News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
Researchers discovered a new type of jeilongvirus in a Florida mouse, which can infect humans and non-human primates, posing a risk of serious illness. The virus is genetically distinct from others and can cause disease in various species.
Researchers found that Weddell seals strategically conduct extreme dives earlier in the day to maximize their oxygen stores and foraging success. By avoiding midday dives, the seals can spend more time underwater, taking advantage of high-light conditions, which is ideal for visual hunting.
Dr. Andero Galí's groundbreaking research connects mouse and human fear responses, using techniques like in vivo calcium imaging in mice and human fear response studies. His approach aims to create a more comprehensive understanding of the human brain by breaking down traditional barriers between animal and human studies.
A targeted outreach initiative in Palm Beach County led to an increase in reported sightings of invasive reptiles, including Nile monitors and Argentine black-and-white tegus. The effort engaged over 112,000 people and resulted in 55 reported sightings, highlighting the effectiveness of community involvement in detecting invasive species.
A new study found that older macaques with smaller social networks suffer less from infectious disease. The research suggests a powerful reason for reduced social connections in aging animals, including humans.
Researchers have found that Burmese pythons can swallow deer and other large prey whole, with a gape circumference of over 81 centimeters. This increased capacity could lead to a significant impact on native wildlife populations in Florida and potentially beyond.
A team of researchers at the University of Toronto has developed a rapid screening system to identify compounds that can stop the growth of amyloid proteins. The study found 40 compounds that demonstrate the ability to inhibit amyloid formation, providing a promising lead for future disease treatments.
Researchers found a highly pathogenic H5N1 strain isolated from a dairy worker that killed all infected ferrets, but the worker experienced mild symptoms and recovered. The study suggests that this particular strain may have died out and has not been detected in nature since.
A new co-culture system uses photosynthetic microorganisms to remove waste products and enhance muscle cell growth, resulting in a 30% reduction of lactate and over 90% reduction of ammonia. This innovation provides a low-cost, sustainable alternative to animal serum for cultured meat production.
Researchers studied an isolated population of sparrows on Lundy Island and found that older birds tend to have fewer friends, similar to humans. The study suggests that there is no 'evolutionary pressure' to maintain social connections in older age, leading to a decline in friendships.
A new study reveals that Oriental hornets are the only animals capable of consuming high concentrations of alcohol chronically without ill effects. The research found that the hornets metabolize alcohol rapidly and show no signs of intoxication or illness, even after consuming high amounts.
A comprehensive study examining over 16,000 necropsy records from 292 vertebrate species found significant differences in cancer prevalence. Cancer rates increase with body size and cellular mutation rates but decrease with longer gestation periods.
A Simon Fraser University study ranks Canadian terrestrial vertebrates by their level of evolutionary distinctness, finding that amphibians and reptiles are the most distinct species. The spiny softshell turtle is the most evolutionarily distinct terrestrial animal in Canada.
Researchers identified a key gene pathway involving zinc that improves survival and weight gain in mouse models with short bowel syndrome. Zinc-based supplements were shown to improve intestinal function, absorb nutrients, and fluids, leading to better recovery rates.
A study in mice reveals that individualistic reward-seeking strategies predict responses to nicotine, with profiles influenced by personality traits and dopamine activity. The findings suggest environmental adaptations shape behavioral traits and sensitivity to nicotine, potentially contributing to addiction susceptibility.
Researchers found that 57% of tested chemicals altered fruit fly larvae behavior significantly, even at non-lethal doses. Long-term survival was compromised in a dose-dependent manner, with a 60% drop in egg-laying rates observed among exposed mosquitoes and Painted Lady butterflies.
A new study published in PLOS Biology suggests that male birds contribute less to helping their families because they prioritize scouting for new habitats and breeding opportunities. This trade-off with dispersal may explain why one sex invests more in family help than the other across various animal societies.
A study by a University of Mississippi professor found that the vocalizations of baby chickens, known as 'peeps' and 'whistles', can indicate stress levels in avian animals. This breakthrough could improve animal welfare in the poultry industry and lead to more humane practices.
A study across 292 species found that neoplasia (uncontrolled growth) rates decrease with longer gestation times, while malignancy rates increase with higher adult masses. This contradicts Peto's paradox and suggests complex interactions between life history traits.
Fossils from over 600,000 years ago show a shift in animal communities between warm and cold climate fluctuations. The Notarchirico site provides evidence of the emergence and disappearance of species such as cave lions, straight-tusked elephants, and red deer.
