Researchers discovered that cyclotides from violets increase the power of TMZ in killing glioblastoma cancer cells by up to eight-fold. This breakthrough could lead to better treatment options for patients with this fatal form of brain cancer.
Researchers at the University of Bristol have reduced simulation time for an optical quantum computer from 600 million years to just a few months, achieving a one-billion-fold speedup. This breakthrough paves the way for future studies on quantum advantage and computational power.
University of Rochester researchers adapt excited state lifetime thermometry to extract temperatures of nanoscale materials from light emitted by nitrogen vacancy centers in single nanodiamonds. The technique allows for precise measurement of temperature changes on fast time scales and is safe for imaging sensitive nanoscale materials ...
Case Western Reserve University researchers create nanoparticles that generate a protein mesh to stabilize blood clots and reduce blood loss. The technology could help save lives by rapidly stabilizing clots to reduce blood loss from traumatic injuries.
New research reveals that zoos and aquariums can prioritize evidence-based environmental enrichment to benefit a wider range of species. The study highlights the need for greater diversity in enrichment types and species researched, as well as more attention to social enrichment.
A new study published in the British Journal of Sports Medicine found that resuming non-contact physical activity 72 hours after a concussion is safe for children and youth. The study, which involved 456 participants, showed that early return to physical activity can reduce symptoms and delayed recovery.
Recent experiments achieved a burning plasma state in fusion, helping steer fusion research closer to its ultimate goal of a self-sustaining reaction. The results showed gradual improvements that could keep more energy inside the reaction, representing a significant step toward self-sustaining fusion.
A recent study found that people with Parkinson's Disease who consume more flavonoids have a lower mortality risk than those who don't. The researchers discovered that higher flavonoid intake is associated with improved survival rates in both men and women, particularly when it comes to anthocyanin-rich foods like berries and red wine.
Researchers have identified 15 biological markers that can predict severe depression in pregnant women with 83% accuracy. This finding has the potential to improve prenatal care and reduce depressive symptoms in mothers.
Researchers from NC State University have demonstrated a new type of flexible robotic gripper that can lift delicate egg yolks without breaking them. The grippers use a kirigami technique to convert 2D sheets into curved 3D structures, allowing for precise control over the final shape and structure.
A national survey reveals that over 85% of primary care practices struggle to access pediatric medication advice and evidence-based psychotherapy. Policy changes may be necessary to address these barriers and improve child behavioral health treatment.
A bibliometric analysis of Annals of Family Medicine submissions from 2015 to 2020 found that women represented 46.33% of all manuscript submissions during the COVID-19 pandemic. Women submitted fewer original research articles and briefs than men, potentially impacting future promotions.
The increasing salinity in freshwater habitats poses a significant threat to biodiversity and ecosystem services. The study proposes a research agenda to address the knowledge gaps and tackle the urgent needs from a global, regional, local, and temporal perspective.
Researchers analyzed 54,045 georeferenced pieces of building timber to track changes in building activity across Europe from 1250 to 1699. They found clear evidence for the Late Medieval Crisis, the Thirty Years' War, and economic boom periods, with building activity tracking historical price of grain and lead pollution.
Researchers employed microscopy techniques to study the atomic structure and vibrations of perovskite oxides in superlattices. The discovery enables the rational design of materials with unique photonic and phononic properties.
Research published in PLOS ONE found that flat-faced breeds like Neapolitan mastiffs and English bulldogs are disproportionately affected by the condition. The study suggests that breed-specific characteristics may contribute to the development of cherry eye.
Researchers from Swansea University and University of Cape Town used GPS collars to study baboons' collective behavior in urban and natural spaces. The study found that despite changes in movement patterns, leader-follower roles remained consistent, suggesting flexibility and robustness in group cohesion.
Researchers studied Paradise, California's response to the 2018 Camp Fire. They found that community responses vary greatly due to distinct fire and demographic characteristics.
Researchers developed MonoCon, a new AI technique that enables accurate identification of 3D objects in 2D images. By incorporating auxiliary context, the method improves object detection and estimation accuracy, paving the way for safer and more robust autonomous vehicles.
A new study published in Environmental Research found that dust removal does not mitigate exposure to TDCIPP, a carcinogenic chemical commonly used in automobile seat foam. The researchers suggest that wearing a mask in the car may be an effective way to reduce exposure.
Researchers found that males keep track of the order of their songs and how often each one is sung for up to 30 minutes. This complex behavior allows them to curate both their current playlist and the next one, with variations in song order and repeats.
