Articles tagged with Open Access
The accumulation of nuclear lipid droplets (nLDs) is linked to metabolic conditions such as fatty liver disease, obesity-related disorders, and premature aging. Lifestyle interventions like caloric restriction can reduce nLD buildup, suggesting a potential therapeutic target for slowing cellular aging.
A recent study has explored a new imaging approach that uses swept-source optical coherence tomography to visualize the upper airway with high precision. By integrating computational fluid dynamics, researchers were able to identify areas of turbulence and pinpoint obstruction sites, leading to more accurate diagnoses and treatment pla...
Dr. Marco Demaria joins Aging-US as Editor-in-Chief with expertise in cellular senescence and aging research. He aims to develop new therapeutic approaches to mitigate age-related diseases.
Researchers developed a new tool to measure biological aging in individual cell types, providing insights into diseases like Alzheimer's and liver pathologies. The study found that certain brain cells and liver cells show signs of accelerated aging, making it a better tool for detecting diseases.
Genetic testing for cancer risk should always include healthcare providers and genetic counseling to ensure users fully understand their results and receive proper guidance. The authors call on the FDA to provide clear rules for using these tests, particularly for minors.
The journal Medicinal Plant Biology has been successfully indexed in Web of Science's ESCI, enhancing article visibility and positioning them for potential indexing in higher-level databases. This milestone reflects the journal's high quality and growth prospects, promoting open-access content to a broader academic community.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
A study published in Journal of Medical Internet Research found that open-world video games provide cognitive escapism, reducing stress levels and improving mental health. Popular titles like The Legend of Zelda: Breath of the Wild offer a sense of freedom and autonomy.
Three Nobel Prize-winners, Ben Feringa, Jennifer Doudna, and Kip Thorne, share their groundbreaking discoveries in molecular-level chemistry, genetics, and gravitational physics. Their articles inspire young readers to pursue STEM careers and explore the latest scientific advancements.
A new study found that heat therapy positively modulates multiple physiological parameters in APP/PS1 mice, with improved memory in males and worsening effects on females. This highlights the importance of personalized treatments based on sex-specific responses to therapy.
Researchers found significantly higher levels of p16INK4a in young people with sickle cell disease, indicating accelerated cellular aging. This discovery may lead to new treatments targeting cell aging and improved quality of life for SCD patients.
JMIR Aging has achieved top ranking, with a Journal Impact Factor of 5.0, making it the #1 ranked journal in the 'Gerontology' category. The inclusion in SCIE and SSCI underscores its exceptional quality and impact.
Researchers have developed a new generation of cell-penetrating antibodies that can target cancer cells and deliver therapeutic molecules directly into tumor cells. The 3E10 antibody shows great promise for treating cancers with defective DNA repair pathways.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
Marco Celotto and Simone Russo were awarded the Lagomarsino Prize for their groundbreaking research in neuroscience, which combined excellent scientific results with outstanding methods for data analysis, data management, and Open Science. Their work has led to pioneering discoveries on brain stimulation and its potential applications ...
PLOS has been awarded a $3.3 million grant from the Bill & Melinda Gates Foundation to transition towards APC-free publishing and promote open access options for authors without funding. The grant will also support improvements in funding metadata capture and peer review transparency.
A new research paper published in Oncotarget introduces an innovative AI tool combining CT scans and body composition data to predict severe liver problems in primary sclerosing cholangitis (PSC) patients. The model achieved impressive results, correctly identifying at-risk patients with 97% accuracy.
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
The latest report in the State of Open Data series provides quantitative analysis on the growth of open data sharing globally. Key findings show a strong growth in papers linking to data from universities, and policies for open data sharing are now more consistent globally.
A new review reveals how sleep disturbances exacerbate dementia symptoms, impacting overall health and caregiver well-being. The study emphasizes the need for holistic approaches to address coexisting conditions like cardiovascular disease and diabetes.
This editorial introduces persistence landscapes as a mathematical method to identify and correct biases in medical imaging. Persistence landscapes offer a way to reduce random noise while preserving important details, making it easier for clinicians to focus on meaningful image parts.
The Institute of Open Science Practices (IOSP) is hosting its inaugural global conference, exploring cutting-edge scientific infrastructure and open science principles. Notable members will discuss technologies that make open science the default practice across diverse academic fields.
Research highlights Nup93's critical role in endothelial cell function and vascular health, with promising findings for new treatments to slow down aging. Low Nup93 levels are associated with inflammation and cellular aging, while restoring its levels can reverse harmful effects.
Researchers introduce a new tool called 'persistence images' that uncovers hidden biases in medical imaging data, advancing fairness in healthcare AI. The technology helps detect bias, filter out noise, and improve overall accuracy, leading to more reliable diagnoses and better patient outcomes.
The journal Technology in Horticulture has been successfully indexed in ESCI, enhancing its discoverability and potential indexing in higher-ranked databases. This recognition promotes open-access content and academic exchange worldwide.
This systematic review analyzes 33 biological clocks used for aging and mortality quantification, categorizing them into epigenetic and phenotypic clocks. Epigenetic clocks demonstrate precision in estimating chronological age through DNA methylation, while phenotypic clocks predict mortality using easily measurable clinical variables.
Researchers introduce persistence barcodes, a tool that reduces diagnostic bias and uncovers subtle details in medical images. The method preserves key structural details, enabling clearer insights into the data.