A new parasite, Pachysentis canicola, has been discovered on the Channel Island fox, causing severe intestinal damage and inflammation in infected individuals. The study highlights the importance of biosecurity in the Channel Islands National Park and underscores the impact of human activity on isolated ecosystems.
A new tracking method using mobile phone networks and Bluetooth technology provides reliable high-frequency tracking data for urban living animals. Field testing with birds demonstrated the feasibility of this approach to study movements and social networks.
The study found that uneven distribution of resources gives some individuals more access to play than others. Wildlife is a major draw for nature-based tourism, but human recreation has unintended consequences for biodiversity. To coexist with wildlife, it's essential to follow common-sense rules and minimize disturbance.
Researchers at USC Dornsife discover that mifepristone increases mitophagy to the same extent as rapamycin, potentially extending lifespan. The study found that combining the two drugs does not offer additional benefits and slightly reduces lifespan, suggesting they act through the same biological pathway.
Researchers at SFSU have created three-dimensional molecular and anatomical maps of the inner neuronal circuitry of octopus arms. These 3D reconstructions revealed that cells at the tip of an arm are different from those at the base, allowing for new questions to be posed about how cells communicate with one another.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
The international project will analyze temperature-sensitive proteins in animals adapted to different thermal environments to understand how they perceive temperature changes. The study aims to uncover the molecular mechanisms underlying cold perception in animals, enabling them to initiate physiological responses crucial for survival.
A new study by researchers from The Hebrew University of Jerusalem challenges conventional beliefs about decomposition processes in arid environments. Larger insects such as termites and beetles play a crucial role in decomposition, with peak rates during the summer in arid sites.
A KAUST-led global study found that livestock management and climate explain woody species coverage in arid environments. Managing grazing pressure and type of herbivore can allow for more sustainable production in these ecosystems.
Histomonosis, a deadly parasite that decimates turkey flocks, is being studied for its transmission routes and potential treatments. Researchers aim to understand how the parasite survives and spreads, with a focus on fecal-oral transmission via contaminated feces or cecal droppings.
A research team, led by Francesco Ferretti, located signs of white sharks at four sites in the Sicilian Channel, a stronghold of the endangered species. The team used improved methods and technologies, including eDNA sampling and camera traps, to detect the presence of the sharks.
Researchers from UT Arlington sequenced RNA genes of pythons, discovering conserved pathways in humans that are activated uniquely by these snakes. This knowledge helps explain intestinal regeneration and metabolism changes, offering potential therapeutic targets.
Dr. Wai Hong Lo, PhD, has been appointed as the new Editor-in-Chief of ASSAY and Drug Development Technologies, succeeding Dr. Bruce Melancon. Dr. Lo aims to enhance online accessibility, incorporate visuals, and increase social media engagement to reach a broader audience.
Researchers found Edaravone inhibits growth of brain tumor stem cells and prolongs survival in mice with glioblastoma. The study suggests repurposing Edaravone as a potential treatment for this aggressive brain cancer.
Providencia rustigianii carries a type III secretion system and cytolethal distending toxin virulence gene, increasing its pathogenicity, similar to Salmonella.
Glioblastoma, the most malignant primary brain tumour, has an 18-month median survival rate despite treatment. New research from the University of Ottawa suggests a drug used to slow ALS progression may also suppress glioblastoma's self-renewing cancerous stem cells.
A new study found that artificial nests outperform natural nests in boosting African penguin breeding success by 16.5%, but each type of nest has strengths and weaknesses. Colony-specific conservation strategies are needed to address the unique threats faced by each colony.
Researchers developed a new algorithm to decode neural signals representing hand postures, enabling more precise control of neuroprostheses. The study, conducted on rhesus monkeys, shows that posture-related activity in the primate grasping circuit is crucial for accurate control.
A recent study employs zebrafish to model Nager syndrome, revealing the role of sf3b4 mutations in facial development and apoptosis. The research suggests that FGF8 plays a critical role in disease pathogenesis and provides a potential therapeutic strategy.
A study has revealed that the cpb2 gene enhances the persistence of C. perfringens in swine, with potential implications for disease management. The researchers found that cpb2 is associated with host species-specific adaptations, particularly favoring the porcine intestinal environment.