A virtual reality 'Shopping Task' has been developed to measure cognition and assess age-related decline. The study found that the immersive environment engaged key brain structures, including the hippocampus and entorhinal cortex.
Researchers discovered adaptations allowing desert fish to thrive in harsh conditions by maintaining genetic diversity and adapting genes for aridity. This finding challenges the idea that small populations are evolutionary dead ends.
A recent study by Cardiff University found that urban greening strategies like green roofs and parks are unlikely to reduce both heatwaves and flooding simultaneously. The team's research suggests that local climate conditions significantly impact the effectiveness of these measures.
Proton pump inhibitors are underutilized in high-risk patients due to knowledge gaps and barriers among specialties. Multi-component interventions can improve guideline-based use to prevent upper gastrointestinal bleeding.
Lab tests show current anti-COVID pills remain effective against omicron, but available antibody therapies are substantially less effective. Researchers tested various treatments and found that some antibodies have lost their ability to neutralize omicron at realistic dosages.
A mixed-method review and meta-analysis found that integrated palliative care in ambulatory settings has limited effect on reducing symptom burden, but improves health care utilization for U.S. adults with non-cancer related chronic illnesses. The models were also effective in increasing advanced directive documentation.
A recent study by University of Pittsburgh biologists found a wide range of plant viruses associated with pollen grains from 24 plant species across the US. The research, published in Nature Communications, identifies six new species and three variants of known viruses, highlighting the potential for honeybees to spread these diseases.
Common chronic conditions like high cholesterol, pulmonary diseases, and anxiety disorders saw significant declines in new diagnoses during the COVID-19 pandemic. A substantial increase in primary care physicians, face-to-face visits, and proactive care is needed to address this decline and prevent poor health outcomes.
Researchers at OHSU are developing a new approach to scientific imaging to study the dynamic organization of cells by examining how tiny molecules make cells work. The W. M. Keck Foundation has awarded $1 million to develop a one-of-a-kind imaging and computational system.
Researchers have developed a novel combination of two drugs delivered in nanoparticles that extend the survival of mice with medulloblastoma. The treatment targets the mTOR pathway and reduces off-target toxicity, making it a potential less toxic alternative to current treatments.
Researchers report successful treatment of two young infants with PROS using breast cancer drug alpelisib, inducing rapid and significant clinical improvement in symptoms. The treatment was well-tolerated and showed promising results, supporting the use of low-dose alpelisib in these patients.
Researchers found that vitamin D and/or omega-3 fatty acid supplements significantly lowered the rate of autoimmune diseases like rheumatoid arthritis, polymyalgia rheumatica, and psoriasis. The largest benefit was seen after two years of supplementation with daily doses of vitamin D (2000 IU) and marine omega-3 fatty acids (1000 mg).
Scientists at Weill Cornell Medicine developed a new imaging technique to capture bacteriorhodopsin's motions in response to light on a millisecond time scale. This study reveals the protein's kinetics, including the speed of transitions between open and closed states, which informs optogenetics research.
The study found that black carbon decreased significantly in Beijing since the implementation of the Clean Air Action Plan, with a 71% reduction over nine years. However, this decrease was not accompanied by an equivalent decrease in aerosol extinction coefficient, leading to mixed effects on optical properties.
A study published in PLOS ONE found that younger people are more interested in owning exotic pets, such as pythons, than older generations. The research suggests a growing trend towards unusual pet ownership among younger populations.
A recent study from Ohio State University found that labeling identical products as 'new and improved' resulted in higher overall liking ratings compared to those labeled as 'consumer complaint.' The researchers suggest that this negative bias has a bigger impact on consumer perception than positive labels.
A study from Johns Hopkins Malaria Research Institute uses CRISPR/Cas9 gene-editing to delete a protein called CTL4 from mosquitoes, resulting in a 64% decrease in infection prevalence. The researchers believe targeting the CTL4 protein could be a new strategy for controlling malaria.
A team of researchers from Japan Advanced Institute of Science and Technology successfully detects thermally excited magnons in a yttrium iron garnet sample using a diamond-based quantum sensor. This breakthrough enables the detection of thermal magnon currents, opening doors to heat-controlled quantum devices.
A new UBC study confirms that men are at increased risk of mental illness, including anxiety and depression, when they transition out of relationships. The study found that men often downplay issues in their relationships, leading to further conflict, and may turn to substances to cope with feelings such as anger and regret.
