemase protein levels in the medial prefrontal cortex and hippocampal subfields of aged rats compared to young rats, suggesting a role in age-associated decline of NMDA receptor function. No sex differences were observed in serine racemase expression.
Modulation of senescence features using weo electrolyzed water
Weo electrolyzed water (WEW) has been shown to attenuate cellular senescence in both normal fibroblasts and breast cancer cells. The study found that WEW modulated markers of cellular senescence, inflammation, and stress response genes in a cell type-dependent manner.
Germicidal lamps using UV-C radiation may pose health safety issues
Researchers investigated the biological repercussions of UV-C radiation exposure from readily available domestic lamps and found that even brief exposure can lead to irreversible alterations in skin cells and retinal cells. The study highlights the need to prioritize safe utilization of these lamps to prevent potential harm.
Age-associated gene expression changes in mouse sweat glands
Researchers investigated molecular changes in aging mouse sweat glands, finding 171 mRNAs enriched in secretory cells. Altered mRNA and protein abundance were associated with age-related declines in sweat gland function.
Association between neighborhood deprivation and DNA methylation in an autopsy cohort
Researchers found a significant association between neighborhood deprivation and DNA methylation in brain tissue, which may be linked to immune response. The study identified one CpG site (cg26514961, PLXNC1 gene) significantly associated with neighborhood deprivation after controlling for covariates.
The beginning of becoming a human
Researchers Polina A. Loseva and Vadim N. Gladyshev challenge the existing definition of human life, suggesting a new meaning for the 14-day stage in organismal life grounded in recent mechanistic advances and insights from aging studies. This stage defines the separation of soma from the germline and marks the boundary between rejuven...
Association of inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
A novel deep proteomic approach unveils molecular signatures affected by aging and resistance training
Researchers used a novel deep proteomics approach to investigate the effects of aging and resistance training on skeletal muscle. The study found that aging predominantly affects non-contractile proteins, while resistance training has minimal effects on protein abundance.
Identifying proteins causally related to COVID-19, healthspan and lifespan
Researchers identified 35-63 proteins affecting severe COVID-19, hospitalization, SARS-COV2 infection, and 4-32 proteins for healthspan and lifespan. Novel proteins involved in inflammation, immunity, apoptosis and metabolism were also found.
The coupling between healthspan and lifespan in Caenorhabditis depends on…
Researchers assessed swimming performance and survival under stress to evaluate the effects of three compounds on health and lifespan in Caenorhabditis. The study found complex relationships among median lifespan, oxidative stress resistance, thermotolerance, and mobility vigor.
The impact of ketogenic diets on cognitive behavior, motor function, and blood lipids
Researchers found that ketogenic diets reduced plasma levels of total Tau in females, mitigated elevations in plasma lipids, and improved circulating lipids. However, neither continuous nor intermittent ketogenic diets improved measures of cognitive or motor behavior in the TgF344-AD rat model.
Evidence of a pan-tissue decline in stemness during human aging
Researchers found that ~60% of tissues exhibit a significant negative correlation between age and stemness score, indicating a pan-tissue decline in stemness. This study adds weight to the idea that stem cell deterioration contributes to human aging, with hematopoietic stem cells from older individuals showing higher stemness scores.
Geraniol attenuates oxidative stress and cognitive impairment in mouse aging model
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
CMS121 mitigates aging-related obesity and metabolic dysfunction
Researchers found that CMS121 reduced body weight gain by 40% and improved glucose and lipid indexes in aging mice. The compound also showed anti-inflammatory effects and increased mitochondrial biogenesis, suggesting potential therapeutic applications for metabolic diseases.
Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
PR55α-controlled PP2A Inhibits p16 Expression and Blocks Cellular Senescence Induction
Researchers have discovered that PR55α, a regulatory subunit of PP2A phosphatase, inhibits p16 expression and blocks cellular senescence induction by γ-irradiation. This finding provides a new insight into the regulation of the p16/RB pathway in response to stressors.
“From Osimertinib to Preemptive Combinations” by Dr. Blagosklonny
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
Association of prenatal vitamins and metals with epigenetic aging at birth and in childhood
Researchers found associations between prenatal vitamin and metal exposures and epigenetic aging biomarkers in early life. A one standard deviation increase in essential metals was associated with lower Horvath EAA at birth, while arsenic was linked to greater EAA at birth and in childhood.
Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions
Researchers investigated the impact of senolytic treatments on DNA methylation clocks and epigenetic age. Results showed significant increases in epigenetic age acceleration with Dasatinib and Quercetin treatment, but not with Fisetin addition.
A call for standardization of controls in lifespan studies
The lack of standardized controls in lifespan studies leads to misleading outcomes and makes it difficult to compare results. Researchers propose solutions for quality control by checking inter- and intra-study consistency of lifespan data.
Mapping the core senescence phenotype of human colon fibroblasts
Researchers define a 'core senescent profile' in human colon fibroblasts, revealing potential driver proteins involved in CRC. The study's findings provide insights into therapies for improving overall health and preventing CRC.
New study: Defining the progeria phenome
Researchers have defined what a premature aging disease is and developed tools to diagnose progeria patients, allowing them to identify new syndromes. The study also identified correlations between progeroid syndromes and other conditions, providing a significant step forward in understanding premature aging.
GV1001 reduces neurodegeneration and prolongs lifespan in mouse model of Alzheimer’s disease
Researchers found GV1001 decreases BACE and Aβ1-42 levels, reducing neurodegeneration and senescence in 3xTg-AD mice. It also increases survival, telomere length, and telomerase activity, contributing to improved lifespan.
IL-17 promotes IL-18 production in osteoarthritis synovial fibroblasts via…
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
Epigenetic drift underlies epigenetic clock signals, but…
Researchers develop epigenetic clocks based on regional disorder of DNA methylation patterns, identifying common responses and critical differences from canonical clocks. These findings suggest a fundamental decoupling of epigenetic aging processes.
Going viral: New models show how human behavior influences pandemic trends
Researchers created mathematical models to examine aspects of human behavior affecting pandemic trends. They found that risk perception and adherence to preventive measures are crucial in understanding why similar policies resulted in different outcomes.
Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma
Researchers identified senescence-related tumor microenvironment genes associated with poor prognosis, genetic alterations, and reduced responsiveness to immunotherapy in HNSC. The study highlights the importance of precision medicine approaches for personalized treatment.
XRCC1: A potential prognostic and immunological biomarker in low-grade gliomas
Researchers found XRCC1 to have both positive and negative correlations with prognosis across different tumors. The study also revealed associations between XRCC1 expression and DNA methylation patterns, TMB, MSI, immune cell infiltration levels, and immune checkpoint gene expression.
Aberrant RBMX expression relevant for cancer prognosis and immunotherapy response
A new study reveals that RNA binding motif protein X-linked (RBMX) plays a crucial role in predicting cancer prognosis and response to immunotherapy. Abnormal expression of RBMX is associated with immune regulation, tumor microenvironment, and therapeutic effects of immune checkpoint inhibitors.
Exploring clonal hematopoiesis and its impact on aging, cancer, and patient care
Researchers discuss clonal hematopoiesis, a condition where cells harbor somatic mutations, and its association with aging, solid tumors, and treatment outcomes. Emerging evidence suggests that CH may play a role in cancer development and survival.
Systemic changes induced by ASCOT in plasma proteome of women with impaired ovarian reserves
Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.