A study published in Biology Letters reveals that harbor seals in Alaska's Iliamna Lake are genetically isolated from other seal populations across the Pacific. The researchers found significant differences between the lake seals and marine populations, suggesting they may be a unique endemic form of harbor seal.
Researchers detected microplastic particles in the breath of wild bottlenose dolphins, suggesting inhalation may be a key route of exposure. The study supports the idea that dolphins could be exposed to potentially harmful microplastics through this pathway.
Wildlife rangers from the Uganda Wildlife Authority successfully monitored lion populations in the Murchison Falls Nile Delta, estimating a density of 13.91 lions per 100 km². The study highlights the cost-effectiveness and value of rangers' skills in conservation efforts.
An international team of researchers has discovered seven new species of tree frogs in Madagascar, characterized by their high-pitched whistling calls. The unique vocalizations are believed to serve as self-promotional advertisement calls to convey information about the male frog's suitability as a mate.
Researchers found that male mice deescalate aggressive encounters by running over to a female mouse to distract the aggressive male mouse. This 'bait-and-switch' tactic reduces further conflict and helps maintain social hierarchy in groups of mice.
A recent study led by University of Wyoming scientists found that managing free-roaming horses within the Bureau of Land Management's maximum appropriate management levels would benefit sage grouse populations. Grazing by wild horses can reduce shrub density, vegetation cover, and abundance of key forbs used by sage grouse.
In a study published in Journal of Evolutionary Biology, researchers found that mountain chickadees sing differently than their close relatives, the black-capped chickadee. The birds' unique songs help them distinguish between friends and foes, reducing interbreeding and competition.
Researchers at University College Cork found that wild birds' gut microbiome impacts their growth, weight, and survival. The study manipulated the birds' microbiome by feeding them beneficial bacteria Lactobacillus kimchicus.
A novel nanoparticle therapy targets fat absorption in the small intestine, showing significant potential to prevent diet-induced obesity. The treatment involves inhibiting an enzyme called Sterol O-acyltransferase 2 (SOAT2), which plays a critical role in fat absorption.
In a 30-year experiment, scientists witnessed rapid evolution of marine snails in response to pollution and climate change. The snails' adaptation was driven by genetic diversity and gene flow from neighboring populations, allowing them to rapidly adapt to their new environment.
Researchers investigate how liver necroptosis triggers inflammation in both organs, leading to cognitive impairment. Studying aging mouse models, they found that liver necroptosis causes systemic inflammation affecting brain function.
Carl-Philipp Heisenberg, a developmental biologist, has received a five-year €1M NOMIS grant to investigate the role of cytokinesis in early embryo development. His research aims to challenge the current understanding and uncover the mechanisms that shape complex life forms.
Researchers used fluorescein angiography to visualize neural blood flow in rats and rabbits with chronic nerve compression neuropathy, correlating findings with electrodiagnostic testing. The study showed promising results for the method's potential to improve diagnosis and treatment outcomes in carpal tunnel surgery.
Researchers have developed a cell culture platform to form two distinct, interconnected vascular networks, replicating human physiology and reducing animal testing costs. This breakthrough enables the study of cellular interactions in vascularized tissues.
A new study uses insect evidence from illegally killed rhinos to determine the post-mortem interval. This technique has been used to construct cases against poachers and has led to a rebound in rhino populations over the past 30 years.
A new University of Colorado Boulder study sheds light on why paternal mitochondrial DNA is eliminated during development. The research found that delaying this process can lead to lasting neurological and behavioral problems in adults. Treatments such as Vitamin K2 may offer new hope for preventing or treating these disorders.
A study published in Scientific Reports found that rats' social structures are more complex than previously thought, with varying patterns of dominance and coexistence. The researchers' findings suggest that psychiatric medications may need to be re-evaluated due to the complexity of rat social dynamics.
A recent study by The Jackson Laboratory reveals that reducing calorie intake can significantly extend the lifespan of mice, with the most robust animals living the longest. However, the researchers found that losing weight on these diets had a negative impact on lifespan in humans.
A new study published in Journal of Biogeography finds that malaria-like blood parasites increase in prevalence with the number of bird species present, highlighting the importance of host diversity. The research also shows that parasites can spread more rapidly when they specialize in closely related or functionally similar bird species.
A recent study by Imperial College London has found that dogs swimming in contaminated ponds are releasing harmful levels of two pesticide medications. The chemicals, imidacloprid and fipronil, were used as flea and tick treatments for cats and dogs, posing a significant threat to aquatic life.