A study found that team-based primary care, coupled with payment reform, can reduce emergency department use among patients. The analysis showed lower rates of increase in ED visits among those transitioning to a team-based capitated practice compared to non-team-based capitated practices.
University of Delaware professors Wei-Jun Cai and David Kirchman have been named AAAS Fellows for their important contributions to STEM fields. Cai was recognized for his work on the global carbon cycle and ocean acidification, while Kirchman was honored for his research on marine biosciences and microbial ecology.
Researchers found that cancer immunotherapy pembrolizumab can reverse HIV latency, allowing killer T cells to regain function and kill infected cells. The treatment, which blocks exhaustion markers, also perturbs the HIV reservoir, showing promise for a cure.
A new analysis predicts climate change will decline suitable regions for coffee arabica, cashews, and avocados in major producing countries. Suitable areas may expand at higher altitudes and latitudes, particularly for cashews and avocados.
A study published in Scientific Reports uses fossilized mollusk shells to investigate ocean chemistry during the end-Permian mass extinction. The analysis found no signs of severe ocean acidification, contradicting previous theories.
Researchers at UCI discovered that AdipoR1 protein deficiency leads to ceramide accumulation in the retina, causing progressive photoreceptor cell death. A pharmacological treatment combining desipramine and L-cycloserine reduced ceramide levels, protecting photoreceptors and improving vision.
A new study reveals that the genes present in a microbial community can predict its dynamic metabolic activity, with implications for the nitrogen cycle and other biogeochemical processes. The research provides insights into how scientists can infer metabolite dynamics from aggregate gene content, design microbial communities for speci...
Researchers created a computer model that simulates the way slime moulds construct their network, finding networks with improved travel time or resilience to disruption. The models were validated using three key metrics and showed good correlation with actual slime mould results.
Researchers have developed a compact terahertz laser that operates at room temperature and produces 120 individual frequencies spanning the 0.25 - 1.3 THz range. This breakthrough technology has the potential to bridge the gap for applications in imaging, security, and communications.
Dr. John Pierce Wise leads a team to investigate chromosome instability in lungs caused by metal exposure, with hopes of preventing and reversing lung cancer in people. The research aims to understand why humans are more susceptible to metals-induced lung cancer than whales.
Researchers identified the 'key' controlling potassium ion flow across cell membranes, resolving a decades-old problem and providing a new understanding of how channels are gated. The discovery has potential implications for treating diseases such as cancers, epilepsy, and diabetes by targeting ion channel deregulation.
Scientists confirmed the fourth signature of superconducting transition in cuprates, revealing how electrons pair up and condense into a quantum condensate. The discovery provides a holistic picture of unconventional superconductivity and gives researchers two knobs to tune for higher temperatures.
Researchers found that runners can maintain their natural stride with heavily cushioned shoes, contrary to previous assumptions. The study used custom sandals to measure leg stiffness and running style, revealing no significant impact from shoe cushioning.
A KAIST research team has developed graphene-inorganic-hybrid micro-supercapacitors made of leaves using femtosecond direct laser writing lithography. The innovation enables mass production of flexible and green graphene-based electronic devices, reducing waste and environmental issues associated with traditional batteries.
A national survey of over 900 youths found that knowledge of health risks associated with unprotected oral sex is a significant barrier to using protection. Many respondents reported a lack of information about adequate protection methods and underestimated the severity of risk.
A new study from Queen Mary University of London demonstrates the effectiveness of a compact Covid-19 testing kit, which uses low-cost hardware and is relatively inexpensive to make. The kit offers a promising solution for remote areas with limited access to well-equipped testing labs or trained personnel.
Researchers developed AI models trained on clinical data from a statewide health information exchange to predict healthcare resource utilization for individuals with COVID-19. The models demonstrated accurate public health predictions and provided valuable insights into patient-level need for healthcare resources.
A team of astronomers has discovered a mysterious object releasing giant bursts of energy three times an hour, which could be a neutron star or white dwarf with an ultra-powerful magnetic field. The object is incredibly bright and smaller than the Sun, emitting highly-polarised radio waves.
Researchers at Flinders University found that autistic individuals with eating disorders also report higher weight and shape concerns, suggesting a unique combination of symptoms. The study highlights the need for best-practice guidelines to address co-occurring autism and eating disorders in treatment.
Researchers discovered that Chaoborus larvae adjust their air-sacs' volume by changing the pH level, utilizing resilin's elastic properties. This unusual adaptation enables them to float neutrally buoyant in water.