The journal welcomes Dr. Ana Novoa Perez, Prof. Tammy Robinson, Prof. Phil Hulme, and Dr. Andrew Liebhold to bring expertise in invasion science, aiming to expand global reach and impact.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
The Making Sense of Science series aims to develop dialogue on the role of science in informing policies, bridging gaps between scientific knowledge and societal needs. Experts discuss the importance of public trust in scientific knowledge and the need for co-design that reflects multiple stakeholders' aspirations.
The MIT Press has released a comprehensive report on the future of open access publishing and policy, addressing key research questions to advance sustainable open science practices. The report builds an evidence base to support the impact of open access policies on research ecosystems.
A new approach using topological data analysis (TDA) enhances the reliability and reduces bias in AI systems used for medical diagnosis in radiology. TDA captures intricate features and provides a holistic view of medical images, leading to more accurate diagnoses and equitable patient care.
The International Mycological Association has partnered with Pensoft to transition its flagship journal, IMA Fungus, to the ARPHA publishing platform. The new collaboration aims to improve and streamline the publication process, providing faster review cycles and more efficient communication.
Researchers explore potential synergies between chemotherapy, cannabinoids, and intermittent serum starvation in treating colorectal cancer. Combining these therapies could create a strong synergy by depriving cancer cells of glucose, making them more susceptible to treatment.
Researchers are conducting a multi-year study to understand small airway abnormalities and their role in emphysema development. The SPIROMICS Study of Early Disease Progression (SOURCE) aims to provide novel insights into COPD progression and inform the development of new therapies.
Researchers developed a new photoacoustic imaging technique that addresses skin tone bias in breast cancer detection. The technique, combined with specific wavelengths and beamforming methods, enhances target visibility across all skin tones, providing clearer images with improved signal-to-noise ratios.
Pensoft Publishers will host a side event at COP29, showcasing the impact of open science on effective policy-making. The event aims to demonstrate how open-access research informs evidence-based policies, enabling successful implementation of biodiversity and climate frameworks.
Researchers from Indiana University have uncovered how the EphA2 protein receptor contributes to cataract formation. The study found that canonical ligand-dependent EphA2 signaling remains stable in aging lens tissue, while non-canonical signaling increases with age, affecting lens fiber cell maturation.
The review explores the impact of extracellular matrix (ECM) geometry on immune cell behavior and treatment efficacy. Specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), create physical barriers that limit immune cell access to tumors.
A new study introduces the Meuhedet Electronic Frailty Index (MEFI) to assess frailty in older people and identify those at risk for serious health outcomes. The index classifies individuals as 'fit,' 'mildly frail,' or 'severely frail' and has been shown to predict mortality and hospitalization with high accuracy.
The Collective Pathway to Open Publishing (CPOP) pilot program aims to support Humanities and Social Sciences (HSS) journals by combining OA agreements with 'read' income. CPOP will make all articles in participating journals open access if thresholds are met, expanding their international reach and impact.
AI models trained on limited data may misdiagnose certain populations, particularly those in underserved communities. Researchers propose six key strategies to develop fair AI models, including using diverse datasets and transparent decision-making processes.
Research found that iron oxide nanoparticles reduce the lifespan, longevity, and reproductive ability of Enchytraeus crypticus in a 202-day study. Population density may influence nanoparticle toxicity, with lower-density groups experiencing greater harm.
Researchers analyzed tumor samples from 64 SCLC patients, identifying promising results for biomarkers DLL3 and TTF-1. These biomarkers showed potential as targets for therapies like Tarlatamab and improved survival rates in patients with TTF-1-positive tumors.
Researchers discovered Werner syndrome gene WRN plays a crucial role in maintaining constitutive heterochromatin structure, essential for DNA stability. Loss of WRN function disrupts protein interactions, potentially accelerating aging due to cellular disorganization.
Researchers document remarkable response to pembrolizumab in patient with metastatic adenosquamous pancreatic cancer (ASCP) and KRAS G12C mutation. The study highlights potential shift in treatment of ASCP, a rare form of pancreatic cancer traditionally underserved by current therapies.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
Researchers discovered that tumor dormancy in breast cancer can be triggered by specific signaling changes within small cell clusters, called tumor emboli. Key mechanisms include reduced activity of mTOR and structural shifts in E-cadherin, which are regulated by the PI3K pathway.
Researchers developed a large-scale optical programmable logic array that can execute complex models like Conway's Game of Life, marking a significant advancement in optical computing. The array uses parallel spectrum modulation to achieve an 8-input system, significantly expanding the capabilities of optical logic operations.
Researchers at UCLA developed a new type of imaging technology that forms images in only one direction, enabling efficient and compact methods for asymmetric visual information processing and communication. The technology works exceptionally well under partially coherent light, achieving high-quality imaging with high power efficiency.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
Researchers propose a comprehensive biomarker-based approach to assess cardiovascular risk by combining markers of chronic inflammation with cardiac health indicators. This approach reveals the significant impact of aging-related inflammation, or 'inflammaging,' on heart health and opens new avenues for targeted interventions.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Researchers humanize the lupus-derived autoantibody 3E10, preserving its therapeutic efficacy, to create novel cell-penetrating antibodies targeting tumors and RAD51. Humanized variants exhibit faster cell uptake and superior in vivo tumor targeting.
Researchers reported a complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer patient with brain metastases. The patient achieved overall survival of 87 months and progression-free survival of 73 months after treatment sequencing.
A new study found that fibroblast growth factor 21 (FGF21) is an independent predictor of all-cause mortality in older adults. The Polsenior2 study revealed that middle and high FGF21 levels were associated with increased mortality risk, particularly when adjusted for age, co-morbidities, and blood parameters.